Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Lysosome-associated membrane glycoprotein 3 (LAMP-3) (Lysosomal-associated membrane protein 3) (DC-lysosome-associated membrane glycoprotein) (DC LAMP) (Protein TSC403) (CD antigen CD208)

 LAMP3_HUMAN             Reviewed;         416 AA.
Q9UQV4; D3DNS4; O94781; Q8NEC8;
21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
20-FEB-2007, sequence version 3.
27-SEP-2017, entry version 116.
RecName: Full=Lysosome-associated membrane glycoprotein 3;
Short=LAMP-3;
Short=Lysosomal-associated membrane protein 3;
AltName: Full=DC-lysosome-associated membrane glycoprotein;
Short=DC LAMP;
AltName: Full=Protein TSC403;
AltName: CD_antigen=CD208;
Flags: Precursor;
Name=LAMP3; Synonyms=DCLAMP, TSC403;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT VAL-318.
TISSUE=Lung;
PubMed=9721848;
Ozaki K., Nagata M., Suzuki M., Fujiwara T., Ueda K., Miyoshi Y.,
Takahashi E., Nakamura Y.;
"Isolation and characterization of a novel human lung-specific gene
homologous to lysosomal membrane glycoprotein 1 and 2; significantly
increased expression in cancers of various tissues.";
Cancer Res. 58:3499-3503(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
SPECIFICITY.
PubMed=9768752; DOI=10.1016/S1074-7613(00)80615-9;
de Saint-Vis B.M., Vincent J., Vandenabeele S., Vanbervliet B.,
Pin J.J., Ait-Yahia S., Patel S., Mattei M.-G., Banchereau J.,
Zurawski S., Davoust J., Caux C., Lebecque S.;
"A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced
upon DC maturation, is transiently expressed in MHC class II
compartment.";
Immunity 9:325-336(1998).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT VAL-318.
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-32.
TISSUE=Testis;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
PubMed=21930964; DOI=10.4049/jimmunol.1100600;
Duchez S., Rodrigues M., Bertrand F., Valitutti S.;
"Reciprocal polarization of T and B cells at the immunological
synapse.";
J. Immunol. 187:4571-4580(2011).
[6]
X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS) OF 222-381, SUBUNIT,
GLYCOSYLATION AT ASN-291, AND DISULFIDE BONDS.
PubMed=22809326; DOI=10.1186/1741-7007-10-62;
Wilke S., Krausze J., Bussow K.;
"Crystal structure of the conserved domain of the DC lysosomal
associated membrane protein: implications for the lysosomal
glycocalyx.";
BMC Biol. 10:62-62(2012).
-!- FUNCTION: May play a role in dendritic cell function and in
adaptive immunity. {ECO:0000269|PubMed:9768752}.
-!- SUBUNIT: Monomer. {ECO:0000269|PubMed:22809326}.
-!- SUBCELLULAR LOCATION: Lysosome membrane
{ECO:0000269|PubMed:21930964, ECO:0000269|PubMed:9768752}; Single-
pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle
membrane {ECO:0000269|PubMed:9768752}; Single-pass type I membrane
protein {ECO:0000255}. Note=During dendritic cell maturation,
detected on cytoplasmic vesicles (the MHC II compartment) that
contain MHC II proteins, LAMP1, LAMP2 and LAMP3 (PubMed:9768752).
Detected on lysosomes in mature dendritic cells (PubMed:9768752).
{ECO:0000269|PubMed:9768752}.
-!- TISSUE SPECIFICITY: Detected in tonsil interdigitating dendritic
cells, in spleen, lymph node, Peyer's patches in the small
instestine, in thymus medulla and in B-cells (at protein level).
Expressed in lymphoid organs and dendritic cells. Expressed in
lung. Up-regulated in carcinomas of the esophagus, colon, rectum,
ureter, stomach, breast, fallopian tube, thyroid and parotid
tissues. {ECO:0000269|PubMed:21930964, ECO:0000269|PubMed:9721848,
ECO:0000269|PubMed:9768752}.
-!- DEVELOPMENTAL STAGE: Up-regulated during dendritic cell
maturation.
-!- SIMILARITY: Belongs to the LAMP family. {ECO:0000255|PROSITE-
ProRule:PRU00740}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AB013924; BAA34533.1; -; mRNA.
EMBL; AJ005766; CAA06691.1; -; mRNA.
EMBL; CH471052; EAW78337.1; -; Genomic_DNA.
EMBL; CH471052; EAW78338.1; -; Genomic_DNA.
EMBL; BC032940; AAH32940.1; -; mRNA.
CCDS; CCDS3242.1; -.
RefSeq; NP_055213.2; NM_014398.3.
UniGene; Hs.518448; -.
PDB; 4AKM; X-ray; 2.69 A; A/B=222-381.
PDBsum; 4AKM; -.
ProteinModelPortal; Q9UQV4; -.
SMR; Q9UQV4; -.
BioGrid; 117983; 69.
IntAct; Q9UQV4; 6.
MINT; MINT-7996363; -.
STRING; 9606.ENSP00000265598; -.
iPTMnet; Q9UQV4; -.
PhosphoSitePlus; Q9UQV4; -.
BioMuta; LAMP3; -.
DMDM; 126302564; -.
PaxDb; Q9UQV4; -.
PeptideAtlas; Q9UQV4; -.
PRIDE; Q9UQV4; -.
DNASU; 27074; -.
Ensembl; ENST00000265598; ENSP00000265598; ENSG00000078081.
GeneID; 27074; -.
KEGG; hsa:27074; -.
UCSC; uc003flh.5; human.
CTD; 27074; -.
DisGeNET; 27074; -.
EuPathDB; HostDB:ENSG00000078081.7; -.
GeneCards; LAMP3; -.
HGNC; HGNC:14582; LAMP3.
HPA; CAB025133; -.
HPA; HPA051467; -.
MIM; 605883; gene.
neXtProt; NX_Q9UQV4; -.
OpenTargets; ENSG00000078081; -.
PharmGKB; PA30286; -.
eggNOG; KOG4818; Eukaryota.
eggNOG; ENOG410XQ96; LUCA.
GeneTree; ENSGT00530000063068; -.
HOGENOM; HOG000004835; -.
HOVERGEN; HBG081889; -.
InParanoid; Q9UQV4; -.
KO; K06562; -.
OMA; CQSSGYQ; -.
OrthoDB; EOG091G09EV; -.
PhylomeDB; Q9UQV4; -.
TreeFam; TF316339; -.
GeneWiki; LAMP3; -.
GenomeRNAi; 27074; -.
PRO; PR:Q9UQV4; -.
Proteomes; UP000005640; Chromosome 3.
Bgee; ENSG00000078081; -.
CleanEx; HS_LAMP3; -.
ExpressionAtlas; Q9UQV4; baseline and differential.
Genevisible; Q9UQV4; HS.
GO; GO:0097233; C:alveolar lamellar body membrane; ISS:ParkinsonsUK-UCL.
GO; GO:0005769; C:early endosome; IDA:ParkinsonsUK-UCL.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO; GO:0005765; C:lysosomal membrane; TAS:ProtInc.
GO; GO:0005634; C:nucleus; IDA:HPA.
GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:ParkinsonsUK-UCL.
GO; GO:0005886; C:plasma membrane; IDA:ParkinsonsUK-UCL.
GO; GO:0031982; C:vesicle; IDA:ParkinsonsUK-UCL.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:ParkinsonsUK-UCL.
GO; GO:1901799; P:negative regulation of proteasomal protein catabolic process; IMP:ParkinsonsUK-UCL.
GO; GO:0010628; P:positive regulation of gene expression; IMP:ParkinsonsUK-UCL.
GO; GO:0010506; P:regulation of autophagy; IMP:ParkinsonsUK-UCL.
GO; GO:1903900; P:regulation of viral life cycle; IMP:ParkinsonsUK-UCL.
GO; GO:0035455; P:response to interferon-alpha; IMP:ParkinsonsUK-UCL.
InterPro; IPR002000; Lysosome-assoc_membr_glycop.
PANTHER; PTHR11506; PTHR11506; 1.
Pfam; PF01299; Lamp; 1.
PRINTS; PR00336; LYSASSOCTDMP.
PROSITE; PS51407; LAMP_3; 1.
1: Evidence at protein level;
3D-structure; Adaptive immunity; Complete proteome;
Cytoplasmic vesicle; Disulfide bond; Glycoprotein; Immunity; Lysosome;
Membrane; Polymorphism; Reference proteome; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 27 {ECO:0000255}.
CHAIN 28 416 Lysosome-associated membrane glycoprotein
3.
/FTId=PRO_0000223695.
TOPO_DOM 28 381 Lumenal. {ECO:0000255}.
TRANSMEM 382 402 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00740}.
TOPO_DOM 403 416 Cytoplasmic. {ECO:0000255|PROSITE-
ProRule:PRU00740}.
COMPBIAS 74 215 Thr-rich.
CARBOHYD 112 112 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 158 158 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 164 164 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 200 200 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 232 232 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 266 266 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 291 291 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:22809326}.
DISULFID 237 274 {ECO:0000255|PROSITE-ProRule:PRU00740,
ECO:0000269|PubMed:22809326}.
DISULFID 339 376 {ECO:0000255|PROSITE-ProRule:PRU00740,
ECO:0000269|PubMed:22809326}.
VARIANT 32 32 E -> G (in dbSNP:rs17853113).
{ECO:0000269|PubMed:15489334}.
/FTId=VAR_030827.
VARIANT 318 318 I -> V (in dbSNP:rs482912).
{ECO:0000269|PubMed:9721848,
ECO:0000269|Ref.3}.
/FTId=VAR_025343.
CONFLICT 145 145 T -> A (in Ref. 1; BAA34533).
{ECO:0000305}.
CONFLICT 186 186 V -> D (in Ref. 1; BAA34533).
{ECO:0000305}.
STRAND 226 232 {ECO:0000244|PDB:4AKM}.
STRAND 235 248 {ECO:0000244|PDB:4AKM}.
STRAND 251 253 {ECO:0000244|PDB:4AKM}.
STRAND 259 262 {ECO:0000244|PDB:4AKM}.
HELIX 265 267 {ECO:0000244|PDB:4AKM}.
STRAND 269 273 {ECO:0000244|PDB:4AKM}.
STRAND 276 285 {ECO:0000244|PDB:4AKM}.
STRAND 288 296 {ECO:0000244|PDB:4AKM}.
STRAND 301 311 {ECO:0000244|PDB:4AKM}.
STRAND 313 315 {ECO:0000244|PDB:4AKM}.
STRAND 318 323 {ECO:0000244|PDB:4AKM}.
STRAND 328 331 {ECO:0000244|PDB:4AKM}.
STRAND 337 339 {ECO:0000244|PDB:4AKM}.
STRAND 343 346 {ECO:0000244|PDB:4AKM}.
STRAND 348 363 {ECO:0000244|PDB:4AKM}.
SEQUENCE 416 AA; 44346 MW; D615895D382B8F88 CRC64;
MPRQLSAAAA LFASLAVILH DGSQMRAKAF PETRDYSQPT AAATVQDIKK PVQQPAKQAP
HQTLAARFMD GHITFQTAAT VKIPTTTPAT TKNTATTSPI TYTLVTTQAT PNNSHTAPPV
TEVTVGPSLA PYSLPPTITP PAHTTGTSSS TVSHTTGNTT QPSNQTTLPA TLSIALHKST
TGQKPVQPTH APGTTAAAHN TTRTAAPAST VPGPTLAPQP SSVKTGIYQV LNGSRLCIKA
EMGIQLIVQD KESVFSPRRY FNIDPNATQA SGNCGTRKSN LLLNFQGGFV NLTFTKDEES
YYISEVGAYL TVSDPETIYQ GIKHAVVMFQ TAVGHSFKCV SEQSLQLSAH LQVKTTDVQL
QAFDFEDDHF GNVDECSSDY TIVLPVIGAI VVGLCLMGMG VYKIRLRCQS SGYQRI


Related products :

Catalog number Product name Quantity
E1464m ELISA CD107 antigen-like family member B,Lamp2,LAMP-2,Lamp-2,LGP-B,Lysosomal membrane glycoprotein type B,Lysosome-associated membrane glycoprotein 2,Lysosome-associated membrane protein 2,Mouse,Mus m 96T
U1464m CLIA CD107 antigen-like family member B,Lamp2,LAMP-2,Lamp-2,LGP-B,Lysosomal membrane glycoprotein type B,Lysosome-associated membrane glycoprotein 2,Lysosome-associated membrane protein 2,Mouse,Mus mu 96T
E1464m ELISA kit CD107 antigen-like family member B,Lamp2,LAMP-2,Lamp-2,LGP-B,Lysosomal membrane glycoprotein type B,Lysosome-associated membrane glycoprotein 2,Lysosome-associated membrane protein 2,Mouse, 96T
U1464r CLIA CD107 antigen-like family member B,Lamp2,LAMP-2,Lamp-2,LGP-110,LGP-96,LGP-B,Lysosomal membrane glycoprotein type B,Lysosome-associated membrane glycoprotein 2,Lysosome-associated membrane protein 96T
E1464r ELISA CD107 antigen-like family member B,Lamp2,LAMP-2,Lamp-2,LGP-110,LGP-96,LGP-B,Lysosomal membrane glycoprotein type B,Lysosome-associated membrane glycoprotein 2,Lysosome-associated membrane protei 96T
E1464r ELISA kit CD107 antigen-like family member B,Lamp2,LAMP-2,Lamp-2,LGP-110,LGP-96,LGP-B,Lysosomal membrane glycoprotein type B,Lysosome-associated membrane glycoprotein 2,Lysosome-associated membrane p 96T
E1464h ELISA CD107 antigen-like family member B,Homo sapiens,Human,LAMP2,LAMP-2,Lysosome-associated membrane glycoprotein 2,Lysosome-associated membrane protein 2 96T
U1464h CLIA CD107 antigen-like family member B,Homo sapiens,Human,LAMP2,LAMP-2,Lysosome-associated membrane glycoprotein 2,Lysosome-associated membrane protein 2 96T
E1464h ELISA kit CD107 antigen-like family member B,Homo sapiens,Human,LAMP2,LAMP-2,Lysosome-associated membrane glycoprotein 2,Lysosome-associated membrane protein 2 96T
E1464c ELISA Chicken,Gallus gallus,LAMP2,LAMP-2,Lysosome-associated membrane glycoprotein 2,Lysosome-associated membrane protein 2 96T
U1464c CLIA Chicken,Gallus gallus,LAMP2,LAMP-2,Lysosome-associated membrane glycoprotein 2,Lysosome-associated membrane protein 2 96T
E1464c ELISA kit Chicken,Gallus gallus,LAMP2,LAMP-2,Lysosome-associated membrane glycoprotein 2,Lysosome-associated membrane protein 2 96T
EIAAB37665 85 kDa lysosomal membrane sialoglycoprotein,CD36 antigen-like 2,Cd36l2,LGP85,LIMP II,Limpii,Lysosome membrane protein 2,Lysosome membrane protein II,Rat,Rattus norvegicus,Scarb2,Scavenger receptor cla
EIAAB37664 85 kDa lysosomal membrane sialoglycoprotein,CD36 antigen-like 2,CD36L2,Homo sapiens,Human,LGP85,LIMP II,LIMPII,Lysosome membrane protein 2,Lysosome membrane protein II,SCARB2,Scavenger receptor class
EIAAB37666 85 kDa lysosomal membrane sialoglycoprotein,LGP85,LIMP II,Lysosome membrane protein 2,Lysosome membrane protein II,Mouse,Mus musculus,Scarb2,Scavenger receptor class B member 2
K88104R Lysosome Associated Membrane Protein 2 (LAMP-2)Rabbit Aff.Pur. 100ug
K88104R Lysosome Associated Membrane Protein 2 (LAMP-2) host: Rabbit 100ug
PC-541 Antibodies: LAMP-1 (Lysosome Associated Membrane Protein 1) Clone: Polyclonal 100 ug
MD-14-0628 Rabbit Anti-Lysosome Associated Membrane Protein 2 (LAMP-2) 100
PC-542 Antibodies: LAMP-2 (Lysosome Associated Membrane Protein 2) Clone: Polyclonal 100 ug
MD-14-0627 Rabbit Anti-Lysosome Associated Membrane Protein 1 (LAMP-1) 100
Y090103 Anti-LAMP-1 (110 kDa lysosomal membrane glycoprotein) Antibody 100ul
CD15 Lysosome-Associated Membrane Glycoprotein 1 LAMP1 (C-Fc-His tag) 500
EH1633 Lysosome-associated membrane glycoprotein 2 Elisa Kit 96T
CD15 Lysosome-Associated Membrane Glycoprotein 1 LAMP1 (C-Fc-His tag) lmg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur