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Lymphocyte antigen 6 complex locus protein G6d (Protein Ly6-D) (Megakaryocyte-enhanced gene transcript 1 protein)

 LY66D_HUMAN             Reviewed;         133 AA.
O95868; A2BEY8; B0UXC1; B0V019; B0V1Y6; Q4VX50;
18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
12-SEP-2018, entry version 116.
RecName: Full=Lymphocyte antigen 6 complex locus protein G6d;
Short=Protein Ly6-D;
AltName: Full=Megakaryocyte-enhanced gene transcript 1 protein;
Flags: Precursor;
Name=LY6G6D; Synonyms=C6orf23, G6D, MEGT1, NG25;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
PubMed=12079290; DOI=10.1006/geno.2002.6794;
Mallya M., Campbell R.D., Aguado B.;
"Transcriptional analysis of a novel cluster of LY-6 family members in
the human and mouse major histocompatibility complex: five genes with
many splice forms.";
Genomics 80:113-123(2002).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=10384126;
Ribas G., Neville M., Wixon J.L., Cheng J., Campbell R.D.;
"Genes encoding three new members of the leukocyte antigen 6
superfamily and a novel member of Ig superfamily, together with genes
encoding the regulatory nuclear chloride ion channel protein (hRNCC)
and an N omega-N omega-dimethylarginine dimethylaminohydrolase
homologue, are found in a 30-kb segment of the MHC class III region.";
J. Immunol. 163:278-287(1999).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=14656967; DOI=10.1101/gr.1736803;
Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S.,
Campbell R.D., Hood L.;
"Analysis of the gene-dense major histocompatibility complex class III
region and its comparison to mouse.";
Genome Res. 13:2621-2636(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Shiina S., Tamiya G., Oka A., Inoko H.;
"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=14574404; DOI=10.1038/nature02055;
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
"The DNA sequence and analysis of human chromosome 6.";
Nature 425:805-811(2003).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
GLYCOSYLATION, SUBCELLULAR LOCATION, SUBUNIT, AND GPI-ANCHOR.
PubMed=17008713; DOI=10.1110/ps.062242606;
Mallya M., Campbell R.D., Aguado B.;
"Characterization of the five novel Ly-6 superfamily members encoded
in the MHC, and detection of cells expressing their potential
ligands.";
Protein Sci. 15:2244-2256(2006).
-!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:17008713}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17008713};
Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17008713}. Cell
projection, filopodium {ECO:0000269|PubMed:17008713}.
-!- TISSUE SPECIFICITY: Expressed in the adult lung, and in fetal
liver, lung, kidney, brain and spleen.
{ECO:0000269|PubMed:12079290}.
-!- PTM: O-glycosylated. {ECO:0000269|PubMed:17008713}.
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EMBL; AJ315535; CAC85540.1; -; mRNA.
EMBL; AJ012008; CAB46082.1; -; Genomic_DNA.
EMBL; AF129756; AAD18077.1; -; Genomic_DNA.
EMBL; BA000025; BAB63380.1; -; Genomic_DNA.
EMBL; AL662899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AL670886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BX248244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AL844216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CR354443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CR759787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CR936239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471081; EAX03486.1; -; Genomic_DNA.
EMBL; BC125138; AAI25139.1; -; mRNA.
CCDS; CCDS34404.1; -.
RefSeq; NP_067069.2; NM_021246.2.
UniGene; Hs.591792; -.
ProteinModelPortal; O95868; -.
BioGrid; 121850; 2.
IntAct; O95868; 1.
STRING; 9606.ENSP00000364985; -.
iPTMnet; O95868; -.
PhosphoSitePlus; O95868; -.
BioMuta; LY6G6D; -.
PaxDb; O95868; -.
PeptideAtlas; O95868; -.
PRIDE; O95868; -.
ProteomicsDB; 51109; -.
Ensembl; ENST00000375825; ENSP00000364985; ENSG00000244355.
Ensembl; ENST00000400080; ENSP00000382952; ENSG00000206402.
Ensembl; ENST00000419389; ENSP00000389619; ENSG00000226603.
Ensembl; ENST00000420378; ENSP00000397576; ENSG00000234443.
Ensembl; ENST00000434515; ENSP00000392651; ENSG00000235302.
Ensembl; ENST00000440095; ENSP00000390777; ENSG00000225993.
Ensembl; ENST00000444880; ENSP00000395722; ENSG00000236902.
GeneID; 58530; -.
KEGG; hsa:58530; -.
UCSC; uc003nwf.1; human.
CTD; 58530; -.
EuPathDB; HostDB:ENSG00000244355.7; -.
GeneCards; LY6G6D; -.
HGNC; HGNC:13935; LY6G6D.
MIM; 606038; gene.
neXtProt; NX_O95868; -.
OpenTargets; ENSG00000244355; -.
PharmGKB; PA37829; -.
eggNOG; ENOG410KG8W; Eukaryota.
eggNOG; ENOG4110SIH; LUCA.
GeneTree; ENSGT00900000141441; -.
HOGENOM; HOG000113412; -.
HOVERGEN; HBG107444; -.
InParanoid; O95868; -.
KO; K06846; -.
PhylomeDB; O95868; -.
Reactome; R-HSA-163125; Post-translational modification: synthesis of GPI-anchored proteins.
GenomeRNAi; 58530; -.
PRO; PR:O95868; -.
Proteomes; UP000005640; Chromosome 6.
Bgee; ENSG00000244355; Expressed in 62 organ(s), highest expression level in colon.
CleanEx; HS_LY6G6D; -.
ExpressionAtlas; O95868; baseline and differential.
Genevisible; O95868; HS.
GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IDA:UniProtKB.
GO; GO:0095500; P:acetylcholine receptor signaling pathway; IEA:Ensembl.
GO; GO:0051260; P:protein homooligomerization; IDA:UniProtKB.
InterPro; IPR026524; LY6G6d/LY6G6f.
PANTHER; PTHR32286; PTHR32286; 1.
1: Evidence at protein level;
Cell membrane; Cell projection; Complete proteome; Disulfide bond;
Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Polymorphism;
Reference proteome; Signal.
SIGNAL 1 19 {ECO:0000255}.
CHAIN 20 104 Lymphocyte antigen 6 complex locus
protein G6d.
/FTId=PRO_0000323707.
PROPEP 105 133 Removed in mature form. {ECO:0000255}.
/FTId=PRO_0000323708.
DOMAIN 22 116 UPAR/Ly6.
LIPID 104 104 GPI-anchor amidated serine.
{ECO:0000255}.
CARBOHYD 40 40 O-linked (GalNAc...) threonine.
{ECO:0000255}.
CARBOHYD 41 41 O-linked (GalNAc...) threonine.
{ECO:0000255}.
DISULFID 27 35 {ECO:0000250}.
DISULFID 42 71 {ECO:0000250}.
DISULFID 77 96 {ECO:0000250}.
VARIANT 9 9 L -> V (in dbSNP:rs3749952).
/FTId=VAR_039564.
VARIANT 34 34 S -> T (in dbSNP:rs9267550).
/FTId=VAR_039565.
SEQUENCE 133 AA; 13691 MW; C5CE88EEAFE5F2FD CRC64;
MKPQFVGILL SSLLGAALGN RMRCYNCGGS PSSSCKEAVT TCGEGRPQPG LEQIKLPGNP
PVTLIHQHPA CVAAHHCNQV ETESVGDVTY PAHRDCYLGD LCNSAVASHV APAGILAAAA
TALTCLLPGL WSG


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