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Low-density lipoprotein receptor-related protein

 A0A0G2K0H3_RAT          Unreviewed;      1613 AA.
A0A0G2K0H3;
22-JUL-2015, integrated into UniProtKB/TrEMBL.
22-JUL-2015, sequence version 1.
20-DEC-2017, entry version 26.
RecName: Full=Low-density lipoprotein receptor-related protein {ECO:0000256|PIRNR:PIRNR036314};
Name=Lrp6 {ECO:0000313|Ensembl:ENSRNOP00000071445,
ECO:0000313|RGD:1304749};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000071445, ECO:0000313|Proteomes:UP000002494};
[1] {ECO:0000313|Ensembl:ENSRNOP00000071445, ECO:0000313|Proteomes:UP000002494}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000071445,
ECO:0000313|Proteomes:UP000002494};
PubMed=15057822; DOI=10.1038/nature02426;
Rat Genome Sequencing Project Consortium;
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
Collins F.S.;
"Genome sequence of the Brown Norway rat yields insights into
mammalian evolution.";
Nature 428:493-521(2004).
[2] {ECO:0000313|Ensembl:ENSRNOP00000071445}
IDENTIFICATION.
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000071445};
Ensembl;
Submitted (JUN-2015) to UniProtKB.
-!- FUNCTION: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers
beta-catenin signaling through inducing aggregation of receptor-
ligand complexes into ribosome-sized signalsomes.
{ECO:0000256|PIRNR:PIRNR036314}.
-!- SUBUNIT: Homodimer; disulfide-linked. Forms phosphorylated
oligomer aggregates on Wnt-signaling.
{ECO:0000256|PIRNR:PIRNR036314}.
-!- SIMILARITY: Belongs to the LDLR family.
{ECO:0000256|PIRNR:PIRNR036314}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSRNOP00000071445}.
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EMBL; AABR07062321; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AABR07062322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_017448147.1; XM_017592658.1.
UniGene; Rn.229041; -.
Ensembl; ENSRNOT00000082102; ENSRNOP00000071445; ENSRNOG00000006338.
GeneID; 312781; -.
CTD; 4040; -.
RGD; 1304749; Lrp6.
GeneTree; ENSGT00760000118968; -.
OMA; WQELDQP; -.
Reactome; R-RNO-3772470; Negative regulation of TCF-dependent signaling by WNT ligand antagonists.
Reactome; R-RNO-4641262; Disassembly of the destruction complex and recruitment of AXIN to the membrane.
Reactome; R-RNO-4641263; Regulation of FZD by ubiquitination.
Proteomes; UP000002494; Chromosome 4.
Bgee; ENSRNOG00000006338; -.
ExpressionAtlas; A0A0G2K0H3; baseline.
GO; GO:0005901; C:caveola; IBA:GO_Central.
GO; GO:0009986; C:cell surface; ISO:RGD.
GO; GO:0031410; C:cytoplasmic vesicle; ISO:RGD.
GO; GO:0005769; C:early endosome; ISO:RGD.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0016020; C:membrane; ISO:RGD.
GO; GO:0043025; C:neuronal cell body; IDA:RGD.
GO; GO:0005886; C:plasma membrane; ISO:RGD.
GO; GO:0043235; C:receptor complex; IBA:GO_Central.
GO; GO:0045202; C:synapse; IDA:RGD.
GO; GO:1990909; C:Wnt signalosome; ISO:RGD.
GO; GO:1990851; C:Wnt-Frizzled-LRP5/6 complex; ISO:RGD.
GO; GO:0034185; F:apolipoprotein binding; ISO:RGD.
GO; GO:0071936; F:coreceptor activity involved in Wnt signaling pathway; ISO:RGD.
GO; GO:0005109; F:frizzled binding; ISO:RGD.
GO; GO:0042802; F:identical protein binding; ISO:RGD.
GO; GO:0019210; F:kinase inhibitor activity; ISO:RGD.
GO; GO:0005041; F:low-density lipoprotein receptor activity; ISO:RGD.
GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
GO; GO:0005102; F:receptor binding; ISO:RGD.
GO; GO:0019534; F:toxin transmembrane transporter activity; ISO:RGD.
GO; GO:0042813; F:Wnt-activated receptor activity; IBA:GO_Central.
GO; GO:0017147; F:Wnt-protein binding; ISO:RGD.
GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD.
GO; GO:0003401; P:axis elongation; ISO:RGD.
GO; GO:0090245; P:axis elongation involved in somitogenesis; ISO:RGD.
GO; GO:0046849; P:bone remodeling; ISO:RGD.
GO; GO:0060444; P:branching involved in mammary gland duct morphogenesis; ISO:RGD.
GO; GO:0060070; P:canonical Wnt signaling pathway; IMP:RGD.
GO; GO:0061310; P:canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development; ISO:RGD.
GO; GO:0061324; P:canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; ISO:RGD.
GO; GO:0042074; P:cell migration involved in gastrulation; ISO:RGD.
GO; GO:0098609; P:cell-cell adhesion; IMP:RGD.
GO; GO:0071397; P:cellular response to cholesterol; ISO:RGD.
GO; GO:0021587; P:cerebellum morphogenesis; ISO:RGD.
GO; GO:0021795; P:cerebral cortex cell migration; ISO:RGD.
GO; GO:0021987; P:cerebral cortex development; ISO:RGD.
GO; GO:0007268; P:chemical synaptic transmission; IMP:RGD.
GO; GO:0060026; P:convergent extension; ISO:RGD.
GO; GO:0071542; P:dopaminergic neuron differentiation; ISO:RGD.
GO; GO:0009950; P:dorsal/ventral axis specification; ISO:RGD.
GO; GO:0048596; P:embryonic camera-type eye morphogenesis; ISO:RGD.
GO; GO:0042733; P:embryonic digit morphogenesis; ISO:RGD.
GO; GO:0035115; P:embryonic forelimb morphogenesis; ISO:RGD.
GO; GO:0035116; P:embryonic hindlimb morphogenesis; ISO:RGD.
GO; GO:0030326; P:embryonic limb morphogenesis; ISO:RGD.
GO; GO:0009880; P:embryonic pattern specification; ISO:RGD.
GO; GO:0060059; P:embryonic retina morphogenesis in camera-type eye; ISO:RGD.
GO; GO:0035261; P:external genitalia morphogenesis; ISO:RGD.
GO; GO:0060325; P:face morphogenesis; ISO:RGD.
GO; GO:0030900; P:forebrain development; ISO:RGD.
GO; GO:0021872; P:forebrain generation of neurons; ISO:RGD.
GO; GO:0021861; P:forebrain radial glial cell differentiation; ISO:RGD.
GO; GO:0021943; P:formation of radial glial scaffolds; ISO:RGD.
GO; GO:0001702; P:gastrulation with mouth forming second; ISO:RGD.
GO; GO:0048699; P:generation of neurons; ISO:RGD.
GO; GO:0001947; P:heart looping; ISO:RGD.
GO; GO:0035108; P:limb morphogenesis; ISO:RGD.
GO; GO:0060603; P:mammary gland duct morphogenesis; ISO:RGD.
GO; GO:0060596; P:mammary placode formation; ISO:RGD.
GO; GO:0030901; P:midbrain development; ISO:RGD.
GO; GO:0030917; P:midbrain-hindbrain boundary development; ISO:RGD.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISO:RGD.
GO; GO:0045599; P:negative regulation of fat cell differentiation; ISO:RGD.
GO; GO:2000051; P:negative regulation of non-canonical Wnt signaling pathway; ISO:RGD.
GO; GO:2000151; P:negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis; ISO:RGD.
GO; GO:2000162; P:negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis; ISO:RGD.
GO; GO:2000168; P:negative regulation of planar cell polarity pathway involved in neural tube closure; ISO:RGD.
GO; GO:2000164; P:negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis; ISO:RGD.
GO; GO:2000166; P:negative regulation of planar cell polarity pathway involved in pericardium morphogenesis; ISO:RGD.
GO; GO:2000149; P:negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis; ISO:RGD.
GO; GO:0006469; P:negative regulation of protein kinase activity; ISO:RGD.
