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Lymphocyte enhancer binding factor 1 (Lymphocyte enhancer binding factor 1 Lef1) (Lymphoid enhancer-binding factor 1)

 Q9W7C0_DANRE            Unreviewed;       365 AA.
Q9W7C0;
01-NOV-1999, integrated into UniProtKB/TrEMBL.
01-NOV-1999, sequence version 1.
25-OCT-2017, entry version 131.
SubName: Full=Lymphocyte enhancer binding factor 1 {ECO:0000313|EMBL:AAI62097.1};
SubName: Full=Lymphocyte enhancer binding factor 1 Lef1 {ECO:0000313|EMBL:AAD41489.1};
SubName: Full=Lymphoid enhancer-binding factor 1 {ECO:0000313|Ensembl:ENSDARP00000114249};
Name=lef1 {ECO:0000313|EMBL:AAD41489.1,
ECO:0000313|Ensembl:ENSDARP00000114249,
ECO:0000313|ZFIN:ZDB-GENE-990714-26};
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955 {ECO:0000313|EMBL:AAD41489.1};
[1] {ECO:0000313|EMBL:AAD41489.1}
NUCLEOTIDE SEQUENCE.
PubMed=10446273; DOI=10.1016/S0925-4773(99)00101-X;
Dorsky R.I., Snyder A., Cretekos C.J., Grunwald D.J., Geisler R.,
Haffter P., Moon R.T., Raible D.W.;
"Maternal and embryonic expression of zebrafish lef1.";
Mech. Dev. 86:147-150(1999).
[2] {ECO:0000313|EMBL:AAI62097.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSDARP00000114249}
IDENTIFICATION.
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000114249};
Ensembl;
Submitted (FEB-2012) to UniProtKB.
[4] {ECO:0000313|Ensembl:ENSDARP00000114249, ECO:0000313|Proteomes:UP000000437}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000114249,
ECO:0000313|Proteomes:UP000000437};
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
Saunders D., Wallis J., Babbage A., Hammond S.,
Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the
human genome.";
Nature 496:498-503(2013).
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
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EMBL; BX572104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CR391978; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AF136454; AAD41489.1; -; mRNA.
EMBL; BC162097; AAI62097.1; -; mRNA.
RefSeq; NP_571501.1; NM_131426.1.
UniGene; Dr.64686; -.
STRING; 7955.ENSDARP00000114249; -.
Ensembl; ENSDART00000132405; ENSDARP00000114249; ENSDARG00000031894.
GeneID; 30701; -.
KEGG; dre:30701; -.
CTD; 51176; -.
ZFIN; ZDB-GENE-990714-26; lef1.
eggNOG; KOG3248; Eukaryota.
eggNOG; ENOG41109RU; LUCA.
GeneTree; ENSGT00390000009964; -.
HOGENOM; HOG000116032; -.
HOVERGEN; HBG000419; -.
KO; K04492; -.
TreeFam; TF318448; -.
Reactome; R-DRE-201722; Formation of the beta-catenin:TCF transactivating complex.
Reactome; R-DRE-3769402; Deactivation of the beta-catenin transactivating complex.
Reactome; R-DRE-4086398; Ca2+ pathway.
Reactome; R-DRE-4641265; Repression of WNT target genes.
Proteomes; UP000000437; Chromosome 1.
Bgee; ENSDARG00000031894; -.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
GO; GO:0005667; C:transcription factor complex; IBA:GO_Central.
GO; GO:0070016; F:armadillo repeat domain binding; IBA:GO_Central.
GO; GO:0008013; F:beta-catenin binding; IBA:GO_Central.
GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
GO; GO:0008301; F:DNA binding, bending; ISS:UniProtKB.
GO; GO:0035326; F:enhancer binding; IBA:GO_Central.
GO; GO:0030331; F:estrogen receptor binding; IBA:GO_Central.
GO; GO:0045295; F:gamma-catenin binding; IBA:GO_Central.
GO; GO:0043565; F:sequence-specific DNA binding; IPI:ZFIN.
GO; GO:0003705; F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; IBA:GO_Central.
GO; GO:0046632; P:alpha-beta T cell differentiation; IBA:GO_Central.
GO; GO:0060561; P:apoptotic process involved in morphogenesis; IBA:GO_Central.
GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central.
GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IBA:GO_Central.
GO; GO:0060070; P:canonical Wnt signaling pathway; IMP:ZFIN.
GO; GO:0033336; P:caudal fin development; IMP:ZFIN.
GO; GO:0001837; P:epithelial to mesenchymal transition; IBA:GO_Central.
GO; GO:0048069; P:eye pigmentation; IBA:GO_Central.
GO; GO:0060325; P:face morphogenesis; IBA:GO_Central.
GO; GO:0033333; P:fin development; IMP:ZFIN.
GO; GO:0033334; P:fin morphogenesis; IMP:ZFIN.
GO; GO:0031101; P:fin regeneration; IMP:ZFIN.
GO; GO:0021873; P:forebrain neuroblast division; IBA:GO_Central.
GO; GO:0021879; P:forebrain neuron differentiation; IMP:ZFIN.
GO; GO:0021861; P:forebrain radial glial cell differentiation; IBA:GO_Central.
GO; GO:0021943; P:formation of radial glial scaffolds; IBA:GO_Central.
GO; GO:0021979; P:hypothalamus cell differentiation; IMP:ZFIN.
GO; GO:0021854; P:hypothalamus development; IMP:ZFIN.
GO; GO:0048747; P:muscle fiber development; IMP:ZFIN.
GO; GO:0071866; P:negative regulation of apoptotic process in bone marrow; IBA:GO_Central.
GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central.
GO; GO:0032696; P:negative regulation of interleukin-13 production; IBA:GO_Central.
GO; GO:0032713; P:negative regulation of interleukin-4 production; IBA:GO_Central.
GO; GO:0032714; P:negative regulation of interleukin-5 production; IBA:GO_Central.
GO; GO:0001755; P:neural crest cell migration; IMP:ZFIN.
GO; GO:0022008; P:neurogenesis; IGI:ZFIN.
GO; GO:0030223; P:neutrophil differentiation; IBA:GO_Central.
GO; GO:0071895; P:odontoblast differentiation; IBA:GO_Central.
GO; GO:0001649; P:osteoblast differentiation; IBA:GO_Central.
GO; GO:0048341; P:paraxial mesoderm formation; IBA:GO_Central.
GO; GO:0033339; P:pectoral fin development; IMP:ZFIN.
GO; GO:0071864; P:positive regulation of cell proliferation in bone marrow; IBA:GO_Central.
GO; GO:0010628; P:positive regulation of gene expression; IMP:ZFIN.
GO; GO:0050769; P:positive regulation of neurogenesis; IMP:ZFIN.
GO; GO:0048916; P:posterior lateral line development; IMP:ZFIN.
GO; GO:0048922; P:posterior lateral line neuromast deposition; IMP:ZFIN.
GO; GO:0048919; P:posterior lateral line neuromast development; IMP:ZFIN.
GO; GO:0060784; P:regulation of cell proliferation involved in tissue homeostasis; IMP:ZFIN.
GO; GO:0022407; P:regulation of cell-cell adhesion; IBA:GO_Central.
GO; GO:1900052; P:regulation of retinoic acid biosynthetic process; IGI:ZFIN.
GO; GO:0016202; P:regulation of striated muscle tissue development; IBA:GO_Central.
GO; GO:0001756; P:somitogenesis; IMP:ZFIN.
GO; GO:0002040; P:sprouting angiogenesis; IBA:GO_Central.
GO; GO:0061153; P:trachea gland development; IBA:GO_Central.
GO; GO:0016055; P:Wnt signaling pathway; IMP:ZFIN.
Gene3D; 1.10.30.10; -; 1.
Gene3D; 4.10.900.10; -; 1.
InterPro; IPR027397; Catenin_binding_dom.
InterPro; IPR013558; CTNNB1-bd_N.
InterPro; IPR009071; HMG_box_dom.
InterPro; IPR036910; HMG_box_dom_sf.
InterPro; IPR028769; LEF1.
InterPro; IPR024940; TCF/LEF.
PANTHER; PTHR10373; PTHR10373; 1.
PANTHER; PTHR10373:SF11; PTHR10373:SF11; 1.
Pfam; PF08347; CTNNB1_binding; 1.
Pfam; PF00505; HMG_box; 1.
SMART; SM00398; HMG; 1.
SUPFAM; SSF47095; SSF47095; 1.
PROSITE; PS50118; HMG_BOX_2; 1.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000000437};
DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267,
ECO:0000256|SAAS:SAAS00879239};
Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
Reference proteome {ECO:0000313|Proteomes:UP000000437}.
DOMAIN 265 333 HMG box. {ECO:0000259|PROSITE:PS50118}.
DNA_BIND 265 333 HMG box. {ECO:0000256|PROSITE-
ProRule:PRU00267}.
SEQUENCE 365 AA; 41059 MW; 9FC39E11FDF51350 CRC64;
MPQLSGGGGG GDPELCATDE MIPFKDEGDP HKEQIFAEIS HSEEEGDLAE IKSSLVNETE
ISPNSNSHDA ARQSQITPDS YHEKHRDHPD DGKLQDLYSK GHPYPSYPGY IMMTNMNNEP
YMNNGSLSPP IPRTSNKVPV VQPSHAVHPL TPLITYSDEH FAPGPHSGHH PQDVNPKQAG
MPRHHPGPDI PNFYPLSPGG VGQMTPPLGW FSHHMVPGPP GPHATGIPHP AIVNPQVKQE
HDTDLMHMKP QHEQRKEQEP KRPHIKKPLN AFMLYMKEMR ANVVAECTLK ESAAINQILG
RRWHALSREE QAKYYELARK ERQLHMQLYP GWSARDNYGK KKKRKREKIQ EPASGTGQRM
KTAYI


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