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Lysine--tRNA ligase (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS)

 SYK_MYCMS               Reviewed;         500 AA.
Q6MUG2;
15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
07-JUN-2017, entry version 89.
RecName: Full=Lysine--tRNA ligase {ECO:0000255|HAMAP-Rule:MF_00252};
EC=6.1.1.6 {ECO:0000255|HAMAP-Rule:MF_00252};
AltName: Full=Lysyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_00252};
Short=LysRS {ECO:0000255|HAMAP-Rule:MF_00252};
Name=lysS {ECO:0000255|HAMAP-Rule:MF_00252};
OrderedLocusNames=MSC_0069;
Mycoplasma mycoides subsp. mycoides SC (strain PG1).
Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
NCBI_TaxID=272632;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=PG1;
PubMed=14762060; DOI=10.1101/gr.1673304;
Westberg J., Persson A., Holmberg A., Goesmann A., Lundeberg J.,
Johansson K.-E., Pettersson B., Uhlen M.;
"The genome sequence of Mycoplasma mycoides subsp. mycoides SC type
strain PG1T, the causative agent of contagious bovine pleuropneumonia
(CBPP).";
Genome Res. 14:221-227(2004).
-!- CATALYTIC ACTIVITY: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate
+ L-lysyl-tRNA(Lys). {ECO:0000255|HAMAP-Rule:MF_00252}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000255|HAMAP-Rule:MF_00252};
Note=Binds 3 Mg(2+) ions per subunit. {ECO:0000255|HAMAP-
Rule:MF_00252};
-!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00252}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00252}.
-!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase
family. {ECO:0000255|HAMAP-Rule:MF_00252}.
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EMBL; BX293980; CAE76722.1; -; Genomic_DNA.
RefSeq; NP_975080.1; NC_005364.2.
RefSeq; WP_011166280.1; NC_005364.2.
ProteinModelPortal; Q6MUG2; -.
SMR; Q6MUG2; -.
STRING; 272632.MSC_0069; -.
EnsemblBacteria; CAE76722; CAE76722; MSC_0069.
GeneID; 2744719; -.
KEGG; mmy:MSC_0069; -.
PATRIC; fig|272632.4.peg.70; -.
eggNOG; ENOG4105CRK; Bacteria.
eggNOG; COG1190; LUCA.
HOGENOM; HOG000236578; -.
KO; K04567; -.
OMA; EDPYPHK; -.
Proteomes; UP000001016; Chromosome.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004824; F:lysine-tRNA ligase activity; IEA:UniProtKB-EC.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO; GO:0006430; P:lysyl-tRNA aminoacylation; IEA:InterPro.
CDD; cd00775; LysRS_core; 1.
HAMAP; MF_00252; Lys_tRNA_synth_class2; 1.
InterPro; IPR004364; aa-tRNA-synt_II.
InterPro; IPR006195; aa-tRNA-synth_II.
InterPro; IPR002313; Lys-tRNA-ligase_II.
InterPro; IPR018149; Lys-tRNA-synth_II_C.
InterPro; IPR012340; NA-bd_OB-fold.
InterPro; IPR004365; NA-bd_OB_tRNA.
Pfam; PF00152; tRNA-synt_2; 1.
Pfam; PF01336; tRNA_anti-codon; 1.
PRINTS; PR00982; TRNASYNTHLYS.
SUPFAM; SSF50249; SSF50249; 1.
TIGRFAMs; TIGR00499; lysS_bact; 1.
PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
3: Inferred from homology;
Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm;
Ligase; Magnesium; Metal-binding; Nucleotide-binding;
Protein biosynthesis; Reference proteome.
CHAIN 1 500 Lysine--tRNA ligase.
/FTId=PRO_1000012896.
METAL 410 410 Magnesium 1. {ECO:0000255|HAMAP-
Rule:MF_00252}.
METAL 417 417 Magnesium 1. {ECO:0000255|HAMAP-
Rule:MF_00252}.
METAL 417 417 Magnesium 2. {ECO:0000255|HAMAP-
Rule:MF_00252}.
SEQUENCE 500 AA; 58071 MW; 7A168DE36BC4B24F CRC64;
MLDNRKFSEQ ELVRRNKYKT LVEQNKDPYK VTNWKRNTTL LKLNEKYKDY SKEDLLNLNQ
ELVVVAGRIK LYREAGKKAA FVNIDDQDSS IQLYVRLDEI GDQSFEDFRN FDLGDIIGVK
GIMMRTDHGE LSIRCKEVVL LSKALRPLPD KHAGIQDIEE KYRRRYVDLI VNHDVRKTFQ
ARTKIIRTLQ NFLDNKGYME VETPILHSLK GGASAKPFIT HYNVLNTDVY LRIATELHLK
RLIVGGFEGV YEIGRIFRNE GMSTRHNPEF TSIELYVAYE DMFFLMNLTE EIFRVCNAAV
NSNSIIEYNN VKIDLSKPFK RLHMVDGIKQ VTGVDFWKEM TVQQALELAK KHKVHVEKHQ
ESVGHIINLF YEEFVESTIV EPTFVYGHPK EISPLAKSNP SDPRFTDRFE LFILGREYAN
AFSELNDPID QYERFKAQIE EESKGNDEAN DMDIDFIEAL EHAMPPTAGI GIGIDRLVML
LTNSESIKDV LLFPQMKPRE


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