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Lymphocyte antigen 96 (Ly-96) (Protein MD-2)

 LY96_CRIGR              Reviewed;         160 AA.
P58755;
27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
27-MAR-2002, sequence version 1.
25-OCT-2017, entry version 65.
RecName: Full=Lymphocyte antigen 96;
Short=Ly-96;
AltName: Full=Protein MD-2;
Flags: Precursor;
Name=LY96; Synonyms=MD2;
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Cricetidae; Cricetinae; Cricetulus.
NCBI_TaxID=10029;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND VARIANT TYR-95.
TISSUE=Ovarian carcinoma;
PubMed=11435474; DOI=10.1084/jem.194.1.79;
Schromm A.B., Lien E., Henneke P., Chow J.C., Yoshimura A., Heine H.,
Latz E., Monks B.G., Schwartz D.A., Miyake K., Golenbock D.T.;
"Molecular genetic analysis of an endotoxin nonresponder mutant cell
line. A point mutation in a conserved region of MD-2 abolishes
endotoxin-induced signaling.";
J. Exp. Med. 194:79-88(2001).
-!- FUNCTION: Binds bacterial lipopolysaccharide (LPS). Cooperates
with TLR4 in the innate immune response to bacterial
lipopolysaccharide (LPS), and with TLR2 in the response to cell
wall components from Gram-positive and Gram-negative bacteria.
Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing
both LY96 and TLR4, but not TLR4 alone, respond to LPS.
{ECO:0000250|UniProtKB:Q9Y6Y9, ECO:0000269|PubMed:11435474}.
-!- SUBUNIT: Heterogeneous homopolymer formed from homodimers;
disulfide-linked. Belongs to the lipopolysaccharide (LPS)
receptor, a multi-protein complex containing at least CD14, LY96
and TLR4. Binds to the extracellular domains of TLR2 and TLR4.
Ligand binding induces interaction with TLR4 and oligomerization
of the complex. {ECO:0000250|UniProtKB:Q9Y6Y9}.
-!- SUBCELLULAR LOCATION: Secreted, extracellular space
{ECO:0000250|UniProtKB:Q9Y6Y9}. Secreted
{ECO:0000250|UniProtKB:Q9Y6Y9}. Note=Retained in the extracellular
space at the cell surface by interaction with TLR4.
{ECO:0000250|UniProtKB:Q9Y6Y9}.
-!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9Y6Y9}.
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EMBL; AF325501; AAK57984.1; -; mRNA.
RefSeq; NP_001233702.1; NM_001246773.1.
ProteinModelPortal; P58755; -.
SMR; P58755; -.
Ensembl; ENSCGRT00000010955; ENSCGRP00000010781; ENSCGRG00000007875.
GeneID; 100689342; -.
KEGG; cge:100689342; -.
CTD; 23643; -.
HOVERGEN; HBG032514; -.
KO; K05400; -.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
GO; GO:0031226; C:intrinsic component of plasma membrane; ISS:UniProtKB.
GO; GO:0046696; C:lipopolysaccharide receptor complex; ISS:UniProtKB.
GO; GO:0001875; F:lipopolysaccharide receptor activity; ISS:UniProtKB.
GO; GO:0071222; P:cellular response to lipopolysaccharide; ISS:UniProtKB.
GO; GO:0032497; P:detection of lipopolysaccharide; ISS:UniProtKB.
GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0031666; P:positive regulation of lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISS:UniProtKB.
GO; GO:0034142; P:toll-like receptor 4 signaling pathway; ISS:UniProtKB.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR003172; ML_dom.
Pfam; PF02221; E1_DerP2_DerF2; 1.
SMART; SM00737; ML; 1.
SUPFAM; SSF81296; SSF81296; 1.
2: Evidence at transcript level;
Disulfide bond; Glycoprotein; Immunity; Inflammatory response;
Innate immunity; Polymorphism; Secreted; Signal.
SIGNAL 1 16 {ECO:0000255}.
CHAIN 17 160 Lymphocyte antigen 96.
/FTId=PRO_0000018618.
REGION 119 123 Interaction with lipopolysaccharide.
{ECO:0000250|UniProtKB:Q9Y6Y9}.
CARBOHYD 26 26 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 77 77 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 101 101 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 150 150 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 25 51 {ECO:0000250|UniProtKB:Q9Y6Y9}.
DISULFID 37 148 {ECO:0000250|UniProtKB:Q9Y6Y9}.
DISULFID 95 105 {ECO:0000250|UniProtKB:Q9Y6Y9}.
VARIANT 95 95 C -> Y (in endotoxin nonresponder).
{ECO:0000269|PubMed:11435474}.
SEQUENCE 160 AA; 18357 MW; 0E533B1AA5B46DD6 CRC64;
MLPFILFSTL LPLIFTESEQ QLWFCNSSDA TFSYSYCDSM KFPFSITAEP CITLKGTNGF
LHIKFIPRRD LKKLYFNLSI NVNSIEVPTR KEIICHGYDD NYSFCKALKG ETVNTVVPFS
FKGILFPKGQ YRCVAEAIVG DNEEKLFCLN FTIIHHPNVN


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