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Malic enzyme

 Q9VG31_DROME            Unreviewed;       763 AA.
Q9VG31;
01-MAY-2000, integrated into UniProtKB/TrEMBL.
01-MAY-2000, sequence version 1.
22-NOV-2017, entry version 142.
RecName: Full=Malic enzyme {ECO:0000256|RuleBase:RU003426};
Name=Men {ECO:0000313|EMBL:AAF54859.1,
ECO:0000313|FlyBase:FBgn0002719};
Synonyms=anon-WO0118547.278 {ECO:0000313|EMBL:AAF54859.1},
Dmel\CG10120 {ECO:0000313|EMBL:AAF54859.1},
MDH {ECO:0000313|EMBL:AAF54859.1},
Mdh-NADP {ECO:0000313|EMBL:AAF54859.1},
ME {ECO:0000313|EMBL:AAF54859.1}, Me {ECO:0000313|EMBL:AAF54859.1},
mem {ECO:0000313|EMBL:AAF54859.1}, MEN {ECO:0000313|EMBL:AAF54859.1},
men {ECO:0000313|EMBL:AAF54859.1};
ORFNames=CG10120 {ECO:0000313|EMBL:AAF54859.1,
ECO:0000313|FlyBase:FBgn0002719},
Dmel_CG10120 {ECO:0000313|EMBL:AAF54859.1};
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF54859.1, ECO:0000313|Proteomes:UP000000803};
[1] {ECO:0000313|EMBL:AAF54859.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[2] {ECO:0000313|EMBL:AAF54859.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537568;
Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
"Finishing a whole-genome shotgun: release 3 of the Drosophila
melanogaster euchromatic genome sequence.";
Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
[3] {ECO:0000313|EMBL:AAF54859.1, ECO:0000313|Proteomes:UP000000803}
GENOME REANNOTATION.
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[4] {ECO:0000313|EMBL:AAF54859.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537573;
Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
Ashburner M., Celniker S.E.;
"The transposable elements of the Drosophila melanogaster euchromatin:
a genomics perspective.";
Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
[5] {ECO:0000313|EMBL:AAF54859.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537574;
Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
Karpen G.H.;
"Heterochromatic sequences in a Drosophila whole-genome shotgun
assembly.";
Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
[6] {ECO:0000313|EMBL:AAM49909.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Berkeley {ECO:0000313|EMBL:AAM49909.1};
Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.,
Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E.,
George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G.,
Miranda A., Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S.,
Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M.,
Celniker S.;
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
[7] {ECO:0000313|EMBL:AAF54859.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
Ashburner M., Anxolabehere D.;
"Combined evidence annotation of transposable elements in genome
sequences.";
PLoS Comput. Biol. 1:166-175(2005).
[8] {ECO:0000313|EMBL:AAF54859.1}
NUCLEOTIDE SEQUENCE.
Berkeley Drosophila Genome Project;
Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E.,
Yu C., Rubin G.;
"Drosophila melanogaster release 4 sequence.";
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
[9] {ECO:0000313|EMBL:AAF54859.1}
NUCLEOTIDE SEQUENCE.
Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
Svirskas R., Rubin G.;
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
[10] {ECO:0000313|EMBL:AAF54859.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=17569856; DOI=10.1126/science.1139815;
Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
"The Release 5.1 annotation of Drosophila melanogaster
heterochromatin.";
Science 316:1586-1591(2007).
[11] {ECO:0000313|EMBL:AAF54859.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=17569867; DOI=10.1126/science.1139816;
Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
Dimitri P., Karpen G.H., Celniker S.E.;
"Sequence finishing and mapping of Drosophila melanogaster
heterochromatin.";
Science 316:1625-1628(2007).
[12] {ECO:0000313|EMBL:AAF54859.1}
NUCLEOTIDE SEQUENCE.
FlyBase;
Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
Note=Divalent metal cations. Prefers magnesium or manganese.
{ECO:0000256|PIRSR:PIRSR000106-3};
-!- SIMILARITY: Belongs to the malic enzymes family.
{ECO:0000256|RuleBase:RU003426}.
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EMBL; AE014297; AAF54859.1; -; Genomic_DNA.
EMBL; AY118540; AAM49909.1; -; mRNA.
RefSeq; NP_524880.2; NM_080141.4.
UniGene; Dm.1769; -.
MINT; MINT-1621002; -.
STRING; 7227.FBpp0082129; -.
EnsemblMetazoa; FBtr0082660; FBpp0082129; FBgn0002719.
GeneID; 47173; -.
CTD; 47173; -.
FlyBase; FBgn0002719; Men.
eggNOG; KOG1257; Eukaryota.
eggNOG; COG0281; LUCA.
GeneTree; ENSGT00390000000754; -.
OMA; KVLDYAY; -.
OrthoDB; EOG091G04H9; -.
GenomeRNAi; 47173; -.
Proteomes; UP000000803; Chromosome 3R.
Bgee; FBgn0002719; -.
GO; GO:0005829; C:cytosol; IDA:FlyBase.
GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:InterPro.
GO; GO:0004473; F:malate dehydrogenase (decarboxylating) (NADP+) activity; IDA:FlyBase.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0051287; F:NAD binding; IEA:InterPro.
GO; GO:0008340; P:determination of adult lifespan; IMP:FlyBase.
GO; GO:0006108; P:malate metabolic process; IMP:FlyBase.
GO; GO:0006090; P:pyruvate metabolic process; IBA:GO_Central.
GO; GO:0010941; P:regulation of cell death; IMP:FlyBase.
GO; GO:0030431; P:sleep; IMP:FlyBase.
Gene3D; 3.40.50.10380; -; 1.
InterPro; IPR015884; Malic_enzyme_CS.
InterPro; IPR012301; Malic_N_dom.
InterPro; IPR037062; Malic_N_dom_sf.
InterPro; IPR012302; Malic_NAD-bd.
InterPro; IPR001891; Malic_OxRdtase.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
Pfam; PF00390; malic; 1.
Pfam; PF03949; Malic_M; 1.
PIRSF; PIRSF000106; ME; 1.
PRINTS; PR00072; MALOXRDTASE.
SMART; SM01274; malic; 1.
SMART; SM00919; Malic_M; 1.
SUPFAM; SSF51735; SSF51735; 1.
PROSITE; PS00331; MALIC_ENZYMES; 1.
1: Evidence at protein level;
Complete proteome {ECO:0000313|Proteomes:UP000000803};
Metal-binding {ECO:0000256|PIRSR:PIRSR000106-3,
ECO:0000256|RuleBase:RU003426};
Oxidoreductase {ECO:0000256|RuleBase:RU003426,
ECO:0000313|EMBL:AAF54859.1};
Proteomics identification {ECO:0000213|PeptideAtlas:Q9VG31};
Reference proteome {ECO:0000313|Proteomes:UP000000803}.
DOMAIN 282 463 malic. {ECO:0000259|SMART:SM01274}.
DOMAIN 473 726 Malic_M. {ECO:0000259|SMART:SM00919}.
ACT_SITE 305 305 Proton donor.
{ECO:0000256|PIRSR:PIRSR000106-1}.
ACT_SITE 376 376 Proton acceptor.
{ECO:0000256|PIRSR:PIRSR000106-1}.
METAL 448 448 Divalent metal cation.
{ECO:0000256|PIRSR:PIRSR000106-3}.
METAL 449 449 Divalent metal cation.
{ECO:0000256|PIRSR:PIRSR000106-3}.
METAL 472 472 Divalent metal cation.
{ECO:0000256|PIRSR:PIRSR000106-3}.
SEQUENCE 763 AA; 84626 MW; 5EB3613F890ADD11 CRC64;
MGNSSSICAD RNVITNFDEN GTPVYPTANN SQSPSSYSRG KERELGCYTK RNSNSNNNNS
HERESQSCCS SRVCKNHTTT TTTTLEYELS NFAKLTTRIT TQSAAEVDTS PHTDTETHRD
RDSNPGNIAL ATDLELPKGL PLSLSSRHHW NQLQSSLHAL HHQQQQQQQQ LRSYSSTSET
NLEDKMSKPD SKLDKYAQRD RLGLWGTGDN EVVGSLSGFT RLLDKRYSKG LAFTHEERQQ
LGIHGMLPYV VREPSEQVEH CRALLARLDQ DLDKYMYLIS LSERNERLFY NVLSSDIAYM
MPLVYTPTVG LACQRYSLIH QNAKGMFISI KDKGHIYDVL KNWPETDVRA IVVTDGERIL
GLGDLGANGM GIPVGKLSLY TALAGIKPSQ CLPITLDVGT NTESILEDPL YIGLRERRAT
GDLYDEFIDE FMHACVRRFG QNCLIQFEDF ANANAFRLLS KYRDSFCTFN DDIQGTASVA
VAGLLASLKI KKTQLKDNTL LFLGAGEAAL GIANLCLMAM KVEGLTEEEA KARIWMVDSR
GVITRDRPKG GLTEHKLHFA QLHEPIDTLA EAVRKVRPNV LIGAAAQGGA FNQEILELMA
DINETPIIFA LSNPTSKAEC TAEEAYTYTK GRCIFASGSP FAPVTYNNKK FYPGQGNNSY
IFPGVALGVL CAGMLNIPEQ VFLVAAERLA ELVSKDDLAK GSLYPPLSSI VSCSMAIAER
IVEYAYKNGL ATVRPEPVNK LAFIKAQMYD LDYPRSVPAT YKM


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