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Major allergen I polypeptide chain 1 (AG4) (Allergen Cat-1) (Allergen Fel d I-A) (Allergen FdI) (Allergen Fel dI) (allergen Fel d 1-A)

 FEL1A_FELCA             Reviewed;          92 AA.
P30438; P30439;
01-APR-1993, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 2.
23-MAY-2018, entry version 110.
RecName: Full=Major allergen I polypeptide chain 1;
AltName: Full=AG4;
AltName: Full=Allergen Cat-1;
AltName: Full=Allergen Fel d I-A;
Short=Allergen FdI;
Short=Allergen Fel dI;
AltName: Allergen=Fel d 1-A;
Flags: Precursor;
Name=CH1;
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
Felinae; Felis.
NCBI_TaxID=9685;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 23-92 (ISOFORMS 1
AND 2).
TISSUE=Salivary gland;
PubMed=1946388; DOI=10.1073/pnas.88.21.9690;
Morgenstern J.P., Griffith I.J., Brauer A.W., Rogers B.L., Bond J.F.,
Chapman M.D., Kuo M.-C.;
"Amino acid sequence of Fel dI, the major allergen of the domestic
cat: protein sequence analysis and cDNA cloning.";
Proc. Natl. Acad. Sci. U.S.A. 88:9690-9694(1991).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
TISSUE=Liver;
PubMed=1572548; DOI=10.1016/0378-1119(92)90405-E;
Griffith I.J., Craig S., Pollock J., Yu X.-B., Morgenstern J.P.,
Rogers B.L.;
"Expression and genomic structure of the genes encoding FdI, the major
allergen from the domestic cat.";
Gene 113:263-268(1992).
[3]
PROTEIN SEQUENCE OF 23-62, AND CHARACTERIZATION.
PubMed=1712068; DOI=10.1016/0161-5890(91)90141-6;
Duffort O.A., Carreira J., Nitti G., Polo F., Lombardero M.;
"Studies on the biochemical structure of the major cat allergen Felis
domesticus I.";
Mol. Immunol. 28:301-309(1991).
[4]
CHARACTERIZATION.
PubMed=6747135; DOI=10.1016/0091-6749(84)90278-1;
Leitermann K., Ohman J.L. Jr.;
"Cat allergen 1: biochemical, antigenic, and allergenic properties.";
J. Allergy Clin. Immunol. 74:147-153(1984).
[5]
X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
PubMed=12851385; DOI=10.1074/jbc.M304740200;
Kaiser L., Gronlund H., Sandalova T., Ljunggren H.G.,
van Hage-Hamsten M., Achour A., Schneider G.;
"The crystal structure of the major cat allergen Fel d 1, a member of
the secretoglobin family.";
J. Biol. Chem. 278:37730-37735(2003).
-!- SUBUNIT: Heterotetramer composed of two non-covalently linked
disulfide-linked heterodimer of chains 1 and 2.
-!- SUBCELLULAR LOCATION: Secreted.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=Leader A, Major;
IsoId=P30438-1; Sequence=Displayed;
Name=2; Synonyms=Leader B, Minor;
IsoId=P30438-2; Sequence=VSP_015665;
-!- TISSUE SPECIFICITY: Saliva and sebaceous glands.
-!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE.
Major allergen produced by the domestic cat. Implicated as an
asthma-inducing agent in human. This protein is sticky and easily
adheres to walls, carpet, clothing, furniture and bedding.
-!- SIMILARITY: Belongs to the secretoglobin family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAA44343.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=CAA44344.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; M74952; AAC37318.1; -; mRNA.
EMBL; M74953; AAC41617.1; -; mRNA.
EMBL; X62477; CAA44344.1; ALT_INIT; Genomic_DNA.
EMBL; X62477; CAA44343.1; ALT_INIT; Genomic_DNA.
PIR; A56413; A56413.
PIR; JC1136; JC1136.
RefSeq; NP_001041618.1; NM_001048153.1.
PDB; 1PUO; X-ray; 1.85 A; A/B=23-92.
PDB; 1ZKR; X-ray; 1.64 A; A/B=23-92.
PDB; 2EJN; X-ray; 1.64 A; A/B=23-92.
PDB; 5VYF; X-ray; 2.90 A; C/F=23-92.
PDBsum; 1PUO; -.
PDBsum; 1ZKR; -.
PDBsum; 2EJN; -.
PDBsum; 5VYF; -.
ProteinModelPortal; P30438; -.
SMR; P30438; -.
Allergome; 3278; Fel d 1.0101.
Allergome; 345; Fel d 1.
GeneID; 677877; -.
HOVERGEN; HBG051604; -.
InParanoid; P30438; -.
EvolutionaryTrace; P30438; -.
Proteomes; UP000011712; Unplaced.
GO; GO:0005576; C:extracellular region; IBA:GO_Central.
GO; GO:0005496; F:steroid binding; IBA:GO_Central.
CDD; cd00633; Secretoglobin; 1.
InterPro; IPR006178; Allergen_Fel_d_I_chain1.
InterPro; IPR016126; Secretoglobin.
InterPro; IPR035960; Secretoglobin_sf.
PANTHER; PTHR21226; PTHR21226; 1.
Pfam; PF01099; Uteroglobin; 1.
PRINTS; PR00827; FELALLERGEN.
SUPFAM; SSF48201; SSF48201; 1.
PROSITE; PS51311; SCGB; 1.
1: Evidence at protein level;
3D-structure; Allergen; Alternative splicing; Complete proteome;
Direct protein sequencing; Disulfide bond; Polymorphism;
Reference proteome; Secreted; Signal.
SIGNAL 1 22 {ECO:0000269|PubMed:1712068}.
CHAIN 23 92 Major allergen I polypeptide chain 1.
/FTId=PRO_0000036370.
DISULFID 25 25 Interchain (with C-90 in chain 2).
DISULFID 66 66 Interchain (with C-65 in chain 2).
DISULFID 92 92 Interchain (with C-24 in chain 2).
VAR_SEQ 1 21 MKGACVLVLLWAALLLISGGN -> MLDAALPPCPTVAATA
D (in isoform 2). {ECO:0000305}.
/FTId=VSP_015665.
VARIANT 51 51 K -> N.
CONFLICT 5 5 C -> R (in Ref. 1; AAC37318).
{ECO:0000305}.
CONFLICT 18 18 S -> W (in Ref. 1; AAC37318).
{ECO:0000305}.
CONFLICT 82 82 V -> L (in Ref. 1; AAC41617/AAC37318).
{ECO:0000305}.
HELIX 26 37 {ECO:0000244|PDB:1ZKR}.
HELIX 40 50 {ECO:0000244|PDB:1ZKR}.
HELIX 54 70 {ECO:0000244|PDB:1ZKR}.
HELIX 73 87 {ECO:0000244|PDB:1ZKR}.
SEQUENCE 92 AA; 10086 MW; 083145F55EE8AAB3 CRC64;
MKGACVLVLL WAALLLISGG NCEICPAVKR DVDLFLTGTP DEYVEQVAQY KALPVVLENA
RILKNCVDAK MTEEDKENAL SVLDKIYTSP LC


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