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Lymphocyte antigen 96 (Ly-96) (Protein MD-2)

 LY96_BOVIN              Reviewed;         160 AA.
P58754;
27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
27-MAR-2002, sequence version 1.
10-MAY-2017, entry version 70.
RecName: Full=Lymphocyte antigen 96;
Short=Ly-96;
AltName: Full=Protein MD-2 {ECO:0000303|PubMed:17559944};
Flags: Precursor;
Name=LY96; Synonyms=MD2;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lymph node;
Guionaud C.T., Dubey C., Zumkehr J.R., Sonstegard T.S., Jungi T.W.;
"Role of bovine TLR2, TLR4 and CD14 in the recognition of bacterial
constituents.";
Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
[2]
FUNCTION, SUBCELLULAR LOCATION, AND SUBUNIT.
PubMed=17559944; DOI=10.1016/j.vetimm.2007.04.017;
Sauter K.S., Brcic M., Franchini M., Jungi T.W.;
"Stable transduction of bovine TLR4 and bovine MD-2 into LPS-
nonresponsive cells and soluble CD14 promote the ability to respond to
LPS.";
Vet. Immunol. Immunopathol. 118:92-104(2007).
-!- FUNCTION: Binds bacterial lipopolysaccharide (LPS). Cooperates
with TLR4 in the innate immune response to bacterial
lipopolysaccharide (LPS), and with TLR2 in the response to cell
wall components from Gram-positive and Gram-negative bacteria (By
similarity). Enhances TLR4-dependent activation of NF-kappa-B.
Cells expressing both LY96 and TLR4, but not TLR4 alone, respond
to LPS. {ECO:0000250|UniProtKB:Q9Y6Y9,
ECO:0000269|PubMed:17559944}.
-!- SUBUNIT: Heterogeneous homopolymer formed from homodimers;
disulfide-linked (By similarity). Belongs to the
lipopolysaccharide (LPS) receptor, a multi-protein complex
containing at least CD14, LY96 and TLR4 (PubMed:17559944). Binds
to the extracellular domains of TLR2 and TLR4. Ligand binding
induces interaction with TLR4 and oligomerization of the complex
(By similarity). {ECO:0000250|UniProtKB:Q9Y6Y9,
ECO:0000269|PubMed:17559944}.
-!- SUBCELLULAR LOCATION: Secreted, extracellular space
{ECO:0000269|PubMed:17559944}. Secreted
{ECO:0000250|UniProtKB:Q9Y6Y9}. Note=Retained in the extracellular
space at the cell surface by interaction with TLR4.
{ECO:0000305|PubMed:17559944}.
-!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9Y6Y9}.
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EMBL; AF368418; AAL16721.1; -; mRNA.
UniGene; Bt.45646; -.
ProteinModelPortal; P58754; -.
SMR; P58754; -.
HOVERGEN; HBG032514; -.
InParanoid; P58754; -.
Proteomes; UP000009136; Unplaced.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
GO; GO:0031226; C:intrinsic component of plasma membrane; ISS:UniProtKB.
GO; GO:0046696; C:lipopolysaccharide receptor complex; ISS:UniProtKB.
GO; GO:0001875; F:lipopolysaccharide receptor activity; ISS:UniProtKB.
GO; GO:0071222; P:cellular response to lipopolysaccharide; ISS:UniProtKB.
GO; GO:0032497; P:detection of lipopolysaccharide; ISS:UniProtKB.
GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISS:UniProtKB.
GO; GO:0034142; P:toll-like receptor 4 signaling pathway; ISS:UniProtKB.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR003172; ML_dom.
Pfam; PF02221; E1_DerP2_DerF2; 1.
SMART; SM00737; ML; 1.
SUPFAM; SSF81296; SSF81296; 1.
1: Evidence at protein level;
Complete proteome; Disulfide bond; Glycoprotein; Immunity;
Inflammatory response; Innate immunity; Reference proteome; Secreted;
Signal.
SIGNAL 1 16 {ECO:0000255}.
CHAIN 17 160 Lymphocyte antigen 96.
/FTId=PRO_0000018617.
REGION 119 123 Interaction with lipopolysaccharide.
{ECO:0000250|UniProtKB:Q9Y6Y9}.
CARBOHYD 26 26 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 114 114 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 150 150 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 25 51 {ECO:0000250|UniProtKB:Q9Y6Y9}.
DISULFID 37 148 {ECO:0000250|UniProtKB:Q9Y6Y9}.
DISULFID 95 105 {ECO:0000250|UniProtKB:Q9Y6Y9}.
SEQUENCE 160 AA; 18484 MW; D97760E5FE93B352 CRC64;
MFPFMLFSTL FSSIFTEPRE KMWICNSSDA SLWYNYCDDM KFPISVKVEP CVTIKGTKGK
LHLYYIARRD IQKLYLNLHI SIKSMTLPMR KEVICREYGG DYSFCGALKG ETVNTTIPFS
FQGIRFSPGQ YHCVVEAISG NSEEMLFCLN FTIIHYSSLN


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