GO; GO:0001933; P:negative regulation of protein phosphorylation; ISO:RGD.
GO; GO:0071901; P:negative regulation of protein serine/threonine kinase activity; ISO:RGD.
GO; GO:0034392; P:negative regulation of smooth muscle cell apoptotic process; ISO:RGD.
GO; GO:0030178; P:negative regulation of Wnt signaling pathway; ISO:RGD.
GO; GO:0014033; P:neural crest cell differentiation; ISO:RGD.
GO; GO:0014029; P:neural crest formation; ISO:RGD.
GO; GO:0001843; P:neural tube closure; ISO:RGD.
GO; GO:0021915; P:neural tube development; ISO:RGD.
GO; GO:0042475; P:odontogenesis of dentin-containing tooth; ISO:RGD.
GO; GO:0060021; P:palate development; ISO:RGD.
GO; GO:0003344; P:pericardium morphogenesis; ISO:RGD.
GO; GO:0043065; P:positive regulation of apoptotic process; ISO:RGD.
GO; GO:0045780; P:positive regulation of bone resorption; ISO:RGD.
GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; ISO:RGD.
GO; GO:0045787; P:positive regulation of cell cycle; ISO:RGD.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IMP:RGD.
GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; ISO:RGD.
GO; GO:0010976; P:positive regulation of neuron projection development; ISO:RGD.
GO; GO:0045778; P:positive regulation of ossification; ISO:RGD.
GO; GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; ISO:RGD.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISO:RGD.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
GO; GO:2000055; P:positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification; ISO:RGD.
GO; GO:0036342; P:post-anal tail morphogenesis; ISO:RGD.
GO; GO:0090009; P:primitive streak formation; ISO:RGD.
GO; GO:0072659; P:protein localization to plasma membrane; ISO:RGD.
GO; GO:0090118; P:receptor-mediated endocytosis involved in cholesterol transport; ISO:RGD.
GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; ISO:RGD.
GO; GO:0060284; P:regulation of cell development; ISO:RGD.
GO; GO:0042127; P:regulation of cell proliferation; ISO:RGD.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:RGD.
GO; GO:0051593; P:response to folic acid; ISO:RGD.
GO; GO:0043434; P:response to peptide hormone; IEP:RGD.
GO; GO:0060042; P:retina morphogenesis in camera-type eye; ISO:RGD.
GO; GO:0048705; P:skeletal system morphogenesis; ISO:RGD.
GO; GO:0001756; P:somitogenesis; ISO:RGD.
GO; GO:0021794; P:thalamus development; ISO:RGD.
GO; GO:0060535; P:trachea cartilage morphogenesis; ISO:RGD.
GO; GO:0016055; P:Wnt signaling pathway; ISO:RGD.
GO; GO:0044332; P:Wnt signaling pathway involved in dorsal/ventral axis specification; ISO:RGD.
GO; GO:0021874; P:Wnt signaling pathway involved in forebrain neuroblast division; ISO:RGD.
GO; GO:0090244; P:Wnt signaling pathway involved in somitogenesis; ISO:RGD.
CDD; cd00112; LDLa; 3.
Gene3D; 2.120.10.30; -; 4.
InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR036055; LDL_receptor-like_sf.
InterPro; IPR023415; LDLR_class-A_CS.
InterPro; IPR000033; LDLR_classB_rpt.
InterPro; IPR002172; LDrepeatLR_classA_rpt.
InterPro; IPR017049; LRP5/6.
Pfam; PF00057; Ldl_recept_a; 3.
Pfam; PF00058; Ldl_recept_b; 11.
PIRSF; PIRSF036314; LDL_recpt-rel_p5/6; 1.
PRINTS; PR00261; LDLRECEPTOR.
SMART; SM00181; EGF; 4.
SMART; SM00192; LDLa; 3.
SMART; SM00135; LY; 20.
SUPFAM; SSF57424; SSF57424; 3.
PROSITE; PS01209; LDLRA_1; 2.
PROSITE; PS50068; LDLRA_2; 3.
PROSITE; PS51120; LDLRB; 20.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000002494};
Developmental protein {ECO:0000256|PIRNR:PIRNR036314};
Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00124,
ECO:0000256|SAAS:SAAS00895822};
EGF-like domain {ECO:0000256|SAAS:SAAS00063520};
Membrane {ECO:0000256|PIRNR:PIRNR036314,
ECO:0000256|SAAS:SAAS00492819};
Receptor {ECO:0000256|PIRNR:PIRNR036314};
Reference proteome {ECO:0000313|Proteomes:UP000002494};
Repeat {ECO:0000256|SAAS:SAAS00780418};
Signal {ECO:0000256|PIRNR:PIRNR036314};
Transmembrane {ECO:0000256|PIRNR:PIRNR036314,
ECO:0000256|SAAS:SAAS00492819};
Transmembrane helix {ECO:0000256|PIRNR:PIRNR036314,
ECO:0000256|SAAS:SAAS00492819};
Wnt signaling pathway {ECO:0000256|PIRNR:PIRNR036314}.
SIGNAL 1 19 {ECO:0000256|PIRNR:PIRNR036314}.
CHAIN 20 1613 Low-density lipoprotein receptor-related
protein. {ECO:0000256|PIRNR:PIRNR036314}.
/FTId=PRO_5010897963.
TRANSMEM 1374 1394 Helical. {ECO:0000256|PIRNR:PIRNR036314}.
REPEAT 63 106 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 107 149 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 150 193 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 194 236 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 237 247 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
DOMAIN 285 324 EGF-like. {ECO:0000259|SMART:SM00181}.
REPEAT 372 414 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 415 457 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 458 501 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 502 544 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 545 587 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
DOMAIN 591 628 EGF-like. {ECO:0000259|SMART:SM00181}.
REPEAT 674 716 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 717 759 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 760 802 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 803 839 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 843 885 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
DOMAIN 892 930 EGF-like. {ECO:0000259|SMART:SM00181}.
REPEAT 977 1025 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 1026 1068 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 1069 1113 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 1114 1156 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 1157 1198 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
DOMAIN 1206 1250 EGF-like. {ECO:0000259|SMART:SM00181}.
DISULFID 1270 1285 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 1288 1300 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 1295 1313 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 1307 1322 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 1326 1338 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 1333 1351 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 1345 1360 {ECO:0000256|PROSITE-ProRule:PRU00124}.
SEQUENCE 1613 AA; 180344 MW; 90211DE0A0A4F7C7 CRC64;
MGAVLRSLLA CSFCVLLRAA PLLLYANRRD LRLVDATNGK ENATIVVGGL EDAAAVDFVF
GHGLIYWSDV SEEAIKRTEF NKTESVQNVV VSGLLSPDGL ACDWLGEKLY WTDSETNRIE
VSNLDGSLRK VLFWQELDQP RAIALDPSSG FMYWTDWGEV PKIERAGMDG SSRFVIINTE
IYWPNGLTLD YEERKLYWAD AKLNFIHKSN LDGTNRQAVV KGSLPHPFAL TLFEDTLYWT
DWNTHSILAC NKYTGEGLRE IHSNIFSPMD IHAFSQQRQP NATNPCGIDN GGCSHLCLMS
PVKPFYQCAC PTGVKLLESG KTCKDGATEL LLLARRTDLR RISLDTPDFT DIVLQLEDIR
HAIAIDYDPV EGYVYWTDDE VRAIRRSFID GSGSQFVVTA QIAHPDGIAV DWVARNLYWT
DTGTDRIEVT RLNGTMRKIL ISEDLEEPRA IVLDPMAGYM YWTDWGEIPK IERAALDGSD
RVVLVNTSLG WPNGLALDYD EGTIYWGDAK TDKIEVMNTD GTGRRVLVED KIPHIFGFTL
LGDYVYWTDW QRRSIERVHK RSAEREVIID QLPDLMGLKA TSVHRVIGSN PCAEENGGCS
HLCLYRPQGL RCACPIGFEL ISDMKTCIVP EAFLLFSRRA DIRRISLETN NNNVAIPLTG
VKEASALDFD VTDNRIYWTD ISLKTISRAF MNGSALEHVV EFGLDYPEGM AVDWLGKNLY
WADTGTNRIE VSKLDGQHRQ VLVWKDLDSP RALALDPAEG FMYWTEWGGK PKIDRAAMDG
SERTTLVPNV GRANGLTIDY AKRRLYWTDL DTNLIESSNM LGLNREVIAD DLPHPFGLTQ
YQDYIYWTDW SRRSIERANK TSGQNRTIIQ GHLDYVMDIL VFHSSRQAGW NECASSNGHC
SHLCLAVPVG GFVCGCPAHY SLNADNRTCS APTTFLLFSQ KSAINRMVID EQQSPDIILP
IHSLRNVRAI DYDPLDKQLY WIDSRQNMIR KAQEDGGQGF TVVVSSVPNQ NLEIQPYDLS
IDIYSRYIYW TCEATNVIDV TRLDGRSVGV VLKGEQDRPR AIVVNPEKGY MYFTNLQERS
PKIERAALDG TEREVLFFSG LSKPVALALD SKLSRLFWAD SDLRRIESSD LSGANRIVLE
DSNILQPVGL TVFENWLYWI DKQQQMIEKI DMTGREGRTK VQARIAQLSD IHAVKELNLQ
EYRQHPCAQD NGGCSHICLV KGDGTTRCSC PMHLVLLQDE LSCGEPPTCS PQQFTCFTGD
IDCIPVAWRC DGFTECEDHS DELNCPVCSE SQFQCASGQC IDGALRCNGD ANCQDKSDEK
NCEVLCLIDQ FRCANGQCVG KHKKCDHNVD CSDRSDELDC YPTEEPAPQA TNTVGSVIGV
IVTIFVSGTI YFICQRMLCP RMKGDGETMT NDYVVHGPAS VPLGYVPHPS SLSGSLPGMS
RGKSMISSLS IMGGSSGPPY DRAHVTGASS SSSSSTKGTY FPAILNPPPS PATERSHYTM
EFGYSSNSPS THRSYSYRPY SYRHFAPPTT PCSTDVCDSD YAPSRRMTSV ATAKGYTSDL
NYDSEPVPPP PTPRSQYLSA EENYESCPPS PYTERSYSHH LYPPPPSPCT DSS


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E08L0278 Canine low-density lipoprotein receptor-related protein 1 96 Tests/kit
ER215 Low-density lipoprotein receptor-related protein 2 Elisa Kit 96T
E03L0278 Mouse low-density lipoprotein receptor-related protein 1 96 Tests/kit
C389 Low-Density Lipoprotein Receptor-Related Protein 12 LRP12 lmg
E05L0279 Guinea low-density lipoprotein-receptor-related protein 6 96 Tests/kit
E05L0278 Guinea low-density lipoprotein receptor-related protein 1 96 Tests/kit
SL0454Ra Rat low-density lipoprotein-receptor-related protein,LRP-1 ELISA Kit 96T
E02L0279 Rat Low-density lipoprotein-receptor-related protein 6 ELISA 96T/kit
E02L0278 Rat anti-low-density lipoprotein receptor-related protein 1 96 Tests/kit
E0209Ra Rat low-density lipoprotein-receptor-related protein,LRP-1 ELISA Kit 96T
E08L0279 Canine low-density lipoprotein-receptor-related protein 6 96 Tests/kit
EH1124 Low-density lipoprotein receptor-related protein 6 Elisa Kit 96T
E07L0279 Porcine low-density lipoprotein-receptor-related protein 6 96 Tests/kit
E07L0278 Porcine low-density lipoprotein receptor-related protein 1 96 Tests/kit
E03L0279 Mouse low-density lipoprotein-receptor-related protein 6 96 Tests/kit
EH701 Low-density lipoprotein receptor-related protein 2 Elisa Kit 96T
E11L0279 Bovine low-density lipoprotein-receptor-related protein 6 96 Tests/kit
201-11-0210 Rat low-density lipoprotein-receptor-related protein,LRP-1 ELISA Kit 96T
YHB0684Ra Rat low-density lipoprotein-receptor-related protein,LRP-1 ELISA Kit 48T


 

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