Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Major viral transcription factor ICP4 (Alpha-4 protein) (Infected cell protein 4) (Transcriptional activator IE175)

 ICP4_HHV11              Reviewed;        1298 AA.
P08392;
01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
01-AUG-1988, sequence version 1.
30-AUG-2017, entry version 99.
RecName: Full=Major viral transcription factor ICP4;
AltName: Full=Alpha-4 protein;
AltName: Full=Infected cell protein 4;
AltName: Full=Transcriptional activator IE175;
Name=ICP4; Synonyms=IE175; ORFNames=RS1;
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus
1).
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
Alphaherpesvirinae; Simplexvirus.
NCBI_TaxID=10299;
NCBI_TaxID=9606; Homo sapiens (Human).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3005980; DOI=10.1093/nar/14.4.1727;
McGeoch D.J., Dolan A., Donald S., Brauer D.H.K.;
"Complete DNA sequence of the short repeat region in the genome of
herpes simplex virus type 1.";
Nucleic Acids Res. 14:1727-1745(1986).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=2839594; DOI=10.1099/0022-1317-69-7-1531;
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C.,
McNab D., Perry L.J., Scott J.E., Taylor P.;
"The complete DNA sequence of the long unique region in the genome of
herpes simplex virus type 1.";
J. Gen. Virol. 69:1531-1574(1988).
[3]
DNA-BINDING DOMAIN.
PubMed=2155403; DOI=10.1093/nar/18.3.531;
Wu C.-L., Wilcox K.W.;
"Codons 262 to 490 from the herpes simplex virus ICP4 gene are
sufficient to encode a sequence-specific DNA binding protein.";
Nucleic Acids Res. 18:531-538(1990).
[4]
FUNCTION, AND PHOSPHORYLATION.
PubMed=1846804;
Papavassiliou A.G., Wilcox K.W., Silverstein S.J.;
"The interaction of ICP4 with cell/infected-cell factors and its state
of phosphorylation modulate differential recognition of leader
sequences in herpes simplex virus DNA.";
EMBO J. 10:397-406(1991).
[5]
FUNCTION, AND INTERACTION WITH HOST GTF2B.
PubMed=8392607;
Smith C.A., Bates P., Rivera-Gonzalez R., Gu B., DeLuca N.A.;
"ICP4, the major transcriptional regulatory protein of herpes simplex
virus type 1, forms a tripartite complex with TATA-binding protein and
TFIIB.";
J. Virol. 67:4676-4687(1993).
[6]
FUNCTION, AND INTERACTION WITH HOST TBP AND TAF1.
PubMed=8649420; DOI=10.1128/MCB.16.6.3085;
Carrozza M.J., DeLuca N.A.;
"Interaction of the viral activator protein ICP4 with TFIID through
TAF250.";
Mol. Cell. Biol. 16:3085-3093(1996).
[7]
INTERACTION WITH ICP27.
PubMed=8995681;
Panagiotidis C.A., Lium E.K., Silverstein S.J.;
"Physical and functional interactions between herpes simplex virus
immediate-early proteins ICP4 and ICP27.";
J. Virol. 71:1547-1557(1997).
[8]
SUBCELLULAR LOCATION.
PubMed=17959681; DOI=10.1128/JVI.01588-07;
Sedlackova L., Rice S.A.;
"Herpes simplex virus type 1 immediate-early protein ICP27 is required
for efficient incorporation of ICP0 and ICP4 into virions.";
J. Virol. 82:268-277(2008).
[9]
FUNCTION.
PubMed=18094162; DOI=10.1128/JVI.02459-07;
Sampath P., Deluca N.A.;
"Binding of ICP4, TATA-binding protein, and RNA polymerase II to
herpes simplex virus type 1 immediate-early, early, and late promoters
in virus-infected cells.";
J. Virol. 82:2339-2349(2008).
[10]
FUNCTION.
PubMed=18216093; DOI=10.1128/JVI.02560-07;
Zabierowski S.E., Deluca N.A.;
"Stabilized binding of TBP to the TATA box of herpes simplex virus
type 1 early (tk) and late (gC) promoters by TFIIA and ICP4.";
J. Virol. 82:3546-3554(2008).
[11]
FUNCTION, AND DOMAIN.
PubMed=22496239; DOI=10.1128/JVI.00651-12;
Wagner L.M., Lester J.T., Sivrich F.L., DeLuca N.A.;
"The N terminus and C terminus of herpes simplex virus 1 ICP4
cooperate to activate viral gene expression.";
J. Virol. 86:6862-6874(2012).
[12]
FUNCTION.
PubMed=23135715; DOI=10.1128/JVI.02844-12;
Wagner L.M., Bayer A., Deluca N.A.;
"Requirement of the N-terminal activation domain of herpes simplex
virus ICP4 for viral gene expression.";
J. Virol. 87:1010-1018(2013).
[13]
FUNCTION.
PubMed=24147125; DOI=10.1371/journal.pone.0078242;
Wagner L.M., DeLuca N.A.;
"Temporal association of herpes simplex virus ICP4 with cellular
complexes functioning at multiple steps in PolII transcription.";
PLoS ONE 8:E78242-E78242(2013).
-!- FUNCTION: Plays an essential role in the regulation of viral gene
expression by both activating and repressing host RNA polymerase
II-mediated transcription. Binds with high affinity to the
sequence 5'-ATCGTC-3'. Activates transcription by recruiting a
form of the host TFIID to promoters and stabilizing the pre-
initiation complex formation. Negatively regulates its own
transcription. This immediate early (IE) protein is absolutely
necessary for the transition from IE transcription to later viral
gene transcription. {ECO:0000269|PubMed:18094162,
ECO:0000269|PubMed:18216093, ECO:0000269|PubMed:1846804,
ECO:0000269|PubMed:22496239, ECO:0000269|PubMed:23135715,
ECO:0000269|PubMed:24147125, ECO:0000269|PubMed:8649420}.
-!- SUBUNIT: Homodimer. Interacts with transcriptional regulator
ICP27; this interaction is required for proper incorporation of
ICP4 into virions. Interacts with host TBP and host TAF1; these
interactions help the stabilization of the pre-nitiation complex
on specific promoters. Interacts with host GTF2B.
{ECO:0000269|PubMed:8392607, ECO:0000269|PubMed:8649420,
ECO:0000269|PubMed:8995681}.
-!- INTERACTION:
P10238:UL54; NbExp=5; IntAct=EBI-7185388, EBI-6883946;
-!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:17959681}.
Host cytoplasm {ECO:0000269|PubMed:17959681}. Virion tegument
{ECO:0000269|PubMed:17959681}. Note=Localizes to the cytoplasm
when phosphorylated. {ECO:0000250}.
-!- DOMAIN: The N-terminal and C-terminal domains are required for the
transcriptional activation function of ICP4.
{ECO:0000269|PubMed:22496239}.
-!- PTM: ADP-ribosylated.
-!- PTM: The long stretch of Ser is a major site of phosphorylation.
Only the phosphorylated forms are capable of interacting with beta
or gamma genes. {ECO:0000269|PubMed:1846804}.
-!- SIMILARITY: Belongs to the herpesviridae ICP4 family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; X14112; CAA32286.1; -; Genomic_DNA.
EMBL; X14112; CAA32278.1; -; Genomic_DNA.
EMBL; X06461; CAA29763.1; -; Genomic_DNA.
EMBL; L00036; AAA96675.1; -; Genomic_DNA.
EMBL; L00036; AAA96688.1; -; Genomic_DNA.
PIR; A23510; EDBE75.
PDB; 5MHJ; X-ray; 2.12 A; A/B=288-487.
PDBsum; 5MHJ; -.
ProteinModelPortal; P08392; -.
SMR; P08392; -.
BioGrid; 971428; 1.
BioGrid; 971429; 8.
IntAct; P08392; 4.
MINT; MINT-6732561; -.
PRIDE; P08392; -.
OrthoDB; VOG09000011; -.
Proteomes; UP000009294; Genome.
GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
GO; GO:0019033; C:viral tegument; IDA:CACAO.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0039695; P:DNA-templated viral transcription; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
GO; GO:0034340; P:response to type I interferon; IDA:BHF-UCL.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR005205; Herpes_ICP4_C.
InterPro; IPR005206; Herpes_ICP4_N.
Pfam; PF03585; Herpes_ICP4_C; 1.
Pfam; PF03584; Herpes_ICP4_N; 1.
1: Evidence at protein level;
3D-structure; Activator; ADP-ribosylation; Complete proteome;
DNA-binding; Early protein; Host cytoplasm; Host nucleus;
Phosphoprotein; Reference proteome; Transcription;
Transcription regulation; Virion; Virion tegument.
CHAIN 1 1298 Major viral transcription factor ICP4.
