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Lrrk2 protein (Fragment)

 Q5BJM3_RAT              Unreviewed;       320 AA.
12-APR-2005, integrated into UniProtKB/TrEMBL.
12-APR-2005, sequence version 1.
28-FEB-2018, entry version 71.
SubName: Full=Lrrk2 protein {ECO:0000313|EMBL:AAH91422.1};
Flags: Fragment;
Name=Lrrk2 {ECO:0000313|EMBL:AAH91422.1};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116 {ECO:0000313|EMBL:AAH91422.1};
[1] {ECO:0000313|EMBL:AAH91422.1}
TISSUE=Spleen {ECO:0000313|EMBL:AAH91422.1};
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
Makowski K.A., Bosak S., Malek J.;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
EMBL; BC091422; AAH91422.1; -; mRNA.
UniGene; Rn.213971; -.
ProteinModelPortal; Q5BJM3; -.
eggNOG; KOG0192; Eukaryota.
eggNOG; KOG0619; Eukaryota.
eggNOG; COG1100; LUCA.
eggNOG; COG4886; LUCA.
HOVERGEN; HBG075871; -.
PhylomeDB; Q5BJM3; -.
GO; GO:0044753; C:amphisome; ISO:RGD.
GO; GO:0044754; C:autolysosome; ISO:RGD.
GO; GO:0030424; C:axon; IDA:RGD.
GO; GO:0099400; C:caveola neck; ISO:RGD.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0032473; C:cytoplasmic side of mitochondrial outer membrane; ISO:RGD.
GO; GO:0031410; C:cytoplasmic vesicle; ISO:RGD.
GO; GO:0005829; C:cytosol; ISO:RGD.
GO; GO:0030425; C:dendrite; IDA:RGD.
GO; GO:0032839; C:dendrite cytoplasm; ISO:RGD.
GO; GO:0005783; C:endoplasmic reticulum; ISO:RGD.
GO; GO:0005768; C:endosome; ISO:RGD.
GO; GO:0070062; C:extracellular exosome; ISO:RGD.
GO; GO:0005615; C:extracellular space; ISO:RGD.
GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
GO; GO:0005798; C:Golgi-associated vesicle; ISO:RGD.
GO; GO:0030426; C:growth cone; ISO:RGD.
GO; GO:0016234; C:inclusion body; ISO:RGD.
GO; GO:0005622; C:intracellular; ISO:RGD.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD.
GO; GO:0030529; C:intracellular ribonucleoprotein complex; ISO:RGD.
GO; GO:0005764; C:lysosome; ISO:RGD.
GO; GO:0016020; C:membrane; IDA:RGD.
GO; GO:0045121; C:membrane raft; ISO:RGD.
GO; GO:0005902; C:microvillus; ISO:RGD.
GO; GO:0005743; C:mitochondrial inner membrane; ISO:RGD.
GO; GO:0005759; C:mitochondrial matrix; ISO:RGD.
GO; GO:0031966; C:mitochondrial membrane; ISO:RGD.
GO; GO:0005741; C:mitochondrial outer membrane; ISO:RGD.
GO; GO:0005739; C:mitochondrion; ISO:RGD.
GO; GO:0097487; C:multivesicular body, internal vesicle; ISO:RGD.
GO; GO:0043005; C:neuron projection; IDA:RGD.
GO; GO:0043025; C:neuronal cell body; IDA:RGD.
GO; GO:0043204; C:perikaryon; ISO:RGD.
GO; GO:0005886; C:plasma membrane; ISO:RGD.
GO; GO:0098794; C:postsynapse; IEA:GOC.
GO; GO:0045202; C:synapse; IDA:RGD.
GO; GO:0008021; C:synaptic vesicle; ISO:RGD.
GO; GO:0005802; C:trans-Golgi network; ISO:RGD.
GO; GO:1990909; C:Wnt signalosome; ISO:RGD.
GO; GO:0003779; F:actin binding; ISO:RGD.
GO; GO:1904713; F:beta-catenin destruction complex binding; ISO:RGD.
GO; GO:0030276; F:clathrin binding; ISO:RGD.
GO; GO:0005525; F:GTP binding; ISO:RGD.
GO; GO:0034211; F:GTP-dependent protein kinase activity; ISO:RGD.
GO; GO:0005096; F:GTPase activator activity; ISO:RGD.
GO; GO:0003924; F:GTPase activity; ISO:RGD.
GO; GO:0042802; F:identical protein binding; ISO:RGD.
GO; GO:0044325; F:ion channel binding; ISO:RGD.
GO; GO:0016301; F:kinase activity; ISO:RGD.
GO; GO:0004708; F:MAP kinase kinase activity; ISO:RGD.
GO; GO:0036479; F:peroxidase inhibitor activity; ISO:RGD.
GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
GO; GO:0051018; F:protein kinase A binding; ISO:RGD.
GO; GO:0004672; F:protein kinase activity; ISO:RGD.
GO; GO:0004674; F:protein serine/threonine kinase activity; ISO:RGD.
GO; GO:0017048; F:Rho GTPase binding; ISO:RGD.
GO; GO:0000149; F:SNARE binding; ISO:RGD.
GO; GO:0017075; F:syntaxin-1 binding; ISO:RGD.
GO; GO:0015631; F:tubulin binding; ISO:RGD.
GO; GO:0000187; P:activation of MAPK activity; ISO:RGD.
GO; GO:0000186; P:activation of MAPKK activity; ISO:RGD.
GO; GO:0019722; P:calcium-mediated signaling; ISO:RGD.
GO; GO:0034613; P:cellular protein localization; ISO:RGD.
GO; GO:1903351; P:cellular response to dopamine; ISO:RGD.
GO; GO:0071287; P:cellular response to manganese ion; ISO:RGD.
GO; GO:0071407; P:cellular response to organic cyclic compound; IEP:RGD.
GO; GO:0034599; P:cellular response to oxidative stress; ISO:RGD.
GO; GO:0009267; P:cellular response to starvation; ISO:RGD.
GO; GO:0008340; P:determination of adult lifespan; ISO:RGD.
GO; GO:0006897; P:endocytosis; ISO:RGD.
GO; GO:0060079; P:excitatory postsynaptic potential; ISO:RGD.
GO; GO:0035640; P:exploration behavior; ISO:RGD.
GO; GO:0007030; P:Golgi organization; ISO:RGD.
GO; GO:0046039; P:GTP metabolic process; ISO:RGD.
GO; GO:0048312; P:intracellular distribution of mitochondria; ISO:RGD.
GO; GO:0035556; P:intracellular signal transduction; ISO:RGD.
GO; GO:0035641; P:locomotory exploration behavior; ISO:RGD.
GO; GO:0007040; P:lysosome organization; ISO:RGD.
GO; GO:0000165; P:MAPK cascade; ISO:RGD.
GO; GO:0051646; P:mitochondrion localization; ISO:RGD.
GO; GO:0007005; P:mitochondrion organization; ISO:RGD.
GO; GO:1902902; P:negative regulation of autophagosome assembly; ISO:RGD.
GO; GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; ISO:RGD.
GO; GO:0090394; P:negative regulation of excitatory postsynaptic potential; ISO:RGD.
GO; GO:0034260; P:negative regulation of GTPase activity; ISO:RGD.
GO; GO:1903206; P:negative regulation of hydrogen peroxide-induced cell death; ISO:RGD.
GO; GO:0016242; P:negative regulation of macroautophagy; ISO:RGD.
GO; GO:1901215; P:negative regulation of neuron death; ISO:RGD.
GO; GO:0010977; P:negative regulation of neuron projection development; IMP:RGD.
GO; GO:0032091; P:negative regulation of protein binding; ISO:RGD.
GO; GO:0001933; P:negative regulation of protein phosphorylation; ISO:RGD.
GO; GO:0010955; P:negative regulation of protein processing; ISO:RGD.
GO; GO:1903215; P:negative regulation of protein targeting to mitochondrion; ISO:RGD.
GO; GO:1903125; P:negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation; ISO:RGD.
GO; GO:0007528; P:neuromuscular junction development; ISO:RGD.
GO; GO:0070997; P:neuron death; ISO:RGD.
GO; GO:0140058; P:neuron projection arborization; IMP:RGD.
GO; GO:0048812; P:neuron projection morphogenesis; ISO:RGD.
GO; GO:0021772; P:olfactory bulb development; ISO:RGD.
GO; GO:0018105; P:peptidyl-serine phosphorylation; ISO:RGD.
GO; GO:0018107; P:peptidyl-threonine phosphorylation; ISO:RGD.
GO; GO:0016310; P:phosphorylation; ISO:RGD.
GO; GO:0010508; P:positive regulation of autophagy; ISO:RGD.
GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; ISO:RGD.
GO; GO:0060161; P:positive regulation of dopamine receptor signaling pathway; ISO:RGD.
GO; GO:1901727; P:positive regulation of histone deacetylase activity; ISO:RGD.
GO; GO:1903980; P:positive regulation of microglial cell activation; IMP:RGD.
GO; GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; IMP:RGD.
GO; GO:0043068; P:positive regulation of programmed cell death; ISO:RGD.
GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISO:RGD.
GO; GO:1902499; P:positive regulation of protein autoubiquitination; ISO:RGD.
GO; GO:0032092; P:positive regulation of protein binding; ISO:RGD.
GO; GO:0033160; P:positive regulation of protein import into nucleus, translocation; ISO:RGD.
GO; GO:0001934; P:positive regulation of protein phosphorylation; ISO:RGD.
GO; GO:0031398; P:positive regulation of protein ubiquitination; ISO:RGD.
GO; GO:1900244; P:positive regulation of synaptic vesicle endocytosis; IMP:RGD.
GO; GO:1904469; P:positive regulation of tumor necrosis factor secretion; IMP:RGD.
GO; GO:0046777; P:protein autophosphorylation; ISO:RGD.
GO; GO:0006468; P:protein phosphorylation; ISO:RGD.
GO; GO:0072593; P:reactive oxygen species metabolic process; ISO:RGD.
GO; GO:0010506; P:regulation of autophagy; ISO:RGD.
GO; GO:2000172; P:regulation of branching morphogenesis of a nerve; ISO:RGD.
GO; GO:1905289; P:regulation of CAMKK-AMPK signaling cascade; ISO:RGD.
GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; ISO:RGD.
GO; GO:0061001; P:regulation of dendritic spine morphogenesis; ISO:RGD.
GO; GO:0060159; P:regulation of dopamine receptor signaling pathway; ISO:RGD.
GO; GO:0010468; P:regulation of gene expression; ISO:RGD.
GO; GO:0035564; P:regulation of kidney size; ISO:RGD.
GO; GO:0040012; P:regulation of locomotion; ISO:RGD.
GO; GO:0035751; P:regulation of lysosomal lumen pH; ISO:RGD.
GO; GO:0042391; P:regulation of membrane potential; ISO:RGD.
GO; GO:0051900; P:regulation of mitochondrial depolarization; ISO:RGD.
GO; GO:1902692; P:regulation of neuroblast proliferation; ISO:RGD.
GO; GO:1901214; P:regulation of neuron death; ISO:RGD.
GO; GO:0014041; P:regulation of neuron maturation; ISO:RGD.
GO; GO:0010738; P:regulation of protein kinase A signaling; ISO:RGD.
GO; GO:1905279; P:regulation of retrograde transport, endosome to Golgi; ISO:RGD.
GO; GO:0051966; P:regulation of synaptic transmission, glutamatergic; ISO:RGD.
GO; GO:2000300; P:regulation of synaptic vesicle exocytosis; ISO:RGD.
GO; GO:1902803; P:regulation of synaptic vesicle transport; ISO:RGD.
GO; GO:0006979; P:response to oxidative stress; ISO:RGD.
GO; GO:0007283; P:spermatogenesis; IEP:RGD.
GO; GO:0021756; P:striatum development; IEP:RGD.
GO; GO:0022028; P:tangential migration from the subventricular zone to the olfactory bulb; ISO:RGD.
GO; GO:1904887; P:Wnt signalosome assembly; ISO:RGD.
Gene3D;; -; 1.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
InterPro; IPR036322; WD40_repeat_dom_sf.
SUPFAM; SSF50978; SSF50978; 1.
2: Evidence at transcript level;
NON_TER 1 1 {ECO:0000313|EMBL:AAH91422.1}.
SEQUENCE 320 AA; 35780 MW; 365E8FD7A0BD0DAF CRC64;

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