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Major capsid protein L1 (Fragment)

 A0A1S6L7I8_9PAPI        Unreviewed;       126 AA.
A0A1S6L7I8;
10-MAY-2017, integrated into UniProtKB/TrEMBL.
10-MAY-2017, sequence version 1.
25-OCT-2017, entry version 5.
RecName: Full=Major capsid protein L1 {ECO:0000256|RuleBase:RU361248, ECO:0000256|SAAS:SAAS00105241};
Flags: Fragment;
Name=L1 {ECO:0000256|RuleBase:RU361248};
Human papillomavirus.
Viruses; dsDNA viruses, no RNA stage; Papillomaviridae;
unclassified Papillomaviridae.
NCBI_TaxID=10566 {ECO:0000313|EMBL:AQT33336.1};
[1] {ECO:0000313|EMBL:AQT33336.1}
NUCLEOTIDE SEQUENCE.
STRAIN=EP05 major capsid protein L1 gene
{ECO:0000313|EMBL:AQT33336.1};
Bolatti E.M., Chouhy D., Hosnjak L., Casal P.E., Kocjan B.J.,
Bottai H., Stella E.J., Sanchez A., Fernandez-Bussy R., Poljak M.,
Giri A.A.;
"Prevalence, persistence and associated factors of human
papillomavirus infection of sun-exposed healthy skin of
immunocompetent individuals along three climatic seasons and
identification of HPV209, a novel Betapapillomavirus.";
Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Forms an icosahedral capsid with a T=7 symmetry and a 50
nm diameter. The capsid is composed of 72 pentamers linked to each
other by disulfide bonds and associated with L2 proteins. Binds to
heparan sulfate proteoglycans on cell surface of basal layer
keratinocytes to provide initial virion attachment. This binding
mediates a conformational change in the virus capsid that
facilitates efficient infection. The virion enters the host cell
via endocytosis. During virus trafficking, L1 protein dissociates
from the viral DNA and the genomic DNA is released to the host
nucleus. The virion assembly takes place within the cell nucleus.
Encapsulates the genomic DNA together with protein L2.
{ECO:0000256|RuleBase:RU361248, ECO:0000256|SAAS:SAAS00514925}.
-!- SUBUNIT: Self-assembles into homopentamers. The capsid has an
icosahedral symmetry and consists of 72 capsomers, with each
capsomer being a pentamer of L1. Interacts with the minor capsid
protein L2; this interaction is necessary for viral genome
encapsidation. {ECO:0000256|RuleBase:RU361248}.
-!- SUBCELLULAR LOCATION: Host nucleus
{ECO:0000256|SAAS:SAAS00559273}.
-!- SUBCELLULAR LOCATION: Virion {ECO:0000256|RuleBase:RU361248,
ECO:0000256|SAAS:SAAS00559275}.
-!- SIMILARITY: Belongs to the papillomaviridae L1 protein family.
{ECO:0000256|RuleBase:RU361248, ECO:0000256|SAAS:SAAS00578944}.
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EMBL; KY242582; AQT33336.1; -; Genomic_DNA.
GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
GO; GO:0039620; C:T=7 icosahedral viral capsid; IEA:UniProtKB-KW.
GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:UniProtKB-KW.
GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-UniRule.
Gene3D; 2.60.175.20; -; 1.
InterPro; IPR002210; Capsid_L1_Papillomavir.
InterPro; IPR036973; Capsid_L1_sf_Papillomavir.
InterPro; IPR011222; dsDNA_vir_gr_I_capsid.
Pfam; PF00500; Late_protein_L1; 1.
PRINTS; PR00865; HPVCAPSIDL1.
SUPFAM; SSF88648; SSF88648; 1.
3: Inferred from homology;
Capsid protein {ECO:0000256|RuleBase:RU361248,
ECO:0000256|SAAS:SAAS00445708};
Disulfide bond {ECO:0000256|SAAS:SAAS00527207};
Host nucleus {ECO:0000256|SAAS:SAAS00527206};
Host-virus interaction {ECO:0000256|RuleBase:RU361248,
ECO:0000256|SAAS:SAAS00058257};
Late protein {ECO:0000256|RuleBase:RU361248};
T=7 icosahedral capsid protein {ECO:0000256|RuleBase:RU361248,
ECO:0000256|SAAS:SAAS00445708};
Viral attachment to host cell {ECO:0000256|RuleBase:RU361248,
ECO:0000256|SAAS:SAAS00058257};
Viral penetration into host cytoplasm {ECO:0000256|SAAS:SAAS00527205};
Virion {ECO:0000256|RuleBase:RU361248, ECO:0000256|SAAS:SAAS00058257,
ECO:0000256|SAAS:SAAS00445708};
Virus endocytosis by host {ECO:0000256|SAAS:SAAS00527205};
Virus entry into host cell {ECO:0000256|RuleBase:RU361248,
ECO:0000256|SAAS:SAAS00058257, ECO:0000256|SAAS:SAAS00527205}.
NON_TER 126 126 {ECO:0000313|EMBL:AQT33336.1}.
SEQUENCE 126 AA; 13966 MW; CFC13CE04E37BE2F CRC64;
MPDPNKFALV DPTIYNSEHE RLVWKLRGLE IGRGGPLGVA CTGNPLFNKY GDTENPNKYP
TKQSRDNRQN VAVDPKQTQL FMIGCSSPIG AHWDLAEFCP EHNGQPGECP PIQLVNSVIQ
DGDMCE


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