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Lysine-specific demethylase 9 (KDM9) (EC 1.14.11.-) (Round spermatid basic protein 1) (Rosbin)

 RSBN1_MOUSE             Reviewed;         795 AA.
Q80T69; B0V3N6; B9EI66; Q3UUB5; Q4VC18; Q7TNJ3; Q8C2Z3;
11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
01-SEP-2009, sequence version 3.
20-JUN-2018, entry version 98.
RecName: Full=Lysine-specific demethylase 9 {ECO:0000303|PubMed:28867287};
Short=KDM9 {ECO:0000303|PubMed:28867287};
EC=1.14.11.- {ECO:0000269|PubMed:28867287};
AltName: Full=Round spermatid basic protein 1;
Short=Rosbin;
Name=Rsbn1; Synonyms=Kiaa3002, Rsbn;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, PHOSPHORYLATION,
TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
PubMed=14724137; DOI=10.1095/biolreprod.103.026096;
Takahashi T., Tanaka H., Iguchi N., Kitamura K., Chen Y., Maekawa M.,
Nishimura H., Ohta H., Miyagawa Y., Matsumiya K., Okuyama A.,
Nishimune Y.;
"Rosbin: a novel homeobox-like protein gene expressed exclusively in
round spermatids.";
Biol. Reprod. 70:1485-1492(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-795.
STRAIN=C57BL/6J; TISSUE=Ovary, and Spinal cord;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 46-795.
TISSUE=Brain;
PubMed=12693553; DOI=10.1093/dnares/10.1.35;
Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
Nakajima D., Nagase T., Ohara O., Koga H.;
"Prediction of the coding sequences of mouse homologues of KIAA gene:
II. The complete nucleotide sequences of 400 mouse KIAA-homologous
cDNAs identified by screening of terminal sequences of cDNA clones
randomly sampled from size-fractionated libraries.";
DNA Res. 10:35-48(2003).
[6]
FUNCTION, AND COFACTOR.
PubMed=28867287; DOI=10.1016/j.cell.2017.07.041;
Brejc K., Bian Q., Uzawa S., Wheeler B.S., Anderson E.C., King D.S.,
Kranzusch P.J., Preston C.G., Meyer B.J.;
"Dynamic Control of X Chromosome Conformation and Repression by a
Histone H4K20 Demethylase.";
Cell 171:E23-E23(2017).
-!- FUNCTION: Histone demethylase that specifically demethylates
dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating
chromosome architecture. {ECO:0000269|PubMed:28867287}.
-!- COFACTOR:
Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
Evidence={ECO:0000269|PubMed:28867287};
Note=Binds 1 Fe(2+) ion per subunit.
{ECO:0000250|UniProtKB:Q9GRZ3};
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14724137}.
-!- TISSUE SPECIFICITY: Testis. Expressed exclusively in haploid round
spermatids. {ECO:0000269|PubMed:14724137}.
-!- DEVELOPMENTAL STAGE: Expressed abundantly in the testis at 23 days
after birth and later. Expressed exclusively in the germ cells.
{ECO:0000269|PubMed:14724137}.
-!- PTM: Phosphorylated by PKA. {ECO:0000305|PubMed:14724137}.
-!- SIMILARITY: Belongs to the round spermatid basic protein 1 family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAH94667.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=BAC39967.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=BAE23712.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=CAQ12904.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AB101658; BAC81206.1; -; mRNA.
EMBL; CU210953; CAQ12178.1; -; Genomic_DNA.
EMBL; CU210868; CAQ12178.1; JOINED; Genomic_DNA.
EMBL; CU210868; CAQ12904.1; ALT_INIT; Genomic_DNA.
EMBL; CU210953; CAQ12904.1; JOINED; Genomic_DNA.
EMBL; BC094667; AAH94667.1; ALT_INIT; mRNA.
EMBL; BC139213; AAI39214.1; -; mRNA.
EMBL; BC139215; AAI39216.1; -; mRNA.
EMBL; AK087685; BAC39967.1; ALT_INIT; mRNA.
EMBL; AK138603; BAE23712.1; ALT_INIT; mRNA.
EMBL; AK122577; BAC65859.1; -; mRNA.
CCDS; CCDS17697.1; -.
RefSeq; NP_766272.2; NM_172684.2.
RefSeq; XP_006501465.1; XM_006501402.3.
UniGene; Mm.29366; -.
ProteinModelPortal; Q80T69; -.
BioGrid; 230881; 2.
IntAct; Q80T69; 1.
STRING; 10090.ENSMUSP00000069246; -.
iPTMnet; Q80T69; -.
PhosphoSitePlus; Q80T69; -.
EPD; Q80T69; -.
MaxQB; Q80T69; -.
PaxDb; Q80T69; -.
PeptideAtlas; Q80T69; -.
PRIDE; Q80T69; -.
Ensembl; ENSMUST00000051139; ENSMUSP00000058934; ENSMUSG00000044098.
Ensembl; ENSMUST00000068879; ENSMUSP00000069246; ENSMUSG00000044098.
GeneID; 229675; -.
KEGG; mmu:229675; -.
UCSC; uc008qtw.1; mouse.
CTD; 54665; -.
MGI; MGI:2444993; Rsbn1.
eggNOG; KOG4425; Eukaryota.
eggNOG; ENOG410XSZP; LUCA.
GeneTree; ENSGT00390000001969; -.
HOVERGEN; HBG094904; -.
InParanoid; Q80T69; -.
KO; K22610; -.
OMA; GDLKHKD; -.
OrthoDB; EOG091G026S; -.
PhylomeDB; Q80T69; -.
TreeFam; TF323256; -.
PRO; PR:Q80T69; -.
Proteomes; UP000000589; Chromosome 3.
Bgee; ENSMUSG00000044098; -.
CleanEx; MM_RSBN1; -.
ExpressionAtlas; Q80T69; baseline and differential.
Genevisible; Q80T69; MM.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR026306; RSBN1/Dpy-21.
PANTHER; PTHR13354; PTHR13354; 1.
1: Evidence at protein level;
Chromatin regulator; Complete proteome; Dioxygenase; Iron;
Isopeptide bond; Metal-binding; Nucleus; Oxidoreductase;
Phosphoprotein; Reference proteome; Transcription;
Transcription regulation; Ubl conjugation.
CHAIN 1 795 Lysine-specific demethylase 9.
/FTId=PRO_0000299413.
MOTIF 252 263 Nuclear localization signal.
{ECO:0000255}.
COMPBIAS 102 164 Pro-rich.
COMPBIAS 113 116 Poly-Arg.
COMPBIAS 184 196 His-rich.
COMPBIAS 252 261 Poly-Lys.
METAL 582 582 Iron, catalytic.
{ECO:0000250|UniProtKB:Q9GRZ3}.
METAL 584 584 Iron, catalytic.
{ECO:0000250|UniProtKB:Q9GRZ3}.
METAL 684 684 Iron, catalytic.
{ECO:0000250|UniProtKB:Q9GRZ3}.
BINDING 579 579 Alpha-ketoglutarate.
{ECO:0000250|UniProtKB:Q9GRZ3}.
BINDING 676 676 Alpha-ketoglutarate.
{ECO:0000250|UniProtKB:Q9GRZ3}.
MOD_RES 80 80 Phosphoserine.
{ECO:0000250|UniProtKB:Q5VWQ0}.
CROSSLNK 290 290 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q5VWQ0}.
CROSSLNK 313 313 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q5VWQ0}.
CROSSLNK 734 734 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q5VWQ0}.
CROSSLNK 774 774 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q5VWQ0}.
CONFLICT 255 256 Missing (in Ref. 3; AAH94667).
{ECO:0000305}.
SEQUENCE 795 AA; 89251 MW; A8E699F1832788B5 CRC64;
MFRSTRTTDQ WRVGERLQCP AGHARAALAR TADGGAVGPF KCVFVGEMAA QVGAVRVVRA
VAAQEEPDKE GKEKPHVGVS PRGVKRQRRA SSGGSQEKRG RPSQDPPLAP PHRRRRSRQH
PGPLPPTNAA PTVPGPVEPL LLPPPPPPSL APAGPTVAAP LPAPGTSALF TFSPLTVSAA
GPKHKGHKER HKHHHHRGSD GDPGACVPGD LKHKDKQENG ERSGGVPLIK APKRETADEN
GKTQRADDFV LKKIKKKKKK KHREDMRGRR LKMYNKEVQT VCAGLTRISK EILTQGQLNS
TSGVNKESFR YLKDEQLCRL NLGMQEYRVP QGVQTPFTTH QEHSIRRNFL KTGTKFSNFI
HEEHQSNGGA LVLHAYMDEL SFLSPMEMER FSEEFLALTF SENEKNAAYY ALAIVHGAAA
YLPDFLDYFA FNFPNTPVKM EILGKKDIET TTISNFHTQV NRTYCCGTYR AGPMRQISLV
GAVDEEVGDY FPEFLDMLEE SPFLKMTLPW GTLSSLQLQC RSQSDDGPIM WVRPGEQMIP
TADMPKSPFK RRRSMNEIKN LQYLPRTSEP REVLFEDRTR AHADHVGQGF DWQSTAAVGV
LKAVQFGEWS DQPRITKDVI CFHAEDFTDV VQRLQLDLHE PPVSQCVQWV DEAKLNQMRR
EGIRYARIQL CDNDIYFIPR NVIHQFKTVS AVCSLAWHIR LKQYHPVVET AQNTESNSNM
DCGLEVDSQC VRIKTESEER CTEMQLLTTA SPSFPPPSEL HLQDLKTQPL PVFKVESRLD
SDQQHSLQAH PSTPV


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