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Lymphocyte transmembrane adapter 1 (Linker for activation of X cells) (Membrane-associated adapter protein LAX)

 LAX1_MOUSE              Reviewed;         407 AA.
Q8BHB3; Q8BS18; Q8CGV1;
20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
20-DEC-2005, sequence version 2.
12-SEP-2018, entry version 108.
RecName: Full=Lymphocyte transmembrane adapter 1;
AltName: Full=Linker for activation of X cells;
AltName: Full=Membrane-associated adapter protein LAX;
Name=Lax1; Synonyms=Lax;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J;
PubMed=12359715; DOI=10.1074/jbc.M208946200;
Zhu M., Janssen E., Leung K., Zhang W.;
"Molecular cloning of a novel gene encoding a membrane-associated
adaptor protein (LAX) in lymphocyte signaling.";
J. Biol. Chem. 277:46151-46158(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J, and NOD; TISSUE=Aorta, and Thymus;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Salivary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
INDUCTION, TISSUE SPECIFICITY, FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=15843560; DOI=10.4049/jimmunol.174.9.5612;
Zhu M., Granillo O., Wen R., Yang K., Dai X., Wang D., Zhang W.;
"Negative regulation of lymphocyte activation by the adaptor protein
LAX.";
J. Immunol. 174:5612-5619(2005).
-!- FUNCTION: Negatively regulates TCR (T-cell antigen receptor)-
mediated signaling in T-cells and BCR (B-cell antigen receptor)-
mediated signaling in B-cells. {ECO:0000269|PubMed:15843560}.
-!- SUBUNIT: When phosphorylated, interacts with GRB2, PIK3R1 and
GRAP2. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass
type III membrane protein {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed in T-cells and B-cells.
{ECO:0000269|PubMed:15843560}.
-!- INDUCTION: Up-regulated in T- and B-cells following TCR and BCR
engagement, respectively. {ECO:0000269|PubMed:15843560}.
-!- PTM: Phosphorylated on tyrosines upon TCR or BCR activation; which
leads to the recruitment of GRB2, PIK3R1 and GRAP2. {ECO:0000250}.
-!- DISRUPTION PHENOTYPE: Mice are viable, fertile and healthy, and
show normal lymphocyte development. However, their T- and B-cells
are hyperresponsive to stimulation via TCR or BCR.
{ECO:0000269|PubMed:15843560}.
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; AY090785; AAM09819.1; -; mRNA.
EMBL; AK040834; BAC30715.1; -; mRNA.
EMBL; AK088503; BAC40394.1; -; mRNA.
EMBL; BC042765; AAH42765.1; -; mRNA.
CCDS; CCDS35711.1; -.
RefSeq; NP_001153121.1; NM_001159649.1.
RefSeq; NP_766430.3; NM_172842.3.
RefSeq; XP_006529620.1; XM_006529557.3.
UniGene; Mm.36534; -.
ProteinModelPortal; Q8BHB3; -.
IntAct; Q8BHB3; 1.
STRING; 10090.ENSMUSP00000131126; -.
iPTMnet; Q8BHB3; -.
PhosphoSitePlus; Q8BHB3; -.
EPD; Q8BHB3; -.
PaxDb; Q8BHB3; -.
PRIDE; Q8BHB3; -.
Ensembl; ENSMUST00000169295; ENSMUSP00000131126; ENSMUSG00000051998.
GeneID; 240754; -.
KEGG; mmu:240754; -.
UCSC; uc007cqs.2; mouse.
CTD; 54900; -.
MGI; MGI:2443362; Lax1.
eggNOG; ENOG410IVGH; Eukaryota.
eggNOG; ENOG41119TZ; LUCA.
GeneTree; ENSGT00390000014063; -.
HOGENOM; HOG000113286; -.
HOVERGEN; HBG081892; -.
InParanoid; Q8BHB3; -.
OMA; CCRDYEN; -.
OrthoDB; EOG091G0FTE; -.
PhylomeDB; Q8BHB3; -.
TreeFam; TF337411; -.
PRO; PR:Q8BHB3; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000051998; Expressed in 46 organ(s), highest expression level in mesenteric lymph node.
CleanEx; MM_LAX1; -.
ExpressionAtlas; Q8BHB3; baseline and differential.
Genevisible; Q8BHB3; MM.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
GO; GO:0016021; C:integral component of membrane; ISO:MGI.
GO; GO:0005886; C:plasma membrane; ISO:MGI.
GO; GO:0019901; F:protein kinase binding; ISO:MGI.
GO; GO:0042169; F:SH2 domain binding; ISO:MGI.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
GO; GO:0050851; P:antigen receptor-mediated signaling pathway; IMP:MGI.
GO; GO:0042113; P:B cell activation; ISO:MGI.
GO; GO:0006955; P:immune response; ISO:MGI.
GO; GO:0048305; P:immunoglobulin secretion; IMP:MGI.
GO; GO:0000188; P:inactivation of MAPK activity; ISO:MGI.
GO; GO:0035556; P:intracellular signal transduction; ISO:MGI.
GO; GO:0046649; P:lymphocyte activation; IMP:MGI.
GO; GO:0050868; P:negative regulation of T cell activation; ISO:MGI.
InterPro; IPR031393; LAX.
PANTHER; PTHR24091; PTHR24091; 1.
Pfam; PF15681; LAX; 1.
ProDom; PD319679; PD319679; 1.
2: Evidence at transcript level;
Adaptive immunity; Cell membrane; Complete proteome; Immunity;
Membrane; Phosphoprotein; Reference proteome; Signal-anchor;
Transmembrane; Transmembrane helix.
CHAIN 1 407 Lymphocyte transmembrane adapter 1.
/FTId=PRO_0000083330.
TOPO_DOM 1 33 Extracellular. {ECO:0000255}.
TRANSMEM 34 54 Helical; Signal-anchor for type III
membrane protein. {ECO:0000255}.
TOPO_DOM 55 407 Cytoplasmic. {ECO:0000255}.
MOD_RES 185 185 Phosphotyrosine.
{ECO:0000250|UniProtKB:Q8IWV1}.
MOD_RES 260 260 Phosphotyrosine.
{ECO:0000250|UniProtKB:Q8IWV1}.
MOD_RES 286 286 Phosphotyrosine.
{ECO:0000250|UniProtKB:Q8IWV1}.
MOD_RES 353 353 Phosphotyrosine.
{ECO:0000250|UniProtKB:Q8IWV1}.
CONFLICT 67 67 P -> S (in Ref. 2; BAC40394 and 3;
AAH42765). {ECO:0000305}.
CONFLICT 145 145 N -> D (in Ref. 2; BAC40394 and 3;
AAH42765). {ECO:0000305}.
CONFLICT 230 230 A -> V (in Ref. 2; BAC30715).
{ECO:0000305}.
CONFLICT 342 342 R -> G (in Ref. 2; BAC40394 and 3;
AAH42765). {ECO:0000305}.
SEQUENCE 407 AA; 44838 MW; 00C3F063A7CFC7BE CRC64;
MYSTPAPPEV TRRNSEPSTR QGTLGSLQGE KGQIIFPGFV VLLTIILVII AACILWSWKK
QKKRPVPYFQ VAPSLTLPPP RHRAKNIYDF LPRQQTELGR HQLSGFSTES LLSRASDSPE
PEAPQANGSL QMHRVSVHTV EYSVNIYDNG TVPQMCRHLA SSTHHVCVRT SRSNPSISSK
ESNDYVNIPT VEDTCETLTR IESTPENHLG LPSALRLEFA EGGHAGCGNA TDHDGFWAPG
PKCSDSLSDG DDLSQTSNDY VNMTGLDLEN IQENRPRGAF QCCRDYENVP WVDTNESQLP
TLEEVASSTV DHREPVWRTL SSVYHMAFQP SAQSEDSAMV HREEQSSEDS SDYETVLVAE
LEGRDWKQGP GTQHPSDEGT PGDLAGKLCE VVYPAGSLAT ETSDEDA


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