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Major allergen Equ c 1 (allergen Equ c 1)

 ALL1_HORSE              Reviewed;         187 AA.
Q95182;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-FEB-1997, sequence version 1.
23-MAY-2018, entry version 116.
RecName: Full=Major allergen Equ c 1;
AltName: Allergen=Equ c 1;
Flags: Precursor;
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796;
[1]
NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, AND ALLERGEN.
TISSUE=Hair, and Sublingual gland;
PubMed=8955138; DOI=10.1074/jbc.271.51.32951;
Gregoire C., Rosinski-Chupin I., Rabillon J., Alzari P.M., David B.,
Dandeu J.-P.;
"cDNA cloning and sequencing reveal the major horse allergen Equ c1 to
be a glycoprotein member of the lipocalin superfamily.";
J. Biol. Chem. 271:32951-32959(1996).
[2]
X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 23-181.
TISSUE=Salivary gland;
PubMed=10787420; DOI=10.1074/jbc.M002854200;
Lascombe M.-B., Gregoire C., Poncet P., Tavares G.A.,
Rosinski-Chupin I., Rabillon J., Goubran-Botros H., Mazie J.-C.,
David B., Alzari P.M.;
"Crystal structure of the allergen Equ c 1: a dimeric lipocalin with
restricted IgE-reactive epitopes.";
J. Biol. Chem. 275:21572-21577(2000).
[3]
MASS SPECTROMETRY.
TISSUE=Dander;
PubMed=11358533; DOI=10.1046/j.1432-1327.2001.02217.x;
Goubran Botros H., Poncet P., Rabillon J., Fontaine T., Laval J.-M.,
David B.;
"Biochemical characterization and surfactant properties of horse
allergens.";
Eur. J. Biochem. 268:3126-3136(2001).
-!- SUBUNIT: Homodimer.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed in liver and in sublingual and
submaxillary salivary glands. Highly concentrated in secretory
fluid such as saliva and urine as well as in hair dandruff
extract.
-!- PTM: Several N-terminal ends may be due to cleavage by signal
peptidase at different sites or may be generated by proteolytic
processing of the secreted protein.
-!- PTM: Analysis of the sugar composition shows the presence of
GalNAc, Gal, NeuAc, GlcNAc, and Man. May be also O-glycosylated.
-!- MASS SPECTROMETRY: Mass=22000; Method=Electrospray; Range=16-187;
Evidence={ECO:0000269|PubMed:11358533};
-!- ALLERGEN: Causes an allergic reaction in human. Potent allergen
responsible for about 80% of anti-horse IgE antibody response in
patients who are chronically exposed to horse allergens.
{ECO:0000269|PubMed:8955138}.
-!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
{ECO:0000305}.
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EMBL; U70823; AAC48691.1; -; mRNA.
RefSeq; NP_001075966.1; NM_001082497.2.
UniGene; Eca.13041; -.
PDB; 1EW3; X-ray; 2.30 A; A=23-181.
PDBsum; 1EW3; -.
ProteinModelPortal; Q95182; -.
SMR; Q95182; -.
STRING; 9796.ENSECAP00000000397; -.
Allergome; 3306; Equ c 1.0101.
Allergome; 331; Equ c 1.
PaxDb; Q95182; -.
PRIDE; Q95182; -.
GeneID; 100034197; -.
KEGG; ecb:100034197; -.
eggNOG; ENOG410J5XW; Eukaryota.
eggNOG; ENOG411154J; LUCA.
HOGENOM; HOG000231458; -.
HOVERGEN; HBG000215; -.
OMA; MHTKVNG; -.
EvolutionaryTrace; Q95182; -.
Proteomes; UP000002281; Unplaced.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0036094; F:small molecule binding; IEA:InterPro.
Gene3D; 2.40.128.20; -; 1.
InterPro; IPR012674; Calycin.
InterPro; IPR002345; Lipocalin.
InterPro; IPR022272; Lipocalin_CS.
InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
InterPro; IPR002971; Maj_urinary.
PANTHER; PTHR11430; PTHR11430; 1.
Pfam; PF00061; Lipocalin; 1.
PRINTS; PR01221; MAJORURINARY.
SUPFAM; SSF50814; SSF50814; 1.
PROSITE; PS00213; LIPOCALIN; 1.
1: Evidence at protein level;
3D-structure; Allergen; Complete proteome; Direct protein sequencing;
Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal;
Transport.
SIGNAL 1 15 Or 16, or 21.
CHAIN 16 187 Major allergen Equ c 1.
/FTId=PRO_0000017982.
CARBOHYD 53 53 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 68 68 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 83 176
VARIANT 62 62 V -> L.
VARIANT 90 90 F -> A.
VARIANT 136 136 F -> L.
VARIANT 146 146 S -> D.
VARIANT 172 173 KI -> QT.
STRAND 25 27 {ECO:0000244|PDB:1EW3}.
HELIX 30 32 {ECO:0000244|PDB:1EW3}.
STRAND 38 46 {ECO:0000244|PDB:1EW3}.
HELIX 47 49 {ECO:0000244|PDB:1EW3}.
STRAND 59 65 {ECO:0000244|PDB:1EW3}.
STRAND 71 79 {ECO:0000244|PDB:1EW3}.
STRAND 82 92 {ECO:0000244|PDB:1EW3}.
STRAND 98 116 {ECO:0000244|PDB:1EW3}.
STRAND 119 126 {ECO:0000244|PDB:1EW3}.
STRAND 133 144 {ECO:0000244|PDB:1EW3}.
HELIX 147 159 {ECO:0000244|PDB:1EW3}.
HELIX 164 166 {ECO:0000244|PDB:1EW3}.
STRAND 167 169 {ECO:0000244|PDB:1EW3}.
HELIX 170 172 {ECO:0000244|PDB:1EW3}.
HELIX 177 179 {ECO:0000244|PDB:1EW3}.
SEQUENCE 187 AA; 21696 MW; 28898F744732FF71 CRC64;
MKLLLLCLGL ILVCAQQEEN SDVAIRNFDI SKISGEWYSI FLASDVKEKI EENGSMRVFV
DVIRALDNSS LYAEYQTKVN GECTEFPMVF DKTEEDGVYS LNYDGYNVFR ISEFENDEHI
ILYLVNFDKD RPFQLFEFYA REPDVSPEIK EEFVKIVQKR GIVKENIIDL TKIDRCFQLR
GNGVAQA


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