Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

MAP kinase kinase kinase win1 (EC 2.7.11.25)

 WIN1_SCHPO              Reviewed;        1436 AA.
O74304; Q9P7R1; Q9UTP1; Q9UTR3;
14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
25-OCT-2017, entry version 141.
RecName: Full=MAP kinase kinase kinase win1;
EC=2.7.11.25;
Name=win1; ORFNames=SPAC1006.09, SPAC1250.06c, SPAPJ730.01;
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
Schizosaccharomycetes; Schizosaccharomycetales;
Schizosaccharomycetaceae; Schizosaccharomyces.
NCBI_TaxID=284812;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
PubMed=9693384; DOI=10.1091/mbc.9.8.2325;
Samejima I., Mackie S., Warbrick E., Weisman R., Fantes P.A.;
"The fission yeast mitotic regulator win1+ encodes an MAP kinase
kinase kinase that phosphorylates and activates Wis1 MAP kinase kinase
in response to high osmolarity.";
Mol. Biol. Cell 9:2325-2335(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=972 / ATCC 24843;
PubMed=11859360; DOI=10.1038/nature724;
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[3]
INTERACTION WITH TEA4.
PubMed=15936270; DOI=10.1016/j.cub.2005.04.061;
Tatebe H., Shimada K., Uzawa S., Morigasaki S., Shiozaki K.;
"Wsh3/Tea4 is a novel cell-end factor essential for bipolar
distribution of Tea1 and protects cell polarity under environmental
stress in S. pombe.";
Curr. Biol. 15:1006-1015(2005).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-224 AND THR-226, AND
IDENTIFICATION BY MASS SPECTROMETRY.
PubMed=18257517; DOI=10.1021/pr7006335;
Wilson-Grady J.T., Villen J., Gygi S.P.;
"Phosphoproteome analysis of fission yeast.";
J. Proteome Res. 7:1088-1097(2008).
-!- FUNCTION: Involved in a signal transduction pathway that is
activated by changes in the osmolarity of the extracellular
environment. Activates the wis1 MAP kinase kinase by
phosphorylation. {ECO:0000269|PubMed:9693384}.
-!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
-!- SUBUNIT: Interacts with tea4. {ECO:0000269|PubMed:15936270}.
-!- INTERACTION:
O60132:tea4; NbExp=2; IntAct=EBI-1099995, EBI-1099982;
-!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
protein kinase family. MAP kinase kinase kinase subfamily.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AJ223190; CAA11161.1; -; Genomic_DNA.
EMBL; CU329670; CAB60239.1; -; Genomic_DNA.
PIR; T37556; T37556.
PIR; T50298; T50298.
PIR; T50457; T50457.
RefSeq; NP_594856.2; NM_001020285.2.
ProteinModelPortal; O74304; -.
BioGrid; 279426; 10.
IntAct; O74304; 1.
STRING; 4896.SPAC1006.09.1; -.
iPTMnet; O74304; -.
MaxQB; O74304; -.
PRIDE; O74304; -.
EnsemblFungi; SPAC1006.09.1; SPAC1006.09.1:pep; SPAC1006.09.
GeneID; 2542988; -.
KEGG; spo:SPAC1006.09; -.
EuPathDB; FungiDB:SPAC1006.09; -.
PomBase; SPAC1006.09; win1.
InParanoid; O74304; -.
KO; K11230; -.
OMA; CAENITS; -.
OrthoDB; EOG092C05H5; -.
PhylomeDB; O74304; -.
BRENDA; 2.7.11.25; 5613.
PRO; PR:O74304; -.
Proteomes; UP000002485; Chromosome I.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:1990315; C:Mcs4 RR-MAPKKK complex; IDA:PomBase.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004709; F:MAP kinase kinase kinase activity; IDA:PomBase.
GO; GO:0071470; P:cellular response to osmotic stress; IMP:PomBase.
GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
GO; GO:0007346; P:regulation of mitotic cell cycle; IBA:GO_Central.
GO; GO:0051403; P:stress-activated MAPK cascade; IMP:PomBase.
InterPro; IPR011009; Kinase-like_dom.
InterPro; IPR017240; MAPKKK_Ssk2/Ssk22.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00069; Pkinase; 1.
PIRSF; PIRSF037579; MAPKKK_SSK22; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 2.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
ATP-binding; Complete proteome; Kinase; Nucleotide-binding;
Phosphoprotein; Reference proteome; Serine/threonine-protein kinase;
Transferase.
CHAIN 1 1436 MAP kinase kinase kinase win1.
/FTId=PRO_0000086816.
DOMAIN 1120 1406 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 1126 1134 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
REGION 282 1123 Interaction with tea4.
