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MICOS complex subunit MIC10 (Mitochondrial contact site complex 10 kDa subunit) (Mitochondrial inner membrane organization component of 10 kDa) (Mitochondrial organizing structure protein 1) (MitOS1)

 MIC10_YEAST             Reviewed;          97 AA.
Q96VH5; D6VQV9;
31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
22-NOV-2017, entry version 101.
RecName: Full=MICOS complex subunit MIC10;
AltName: Full=Mitochondrial contact site complex 10 kDa subunit;
AltName: Full=Mitochondrial inner membrane organization component of 10 kDa;
AltName: Full=Mitochondrial organizing structure protein 1;
Short=MitOS1;
Name=MIC10; Synonyms=MCS10, MIO10, MOS1; OrderedLocusNames=YCL057C-A;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=1574125; DOI=10.1038/357038a0;
Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M.,
Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W.,
Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H.,
Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V.,
Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A.,
de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H.,
Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K.,
Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B.,
Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A.,
Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y.,
Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R.,
Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G.,
Tzermia M., Urrestarazu L.A., Valle G., Vetter I.,
van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H.,
Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C.,
Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.;
"The complete DNA sequence of yeast chromosome III.";
Nature 357:38-46(1992).
[2]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[3]
FUNCTION, IDENTIFICATION IN THE MICOS COMPLEX, SUBCELLULAR LOCATION,
AND DISRUPTION PHENOTYPE.
PubMed=21944719; DOI=10.1016/j.devcel.2011.08.026;
von der Malsburg K., Muller J.M., Bohnert M., Oeljeklaus S.,
Kwiatkowska P., Becker T., Loniewska-Lwowska A., Wiese S., Rao S.,
Milenkovic D., Hutu D.P., Zerbes R.M., Schulze-Specking A.,
Meyer H.E., Martinou J.C., Rospert S., Rehling P., Meisinger C.,
Veenhuis M., Warscheid B., van der Klei I.J., Pfanner N.,
Chacinska A., van der Laan M.;
"Dual role of mitofilin in mitochondrial membrane organization and
protein biogenesis.";
Dev. Cell 21:694-707(2011).
[4]
IDENTIFICATION IN THE MICOS COMPLEX, MASS SPECTROMETRY, SUBCELLULAR
LOCATION, AND TOPOLOGY.
PubMed=22009199; DOI=10.1038/emboj.2011.379;
Harner M., Korner C., Walther D., Mokranjac D., Kaesmacher J.,
Welsch U., Griffith J., Mann M., Reggiori F., Neupert W.;
"The mitochondrial contact site complex, a determinant of
mitochondrial architecture.";
EMBO J. 30:4356-4370(2011).
[5]
FUNCTION, IDENTIFICATION IN THE MICOS COMPLEX, INTERACTION WITH OM45
AND POR1, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
PubMed=21987634; DOI=10.1083/jcb.201107053;
Hoppins S., Collins S.R., Cassidy-Stone A., Hummel E., Devay R.M.,
Lackner L.L., Westermann B., Schuldiner M., Weissman J.S., Nunnari J.;
"A mitochondrial-focused genetic interaction map reveals a scaffold-
like complex required for inner membrane organization in
mitochondria.";
J. Cell Biol. 195:323-340(2011).
[6]
FUNCTION, IDENTIFICATION IN THE MICOS COMPLEX, SUBCELLULAR LOCATION,
AND TOPOLOGY.
PubMed=22114354; DOI=10.1091/mbc.E11-09-0774;
Alkhaja A.K., Jans D.C., Nikolov M., Vukotic M., Lytovchenko O.,
Ludewig F., Schliebs W., Riedel D., Urlaub H., Jakobs S., Deckers M.;
"MINOS1 is a conserved component of mitofilin complexes and required
for mitochondrial function and cristae organization.";
Mol. Biol. Cell 23:247-257(2012).
[7]
NOMENCLATURE.
PubMed=24687277; DOI=10.1083/jcb.201401006;
Pfanner N., van der Laan M., Amati P., Capaldi R.A., Caudy A.A.,
Chacinska A., Darshi M., Deckers M., Hoppins S., Icho T., Jakobs S.,
Ji J., Kozjak-Pavlovic V., Meisinger C., Odgren P.R., Park S.K.,
Rehling P., Reichert A.S., Sheikh M.S., Taylor S.S., Tsuchida N.,
van der Bliek A.M., van der Klei I.J., Weissman J.S., Westermann B.,
Zha J., Neupert W., Nunnari J.;
"Uniform nomenclature for the mitochondrial contact site and cristae
organizing system.";
J. Cell Biol. 204:1083-1086(2014).
-!- FUNCTION: Component of the MICOS complex, a large protein complex
of the mitochondrial inner membrane that plays crucial roles in
the maintenance of crista junctions, inner membrane architecture,
and formation of contact sites to the outer membrane.
