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Lymphocyte antigen 6E (Ly-6E) (Stem cell antigen 2) (Thymic shared antigen 1) (TSA-1)

 LY6E_MOUSE              Reviewed;         130 AA.
Q64253; Q61128;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-DEC-2000, sequence version 2.
23-MAY-2018, entry version 128.
RecName: Full=Lymphocyte antigen 6E;
Short=Ly-6E;
AltName: Full=Stem cell antigen 2;
AltName: Full=Thymic shared antigen 1;
Short=TSA-1;
Flags: Precursor;
Name=Ly6e; Synonyms=Ly67, Sca-2, Tsa-1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
PubMed=8258699;
Macneil I., Kennedy J., Godfrey D.I., Jenkins N.A., Masciantonio M.,
Mineo C., Gilbert D.J., Copeland N.G., Boyd R.L., Zlotnik A.;
"Isolation of a cDNA encoding thymic shared antigen-1. A new member of
the Ly6 family with a possible role in T cell development.";
J. Immunol. 151:6913-6923(1993).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J; TISSUE=Thymus;
PubMed=8202484; DOI=10.1073/pnas.91.12.5296;
Classon B.J., Coverdale L.;
"Mouse stem cell antigen Sca-2 is a member of the Ly-6 family of cell
surface proteins.";
Proc. Natl. Acad. Sci. U.S.A. 91:5296-5300(1994).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/SvJ;
PubMed=8662090; DOI=10.1007/BF02602589;
Classon B.J., Coverdale L.;
"Genomic organization and expression of mouse thymic shared antigen-1
(TSA-1): evidence for a processed pseudogene.";
Immunogenetics 44:222-226(1996).
[4]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Kidney, and Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[5]
FUNCTION, AND INTERACTION WITH CHRNA4.
PubMed=26276394; DOI=10.1074/jbc.M115.647248;
Wu M., Puddifoot C.A., Taylor P., Joiner W.J.;
"Mechanisms of inhibition and potentiation of alpha4beta2 nicotinic
acetylcholine receptors by members of the Ly6 protein family.";
J. Biol. Chem. 290:24509-24518(2015).
-!- FUNCTION: Involved in T-cell development (PubMed:8258699).
Believed to act as a modulator of nicotinic acetylcholine
receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-
containing nAChRs maximum response (PubMed:26276394).
{ECO:0000269|PubMed:26276394, ECO:0000305|PubMed:8258699}.
-!- SUBUNIT: Interacts with CHRNA4. {ECO:0000269|PubMed:26276394}.
-!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
-!- SEQUENCE CAUTION:
Sequence=AAA19121.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=AAB03366.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; U09192; AAB03366.1; ALT_INIT; mRNA.
EMBL; U04268; AAA19121.1; ALT_INIT; mRNA.
EMBL; U47737; AAB17698.1; -; Genomic_DNA.
RefSeq; NP_001157508.1; NM_001164036.1.
RefSeq; NP_001157509.1; NM_001164037.1.
RefSeq; NP_001157510.1; NM_001164038.1.
RefSeq; NP_001157511.1; NM_001164039.1.
RefSeq; NP_001157512.1; NM_001164040.1.
RefSeq; NP_032555.1; NM_008529.3.
UniGene; Mm.788; -.
ProteinModelPortal; Q64253; -.
BioGrid; 201242; 1.
IntAct; Q64253; 1.
STRING; 10090.ENSMUSP00000056703; -.
PhosphoSitePlus; Q64253; -.
SwissPalm; Q64253; -.
EPD; Q64253; -.
MaxQB; Q64253; -.
PaxDb; Q64253; -.
PeptideAtlas; Q64253; -.
PRIDE; Q64253; -.
GeneID; 17069; -.
KEGG; mmu:17069; -.
CTD; 4061; -.
MGI; MGI:106651; Ly6e.
eggNOG; ENOG410IYXK; Eukaryota.
eggNOG; ENOG4111AYX; LUCA.
HOVERGEN; HBG001732; -.
InParanoid; Q64253; -.
KO; K06846; -.
PhylomeDB; Q64253; -.
ChiTaRS; Ly6e; mouse.
PRO; PR:Q64253; -.
Proteomes; UP000000589; Unplaced.
CleanEx; MM_LY6E; -.
GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0033130; F:acetylcholine receptor binding; IDA:MGI.
GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IDA:MGI.
GO; GO:0095500; P:acetylcholine receptor signaling pathway; IDA:MGI.
GO; GO:0030325; P:adrenal gland development; IMP:MGI.
GO; GO:0048242; P:epinephrine secretion; IMP:MGI.
GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
GO; GO:0042415; P:norepinephrine metabolic process; IMP:MGI.
GO; GO:0035265; P:organ growth; IMP:MGI.
GO; GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IMP:MGI.
InterPro; IPR016054; LY6_UPA_recep-like.
Pfam; PF00021; UPAR_LY6; 1.
SMART; SM00134; LU; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Disulfide bond; Glycoprotein;
GPI-anchor; Lipoprotein; Membrane; Reference proteome; Signal.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 102 Lymphocyte antigen 6E.
/FTId=PRO_0000036140.
PROPEP 103 130 Removed in mature form. {ECO:0000250}.
/FTId=PRO_0000036141.
DOMAIN 21 101 UPAR/Ly6.
LIPID 102 102 GPI-anchor amidated alanine.
{ECO:0000255}.
CARBOHYD 99 99 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 23 48 {ECO:0000250|UniProtKB:P0DP57,
ECO:0000250|UniProtKB:P0DP58}.
DISULFID 26 35 {ECO:0000250|UniProtKB:P0DP57,
ECO:0000250|UniProtKB:P0DP58}.
DISULFID 41 70 {ECO:0000250|UniProtKB:P0DP57,
ECO:0000250|UniProtKB:P0DP58}.
DISULFID 74 92 {ECO:0000250|UniProtKB:P0DP57,
ECO:0000250|UniProtKB:P0DP58}.
DISULFID 93 98 {ECO:0000250|UniProtKB:P0DP57,
ECO:0000250|UniProtKB:P0DP58}.
SEQUENCE 130 AA; 13800 MW; 0D1C25505F61DEB2 CRC64;
MRVFLPVLLA ALLGMEQVHS LMCFSCTDQK NNINCLWPVS CQEKDHYCIT LSAAAGFGNV
NLGYTLNKGC SPICPSENVN LNLGVASVNS YCCQSSFCNF SAAGLGLRAS IPLLGLGLLL
SLLALLQLSP


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