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Lymphocyte transmembrane adapter 1 (Membrane-associated adapter protein LAX)

 LAX1_BOVIN              Reviewed;         387 AA.
Q58CT8;
20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
26-APR-2005, sequence version 1.
31-JAN-2018, entry version 74.
RecName: Full=Lymphocyte transmembrane adapter 1;
AltName: Full=Membrane-associated adapter protein LAX;
Name=LAX1; Synonyms=LAX;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=16305752; DOI=10.1186/1471-2164-6-166;
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
"Characterization of 954 bovine full-CDS cDNA sequences.";
BMC Genomics 6:166-166(2005).
-!- FUNCTION: Negatively regulates TCR (T-cell antigen receptor)-
mediated signaling in T-cells and BCR (B-cell antigen receptor)-
mediated signaling in B-cells. {ECO:0000250}.
-!- SUBUNIT: When phosphorylated, interacts with GRB2, PIK3R1 and
GRAP2. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass
type III membrane protein {ECO:0000250}.
-!- PTM: Phosphorylated on tyrosines upon TCR or BCR activation; which
leads to the recruitment of GRB2, PIK3R1 and GRAP2. {ECO:0000250}.
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EMBL; BT021859; AAX46706.1; -; mRNA.
RefSeq; NP_001015674.1; NM_001015674.1.
UniGene; Bt.37374; -.
STRING; 9913.ENSBTAP00000016385; -.
PaxDb; Q58CT8; -.
PRIDE; Q58CT8; -.
Ensembl; ENSBTAT00000016385; ENSBTAP00000016385; ENSBTAG00000012349.
GeneID; 540424; -.
KEGG; bta:540424; -.
CTD; 54900; -.
eggNOG; ENOG410IVGH; Eukaryota.
eggNOG; ENOG41119TZ; LUCA.
GeneTree; ENSGT00390000014063; -.
HOGENOM; HOG000113286; -.
HOVERGEN; HBG081892; -.
InParanoid; Q58CT8; -.
OMA; CCRDYEN; -.
OrthoDB; EOG091G0FTE; -.
TreeFam; TF337411; -.
Proteomes; UP000009136; Chromosome 16.
Bgee; ENSBTAG00000012349; -.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0042169; F:SH2 domain binding; IEA:Ensembl.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
GO; GO:0042113; P:B cell activation; IEA:Ensembl.
GO; GO:0000188; P:inactivation of MAPK activity; IEA:Ensembl.
GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
GO; GO:0050868; P:negative regulation of T cell activation; IEA:Ensembl.
InterPro; IPR031393; LAX.
PANTHER; PTHR24091; PTHR24091; 1.
Pfam; PF15681; LAX; 1.
ProDom; PD319679; PD319679; 1.
2: Evidence at transcript level;
Adaptive immunity; Cell membrane; Complete proteome; Immunity;
Membrane; Phosphoprotein; Reference proteome; Signal-anchor;
Transmembrane; Transmembrane helix.
CHAIN 1 387 Lymphocyte transmembrane adapter 1.
/FTId=PRO_0000083328.
TOPO_DOM 1 37 Extracellular. {ECO:0000255}.
TRANSMEM 38 58 Helical; Signal-anchor for type III
membrane protein. {ECO:0000255}.
TOPO_DOM 59 387 Cytoplasmic. {ECO:0000255}.
MOD_RES 375 375 Phosphotyrosine.
{ECO:0000250|UniProtKB:Q8IWV1}.
SEQUENCE 387 AA; 41859 MW; 2A0136AC143958DB CRC64;
MDVTTSAWSE TTRRISEPST LQGTLGSLDK AEDHSSSIFS GFAALLAILL VVAVICVLWC
CGKRKKRQVP YLRVTIMPLL TLPRPRQRAK NIYDLLPRRQ EELGRHPSRS IRIVSTESLL
SRNSDSPSSE HVPSRAGDAL HMHRAHTHAM GYAVGIYDNA MRPQMCGNLA PSPHYVNVRA
SRGSPSTSSE DSRDYVNIPT AKEIAETLAS ASNPPRNLFI LPGTKELAPS EEIDEGCGNA
SDCTSLGSPG TENSDPLSDG EGSSQTSNDY VNMAELDLGT PQGKQLQGMF QCRRDYENVP
PGPSSNKQQE EEVTSSNTDH VEGRTDGPET HTPPAVQSGS FLALKDHVAC QSSAHSETGP
WEDAEETSSE DSHDYENVCA AEAGARG


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