ACT_SITE 1244 1244 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10027}.
BINDING 1149 1149 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 224 224 Phosphoserine.
{ECO:0000269|PubMed:18257517}.
MOD_RES 226 226 Phosphothreonine.
{ECO:0000269|PubMed:18257517}.
SEQUENCE 1436 AA; 163273 MW; D55736C3D99D0AAB CRC64;
MENILDPSVV NSHILENGSR RSSINPILDS ELRDKTFEKA HRRSLTLLSS FTSSMLELPN
NGKEENHRRP SVARSSSDRS KASAKEDLFS EAFRMAEQPP AEALTISTPV DPINIDELDR
AYAVSPSDTS NLLHPPTSSS SIPIPIKNAG HSNLDHPIRP SLQSSISSNR IIKSPGIKED
DYMHRGRSIS SPMIDVEHIN STAVPSKTKN LPEKPKRSHK LRNSITFAKI EDHPERKSQL
RRLSSSLKCF DPEYDYNDPS LSIRRDSSTY YFSNVNETYD EEDSDLDSET STVNWVQSVL
NLPSLLSDDL MANPKNKERF EWQYMLTSVL TGDIVRSEKL RLRKIASSRE GRNSDYSDNL
WMEIWCWLTH RSVDSYRENL KHLRTGMVDV LLAIMNFHWD ESNELTPIVA VDNMLQKLDK
YERLYPSRRS ILQEHSLYAS ESFQHKLDVL TAYSNVTHAL EIQVNIIRSW VGNEEMDITK
NTTNSINNVS QISNGPFVER FYRETGLIRA FEQRIMTNMN SVLSKVCNTI VTYADDLKSY
GLPLIADDYM RLLSFPFRLI KEFLNLRLSC AENITSISLF TIDSLLDDLR NTMKVAVHII
QQHTVLIKPF RDDSKFVDEN QSLNNILVAS LKFYFNLLHR KVRNGCALLH FKETEILEGE
WDFLLAVCPH IEHGFQIMSK SLSSLVGEIL TNINRYLKDQ LQGPDTDDSA LITSFYIKVL
DCVRIRFRKL MSFTRILKAH LENSCEYVIK ENSLSLLIQR LEESNHVLTY TASIEHEGAY
VIVPGHLVDS PNILREVLSM TFNKGDNNFE SVPPYAVVLA PDSSICWNGH VTDLDIPEVS
ISIAPNCVRL VTLATANQLS VIEDYFISIV GDTVSLVDSA KANSSKINKQ MTKIKRNSLK
LALSLLDVIQ TIRTRYHGMN CQNLIHYSFS YAIEFAQRLM RLSILDASSI GLIRRKMIQL
AISWVGFIYE DCSPTDRNTF RWTVTALEFA MIMTYGSNIL MIDKKSFEEL KEKVGKCVAL
LLLHFDVMGT KHAGRSMDQQ AGDIPARLVR NNSDRSRLSD NELASFVKEE VMHRIIELES
NRRDRLYKSQ LIGRVLDDTT KENRLLKELA SSKSNITIRW QQGGLIGSGS FGTVYRAVNL
DTGDLMAVKE VALHKPRISR PMIKRIKGEM LVLELFDHPN VVSYYGIEVH REKVNIFMEL
CQGSSLFEFL RYGRIEDELV IQVYVLQLLE GLAYIHSCGV SHQDVKPENI LFDHNGIMKF
TDFGSAKMSG SASTKIFEQL TQQEEEEFEK DSEFLQHLDQ NRGYSLTGTP TYMAPELILG
NPSERVGAMD IWSLGCVIVE MATGSPPWPR LDNHFSLMYH IAAHNPPIIP ADDQLSPLGQ
NFLKRCFVSD PNQRATAAEL LMDPWVYPLR AGTEFDLMNS SVVESAPSTN GAPLEL


Related products :

Catalog number Product name Quantity
EIAAB24783 GCK family kinase MiNK,Map4k6,MAPK_ERK kinase kinase kinase 6,MEK kinase kinase 6,MEKKK 6,Mink,Mink1,Misshapen_NIK-related kinase,Misshapen-like kinase 1,Mitogen-activated protein kinase kinase kinase
EIAAB24784 GCK family kinase MiNK,Map4k6,MAPK_ERK kinase kinase kinase 6,MEK kinase kinase 6,MEKKK 6,Mink,Mink1,Misshapen_NIK-related kinase,Misshapen-like kinase 1,Mitogen-activated protein kinase kinase kinase
EIAAB25239 C-JUN N-terminal kinase kinase 1,Dual specificity mitogen-activated protein kinase kinase 4,JNK kinase 1,JNK-activating kinase 1,JNKK 1,Jnkk1,MAP kinase kinase 4,Map2k4,MAPK_ERK kinase 4,MAPKK 4,MEK 4
EIAAB25244 c-Jun N-terminal kinase kinase 2,Dual specificity mitogen-activated protein kinase kinase 7,JNK kinase 2,JNK-activating kinase 2,JNKK 2,MAP kinase kinase 7,Map2k7,MAPK_ERK kinase 7,MAPKK 7,MEK 7,Mkk7,
EIAAB25245 c-Jun N-terminal kinase kinase 2,Dual specificity mitogen-activated protein kinase kinase 7,JNK kinase 2,JNK-activating kinase 2,JNKK 2,MAP kinase kinase 7,Map2k7,MAPK_ERK kinase 7,MAPKK 7,MEK 7,Rat,R