{ECO:0000269|PubMed:21944719, ECO:0000269|PubMed:21987634,
ECO:0000269|PubMed:22114354}.
-!- SUBUNIT: Component of the mitochondrial contact site and cristae
organizing system (MICOS) complex, composed of at least MIC10,
MIC12, MIC19, MIC26, MIC27 and MIC60. This complex was also known
under the names MINOS or MitOS complex. Interacts with OM45 and
POR1. {ECO:0000269|PubMed:21944719, ECO:0000269|PubMed:21987634,
ECO:0000269|PubMed:22009199, ECO:0000269|PubMed:22114354}.
-!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
{ECO:0000269|PubMed:21944719, ECO:0000269|PubMed:21987634,
ECO:0000269|PubMed:22009199, ECO:0000269|PubMed:22114354}; Single-
pass membrane protein {ECO:0000269|PubMed:21944719,
ECO:0000269|PubMed:21987634, ECO:0000269|PubMed:22009199,
ECO:0000269|PubMed:22114354}. Note=The C-terminus is located in
the intermembrane space, while the location of the N-terminus has
not been determined yet. As some programs predict the presence of
2 closely apposed membrane domains, it has been proposed that the
protein may cross the membrane twice and that both termini may
face the intermembrane space (PubMed:22114354). Enriched at crista
junctions. {ECO:0000269|PubMed:22114354}.
-!- DISRUPTION PHENOTYPE: Partially altered shape of the mitochondrial
network with condensed, fragmented mitochondria accumulating at
the periphery of cells. 60-70% of mitochondria exhibit an
increased inner membrane surface and stacks of lamellar cristae
disconnected from the inner boundary membrane.
{ECO:0000269|PubMed:21944719, ECO:0000269|PubMed:21987634}.
-!- SIMILARITY: Belongs to the MICOS complex subunit Mic10 family.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; X59720; CAC42954.1; -; Genomic_DNA.
EMBL; BK006937; DAA07428.1; -; Genomic_DNA.
PIR; S78709; S78709.
RefSeq; NP_065435.1; NM_001184448.1.
ProteinModelPortal; Q96VH5; -.
BioGrid; 30928; 115.
IntAct; Q96VH5; 9.
MINT; MINT-4988418; -.
STRING; 4932.YCL057C-A; -.
iPTMnet; Q96VH5; -.
MaxQB; Q96VH5; -.
PRIDE; Q96VH5; -.
EnsemblFungi; CAC42954; CAC42954; CAC42954.
EnsemblFungi; YCL057C-A; YCL057C-A; YCL057C-A.
GeneID; 850300; -.
KEGG; sce:YCL057C-A; -.
EuPathDB; FungiDB:YCL057C-A; -.
SGD; S000007547; MIC10.
HOGENOM; HOG000205880; -.
InParanoid; Q96VH5; -.
KO; K17784; -.
OMA; DAIFRTN; -.
OrthoDB; EOG092C5W4P; -.
BioCyc; YEAST:G3O-29419-MONOMER; -.
PRO; PR:Q96VH5; -.
Proteomes; UP000002311; Chromosome III.
GO; GO:0061617; C:MICOS complex; IDA:SGD.
GO; GO:0044284; C:mitochondrial crista junction; IDA:SGD.
GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO; GO:0042407; P:cristae formation; IMP:SGD.
GO; GO:0061024; P:membrane organization; IDA:SGD.
InterPro; IPR007512; Mic10.
PANTHER; PTHR21304; PTHR21304; 1.
Pfam; PF04418; DUF543; 1.
1: Evidence at protein level;
Complete proteome; Membrane; Mitochondrion;
Mitochondrion inner membrane; Reference proteome; Transmembrane;
Transmembrane helix.
CHAIN 1 97 MICOS complex subunit MIC10.
/FTId=PRO_0000221640.
TOPO_DOM 1 35 Mitochondrial matrix. {ECO:0000255}.
TRANSMEM 36 58 Helical. {ECO:0000255}.
TOPO_DOM 59 97 Mitochondrial intermembrane.
{ECO:0000255}.
SEQUENCE 97 AA; 10408 MW; D6C214612BD35E26 CRC64;
MSEQAQTQQP AKSTPSKDSN KNGSSVSTIL DTKWDIVLSN MLVKTAMGFG VGVFTSVLFF
KRRAFPVWLG IGFGVGRGYA EGDAIFRSSA GLRSSKV


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