Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Major viral transcription factor ICP4 homolog (Immediate-early protein 62) (IE62)

 ICP4_VZVD               Reviewed;        1310 AA.
P09310;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-JUL-1989, sequence version 1.
23-MAY-2018, entry version 88.
RecName: Full=Major viral transcription factor ICP4 homolog;
AltName: Full=Immediate-early protein 62;
Short=IE62;
ORFNames=ORF62;
and
ORFNames=ORF71;
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3).
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
Alphaherpesvirinae; Varicellovirus.
NCBI_TaxID=10338;
NCBI_TaxID=9606; Homo sapiens (Human).
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=3018124;
Davison A.J., Scott J.E.;
"The complete DNA sequence of varicella-zoster virus.";
J. Gen. Virol. 67:1759-1816(1986).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2981964; DOI=10.1099/0022-1317-66-2-207;
Davison A.J., Scott J.E.;
"DNA sequence of the major inverted repeat in the varicella-zoster
virus genome.";
J. Gen. Virol. 66:207-220(1985).
[3]
CHARACTERIZATION.
PubMed=3023701;
Felser J.M., Straus S.E., Ostrove J.M.;
"Varicella-zoster virus complements herpes simplex virus type 1
temperature-sensitive mutants.";
J. Virol. 61:225-228(1987).
[4]
FUNCTION.
PubMed=2835512;
Felser J.M., Kinchington P.R., Inchauspe G., Straus S.E.,
Ostrove J.M.;
"Cell lines containing varicella-zoster virus open reading frame 62
and expressing the 'IE' 175 protein complement ICP4 mutants of herpes
simplex virus type 1.";
J. Virol. 62:2076-2082(1988).
[5]
MUTAGENESIS OF GLN-545; ASN-546 AND LYS-548.
PubMed=7907417; DOI=10.1093/nar/22.3.270;
Tyler J.K., Allen K.E., Everett R.D.;
"Mutation of a single lysine residue severely impairs the DNA
recognition and regulatory functions of the VZV gene 62 transactivator
protein.";
Nucleic Acids Res. 22:270-278(1994).
[6]
INTERACTION WITH IE4.
PubMed=10873781; DOI=10.1006/viro.2000.0389;
Spengler M.L., Ruyechan W.T., Hay J.;
"Physical interaction between two varicella zoster virus gene
regulatory proteins, IE4 and IE62.";
Virology 272:375-381(2000).
[7]
SUBCELLULAR LOCATION.
PubMed=10666257; DOI=10.1128/JVI.74.5.2265-2277.2000;
Kinchington P.R., Fite K., Turse S.E.;
"Nuclear accumulation of IE62, the varicella-zoster virus (VZV) major
transcriptional regulatory protein, is inhibited by phosphorylation
mediated by the VZV open reading frame 66 protein kinase.";
J. Virol. 74:2265-2277(2000).
[8]
SUBCELLULAR LOCATION.
PubMed=11533174; DOI=10.1128/JVI.75.19.9106-9113.2001;
Kinchington P.R., Fite K., Seman A., Turse S.E.;
"Virion association of IE62, the varicella-zoster virus (VZV) major
transcriptional regulatory protein, requires expression of the VZV
open reading frame 66 protein kinase.";
J. Virol. 75:9106-9113(2001).
[9]
PHOSPHORYLATION.
PubMed=11507231; DOI=10.1128/JVI.75.18.8854-8858.2001;
Kenyon T.K., Lynch J.M., Hay J., Ruyechan W.T., Grose C.;
"Varicella-zoster virus ORF47 protein serine kinase: characterization
of a cloned, biologically active phosphotransferase and two viral
substrates, ORF62 and ORF63.";
J. Virol. 75:8854-8858(2001).
[10]
INTERACTION WITH IE63.
PubMed=12429517; DOI=10.1006/viro.2002.1555;
Lynch J.M., Kenyon T.K., Grose C., Hay J., Ruyechan W.T.;
"Physical and functional interaction between the varicella zoster
virus IE63 and IE62 proteins.";
Virology 302:71-82(2002).
[11]
INTERACTION WITH HUMAN USF1 PROTEIN.
PubMed=14573800; DOI=10.1099/vir.0.19335-0;
Rahaus M., Desloges N., Yang M., Ruyechan W.T., Wolff M.H.;
"Transcription factor USF, expressed during the entire phase of
Varicella-zoster virus infection, interacts physically with the major
viral transactivator IE62 and plays a significant role in virus
replication.";
J. Gen. Virol. 84:2957-2967(2003).
[12]
INTERACTION WITH HUMAN SP1 PROTEIN.
PubMed=12855699; DOI=10.1074/jbc.M302259200;
Peng H., He H., Hay J., Ruyechan W.T.;
"Interaction between the varicella zoster virus IE62 major
transactivator and cellular transcription factor Sp1.";
J. Biol. Chem. 278:38068-38075(2003).
[13]
NUCLEAR LOCALIZATION SIGNAL, AND PHOSPHORYLATION AT SER-686 AND
SER-722.
PubMed=16439528; DOI=10.1128/JVI.80.4.1710-1723.2006;
Eisfeld A.J., Turse S.E., Jackson S.A., Lerner E.C., Kinchington P.R.;
"Phosphorylation of the varicella-zoster virus (VZV) major
transcriptional regulatory protein IE62 by the VZV open reading frame
66 protein kinase.";
J. Virol. 80:1710-1723(2006).
-!- FUNCTION: Transcriptional transactivator. May interact with and
recruit specific components of the general transcription machinery
to viral promoters and stabilize their formation for transcription
initiation. Negatively regulates its own transcription. This
immediate early (EI) protein may be necessary in virion for viral
pathogenesis. {ECO:0000269|PubMed:2835512}.
-!- SUBUNIT: Interacts with IE4 and IE63. Interacts with host USF1 and
SP1. {ECO:0000269|PubMed:10873781, ECO:0000269|PubMed:12429517,
ECO:0000269|PubMed:12855699, ECO:0000269|PubMed:14573800}.
-!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}. Host cytoplasm
{ECO:0000250}. Virion tegument {ECO:0000250}. Note=Localizes to
the cytoplasm when phosphorylated. {ECO:0000269|PubMed:10666257,
ECO:0000269|PubMed:11533174}.
-!- PTM: Phosphorylated by ORF66 protein kinase on Ser-686 and Ser-
722. Also phosphorylated by ORF47 protein kinase and by human
CSNK2A1/CKII. {ECO:0000269|PubMed:11507231,
ECO:0000269|PubMed:16439528}.
-!- MISCELLANEOUS: Encoded both by ORF62 and ORF71 within the inverted
repeat sequences bounding the Us region of the VZV genome.
-!- SIMILARITY: Belongs to the herpesviridae ICP4 family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; X04370; CAA27954.1; -; Genomic_DNA.
EMBL; X04370; CAA27945.1; -; Genomic_DNA.
EMBL; X02132; CAA26044.1; -; Genomic_DNA.
PIR; A27345; WZBE62.
RefSeq; NP_040184.1; NC_001348.1.
RefSeq; NP_040193.1; NC_001348.1.
SMR; P09310; -.
iPTMnet; P09310; -.
PRIDE; P09310; -.
GeneID; 1487695; -.
GeneID; 1487699; -.
KEGG; vg:1487695; -.
KEGG; vg:1487699; -.
OrthoDB; VOG09000011; -.
Proteomes; UP000002602; Genome.
GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0039695; P:DNA-templated viral transcription; IDA:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR005205; Herpes_ICP4_C.
InterPro; IPR005206; Herpes_ICP4_N.
Pfam; PF03585; Herpes_ICP4_C; 1.
Pfam; PF03584; Herpes_ICP4_N; 1.
1: Evidence at protein level;
Activator; Complete proteome; DNA-binding; Early protein;
Host cytoplasm; Host nucleus; Phosphoprotein; Reference proteome;
Transcription; Transcription regulation; Virion; Virion tegument.
CHAIN 1 1310 Major viral transcription factor ICP4
homolog.
/FTId=PRO_0000115820.
MOTIF 677 685 Nuclear localization signal.
{ECO:0000255}.
COMPBIAS 353 365 Ser-rich.
COMPBIAS 1285 1290 Poly-Ser.
MOD_RES 686 686 Phosphoserine; by viral VZV ORF66.
{ECO:0000269|PubMed:16439528}.
MOD_RES 722 722 Phosphoserine; by viral VZV ORF66.
{ECO:0000269|PubMed:16439528}.
MUTAGEN 545 545 Q->L: Decreases DNA-binding.
{ECO:0000269|PubMed:7907417}.
MUTAGEN 546 546 N->L: Decreases DNA-binding.
{ECO:0000269|PubMed:7907417}.
MUTAGEN 548 548 K->E: Complete loss of DNA-binding.
{ECO:0000269|PubMed:7907417}.
SEQUENCE 1310 AA; 139998 MW; AF58321D95CD9B56 CRC64;
MDTPPMQRST PQRAGSPDTL ELMDLLDAAA AAAEHRARVV TSSQPDDLLF GENGVMVGRE
HEIVSIPSVS GLQPEPRTED VGEELTQDDY VCEDGQDLMG SPVIPLAEVF HTRFSEAGAR
EPTGADRSLE TVSLGTKLAR SPKPPMNDGE TGRGTTPPFP QAFSPVSPAS PVGDAAGNDQ
REDQRSIPRQ TTRGNSPGLP SVVHRDRQTQ SISGKKPGDE QAGHAHASGD GVVLQKTQRP
AQGKSPKKKT LKVKVPLPAR KPGGPVPGPV EQLYHVLSDS VPAKGAKADL PFETDDTRPR
KHDARGITPR VPGRSSGGKP RAFLALPGRS HAPDPIEDDS PVEKKPKSRE FVSSSSSSSS
WGSSSEDEDD EPRRVSVGSE TTGSRSGREH APSPSNSDDS DSNDGGSTKQ NIQPGYRSIS
GPDPRIRKTK RLAGEPGRQR QKSFSLPRSR TPIIPPVSGP LMMPDGSPWP GSAPLPSNRV
RFGPSGETRE GHWEDEAVRA ARARYEASTE PVPLYVPELG DPARQYRALI NLIYCPDRDP
IAWLQNPKLT GVNSALNQFY QKLLPPGRAG TAVTGSVASP VPHVGEAMAT GEALWALPHA
AAAVAMSRRY DRAQKHFILQ SLRRAFASMA YPEATGSSPA ARISRGHPSP TTPATQAPDP
QPSAAARSLS VCPPDDRLRT PRKRKSQPVE SRSLLDKIRE TPVADARVAD DHVVSKAKRR
VSEPVTITSG PVVDPPAVIT MPLDGPAPNG GFRRIPRGAL HTPVPSDQAR KAYCTPETIA
RLVDDPLFPT AWRPALSFDP GALAEIAARR PGGGDRRFGP PSGVEALRRR CAWMRQIPDP
EDVRLLIIYD PLPGEDINGP LESTLATDPG PSWSPSRGGL SVVLAALSNR LCLPSTHAWA
GNWTGPPDVS ALNARGVLLL STRDLAFAGA VEYLGSRLAS ARRRLLVLDA VALERWPRDG
PALSQYHVYV RAPARPDAQA VVRWPDSAVT EGLARAVFAS SRTFGPASFA RIETAFANLY
PGEQPLCLCR GGNVAYTVCT RAGPKTRVPL SPREYRQYVL PGFDGCKDLA RQSRGLGLGA
ADFVDEAAHS HRAANRWGLG AALRPVFLPE GRRPGAAGPE AGDVPTWARV FCRHALLEPD
PAAEPLVLPP VAGRSVALYA SADEARNALP PIPRVMWPPG FGAAETVLEG SDGTRFVFGH
HGGSERPSET QAGRQRRTAD DREHALELDD WEVGCEDAWD SEEGGGDDGD APGSSFGVSI
VSVAPGVLRD RRVGLRPAVK VELLSSSSSS EDEDDVWGGR GGRSPPQSRG


Related products :

Catalog number Product name Quantity
GTX26514 HSV 1 ICP4 Immediate Early Protein [10F1] 100 µg
18-003-42165 Early growth response protein 1 - EGR-1; Krox-24 protein; Transcription factor Zif268; Nerve growth factor-induced protein A; NGFI-A; Transcription factor ETR103; Zinc finger protein 225; AT225 Polycl 0.05 mg Aff Pur
U0416h CLIA AT225,Early growth response protein 1,EGR1,EGR-1,Homo sapiens,Human,KROX24,Nerve growth factor-induced protein A,NGFI-A,Transcription factor ETR103,Transcription factor Zif268,Zinc finger protein 96T
E0416h ELISA kit AT225,Early growth response protein 1,EGR1,EGR-1,Homo sapiens,Human,KROX24,Nerve growth factor-induced protein A,NGFI-A,Transcription factor ETR103,Transcription factor Zif268,Zinc finger p 96T
E0416h ELISA AT225,Early growth response protein 1,EGR1,EGR-1,Homo sapiens,Human,KROX24,Nerve growth factor-induced protein A,NGFI-A,Transcription factor ETR103,Transcription factor Zif268,Zinc finger protei 96T
27-481 The zinc finger transcription factor MTF-1 (metal-responsive transcription factor-1) is conserved from insects to vertebrates. The major role of MTF-1 in both organisms is to control the transcription 0.1 mg
EIAAB45451 bHLHb12,BHLHB12,Class B basic helix-loop-helix protein 12,FIP,FOS-interacting protein,Homo sapiens,Human,Major late transcription factor 2,Upstream stimulatory factor 2,Upstream transcription factor 2
EIAAB08479 Coe1,Early B-cell factor,Ebf,Ebf1,O_E-1,OE-1,Olf1,Olf-1,Olfactory neuronal transcription factor,Rat,Rattus norvegicus,Transcription factor COE1
U0416r CLIA Early growth response protein 1,Egr1,EGR-1,Nerve growth factor-induced protein A,NGFI-A,Rat,Rattus norvegicus,Transcription factor Zif268,Zinc finger protein Krox-24 96T
E0416r ELISA Early growth response protein 1,Egr1,EGR-1,Nerve growth factor-induced protein A,NGFI-A,Rat,Rattus norvegicus,Transcription factor Zif268,Zinc finger protein Krox-24 96T
E0416r ELISA kit Early growth response protein 1,Egr1,EGR-1,Nerve growth factor-induced protein A,NGFI-A,Rat,Rattus norvegicus,Transcription factor Zif268,Zinc finger protein Krox-24 96T
EIAAB45450 Major late transcription factor 2,Mouse,Mus musculus,Upstream stimulatory factor 2,Upstream transcription factor 2,Usf2
EIAAB45452 Major late transcription factor 2,Rat,Rattus norvegicus,Upstream stimulatory factor 2,Upstream transcription factor 2,Usf2
E0416m ELISA kit Early growth response protein 1,Egr1,EGR-1,Egr-1,Krox-24,Mouse,Mus musculus,Nerve growth factor-induced protein A,NGFI-A,Transcription factor Zif268,Zinc finger protein Krox-24 96T
U0416m CLIA Early growth response protein 1,Egr1,EGR-1,Egr-1,Krox-24,Mouse,Mus musculus,Nerve growth factor-induced protein A,NGFI-A,Transcription factor Zif268,Zinc finger protein Krox-24 96T
E0416m ELISA Early growth response protein 1,Egr1,EGR-1,Egr-1,Krox-24,Mouse,Mus musculus,Nerve growth factor-induced protein A,NGFI-A,Transcription factor Zif268,Zinc finger protein Krox-24 96T
EIAAB24887 Basic SAP coiled-coil transcription activator,Bsac,Megakaryoblastic leukemia 1 protein homolog,MKL_myocardin-like protein 1,Mkl1,Mouse,MRTF-A,Mus musculus,Myocardin-related transcription factor A
27-526 Early Growth Response Protein 1 (EGR1, Krox-24 protein, nerve growth factor-induced protein A, Transcription factor ETR103, Zinc finger protein 225) belongs to the EGR family of C2H2-type zinc-finger 0.05 mg
28-572 Early Growth Response Protein 1 (EGR1, Krox-24 protein, nerve growth factor-induced protein A, Transcription factor ETR103, Zinc finger protein 225) belongs to the EGR family of C2H2-type zinc-finger 0.1 mg
E0688m ELISA kit Gdnfif,GDNF-inducible factor,Klf10,Krueppel-like factor 10,mGIF,Mouse,Mus musculus,TGFB-inducible early growth response protein 1,Tieg,Tieg1,TIEG-1,Transcription factor GIF,Transforming gro 96T
EIAAB27823 Alpha-1-fetoprotein transcription factor,B1-binding factor,B1F,CPF,CYP7A promoter-binding factor,FTF,hB1F,Hepatocytic transcription factor,Homo sapiens,Human,Liver receptor homolog 1,LRH-1,NR5A2,Nucle
18-003-42098 Ets domain transcription factor - ESE3 transcription factor; EHF protein; DJ875K15.1.2 (Ets homologous factor (Ets-domain transcription factor. ESE-3B (Isoform 2))); ETS-family transcription factor EH 0.1 mg Protein A
EIAAB32348 Eosinophil major basic protein homolog,Homo sapiens,Human,MBPH,Prepro-major basic protein homolog,Prepro-MBPH,PRG3,Proteoglycan 3,UNQ486_PRO1002
18-003-44015 Transcription factor COE4 - Early B-cell factor 4; EBF-4; Olf-1_EBF-like 4; OE-4; O_E-4 Polyclonal 0.1 mg Protein A
EIAAB08484 Coe2,Early B-cell factor 2,Ebf2,EBF-2,Metencephalon-mesencephalon-olfactory transcription factor 1,MET-mesencephalon-olfactory TF1,MET-mesencephalon-olfactory transcription factor 1,Mmot1,Mouse,Mus mu


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur