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Major allergen I polypeptide chain 2 (AG4) (Allergen Cat-1) (Allergen Fel d I-B) (Allergen FdI) (allergen Fel d 1-B)

 FEL1B_FELCA             Reviewed;         109 AA.
P30440;
01-APR-1993, integrated into UniProtKB/Swiss-Prot.
01-APR-1993, sequence version 1.
25-OCT-2017, entry version 103.
RecName: Full=Major allergen I polypeptide chain 2;
AltName: Full=AG4;
AltName: Full=Allergen Cat-1;
AltName: Full=Allergen Fel d I-B;
Short=Allergen FdI;
AltName: Allergen=Fel d 1-B;
Flags: Precursor;
Name=CH2;
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
Felinae; Felis.
NCBI_TaxID=9685;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 18-100.
PubMed=1946388; DOI=10.1073/pnas.88.21.9690;
Morgenstern J.P., Griffith I.J., Brauer A.W., Rogers B.L., Bond J.F.,
Chapman M.D., Kuo M.-C.;
"Amino acid sequence of Fel dI, the major allergen of the domestic
cat: protein sequence analysis and cDNA cloning.";
Proc. Natl. Acad. Sci. U.S.A. 88:9690-9694(1991).
[2]
NUCLEOTIDE SEQUENCE, ALTERNATIVE SPLICING, AND VARIANTS.
TISSUE=Liver;
PubMed=1572548; DOI=10.1016/0378-1119(92)90405-E;
Griffith I.J., Craig S., Pollock J., Yu X.-B., Morgenstern J.P.,
Rogers B.L.;
"Expression and genomic structure of the genes encoding FdI, the major
allergen from the domestic cat.";
Gene 113:263-268(1992).
[3]
PROTEIN SEQUENCE OF 18-37, AND CHARACTERIZATION.
PubMed=1712068; DOI=10.1016/0161-5890(91)90141-6;
Duffort O.A., Carreira J., Nitti G., Polo F., Lombardero M.;
"Studies on the biochemical structure of the major cat allergen Felis
domesticus I.";
Mol. Immunol. 28:301-309(1991).
[4]
CHARACTERIZATION.
PubMed=6747135; DOI=10.1016/0091-6749(84)90278-1;
Leitermann K., Ohman J.L. Jr.;
"Cat allergen 1: biochemical, antigenic, and allergenic properties.";
J. Allergy Clin. Immunol. 74:147-153(1984).
[5]
X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 18-109.
PubMed=12851385; DOI=10.1074/jbc.M304740200;
Kaiser L., Gronlund H., Sandalova T., Ljunggren H.G.,
van Hage-Hamsten M., Achour A., Schneider G.;
"The crystal structure of the major cat allergen Fel d 1, a member of
the secretoglobin family.";
J. Biol. Chem. 278:37730-37735(2003).
-!- SUBUNIT: Heterotetramer composed of two non-covalently linked
disulfide-linked heterodimer of chains 1 and 2.
-!- SUBCELLULAR LOCATION: Secreted.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Comment=Experimental confirmation may be lacking for some
isoforms.;
Name=1; Synonyms=CH2L;
IsoId=P30440-1; Sequence=Displayed;
Name=2; Synonyms=CH2S;
IsoId=P30440-2; Sequence=VSP_004249;
Name=3; Synonyms=CH2ST, Truncated;
IsoId=P30440-3; Sequence=VSP_004248;
-!- TISSUE SPECIFICITY: The long form is preferentially expressed in
the salivary gland, while the short form is preferentially
expressed in the skin.
-!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE.
Major allergen produced by the domestic cat. Implicated as an
asthma-inducing agent in human. This protein is sticky and easily
adheres to walls, carpet, clothing, furniture and bedding.
-!- SIMILARITY: Belongs to the secretoglobin family. {ECO:0000305}.
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EMBL; M77341; AAC41616.1; -; mRNA.
EMBL; X62478; CAA44345.1; -; Genomic_DNA.
PIR; B53283; B53283.
PIR; C56413; C56413.
PIR; JC1127; JC1127.
RefSeq; NP_001041619.1; NM_001048154.1. [P30440-1]
PDB; 1PUO; X-ray; 1.85 A; A/B=18-109.
PDB; 1ZKR; X-ray; 1.64 A; A/B=18-93.
PDB; 2EJN; X-ray; 1.64 A; A/B=18-93.
PDBsum; 1PUO; -.
PDBsum; 1ZKR; -.
PDBsum; 2EJN; -.
ProteinModelPortal; P30440; -.
SMR; P30440; -.
Allergome; 3278; Fel d 1.0101.
Allergome; 345; Fel d 1.
GeneID; 677879; -.
KEGG; fca:677879; -.
CTD; 677879; -.
eggNOG; ENOG410JIV4; Eukaryota.
eggNOG; ENOG41114U0; LUCA.
HOVERGEN; HBG063446; -.
InParanoid; P30440; -.
EvolutionaryTrace; P30440; -.
Proteomes; UP000011712; Unplaced.
GO; GO:0005615; C:extracellular space; IEA:InterPro.
CDD; cd00633; Secretoglobin; 1.
InterPro; IPR015332; Allergen_Fel_d_1_chain2.
InterPro; IPR016126; Secretoglobin.
InterPro; IPR035960; Secretoglobin_sf.
Pfam; PF09252; Feld-I_B; 1.
SUPFAM; SSF48201; SSF48201; 1.
PROSITE; PS51311; SCGB; 1.
1: Evidence at protein level;
3D-structure; Allergen; Alternative splicing; Complete proteome;
Direct protein sequencing; Disulfide bond; Glycoprotein; Polymorphism;
Reference proteome; Secreted; Signal.
SIGNAL 1 17 {ECO:0000269|PubMed:1712068,
ECO:0000269|PubMed:1946388}.
CHAIN 18 109 Major allergen I polypeptide chain 2.
/FTId=PRO_0000021248.
CARBOHYD 50 50 N-linked (GlcNAc...) asparagine.
DISULFID 24 24 Interchain (with C-92 in chain 1).
DISULFID 65 65 Interchain (with C-66 in chain 1).
DISULFID 90 90 Interchain (with C-25 in chain 1).
VAR_SEQ 82 109 TTISSSKDCMGEAVQNTVEDLKLNTLGR -> PSTNIAWVK
QFRTP (in isoform 3). {ECO:0000305}.
/FTId=VSP_004248.
VAR_SEQ 82 89 TTISSSKD -> IAINEY (in isoform 2).
{ECO:0000305}.
/FTId=VSP_004249.
VARIANT 72 72 I -> L (in CH2LV).
VARIANT 72 72 I -> V (in CH2SV).
VARIANT 74 75 RV -> KF (in CH2SV).
VARIANT 91 91 M -> T (in CH2LV).
VARIANT 96 96 Q -> E (in CH2SV).
VARIANT 105 105 N -> K (in CH2SV).
CONFLICT 24 24 C -> F (in Ref. 3; AA sequence).
{ECO:0000305}.
CONFLICT 32 32 F -> T (in Ref. 3; AA sequence).
{ECO:0000305}.
STRAND 19 23 {ECO:0000244|PDB:1ZKR}.
HELIX 25 35 {ECO:0000244|PDB:1ZKR}.
HELIX 39 48 {ECO:0000244|PDB:1ZKR}.
HELIX 53 68 {ECO:0000244|PDB:1ZKR}.
HELIX 71 73 {ECO:0000244|PDB:1ZKR}.
STRAND 74 76 {ECO:0000244|PDB:1ZKR}.
HELIX 77 85 {ECO:0000244|PDB:1ZKR}.
TURN 88 90 {ECO:0000244|PDB:1ZKR}.
SEQUENCE 109 AA; 11854 MW; 857FB9CD76036CB9 CRC64;
MRGALLVLAL LVTQALGVKM AETCPIFYDV FFAVANGNEL LLDLSLTKVN ATEPERTAMK
KIQDCYVENG LISRVLDGLV MTTISSSKDC MGEAVQNTVE DLKLNTLGR


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