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Macrophage colony-stimulating factor 1 (CSF-1) (MCSF)

 M3WDW6_FELCA            Unreviewed;       257 AA.
M3WDW6;
01-MAY-2013, integrated into UniProtKB/TrEMBL.
10-OCT-2018, sequence version 3.
16-JAN-2019, entry version 38.
SubName: Full=Colony stimulating factor 1 {ECO:0000313|Ensembl:ENSFCAP00000010007};
Name=CSF1 {ECO:0000313|Ensembl:ENSFCAP00000010007};
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
Felinae; Felis.
NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000010007, ECO:0000313|Proteomes:UP000011712};
[1] {ECO:0000313|Ensembl:ENSFCAP00000010007, ECO:0000313|Proteomes:UP000011712}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010007,
ECO:0000313|Proteomes:UP000011712};
PubMed=17975172; DOI=10.1101/gr.6380007;
Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
"Initial sequence and comparative analysis of the cat genome.";
Genome Res. 17:1675-1689(2007).
[2] {ECO:0000313|Ensembl:ENSFCAP00000010007}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010007};
Hillier L.W., Warren W., Obrien S., Wilson R.K.;
"Sequence assembly of the Felis catus genome version 6.2.";
Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSFCAP00000010007}
IDENTIFICATION.
STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010007};
Ensembl;
Submitted (MAR-2013) to UniProtKB.
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EMBL; AANG04003279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9685.ENSFCAP00000010007; -.
Ensembl; ENSFCAT00000010774; ENSFCAP00000010007; ENSFCAG00000010770.
eggNOG; ENOG410II8R; Eukaryota.
eggNOG; ENOG410Z5Q9; LUCA.
GeneTree; ENSGT00390000015805; -.
InParanoid; M3WDW6; -.
Proteomes; UP000011712; Chromosome C1.
Bgee; ENSFCAG00000010770; Expressed in 3 organ(s), highest expression level in liver.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0008083; F:growth factor activity; IEA:InterPro.
GO; GO:0030316; P:osteoclast differentiation; IBA:GO_Central.
GO; GO:0045651; P:positive regulation of macrophage differentiation; IBA:GO_Central.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR008001; MCSF-1.
PANTHER; PTHR10058; PTHR10058; 2.
Pfam; PF05337; CSF-1; 1.
SUPFAM; SSF47266; SSF47266; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000011712};
Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000011712};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
SIGNAL 1 32 {ECO:0000256|SAM:SignalP}.
CHAIN 33 257 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5016424566.
TRANSMEM 198 220 Helical. {ECO:0000256|SAM:Phobius}.
SEQUENCE 257 AA; 29549 MW; D951357DF3F31BE9 CRC64;
MTARGAAGRC PPTTWLSRLL LLVCLLVSRS ITEEVSERCS HMIGNGHLQF LQQLIDSQME
TSCQIAFEFV DQEQLKDPVC YLKKAFLLVQ DIMEDTMRFK DNTPNANVIV TLQELSLRLS
SCFTKDYEEQ DKACVRTFHE TPLQLLEKIK NVFNETKNLL KKDWNVFSKN CNKSFEKCSS
QGHDRQQEGP SDPQLPGFVF RLLVPSIILV LLAVGGLLFY RQRWRSHREP QTVDSPMERP
EGSPLTQDED RQVELPV


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