/FTId=PRO_0000115815.
DNA_BIND 262 490
COMPBIAS 116 121 Poly-Asp.
COMPBIAS 166 169 Poly-Arg.
COMPBIAS 176 199 Poly-Ser.
COMPBIAS 236 243 Poly-Pro.
COMPBIAS 321 324 Poly-Pro.
COMPBIAS 446 453 Poly-Ala.
COMPBIAS 502 508 Poly-Ala.
COMPBIAS 613 616 Poly-Pro.
COMPBIAS 683 688 Poly-Ala.
COMPBIAS 702 707 Poly-Ala.
COMPBIAS 710 722 Poly-Ala.
COMPBIAS 739 742 Poly-Gly.
COMPBIAS 788 793 Poly-Ala.
COMPBIAS 825 831 Poly-Ala.
COMPBIAS 887 890 Poly-Asp.
SEQUENCE 1298 AA; 132844 MW; 4F32E04C95CA9344 CRC64;
MASENKQRPG SPGPTDGPPP TPSPDRDERG ALGWGAETEE GGDDPDHDPD HPHDLDDARR
DGRAPAAGTD AGEDAGDAVS PRQLALLASM VEEAVRTIPT PDPAASPPRT PAFRADDDDG
DEYDDAADAA GDRAPARGRE REAPLRGAYP DPTDRLSPRP PAQPPRRRRH GRWRPSASST
SSDSGSSSSS SASSSSSSSD EDEDDDGNDA ADHAREARAV GRGPSSAAPA APGRTPPPPG
PPPLSEAAPK PRAAARTPAA SAGRIERRRA RAAVAGRDAT GRFTAGQPRR VELDADATSG
AFYARYRDGY VSGEPWPGAG PPPPGRVLYG GLGDSRPGLW GAPEAEEARR RFEASGAPAA
VWAPELGDAA QQYALITRLL YTPDAEAMGW LQNPRVVPGD VALDQACFRI SGAARNSSSF
ITGSVARAVP HLGYAMAAGR FGWGLAHAAA AVAMSRRYDR AQKGFLLTSL RRAYAPLLAR
ENAALTGAAG SPGAGADDEG VAAVAAAAPG ERAVPAGYGA AGILAALGRL SAAPASPAGG
DDPDAARHAD ADDDAGRRAQ AGRVAVECLA ACRGILEALA EGFDGDLAAV PGLAGARPAS
PPRPEGPAGP ASPPPPHADA PRLRAWLREL RFVRDALVLM RLRGDLRVAG GSEAAVAAVR
AVSLVAGALG PALPRDPRLP SSAAAAAADL LFDNQSLRPL LAAAASAPDA ADALAAAAAS
AAPREGRKRK SPGPARPPGG GGPRPPKTKK SGADAPGSDA RAPLPAPAPP STPPGPEPAP
AQPAAPRAAA AQARPRPVAV SRRPAEGPDP LGGWRRQPPG PSHTAAPAAA ALEAYCSPRA
VAELTDHPLF PVPWRPALMF DPRALASIAA RCAGPAPAAQ AACGGGDDDD NPHPHGAAGG
RLFGPLRASG PLRRMAAWMR QIPDPEDVRV VVLYSPLPGE DLAGGGASGG PPEWSAERGG
LSCLLAALAN RLCGPDTAAW AGNWTGAPDV SALGAQGVLL LSTRDLAFAG AVEFLGLLAS
AGDRRLIVVN TVRACDWPAD GPAVSRQHAY LACELLPAVQ CAVRWPAARD LRRTVLASGR
VFGPGVFARV EAAHARLYPD APPLRLCRGG NVRYRVRTRF GPDTPVPMSP REYRRAVLPA
LDGRAAASGT TDAMAPGAPD FCEEEAHSHA ACARWGLGAP LRPVYVALGR EAVRAGPARW
RGPRRDFCAR ALLEPDDDAP PLVLRGDDDG PGALPPAPPG IRWASATGRS GTVLAAAGAV
EVLGAEAGLA TPPRREVVDW EGAWDEDDGG AFEGDGVL


Related products :

Catalog number Product name Quantity
18-003-43308 Transcription factor AP-2 alpha - AP2-alpha; Activating enhancer-binding protein 2 alpha; AP-2 transcription factor; Activator protein 2; AP-2 Polyclonal 0.1 mg Protein A
20-272-191623 AP2 alpha - Mouse monoclonal [AP2a 8G8_5] to AP2 alpha; AP2-alpha; Activating enhancer-binding protein 2 alpha; AP-2 transcription factor; Activator protein 2; AP-2 Monoclonal 0.1 mg
18-272-195538 AP2 alpha - Rabbit polyclonal to AP2 alpha; AP2-alpha; Activating enhancer-binding protein 2 alpha; AP-2 transcription factor; Activator protein 2; AP-2 Polyclonal 0.1 ml
EIAAB33180 Pura,Purine-rich single-stranded DNA-binding protein alpha,Rat,Rattus norvegicus,Transcriptional activator protein Pur-alpha
EIAAB33179 Mouse,Mus musculus,Pura,Purine-rich single-stranded DNA-binding protein alpha,Transcriptional activator protein Pur-alpha
EIAAB33181 Homo sapiens,Human,PUR1,PURA,Purine-rich single-stranded DNA-binding protein alpha,Transcriptional activator protein Pur-alpha
20-272-191983 AP2 alpha + beta - Mouse monoclonal [A6 _ 2 _ 2] to AP2 alpha + beta; AP2-alpha; Activating enhancer-binding protein 2 alpha; AP-2 transcription factor; Activator protein 2; AP-2 Monoclonal 0.1 mg
18-272-195567 AP2 alpha + beta - Rabbit polyclonal to AP2 alpha + beta; AP2-alpha; Activating enhancer-binding protein 2 alpha; AP-2 transcription factor; Activator protein 2; AP-2 Polyclonal 0.05 ml
EIAAB43817 Mouse,Mus musculus,Transcriptional-regulating factor 1,Transcriptional-regulating protein 132,Trerf1,Zinc finger transcription factor TReP-132
18-003-42111 Transcription factor CP2-like protein 1 - CP2-related transcriptional repressor 1; CRTR-1; Transcription factor LBP-9 Polyclonal 0.05 mg Aff Pur
18-003-43083 Transcription factor CP2-like protein 1 - CP2-related transcriptional repressor 1; CRTR-1; Transcription factor LBP-9 Polyclonal 0.05 mg Aff Pur
EIAAB42056 CP2-related transcriptional repressor 1,CRTR1,CRTR-1,Homo sapiens,Human,LBP9,TFCP2L1,Transcription factor CP2-like protein 1,Transcription factor LBP-9
31-162 Transcription Factor AREB6 _ transcription factor 8 _zinc finger homeodomain enhancer-binding protein inhibits interleukin-2 (IL-2) gene expression. May be responsible for transcriptional repression o 0.05 mg
25-462 Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. KLF12 is a membe 0.05 mg
EIAAB45451 bHLHb12,BHLHB12,Class B basic helix-loop-helix protein 12,FIP,FOS-interacting protein,Homo sapiens,Human,Major late transcription factor 2,Upstream stimulatory factor 2,Upstream transcription factor 2
18-783-78549 GOAT ANTI HUMAN NFIL3 - E4 promoter binding-protein 4; Interleukin-3 promoter transcriptional activator; Transcriptional activator NF-IL3A; Interleukin-3 binding-protein 1 Polyclonal 0.1 mg
CSB-EL019083RA Rat Transcriptional activator protein Pur-alpha(PURA) ELISA kit 96T
H7524 Transcriptional activator protein Pur-alpha (PURA), Rat, ELISA Kit 96T
29-167 ZNF398 is a member of the Kruppel family of C2H2-type zinc-finger transcription factor proteins. This protein acts as a transcriptional activator.This gene encodes a member of the Kruppel family of C2 0.05 mg
EIAAB24887 Basic SAP coiled-coil transcription activator,Bsac,Megakaryoblastic leukemia 1 protein homolog,MKL_myocardin-like protein 1,Mkl1,Mouse,MRTF-A,Mus musculus,Myocardin-related transcription factor A
CSB-EL019083RA Rat Transcriptional activator protein Pur-alpha(PURA) ELISA kit SpeciesRat 96T
CSB-EL019083MO Mouse Transcriptional activator protein Pur-alpha(PURA) ELISA kit 96T
CSB-EL019083HU Human Transcriptional activator protein Pur-alpha(PURA) ELISA kit 96T
H7522 Transcriptional activator protein Pur-alpha (PURA), Human, ELISA Kit 96T
H7523 Transcriptional activator protein Pur-alpha (PURA), Mouse, ELISA Kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur