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Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE-1) (Cell surface retention sequence-binding protein 1) (CRSBP-1) (Extracellular link domain-containing protein 1) (Hyaluronic acid receptor)

 LYVE1_HUMAN             Reviewed;         322 AA.
Q9Y5Y7; Q8TC18; Q9UNF4;
03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
03-OCT-2006, sequence version 2.
22-NOV-2017, entry version 124.
RecName: Full=Lymphatic vessel endothelial hyaluronic acid receptor 1;
Short=LYVE-1;
AltName: Full=Cell surface retention sequence-binding protein 1;
Short=CRSBP-1;
AltName: Full=Extracellular link domain-containing protein 1;
AltName: Full=Hyaluronic acid receptor;
Flags: Precursor;
Name=LYVE1; Synonyms=CRSBP1, HAR, XLKD1; ORFNames=UNQ230/PRO263;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
SPECIFICITY.
PubMed=10037799; DOI=10.1083/jcb.144.4.789;
Banerji S., Ni J., Wang S.-X., Clasper S., Su J., Tammi R., Jones M.,
Jackson D.G.;
"LYVE-1, a new homologue of the CD44 glycoprotein is a lymph-specific
receptor for hyaluronan.";
J. Cell Biol. 144:789-801(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Winkelmann J.C., Basu S., Ozdemir E., Blough R.I.;
"HAR: a novel homolog of CD44 and putative hyaluronic acid receptor
encoded by a gene on human chromosome 11p15.";
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=12975309; DOI=10.1101/gr.1293003;
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins: a
bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-116.
TISSUE=Liver;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-53.
TISSUE=Plasma;
PubMed=16335952; DOI=10.1021/pr0502065;
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,
Moore R.J., Smith R.D.;
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,
hydrazide chemistry, and mass spectrometry.";
J. Proteome Res. 4:2070-2080(2005).
[6]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-53.
TISSUE=Liver;
PubMed=19159218; DOI=10.1021/pr8008012;
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
"Glycoproteomics analysis of human liver tissue by combination of
multiple enzyme digestion and hydrazide chemistry.";
J. Proteome Res. 8:651-661(2009).
-!- FUNCTION: Ligand-specific transporter trafficking between
intracellular organelles (TGN) and the plasma membrane. Plays a
role in autocrine regulation of cell growth mediated by growth
regulators containing cell surface retention sequence binding
(CRS). May act as a hyaluronan (HA) transporter, either mediating
its uptake for catabolism within lymphatic endothelial cells
themselves, or its transport into the lumen of afferent lymphatic
vessels for subsequent re-uptake and degradation in lymph nodes.
{ECO:0000269|PubMed:10037799}.
-!- SUBUNIT: Homodimer; disulfide-linked. Interacts with PDGFB and
IGFBP3. Forms a transient ternary complex with PDGFB and PDGFRB in
TGN (By similarity). {ECO:0000250}.
-!- INTERACTION:
O76011:KRT34; NbExp=4; IntAct=EBI-10329546, EBI-1047093;
P60410:KRTAP10-8; NbExp=3; IntAct=EBI-10329546, EBI-10171774;
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10037799};
Single-pass type I membrane protein {ECO:0000269|PubMed:10037799}.
Note=Localized to the plasma membrane and in vesicles near
extranuclear membranes which may represent trans-Golgi network
(TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-
dependent internalization and recycling at the cell surface.
-!- TISSUE SPECIFICITY: Mainly expressed in endothelial cells lining
lymphatic vessels. {ECO:0000269|PubMed:10037799}.
-!- PTM: O-glycosylated. {ECO:0000250}.
-----------------------------------------------------------------------
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EMBL; AF118108; AAD42764.1; -; mRNA.
EMBL; AF127670; AAD49220.2; -; mRNA.
EMBL; AY358925; AAQ89284.1; -; mRNA.
EMBL; BC026231; AAH26231.1; -; mRNA.
CCDS; CCDS7804.1; -.
RefSeq; NP_006682.2; NM_006691.3.
UniGene; Hs.655332; -.
ProteinModelPortal; Q9Y5Y7; -.
SMR; Q9Y5Y7; -.
BioGrid; 116100; 4.
IntAct; Q9Y5Y7; 6.
STRING; 9606.ENSP00000256178; -.
iPTMnet; Q9Y5Y7; -.
PhosphoSitePlus; Q9Y5Y7; -.
SwissPalm; Q9Y5Y7; -.
UniCarbKB; Q9Y5Y7; -.
BioMuta; LYVE1; -.
DMDM; 115502898; -.
PaxDb; Q9Y5Y7; -.
PeptideAtlas; Q9Y5Y7; -.
PRIDE; Q9Y5Y7; -.
DNASU; 10894; -.
Ensembl; ENST00000256178; ENSP00000256178; ENSG00000133800.
GeneID; 10894; -.
KEGG; hsa:10894; -.
UCSC; uc001miv.3; human.
CTD; 10894; -.
DisGeNET; 10894; -.
EuPathDB; HostDB:ENSG00000133800.8; -.
GeneCards; LYVE1; -.
HGNC; HGNC:14687; LYVE1.
HPA; CAB025860; -.
HPA; HPA042953; -.
MIM; 605702; gene.
neXtProt; NX_Q9Y5Y7; -.
OpenTargets; ENSG00000133800; -.
PharmGKB; PA162394799; -.
eggNOG; ENOG410IHIF; Eukaryota.
eggNOG; ENOG41127CQ; LUCA.
GeneTree; ENSGT00530000063822; -.
HOGENOM; HOG000059545; -.
HOVERGEN; HBG103455; -.
InParanoid; Q9Y5Y7; -.
KO; K19012; -.
OMA; SGFETCS; -.
OrthoDB; EOG091G09EL; -.
PhylomeDB; Q9Y5Y7; -.
TreeFam; TF334173; -.
Reactome; R-HSA-2160916; Hyaluronan uptake and degradation.
GeneWiki; LYVE1; -.
GenomeRNAi; 10894; -.
PRO; PR:Q9Y5Y7; -.
Proteomes; UP000005640; Chromosome 11.
Bgee; ENSG00000133800; -.
CleanEx; HS_LYVE1; -.
ExpressionAtlas; Q9Y5Y7; baseline and differential.
Genevisible; Q9Y5Y7; HS.
GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0016020; C:membrane; TAS:ProtInc.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0005540; F:hyaluronic acid binding; IEA:Ensembl.
GO; GO:0004872; F:receptor activity; TAS:ProtInc.
GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:Ensembl.
GO; GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.
GO; GO:0007160; P:cell-matrix adhesion; TAS:ProtInc.
GO; GO:0030214; P:hyaluronan catabolic process; TAS:Reactome.
GO; GO:0006928; P:movement of cell or subcellular component; TAS:ProtInc.
GO; GO:0009611; P:response to wounding; TAS:ProtInc.
GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
Gene3D; 3.10.100.10; -; 1.
InterPro; IPR016186; C-type_lectin-like/link_sf.
InterPro; IPR016187; CTDL_fold.
InterPro; IPR000538; Link_dom.
Pfam; PF00193; Xlink; 1.
PRINTS; PR01265; LINKMODULE.
SMART; SM00445; LINK; 1.
SUPFAM; SSF56436; SSF56436; 1.
PROSITE; PS50963; LINK_2; 1.
1: Evidence at protein level;
Complete proteome; Disulfide bond; Glycoprotein; Membrane;
Polymorphism; Receptor; Reference proteome; Signal; Transmembrane;
Transmembrane helix; Transport.
SIGNAL 1 19 {ECO:0000255}.
CHAIN 20 322 Lymphatic vessel endothelial hyaluronic
acid receptor 1.
/FTId=PRO_0000252133.
TOPO_DOM 20 238 Extracellular. {ECO:0000255}.
TRANSMEM 239 259 Helical. {ECO:0000255}.
TOPO_DOM 260 322 Cytoplasmic. {ECO:0000255}.
DOMAIN 40 130 Link. {ECO:0000255|PROSITE-
ProRule:PRU00323}.
CARBOHYD 53 53 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:16335952,
ECO:0000269|PubMed:19159218}.
CARBOHYD 130 130 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 61 128 {ECO:0000255|PROSITE-ProRule:PRU00323}.
DISULFID 85 106 {ECO:0000255|PROSITE-ProRule:PRU00323}.
VARIANT 116 116 W -> R (in dbSNP:rs17852369).
{ECO:0000269|PubMed:15489334}.
/FTId=VAR_027763.
VARIANT 214 214 T -> I (in dbSNP:rs16907980).
/FTId=VAR_027764.
VARIANT 315 315 V -> M (in dbSNP:rs7948666).
/FTId=VAR_027765.
CONFLICT 75 75 E -> D (in Ref. 1; AAD42764).
{ECO:0000305}.
CONFLICT 125 125 A -> G (in Ref. 1; AAD42764).
{ECO:0000305}.
CONFLICT 139 139 C -> R (in Ref. 1; AAD42764).
{ECO:0000305}.
SEQUENCE 322 AA; 35213 MW; 8B4D6D623F52D559 CRC64;
MARCFSLVLL LTSIWTTRLL VQGSLRAEEL SIQVSCRIMG ITLVSKKANQ QLNFTEAKEA
CRLLGLSLAG KDQVETALKA SFETCSYGWV GDGFVVISRI SPNPKCGKNG VGVLIWKVPV
SRQFAAYCYN SSDTWTNSCI PEIITTKDPI FNTQTATQTT EFIVSDSTYS VASPYSTIPA
PTTTPPAPAS TSIPRRKKLI CVTEVFMETS TMSTETEPFV ENKAAFKNEA AGFGGVPTAL
LVLALLFFGA AAGLGFCYVK RYVKAFPFTN KNQQKEMIET KVVKEEKAND SNPNEESKKT
DKNPEESKSP SKTTVRCLEA EV


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