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Lymphoid enhancer-binding factor 1 (LEF-1)

 LEF1_RAT                Reviewed;         397 AA.
Q9QXN1;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
25-OCT-2017, entry version 134.
RecName: Full=Lymphoid enhancer-binding factor 1;
Short=LEF-1;
Name=Lef1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Kidney;
PubMed=10824856;
Kobielak K., Kobielak A., Trzeciak W.H.;
"Cloning of the lymphoid enhancer binding factor-1 (Lef-1) cDNA from
rat kidney: homology to the mouse sequence.";
Acta Biochim. Pol. 46:885-888(1999).
-!- FUNCTION: Participates in the Wnt signaling pathway. Activates
transcription of target genes in the presence of CTNNB1 and EP300.
May play a role in hair cell differentiation and follicle
morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation
mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha
enhancer function. Binds DNA in a sequence-specific manner. PIASG
antagonizes both Wnt-dependent and Wnt-independent activation by
LEF1 (By similarity). {ECO:0000250}.
-!- SUBUNIT: Binds the armadillo repeat of CTNNB1 and forms a stable
complex. Interacts with TLE1, PIASG, ALYREF/THOC4, EP300, MDFI and
MDFIC (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00267}. Note=Found in nuclear bodies upon PIASG
binding. {ECO:0000250}.
-!- DOMAIN: Proline-rich and acidic regions are implicated in the
activation functions of RNA polymerase II transcription factors.
-!- PTM: Phosphorylated at Thr-153 and/or Ser-164 by NLK.
Phosphorylation by NLK at these sites represses LEF1-mediated
transcriptional activation of target genes of the canonical Wnt
signaling pathway (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the TCF/LEF family. {ECO:0000305}.
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EMBL; AF198533; AAF15601.1; -; mRNA.
RefSeq; NP_569113.1; NM_130429.1.
UniGene; Rn.228611; -.
ProteinModelPortal; Q9QXN1; -.
SMR; Q9QXN1; -.
BioGrid; 250906; 1.
IntAct; Q9QXN1; 1.
MINT; MINT-8388232; -.
STRING; 10116.ENSRNOP00000013694; -.
iPTMnet; Q9QXN1; -.
PhosphoSitePlus; Q9QXN1; -.
PaxDb; Q9QXN1; -.
GeneID; 161452; -.
KEGG; rno:161452; -.
CTD; 51176; -.
RGD; 620241; Lef1.
eggNOG; KOG3248; Eukaryota.
eggNOG; ENOG41109RU; LUCA.
HOGENOM; HOG000116032; -.
HOVERGEN; HBG000419; -.
InParanoid; Q9QXN1; -.
KO; K04492; -.
PhylomeDB; Q9QXN1; -.
PRO; PR:Q9QXN1; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0005667; C:transcription factor complex; IBA:GO_Central.
GO; GO:0070016; F:armadillo repeat domain binding; IBA:GO_Central.
GO; GO:0008013; F:beta-catenin binding; IBA:GO_Central.
GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
GO; GO:0008301; F:DNA binding, bending; ISS:UniProtKB.
GO; GO:0035326; F:enhancer binding; IBA:GO_Central.
GO; GO:0030331; F:estrogen receptor binding; IBA:GO_Central.
GO; GO:0045295; F:gamma-catenin binding; IBA:GO_Central.
GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0003705; F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; IBA:GO_Central.
GO; GO:0046632; P:alpha-beta T cell differentiation; IBA:GO_Central.
GO; GO:0031100; P:animal organ regeneration; IEP:RGD.
GO; GO:0060561; P:apoptotic process involved in morphogenesis; IBA:GO_Central.
GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central.
GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IBA:GO_Central.
GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
GO; GO:0007155; P:cell adhesion; IEP:RGD.
GO; GO:0060710; P:chorio-allantoic fusion; IBA:GO_Central.
GO; GO:0021542; P:dentate gyrus development; IBA:GO_Central.
GO; GO:0030326; P:embryonic limb morphogenesis; IBA:GO_Central.
GO; GO:0001837; P:epithelial to mesenchymal transition; IBA:GO_Central.
GO; GO:0048069; P:eye pigmentation; IBA:GO_Central.
GO; GO:0060325; P:face morphogenesis; IBA:GO_Central.
GO; GO:0021873; P:forebrain neuroblast division; IBA:GO_Central.
GO; GO:0021879; P:forebrain neuron differentiation; IBA:GO_Central.
GO; GO:0021861; P:forebrain radial glial cell differentiation; IBA:GO_Central.
GO; GO:0021943; P:formation of radial glial scaffolds; IBA:GO_Central.
GO; GO:0021854; P:hypothalamus development; IBA:GO_Central.
