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Macrophage colony-stimulating factor 1 (CSF-1) (MCSF)

 M3WDW6_FELCA            Unreviewed;       563 AA.
M3WDW6;
01-MAY-2013, integrated into UniProtKB/TrEMBL.
28-FEB-2018, sequence version 2.
28-MAR-2018, entry version 33.
RecName: Full=Macrophage colony-stimulating factor 1 {ECO:0000256|PIRNR:PIRNR001948};
Short=CSF-1 {ECO:0000256|PIRNR:PIRNR001948};
Short=MCSF {ECO:0000256|PIRNR:PIRNR001948};
Name=CSF1 {ECO:0000313|Ensembl:ENSFCAP00000010007};
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
Felinae; Felis.
NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000010007, ECO:0000313|Proteomes:UP000011712};
[1] {ECO:0000313|Ensembl:ENSFCAP00000010007, ECO:0000313|Proteomes:UP000011712}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010007,
ECO:0000313|Proteomes:UP000011712};
PubMed=17975172; DOI=10.1101/gr.6380007;
Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
"Initial sequence and comparative analysis of the cat genome.";
Genome Res. 17:1675-1689(2007).
[2] {ECO:0000313|Ensembl:ENSFCAP00000010007}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010007};
Hillier L.W., Warren W., Obrien S., Wilson R.K.;
"Sequence assembly of the Felis catus genome version 6.2.";
Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSFCAP00000010007}
IDENTIFICATION.
STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010007};
Ensembl;
Submitted (MAR-2013) to UniProtKB.
-!- FUNCTION: Cytokine that plays an essential role in the regulation
of survival, proliferation and differentiation of hematopoietic
precursor cells, especially mononuclear phagocytes, such as
macrophages and monocytes. Promotes the release of proinflammatory
chemokines, and thereby plays an important role in innate immunity
and in inflammatory processes. Plays an important role in the
regulation of osteoclast proliferation and differentiation, the
regulation of bone resorption, and is required for normal bone
development. Required for normal male and female fertility.
Promotes reorganization of the actin cytoskeleton, regulates
formation of membrane ruffles, cell adhesion and cell migration.
Plays a role in lipoprotein clearance.
{ECO:0000256|PIRNR:PIRNR001948}.
-!- SUBUNIT: Homodimer or heterodimer; disulfide-linked. Interacts
with CSF1R. {ECO:0000256|PIRNR:PIRNR001948}.
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EMBL; AANG03320135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_006935041.1; XM_006934979.3.
STRING; 9685.ENSFCAP00000010007; -.
Ensembl; ENSFCAT00000010774; ENSFCAP00000010007; ENSFCAG00000010770.
eggNOG; ENOG410II8R; Eukaryota.
eggNOG; ENOG410Z5Q9; LUCA.
GeneTree; ENSGT00390000015805; -.
InParanoid; M3WDW6; -.
OMA; DTGHERQ; -.
OrthoDB; EOG091G0TMC; -.
Proteomes; UP000011712; Chromosome C1.
Bgee; ENSFCAG00000010770; -.
GO; GO:1990682; C:CSF1-CSF1R complex; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005157; F:macrophage colony-stimulating factor receptor binding; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:UniProtKB-UniRule.
GO; GO:0060444; P:branching involved in mammary gland duct morphogenesis; IEA:Ensembl.
GO; GO:0003006; P:developmental process involved in reproduction; IEA:Ensembl.
GO; GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
GO; GO:0038145; P:macrophage colony-stimulating factor signaling pathway; IEA:Ensembl.
GO; GO:0060763; P:mammary duct terminal end bud growth; IEA:Ensembl.
GO; GO:0060611; P:mammary gland fat development; IEA:Ensembl.
GO; GO:0030316; P:osteoclast differentiation; IEA:UniProtKB-UniRule.
GO; GO:0002158; P:osteoclast proliferation; IEA:Ensembl.
GO; GO:0001954; P:positive regulation of cell-matrix adhesion; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0010759; P:positive regulation of macrophage chemotaxis; IEA:Ensembl.
GO; GO:1902228; P:positive regulation of macrophage colony-stimulating factor signaling pathway; IEA:Ensembl.
GO; GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IEA:Ensembl.
GO; GO:0045651; P:positive regulation of macrophage differentiation; IEA:Ensembl.
GO; GO:1904141; P:positive regulation of microglial cell migration; IEA:Ensembl.
GO; GO:0045657; P:positive regulation of monocyte differentiation; IEA:Ensembl.
GO; GO:0032946; P:positive regulation of mononuclear cell proliferation; IEA:Ensembl.
GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
GO; GO:0042488; P:positive regulation of odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
GO; GO:0045860; P:positive regulation of protein kinase activity; IEA:Ensembl.
GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IEA:Ensembl.
GO; GO:0030278; P:regulation of ossification; IEA:Ensembl.
GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR008001; MCSF-1.
PANTHER; PTHR10058; PTHR10058; 1.
Pfam; PF05337; CSF-1; 1.
PIRSF; PIRSF001948; MCSF-1; 1.
SUPFAM; SSF47266; SSF47266; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000011712};
Cytokine {ECO:0000256|PIRNR:PIRNR001948};
Growth factor {ECO:0000256|PIRNR:PIRNR001948};
Immunity {ECO:0000256|PIRNR:PIRNR001948};
Inflammatory response {ECO:0000256|PIRNR:PIRNR001948};
Innate immunity {ECO:0000256|PIRNR:PIRNR001948};
Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000011712};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
SIGNAL 1 26 {ECO:0000256|SAM:SignalP}.
CHAIN 27 563 Macrophage colony-stimulating factor 1.
{ECO:0000256|SAM:SignalP}.
/FTId=PRO_5014182841.
TRANSMEM 504 526 Helical. {ECO:0000256|SAM:Phobius}.
SEQUENCE 563 AA; 61701 MW; 927AD11DDA544CEB CRC64;
MMHSLPQTWL SRLLLLVCLL VSRSITEEVS ERCSHMIGNG HLQFLQQLID SQMETSCQIA
FEFVDQEQLK DPVCYLKKAF LLVQDIMEDT MRFKDNTPNA NVIVTLQELS LRLSSCFTKD
YEEQDKACVR TFHETPLQLL EKIKNVFNET KNLLKKDWNV FSKNCNKSFE KCSSQDVVTK
PDCNCLYPKA TPTSDLASVS PQQPLAPSTA PMAGLTRADS EGTEGGSLLP SELPLRTVDL
DPGTAKQRPP RSTCQSFDSP EPPGVEASPI GDSPQPQSSA GAPTPGMEHI LDSVLGTNWT
LEEASGEASE GPVPQGAELS SSRPGGGSIQ AKMTARPSDL LSASFPLSYS ARSQQPEDMT
SIPLPTVGPA RPTGQAQSHT PEKTDRPSAK PRDHQEPGSA RTPSRPPRSL SSLRIPSRPP
RSPGSPSALS AQPGLPGSHS WGHVLPLREL EGRRSTRDRR SPTELEGQAS EGHRPSARFN
SVPLTDTGHD RQQEGPSDPQ LPGFVFRLLV PSIILVLLAV GGLLFYRQRW RSHREPQTVD
SPMERPEGSP LTQDEDRQVE LPV


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