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Major urinary protein 6 (MUP 6) (Alpha-2U-globulin) (Group 1, BS6) (allergen Mus m 1)

 MUP6_MOUSE              Reviewed;         180 AA.
P02762; P70119; Q78EF5; Q91V46;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
16-APR-2002, sequence version 2.
25-APR-2018, entry version 179.
RecName: Full=Major urinary protein 6;
Short=MUP 6;
AltName: Full=Alpha-2U-globulin;
AltName: Full=Group 1, BS6;
AltName: Allergen=Mus m 1;
Flags: Precursor;
Name=Mup6;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3004935;
Clark A.J., Ghazal P., Bingham R.W., Barrett D., Bishop J.O.;
"Sequence structures of a mouse major urinary protein gene and
pseudogene compared.";
EMBO J. 4:3159-3165(1985).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=6329733;
Clark A.J., Clissold P.M., Shawi R.A., Beattie P., Bishop J.O.;
"Structure of mouse major urinary protein genes: different splicing
configurations in the 3'-non-coding region.";
EMBO J. 3:1045-1052(1984).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Liver;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-32.
PubMed=3858875; DOI=10.1073/pnas.82.12.4182;
Ghazal P., Clark J.A., Bishop J.;
"Evolutionary amplification of a pseudogene.";
Proc. Natl. Acad. Sci. U.S.A. 82:4182-4185(1985).
[6]
NUCLEOTIDE SEQUENCE OF 1-32.
PubMed=7937138; DOI=10.1093/nar/22.20.4132;
Caubin J., Iglesias T., Bernal J., Munoz A., Marquez G., Barbero J.L.,
Zaballos A.;
"Isolation of genomic DNA fragments corresponding to genes modulated
in vivo by a transcription factor.";
Nucleic Acids Res. 22:4132-4138(1994).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-10.
PubMed=2824995; DOI=10.1128/MCB.7.10.3705;
Held W.A., Gallagher J.F., Hohman C.M., Kuhn N.J., Sampsell B.M.,
Hughes R.G. Jr.;
"Identification and characterization of functional genes encoding the
mouse major urinary proteins.";
Mol. Cell. Biol. 7:3705-3712(1987).
[8]
NUCLEOTIDE SEQUENCE OF 20-41.
PubMed=7107707; DOI=10.1083/jcb.94.2.414;
Krauter K., Leinwand L., D'Eustachio P., Ruddle F., Darnell J.E. Jr.;
"Structural genes of the mouse major urinary protein are on chromosome
4.";
J. Cell Biol. 94:414-417(1982).
[9]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 134-180.
PubMed=8065364; DOI=10.1128/MCB.14.9.6326;
Belgrader P., Maquat L.E.;
"Nonsense but not missense mutations can decrease the abundance of
nuclear mRNA for the mouse major urinary protein, while both types of
mutations can facilitate exon skipping.";
Mol. Cell. Biol. 14:6326-6336(1994).
[10]
X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
PubMed=1279439; DOI=10.1038/360186a0;
Boecksel Z., Groom C.R., Flower D.R., Wright C.E., Phillips S.E.V.,
Cavaggioni A., Findlay J.B.C., North A.C.T.;
"Pheromone binding to two rodent urinary proteins revealed by X-ray
crystallography.";
Nature 360:186-188(1992).
[11]
X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
PubMed=11316880; DOI=10.1110/ps.52201;
Timm D.E., Baker L.-J., Mueller H., Zidek L., Novotny M.V.;
"Structural basis of pheromone binding to mouse major urinary protein
(MUP-I).";
Protein Sci. 10:997-1004(2001).
[12]
X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
PubMed=14871097; DOI=10.1021/ja038461i;
Bingham R.J., Findlay J.B., Hsieh S.-Y., Kalverda A.P., Kjellberg A.,
Perazzolo C., Phillips S.E., Seshadri K., Trinh C.H., Turnbull W.B.,
Bodenhausen G., Homans S.W.;
"Thermodynamics of binding of 2-methoxy-3-isopropylpyrazine and 2-
methoxy-3-isobutylpyrazine to the major urinary protein.";
J. Am. Chem. Soc. 126:1675-1681(2004).
-!- FUNCTION: Binds pheromones that are released from drying urine of
males. These pheromones affect the sexual behavior of females.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Abundant in the urine of adult male mice but
absent from that of females.
-!- ALLERGEN: Causes an allergic reaction in human.
-!- MISCELLANEOUS: There are about 15 group 1 MUP genes and their
transcripts make up about 5% of male mouse liver RNA.
-!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
{ECO:0000305}.
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EMBL; X03208; CAA26953.1; -; Genomic_DNA.
EMBL; AK013259; BAB28753.1; -; mRNA.
EMBL; BC013649; AAH13649.1; -; mRNA.
EMBL; M17759; AAA39763.1; -; Genomic_DNA.
EMBL; Z32546; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; M17818; AAA40543.1; -; Genomic_DNA.
EMBL; M17814; AAA40540.1; -; Genomic_DNA.
EMBL; M17817; AAA40544.1; -; Genomic_DNA.
EMBL; U12201; AAA99109.1; -; Genomic_DNA.
CCDS; CCDS51187.2; -.
CCDS; CCDS57278.1; -.
PIR; A03216; UAMS.
RefSeq; NP_001128599.1; NM_001135127.2.
RefSeq; NP_001186865.1; NM_001199936.1.
RefSeq; NP_001268908.1; NM_001281979.1.
RefSeq; XP_006537551.1; XM_006537488.2.
UniGene; Mm.335875; -.
UniGene; Mm.422695; -.
UniGene; Mm.457980; -.
UniGene; Mm.457982; -.
UniGene; Mm.482072; -.
UniGene; Mm.482231; -.
PDB; 1I04; X-ray; 2.00 A; A=1-180.
PDB; 1I05; X-ray; 2.00 A; A=1-180.
PDB; 1I06; X-ray; 1.90 A; A=1-180.
PDB; 1MUP; X-ray; 2.40 A; A=15-180.
PDB; 2LB6; NMR; -; A=19-180.
PDB; 2NND; X-ray; 1.60 A; A=19-75, A=82-180.
PDB; 2NNE; X-ray; 1.60 A; A=19-75, A=82-180.
PDBsum; 1I04; -.
PDBsum; 1I05; -.
PDBsum; 1I06; -.
PDBsum; 1MUP; -.
PDBsum; 2LB6; -.
PDBsum; 2NND; -.
PDBsum; 2NNE; -.
ProteinModelPortal; P02762; -.
SMR; P02762; -.
STRING; 10090.ENSMUSP00000092661; -.
Allergome; 3378; Mus m 1.0101.
Allergome; 478; Mus m 1.
Allergome; 8430; Mus m 1.0102.
iPTMnet; P02762; -.
PhosphoSitePlus; P02762; -.
SwissPalm; P02762; -.
SWISS-2DPAGE; P02762; -.
MaxQB; P02762; -.
PaxDb; P02762; -.
PRIDE; P02762; -.
Ensembl; ENSMUST00000080606; ENSMUSP00000079442; ENSMUSG00000078673.
Ensembl; ENSMUST00000095051; ENSMUSP00000092661; ENSMUSG00000078675.
Ensembl; ENSMUST00000107483; ENSMUSP00000103107; ENSMUSG00000078675.
Ensembl; ENSMUST00000107506; ENSMUSP00000103130; ENSMUSG00000078686.
Ensembl; ENSMUST00000122381; ENSMUSP00000113741; ENSMUSG00000078686.
Ensembl; ENSMUST00000201756; ENSMUSP00000143924; ENSMUSG00000106882.
Ensembl; ENSMUST00000201846; ENSMUSP00000144228; ENSMUSG00000106882.
Ensembl; ENSMUST00000202367; ENSMUSP00000144443; ENSMUSG00000107188.
Ensembl; ENSMUST00000202863; ENSMUSP00000143903; ENSMUSG00000107188.
GeneID; 100038948; -.
GeneID; 100039177; -.
GeneID; 100189605; -.
KEGG; mmu:100038948; -.
KEGG; mmu:100039177; -.
KEGG; mmu:100189605; -.
UCSC; uc008tak.3; mouse.
CTD; 100038948; -.
CTD; 100039177; -.
CTD; 100189605; -.
eggNOG; ENOG410J5XW; Eukaryota.
eggNOG; ENOG411154J; LUCA.
GeneTree; ENSGT00530000063356; -.
HOGENOM; HOG000231458; -.
HOVERGEN; HBG000215; -.
InParanoid; P02762; -.
OMA; FPKNDEC; -.
TreeFam; TF338197; -.
EvolutionaryTrace; P02762; -.
Proteomes; UP000000589; Chromosome 4.
Bgee; ENSMUSG00000078673; -.
ExpressionAtlas; P02762; baseline and differential.
Genevisible; P02762; MM.
GO; GO:0005829; C:cytosol; ISS:UniProtKB.
GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0005009; F:insulin-activated receptor activity; ISS:UniProtKB.
GO; GO:0005550; F:pheromone binding; ISS:UniProtKB.
GO; GO:0036094; F:small molecule binding; IEA:InterPro.
GO; GO:0009060; P:aerobic respiration; ISS:UniProtKB.
GO; GO:0071396; P:cellular response to lipid; ISS:UniProtKB.
GO; GO:0006112; P:energy reserve metabolic process; ISS:UniProtKB.
GO; GO:0042593; P:glucose homeostasis; ISS:UniProtKB.
GO; GO:0031649; P:heat generation; ISS:UniProtKB.
GO; GO:0045475; P:locomotor rhythm; ISS:UniProtKB.
GO; GO:0070584; P:mitochondrion morphogenesis; ISS:UniProtKB.
GO; GO:0045721; P:negative regulation of gluconeogenesis; ISS:UniProtKB.
GO; GO:0061179; P:negative regulation of insulin secretion involved in cellular response to glucose stimulus; ISS:UniProtKB.
GO; GO:0051055; P:negative regulation of lipid biosynthetic process; ISS:UniProtKB.
GO; GO:0010888; P:negative regulation of lipid storage; ISS:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
GO; GO:0010907; P:positive regulation of glucose metabolic process; ISS:UniProtKB.
GO; GO:0045834; P:positive regulation of lipid metabolic process; ISS:UniProtKB.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISS:UniProtKB.
Gene3D; 2.40.128.20; -; 1.
InterPro; IPR012674; Calycin.
InterPro; IPR002345; Lipocalin.
InterPro; IPR022272; Lipocalin_CS.
InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
InterPro; IPR002971; Maj_urinary.
PANTHER; PTHR11430; PTHR11430; 1.
Pfam; PF00061; Lipocalin; 1.
PRINTS; PR01221; MAJORURINARY.
SUPFAM; SSF50814; SSF50814; 1.
PROSITE; PS00213; LIPOCALIN; 1.
1: Evidence at protein level;
3D-structure; Allergen; Complete proteome; Disulfide bond;
Pheromone-binding; Reference proteome; Secreted; Signal; Transport.
SIGNAL 1 18
CHAIN 19 180 Major urinary protein 6.
/FTId=PRO_0000017932.
DISULFID 82 175
CONFLICT 145 145 S -> M (in Ref. 1; CAA26953).
{ECO:0000305}.
CONFLICT 158 158 E -> K (in Ref. 9; AAA99109).
{ECO:0000305}.
STRAND 23 27 {ECO:0000244|PDB:1I04}.
HELIX 30 33 {ECO:0000244|PDB:2NND}.
STRAND 38 46 {ECO:0000244|PDB:2NND}.
HELIX 47 50 {ECO:0000244|PDB:2NND}.
STRAND 59 65 {ECO:0000244|PDB:2NND}.
STRAND 67 75 {ECO:0000244|PDB:2NND}.
STRAND 84 91 {ECO:0000244|PDB:2NND}.
STRAND 98 113 {ECO:0000244|PDB:2NND}.
STRAND 115 127 {ECO:0000244|PDB:2NND}.
STRAND 130 142 {ECO:0000244|PDB:2NND}.
HELIX 146 158 {ECO:0000244|PDB:2NND}.
HELIX 163 165 {ECO:0000244|PDB:2NND}.
STRAND 166 168 {ECO:0000244|PDB:2NND}.
TURN 170 172 {ECO:0000244|PDB:1I06}.
SEQUENCE 180 AA; 20649 MW; B4A429BDA0700947 CRC64;
MKMLLLLCLG LTLVCVHAEE ASSTGRNFNV EKINGEWHTI ILASDKREKI EDNGNFRLFL
EQIHVLENSL VLKFHTVRDE ECSELSMVAD KTEKAGEYSV TYDGFNTFTI PKTDYDNFLM
AHLINEKDGE TFQLMGLYGR EPDLSSDIKE RFAQLCEEHG ILRENIIDLS NANRCLQARE


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