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Lymphoid enhancer-binding factor 1 (LEF-1)

 LEF1_RAT                Reviewed;         397 AA.
Q9QXN1;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
31-JAN-2018, entry version 136.
RecName: Full=Lymphoid enhancer-binding factor 1;
Short=LEF-1;
Name=Lef1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Kidney;
PubMed=10824856;
Kobielak K., Kobielak A., Trzeciak W.H.;
"Cloning of the lymphoid enhancer binding factor-1 (Lef-1) cDNA from
rat kidney: homology to the mouse sequence.";
Acta Biochim. Pol. 46:885-888(1999).
-!- FUNCTION: Participates in the Wnt signaling pathway. Activates
transcription of target genes in the presence of CTNNB1 and EP300.
May play a role in hair cell differentiation and follicle
morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation
mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha
enhancer function. Binds DNA in a sequence-specific manner. PIASG
antagonizes both Wnt-dependent and Wnt-independent activation by
LEF1 (By similarity). {ECO:0000250}.
-!- SUBUNIT: Binds the armadillo repeat of CTNNB1 and forms a stable
complex. Interacts with TLE1, PIASG, ALYREF/THOC4, EP300, MDFI and
MDFIC (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00267}. Note=Found in nuclear bodies upon PIASG
binding. {ECO:0000250}.
-!- DOMAIN: Proline-rich and acidic regions are implicated in the
activation functions of RNA polymerase II transcription factors.
-!- PTM: Phosphorylated at Thr-153 and/or Ser-164 by NLK.
Phosphorylation by NLK at these sites represses LEF1-mediated
transcriptional activation of target genes of the canonical Wnt
signaling pathway (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the TCF/LEF family. {ECO:0000305}.
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EMBL; AF198533; AAF15601.1; -; mRNA.
RefSeq; NP_569113.1; NM_130429.1.
UniGene; Rn.228611; -.
ProteinModelPortal; Q9QXN1; -.
SMR; Q9QXN1; -.
BioGrid; 250906; 1.
IntAct; Q9QXN1; 1.
MINT; MINT-8388232; -.
STRING; 10116.ENSRNOP00000013694; -.
iPTMnet; Q9QXN1; -.
PhosphoSitePlus; Q9QXN1; -.
PaxDb; Q9QXN1; -.
GeneID; 161452; -.
KEGG; rno:161452; -.
CTD; 51176; -.
RGD; 620241; Lef1.
eggNOG; KOG3248; Eukaryota.
eggNOG; ENOG41109RU; LUCA.
HOGENOM; HOG000116032; -.
HOVERGEN; HBG000419; -.
InParanoid; Q9QXN1; -.
KO; K04492; -.
PhylomeDB; Q9QXN1; -.
PRO; PR:Q9QXN1; -.
Proteomes; UP000002494; Unplaced.
GO; GO:1990907; C:beta-catenin-TCF complex; ISO:RGD.
GO; GO:0005737; C:cytoplasm; ISO:RGD.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0032993; C:protein-DNA complex; ISO:RGD.
GO; GO:0005667; C:transcription factor complex; ISO:RGD.
GO; GO:0070016; F:armadillo repeat domain binding; ISO:RGD.
GO; GO:0008013; F:beta-catenin binding; ISO:RGD.
GO; GO:0070742; F:C2H2 zinc finger domain binding; ISO:RGD.
GO; GO:0003682; F:chromatin binding; ISO:RGD.
GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; ISO:RGD.
GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
GO; GO:0003700; F:DNA binding transcription factor activity; ISO:RGD.
GO; GO:0008301; F:DNA binding, bending; ISS:UniProtKB.
GO; GO:0035326; F:enhancer binding; ISO:RGD.
GO; GO:0030284; F:estrogen receptor activity; ISO:RGD.
GO; GO:0030331; F:estrogen receptor binding; ISO:RGD.
GO; GO:0045295; F:gamma-catenin binding; ISO:RGD.
GO; GO:0042393; F:histone binding; ISO:RGD.
GO; GO:0042826; F:histone deacetylase binding; ISO:RGD.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; ISO:RGD.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; ISO:RGD.
GO; GO:0043565; F:sequence-specific DNA binding; ISO:RGD.
GO; GO:0003705; F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; ISO:RGD.
GO; GO:0008134; F:transcription factor binding; ISO:RGD.
GO; GO:0044212; F:transcription regulatory region DNA binding; ISO:RGD.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; ISO:RGD.
GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:RGD.
GO; GO:0046632; P:alpha-beta T cell differentiation; ISO:RGD.
GO; GO:0060033; P:anatomical structure regression; ISO:RGD.
GO; GO:0031100; P:animal organ regeneration; IEP:RGD.
GO; GO:1902262; P:apoptotic process involved in blood vessel morphogenesis; ISO:RGD.
GO; GO:0060561; P:apoptotic process involved in morphogenesis; ISO:RGD.
GO; GO:0042100; P:B cell proliferation; ISO:RGD.
GO; GO:0030509; P:BMP signaling pathway; ISO:RGD.
GO; GO:0001569; P:branching involved in blood vessel morphogenesis; ISO:RGD.
GO; GO:0060070; P:canonical Wnt signaling pathway; ISO:RGD.
GO; GO:0007155; P:cell adhesion; IEP:RGD.
GO; GO:0060326; P:cell chemotaxis; ISO:RGD.
GO; GO:0048468; P:cell development; ISO:RGD.
GO; GO:0071345; P:cellular response to cytokine stimulus; ISO:RGD.
GO; GO:0071353; P:cellular response to interleukin-4; ISO:RGD.
GO; GO:0060710; P:chorio-allantoic fusion; ISO:RGD.
GO; GO:0021542; P:dentate gyrus development; ISO:RGD.
GO; GO:0030326; P:embryonic limb morphogenesis; ISO:RGD.
GO; GO:0001837; P:epithelial to mesenchymal transition; ISO:RGD.
GO; GO:0048069; P:eye pigmentation; IBA:GO_Central.
GO; GO:0060325; P:face morphogenesis; ISO:RGD.
GO; GO:0021873; P:forebrain neuroblast division; ISO:RGD.
GO; GO:0021879; P:forebrain neuron differentiation; IBA:GO_Central.
GO; GO:0021861; P:forebrain radial glial cell differentiation; ISO:RGD.
GO; GO:0021943; P:formation of radial glial scaffolds; ISO:RGD.
GO; GO:0021766; P:hippocampus development; ISO:RGD.
GO; GO:0043966; P:histone H3 acetylation; ISO:RGD.
GO; GO:0043967; P:histone H4 acetylation; ISO:RGD.
GO; GO:0021854; P:hypothalamus development; IBA:GO_Central.
GO; GO:0001822; P:kidney development; IEP:RGD.
GO; GO:0030879; P:mammary gland development; ISO:RGD.
GO; GO:0048747; P:muscle fiber development; IBA:GO_Central.
GO; GO:0043066; P:negative regulation of apoptotic process; ISO:RGD.
GO; GO:0071866; P:negative regulation of apoptotic process in bone marrow; ISO:RGD.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISO:RGD.
GO; GO:0022408; P:negative regulation of cell-cell adhesion; ISO:RGD.
GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:RGD.
GO; GO:0043392; P:negative regulation of DNA binding; ISO:RGD.
GO; GO:0071899; P:negative regulation of estrogen receptor binding; ISO:RGD.
GO; GO:0032696; P:negative regulation of interleukin-13 production; ISO:RGD.
GO; GO:0032713; P:negative regulation of interleukin-4 production; ISO:RGD.
GO; GO:0032714; P:negative regulation of interleukin-5 production; ISO:RGD.
GO; GO:0045843; P:negative regulation of striated muscle tissue development; ISO:RGD.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISO:RGD.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
GO; GO:0001755; P:neural crest cell migration; IBA:GO_Central.
GO; GO:0030223; P:neutrophil differentiation; ISO:RGD.
GO; GO:0071895; P:odontoblast differentiation; IMP:RGD.
GO; GO:0042475; P:odontogenesis of dentin-containing tooth; ISO:RGD.
GO; GO:0001649; P:osteoblast differentiation; ISO:RGD.
GO; GO:0060021; P:palate development; ISO:RGD.
GO; GO:0048341; P:paraxial mesoderm formation; ISO:RGD.
GO; GO:0043923; P:positive regulation by host of viral transcription; ISO:RGD.
GO; GO:0090068; P:positive regulation of cell cycle process; ISO:RGD.
GO; GO:0030307; P:positive regulation of cell growth; ISO:RGD.
GO; GO:0030335; P:positive regulation of cell migration; ISO:RGD.
GO; GO:0008284; P:positive regulation of cell proliferation; ISO:RGD.
GO; GO:0071864; P:positive regulation of cell proliferation in bone marrow; ISO:RGD.
GO; GO:0022409; P:positive regulation of cell-cell adhesion; ISO:RGD.
GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; ISO:RGD.
GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
GO; GO:0030854; P:positive regulation of granulocyte differentiation; ISO:RGD.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISO:RGD.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
GO; GO:0022407; P:regulation of cell-cell adhesion; ISO:RGD.
GO; GO:0016202; P:regulation of striated muscle tissue development; IBA:GO_Central.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; ISO:RGD.
GO; GO:0030111; P:regulation of Wnt signaling pathway; ISO:RGD.
GO; GO:0010226; P:response to lithium ion; IEP:RGD.
GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
GO; GO:0050909; P:sensory perception of taste; ISO:RGD.
GO; GO:0043588; P:skin development; IEP:RGD.
GO; GO:0001756; P:somitogenesis; ISO:RGD.
GO; GO:0002040; P:sprouting angiogenesis; ISO:RGD.
GO; GO:0033153; P:T cell receptor V(D)J recombination; ISO:RGD.
GO; GO:0045063; P:T-helper 1 cell differentiation; ISO:RGD.
GO; GO:0043586; P:tongue development; ISO:RGD.
GO; GO:0061153; P:trachea gland development; ISO:RGD.
GO; GO:0006366; P:transcription from RNA polymerase II promoter; ISO:RGD.
GO; GO:0001944; P:vasculature development; ISO:RGD.
GO; GO:0016055; P:Wnt signaling pathway; ISO:RGD.
Gene3D; 1.10.30.10; -; 1.
Gene3D; 4.10.900.10; -; 1.
InterPro; IPR027397; Catenin_binding_dom_sf.
InterPro; IPR013558; CTNNB1-bd_N.
InterPro; IPR009071; HMG_box_dom.
InterPro; IPR036910; HMG_box_dom_sf.
InterPro; IPR028769; LEF1.
InterPro; IPR024940; TCF/LEF.
PANTHER; PTHR10373; PTHR10373; 1.
PANTHER; PTHR10373:SF11; PTHR10373:SF11; 1.
Pfam; PF08347; CTNNB1_binding; 1.
Pfam; PF00505; HMG_box; 1.
SMART; SM00398; HMG; 1.
SUPFAM; SSF47095; SSF47095; 1.
PROSITE; PS50118; HMG_BOX_2; 1.
2: Evidence at transcript level;
Activator; Complete proteome; DNA-binding; Isopeptide bond; Nucleus;
Phosphoprotein; Reference proteome; Transcription;
Transcription regulation; Ubl conjugation; Wnt signaling pathway.
CHAIN 1 397 Lymphoid enhancer-binding factor 1.
/FTId=PRO_0000048597.
DNA_BIND 297 365 HMG box. {ECO:0000255|PROSITE-
ProRule:PRU00267}.
REGION 1 60 CTNNB1-binding. {ECO:0000250}.
COMPBIAS 6 11 Poly-Gly.
COMPBIAS 12 50 Asp/Glu-rich (acidic).
COMPBIAS 75 271 Pro-rich.
COMPBIAS 372 377 Poly-Lys.
MOD_RES 130 130 Phosphoserine.
{ECO:0000250|UniProtKB:Q9UJU2}.
MOD_RES 153 153 Phosphothreonine; by NLK. {ECO:0000250}.
MOD_RES 164 164 Phosphoserine; by NLK. {ECO:0000250}.
CROSSLNK 25 25 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
{ECO:0000250}.
CROSSLNK 267 267 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
{ECO:0000250}.
SEQUENCE 397 AA; 44023 MW; D6BEFF805CB526EA CRC64;
MPQLSGGGGG GDPELCATDE MIPFKDEGDP QKEKIFAEIS HPEEEGDLAD IKSSLVNESE
IIPASNGHEV VGQTQSSQEP YHDKAREHPD DGKHPDGGLY NKGPSYSSYS GYIMMPNMNS
DPYMSNGSLS PPIPRTSNKV PVVQPSHAVH PLTPLITYSD EHFSPGSHPS HIPSEVNPKQ
GMSRHPPAPE MPTFYPLSPG GVGQITPPLG WQGQPVYPIT GGFRQAYPSS LSGDTSMSRF
SHHMIPGPPG PHTTGIPHPA IVTPQVKQEH PHTDSDLMHV KPEHEQRKEQ EPKRPHIKKP
LNAFMLYMKE MRANVVAECT LKESAAINQI LGRRWHALSR EEQAKYYELA RKERQLHMQL
YPGWSARDNY GKKKKRKREK LQESTSGTGP RMTAAYI


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