GO; GO:0001822; P:kidney development; IEP:RGD.
GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
GO; GO:0048747; P:muscle fiber development; IBA:GO_Central.
GO; GO:0071866; P:negative regulation of apoptotic process in bone marrow; IBA:GO_Central.
GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central.
GO; GO:0032696; P:negative regulation of interleukin-13 production; IBA:GO_Central.
GO; GO:0032713; P:negative regulation of interleukin-4 production; IBA:GO_Central.
GO; GO:0032714; P:negative regulation of interleukin-5 production; IBA:GO_Central.
GO; GO:0001755; P:neural crest cell migration; IBA:GO_Central.
GO; GO:0030223; P:neutrophil differentiation; IBA:GO_Central.
GO; GO:0071895; P:odontoblast differentiation; IMP:RGD.
GO; GO:0001649; P:osteoblast differentiation; IBA:GO_Central.
GO; GO:0048341; P:paraxial mesoderm formation; IBA:GO_Central.
GO; GO:0071864; P:positive regulation of cell proliferation in bone marrow; IBA:GO_Central.
GO; GO:0022407; P:regulation of cell-cell adhesion; IBA:GO_Central.
GO; GO:0016202; P:regulation of striated muscle tissue development; IBA:GO_Central.
GO; GO:0010226; P:response to lithium ion; IEP:RGD.
GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
GO; GO:0043588; P:skin development; IEP:RGD.
GO; GO:0001756; P:somitogenesis; IBA:GO_Central.
GO; GO:0002040; P:sprouting angiogenesis; IBA:GO_Central.
GO; GO:0061153; P:trachea gland development; IBA:GO_Central.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 1.10.30.10; -; 1.
Gene3D; 4.10.900.10; -; 1.
InterPro; IPR027397; Catenin_binding_dom.
InterPro; IPR013558; CTNNB1-bd_N.
InterPro; IPR009071; HMG_box_dom.
InterPro; IPR036910; HMG_box_dom_sf.
InterPro; IPR028769; LEF1.
InterPro; IPR024940; TCF/LEF.
PANTHER; PTHR10373; PTHR10373; 1.
PANTHER; PTHR10373:SF11; PTHR10373:SF11; 1.
Pfam; PF08347; CTNNB1_binding; 1.
Pfam; PF00505; HMG_box; 1.
SMART; SM00398; HMG; 1.
SUPFAM; SSF47095; SSF47095; 1.
PROSITE; PS50118; HMG_BOX_2; 1.
2: Evidence at transcript level;
Activator; Complete proteome; DNA-binding; Isopeptide bond; Nucleus;
Phosphoprotein; Reference proteome; Transcription;
Transcription regulation; Ubl conjugation; Wnt signaling pathway.
CHAIN 1 397 Lymphoid enhancer-binding factor 1.
/FTId=PRO_0000048597.
DNA_BIND 297 365 HMG box. {ECO:0000255|PROSITE-
ProRule:PRU00267}.
REGION 1 60 CTNNB1-binding. {ECO:0000250}.
COMPBIAS 6 11 Poly-Gly.
COMPBIAS 12 50 Asp/Glu-rich (acidic).
COMPBIAS 75 271 Pro-rich.
COMPBIAS 372 377 Poly-Lys.
MOD_RES 130 130 Phosphoserine.
{ECO:0000250|UniProtKB:Q9UJU2}.
MOD_RES 153 153 Phosphothreonine; by NLK. {ECO:0000250}.
MOD_RES 164 164 Phosphoserine; by NLK. {ECO:0000250}.
CROSSLNK 25 25 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
{ECO:0000250}.
CROSSLNK 267 267 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
{ECO:0000250}.
SEQUENCE 397 AA; 44023 MW; D6BEFF805CB526EA CRC64;
MPQLSGGGGG GDPELCATDE MIPFKDEGDP QKEKIFAEIS HPEEEGDLAD IKSSLVNESE
IIPASNGHEV VGQTQSSQEP YHDKAREHPD DGKHPDGGLY NKGPSYSSYS GYIMMPNMNS
DPYMSNGSLS PPIPRTSNKV PVVQPSHAVH PLTPLITYSD EHFSPGSHPS HIPSEVNPKQ
GMSRHPPAPE MPTFYPLSPG GVGQITPPLG WQGQPVYPIT GGFRQAYPSS LSGDTSMSRF
SHHMIPGPPG PHTTGIPHPA IVTPQVKQEH PHTDSDLMHV KPEHEQRKEQ EPKRPHIKKP
LNAFMLYMKE MRANVVAECT LKESAAINQI LGRRWHALSR EEQAKYYELA RKERQLHMQL
YPGWSARDNY GKKKKRKREK LQESTSGTGP RMTAAYI


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