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Lymphocyte antigen 6E (Ly-6E) (Retinoic acid-induced gene E protein) (RIG-E) (Stem cell antigen 2) (SCA-2) (Thymic shared antigen 1) (TSA-1)

 LY6E_HUMAN              Reviewed;         131 AA.
Q16553; B2R4X5; D3DWJ2; Q0VDE5;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
27-SEP-2017, entry version 147.
RecName: Full=Lymphocyte antigen 6E;
Short=Ly-6E;
AltName: Full=Retinoic acid-induced gene E protein;
Short=RIG-E;
AltName: Full=Stem cell antigen 2;
Short=SCA-2;
AltName: Full=Thymic shared antigen 1;
Short=TSA-1;
Flags: Precursor;
Name=LY6E; Synonyms=9804, RIGE, SCA2, TSA1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Promyelocytic leukemia;
PubMed=8650192; DOI=10.1073/pnas.93.12.5910;
Mao M., Yu M., Tong J.-H., Ye J., Zhu J., Huang Q.-H., Fu G., Yu L.,
Zhao S.-Y., Waxman S., Lanotte M., Wang Z.-Y., Tan J.-Z., Chan S.-J.,
Chen Z.;
"RIG-E, a human homolog of the murine Ly-6 family, is induced by
retinoic acid during the differentiation of acute promyelocytic
leukemia cell.";
Proc. Natl. Acad. Sci. U.S.A. 93:5910-5914(1996).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain, and Mammary gland;
PubMed=8757598;
Capone M.C., Gorman D.M., Ching E.P., Zlotnik A.;
"Identification through bioinformatics of cDNAs encoding human thymic
shared Ag-1/stem cell Ag-2: a new member of the human Ly-6 family.";
J. Immunol. 157:969-973(1996).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Monocyte;
PubMed=9551972;
Shan X., Bourdeau A., Rhoton A., Wells D.E., Cohen E.H.,
Landgraf B.E., Palfree R.G.E.;
"Characterization and mapping to human chromosome 8q24.3 of Ly-6-
related gene 9804 encoding an apparent homologue of mouse TSA-1.";
J. Immunol. 160:197-208(1998).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Mammary gland;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Involved in T-cell development. Believed to act as a
modulator of nicotinic acetylcholine receptors (nAChRs) activity.
In vitro inhibits alpha-3:beta-4-containing nAChRs maximum
response. {ECO:0000250|UniProtKB:Q64253}.
-!- SUBUNIT: Interacts with CHRNA4. {ECO:0000250|UniProtKB:Q64253}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor,
GPI-anchor {ECO:0000250}.
-!- TISSUE SPECIFICITY: Widely expressed, predominantly in liver,
kidney, ovary, spleen and peripheral blood Leukocytes.
-!- INDUCTION: By retinoic acid; in promyelocytic leukemia NB4 and in
myeloblast HL-60 cell lines. Activated by IFN-alpha in monocytic
cell line U-937 and in peripheral blood monocyte cells.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; Z68179; CAA92321.1; -; mRNA.
EMBL; U42376; AAC50519.1; -; mRNA.
EMBL; U56145; AAC50616.1; -; mRNA.
EMBL; U66711; AAB07513.1; -; Genomic_DNA.
EMBL; AK311983; BAG34922.1; -; mRNA.
EMBL; CH471162; EAW82287.1; -; Genomic_DNA.
EMBL; CH471162; EAW82288.1; -; Genomic_DNA.
EMBL; CH471162; EAW82290.1; -; Genomic_DNA.
EMBL; BC119708; AAI19709.1; -; mRNA.
EMBL; BC119709; AAI19710.1; -; mRNA.
CCDS; CCDS6394.1; -.
RefSeq; NP_001120685.1; NM_001127213.1.
RefSeq; NP_002337.1; NM_002346.2.
UniGene; Hs.521903; -.
ProteinModelPortal; Q16553; -.
BioGrid; 110239; 1.
STRING; 9606.ENSP00000292494; -.
iPTMnet; Q16553; -.
PhosphoSitePlus; Q16553; -.
BioMuta; LY6E; -.
DMDM; 10720072; -.
PaxDb; Q16553; -.
PeptideAtlas; Q16553; -.
PRIDE; Q16553; -.
Ensembl; ENST00000292494; ENSP00000292494; ENSG00000160932.
Ensembl; ENST00000429120; ENSP00000414307; ENSG00000160932.
Ensembl; ENST00000520466; ENSP00000428572; ENSG00000160932.
Ensembl; ENST00000521003; ENSP00000428169; ENSG00000160932.
Ensembl; ENST00000521699; ENSP00000427915; ENSG00000160932.
Ensembl; ENST00000522024; ENSP00000428442; ENSG00000160932.
Ensembl; ENST00000522971; ENSP00000428159; ENSG00000160932.
Ensembl; ENST00000619718; ENSP00000482517; ENSG00000278032.
Ensembl; ENST00000631568; ENSP00000488891; ENSG00000278032.
Ensembl; ENST00000632424; ENSP00000488421; ENSG00000278032.
Ensembl; ENST00000632516; ENSP00000487664; ENSG00000278032.
Ensembl; ENST00000632519; ENSP00000488443; ENSG00000278032.
Ensembl; ENST00000632812; ENSP00000488556; ENSG00000278032.
Ensembl; ENST00000633451; ENSP00000488559; ENSG00000278032.
GeneID; 4061; -.
KEGG; hsa:4061; -.
UCSC; uc003yxm.3; human.
CTD; 4061; -.
DisGeNET; 4061; -.
EuPathDB; HostDB:ENSG00000160932.10; -.
GeneCards; LY6E; -.
HGNC; HGNC:6727; LY6E.
MIM; 601384; gene.
neXtProt; NX_Q16553; -.
OpenTargets; ENSG00000160932; -.
PharmGKB; PA30491; -.
eggNOG; ENOG410IYXK; Eukaryota.
eggNOG; ENOG4111AYX; LUCA.
GeneTree; ENSGT00730000111295; -.
HOGENOM; HOG000035114; -.
HOVERGEN; HBG001732; -.
InParanoid; Q16553; -.
KO; K06846; -.
OMA; SDNYCVT; -.
OrthoDB; EOG091G0V2A; -.
PhylomeDB; Q16553; -.
TreeFam; TF336080; -.
Reactome; R-HSA-163125; Post-translational modification: synthesis of GPI-anchored proteins.
SignaLink; Q16553; -.
ChiTaRS; LY6E; human.
GeneWiki; LY6E; -.
GenomeRNAi; 4061; -.
PRO; PR:Q16553; -.
Proteomes; UP000005640; Chromosome 8.
Bgee; ENSG00000160932; -.
CleanEx; HS_LY6E; -.
ExpressionAtlas; Q16553; baseline and differential.
Genevisible; Q16553; HS.
GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0006501; P:C-terminal protein lipidation; TAS:Reactome.
GO; GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
InterPro; IPR016054; LY6_UPA_recep-like.
Pfam; PF00021; UPAR_LY6; 1.
SMART; SM00134; LU; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond; Glycoprotein;
GPI-anchor; Lipoprotein; Membrane; Reference proteome; Signal.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 101 Lymphocyte antigen 6E.
/FTId=PRO_0000036138.
PROPEP 102 131 Removed in mature form. {ECO:0000255}.
/FTId=PRO_0000036139.
DOMAIN 21 101 UPAR/Ly6.
LIPID 101 101 GPI-anchor amidated serine.
{ECO:0000255}.
CARBOHYD 99 99 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 23 48 {ECO:0000250|UniProtKB:P0DP57,
ECO:0000250|UniProtKB:P0DP58}.
DISULFID 26 35 {ECO:0000250|UniProtKB:P0DP57,
ECO:0000250|UniProtKB:P0DP58}.
DISULFID 41 71 {ECO:0000250|UniProtKB:P0DP57,
ECO:0000250|UniProtKB:P0DP58}.
DISULFID 75 92 {ECO:0000250|UniProtKB:P0DP57,
ECO:0000250|UniProtKB:P0DP58}.
DISULFID 93 98 {ECO:0000250|UniProtKB:P0DP57,
ECO:0000250|UniProtKB:P0DP58}.
SEQUENCE 131 AA; 13507 MW; 0F6D1157741AFC98 CRC64;
MKIFLPVLLA ALLGVERASS LMCFSCLNQK SNLYCLKPTI CSDQDNYCVT VSASAGIGNL
VTFGHSLSKT CSPACPIPEG VNVGVASMGI SCCQSFLCNF SAADGGLRAS VTLLGAGLLL
SLLPALLRFG P


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