EIAAB25246 c-Jun N-terminal kinase kinase 2,Dual specificity mitogen-activated protein kinase kinase 7,Homo sapiens,Human,JNK kinase 2,JNK-activating kinase 2,JNKK 2,JNKK2,MAP kinase kinase 7,MAP2K7,MAPK_ERK kin
EIAAB25240 c-Jun N-terminal kinase kinase 1,Dual specificity mitogen-activated protein kinase kinase 4,Homo sapiens,Human,JNK-activating kinase 1,JNKK,JNKK1,MAP kinase kinase 4,MAP2K4,MAPK_ERK kinase 4,MAPKK 4,M
E1358m ELISA Apoptosis signal-regulating kinase 1,Ask1,ASK-1,Map3k5,MAPK_ERK kinase kinase 5,MEK kinase 5,MEKK 5,Mekk5,Mitogen-activated protein kinase kinase kinase 5,Mouse,Mus musculus 96T
E1358m ELISA kit Apoptosis signal-regulating kinase 1,Ask1,ASK-1,Map3k5,MAPK_ERK kinase kinase 5,MEK kinase 5,MEKK 5,Mekk5,Mitogen-activated protein kinase kinase kinase 5,Mouse,Mus musculus 96T
U1358m CLIA Apoptosis signal-regulating kinase 1,Ask1,ASK-1,Map3k5,MAPK_ERK kinase kinase 5,MEK kinase 5,MEKK 5,Mekk5,Mitogen-activated protein kinase kinase kinase 5,Mouse,Mus musculus 96T
EIAAB24782 B55,GCK family kinase MiNK,Homo sapiens,Human,MAP4K6,MAPK_ERK kinase kinase kinase 6,MEK kinase kinase 6,MEKKK 6,MINK,MINK1,Misshapen_NIK-related kinase,Misshapen-like kinase 1,Mitogen-activated prote
E1358h ELISA kit Apoptosis signal-regulating kinase 1,ASK1,ASK-1,Homo sapiens,Human,MAP3K5,MAPK_ERK kinase kinase 5,MAPKKK5,MEK kinase 5,MEKK 5,MEKK5,Mitogen-activated protein kinase kinase kinase 5 96T
U1358h CLIA Apoptosis signal-regulating kinase 1,ASK1,ASK-1,Homo sapiens,Human,MAP3K5,MAPK_ERK kinase kinase 5,MAPKKK5,MEK kinase 5,MEKK 5,MEKK5,Mitogen-activated protein kinase kinase kinase 5 96T
E1358h ELISA Apoptosis signal-regulating kinase 1,ASK1,ASK-1,Homo sapiens,Human,MAP3K5,MAPK_ERK kinase kinase 5,MAPKKK5,MEK kinase 5,MEKK 5,MEKK5,Mitogen-activated protein kinase kinase kinase 5 96T
18-662-20090 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.1 ml
18-662-20091 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.1 ml
18-662-20092 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.1 ml
15-288-21068 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.05 mg
15-288-21068 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.1 mg
10-782-55047 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 N_A 0.05 mg
10-782-55048 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 N_A 0.05 mg
10-782-55047 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 N_A 0.02 mg
10-782-55048 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 N_A 0.02 mg
18-785-210404 SEK1_MKK4 (Phospho-Ser80) - EC 2.7.12.2; MAP kinase kinase 4; JNK-activating kinase 1; c-Jun N-terminal kinase kinase 1; JNKK; SAPK_ERK kinase 1; SEK1 Polyclonal 0.1 mg
18-785-210403 SEK1_MKK4 (Phospho-Thr261) - EC 2.7.12.2; MAP kinase kinase 4; JNK-activating kinase 1; c-Jun N-terminal kinase kinase 1; JNKK; SAPK_ERK kinase 1; SEK1 Polyclonal 0.1 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur