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Manganese transporter SMF2

 SMF2_YEAST              Reviewed;         549 AA.
P38778; D3DKZ8;
01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
01-FEB-1995, sequence version 1.
05-DEC-2018, entry version 145.
RecName: Full=Manganese transporter SMF2;
Name=SMF2; OrderedLocusNames=YHR050W;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1447206;
West A.H., Clark D.J., Martin J., Neupert W., Hartl F.-U.,
Horwich A.L.;
"Two related genes encoding extremely hydrophobic proteins suppress a
lethal mutation in the yeast mitochondrial processing enhancing
protein.";
J. Biol. Chem. 267:24625-24633(1992).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=8091229; DOI=10.1126/science.8091229;
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J.,
Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J.,
Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y.,
Latreille P., Louis E.J., Macri C., Mardis E., Menezes S., Mouser L.,
Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K.,
Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R.,
Vaudin M.;
"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
VIII.";
Science 265:2077-2082(1994).
[3]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[4]
FUNCTION.
PubMed=10930410; DOI=10.1074/jbc.M004611200;
Cohen A., Nelson H., Nelson N.;
"The family of SMF metal ion transporters in yeast cells.";
J. Biol. Chem. 275:33388-33394(2000).
[5]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=11027260; DOI=10.1128/MCB.20.21.7893-7902.2000;
Portnoy M.E., Liu X.F., Culotta V.C.;
"Saccharomyces cerevisiae expresses three functionally distinct
homologues of the nramp family of metal transporters.";
Mol. Cell. Biol. 20:7893-7902(2000).
-!- FUNCTION: High-affinity manganese transporter involved in
mobilizing manganese from vesicular stores iin conditions of low
manganese ion concentrations. {ECO:0000269|PubMed:10930410,
ECO:0000269|PubMed:11027260}.
-!- SUBCELLULAR LOCATION: Vacuole membrane
{ECO:0000269|PubMed:11027260}; Multi-pass membrane protein
{ECO:0000269|PubMed:11027260}. Note=Targeted to the vacuolar lumen
in presence of excess manganese, where it is degraded.
-!- SIMILARITY: Belongs to the NRAMP family. {ECO:0000305}.
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EMBL; U00062; AAB68900.1; -; Genomic_DNA.
EMBL; BK006934; DAA06742.1; -; Genomic_DNA.
PIR; B45154; B45154.
RefSeq; NP_011917.1; NM_001179180.1.
ProteinModelPortal; P38778; -.
BioGrid; 36482; 106.
DIP; DIP-4171N; -.
STRING; 4932.YHR050W; -.
TCDB; 2.A.55.1.2; the metal ion (mn(2+)-iron) transporter (nramp) family.
PaxDb; P38778; -.
PRIDE; P38778; -.
EnsemblFungi; YHR050W_mRNA; YHR050W_mRNA; YHR050W.
GeneID; 856447; -.
KEGG; sce:YHR050W; -.
SGD; S000001092; SMF2.
HOGENOM; HOG000152204; -.
InParanoid; P38778; -.
KO; K12346; -.
OMA; EDPTMDI; -.
OrthoDB; EOG092C1BTT; -.
BioCyc; YEAST:G3O-31105-MONOMER; -.
Reactome; R-SCE-1222556; ROS, RNS production in phagocytes.
Reactome; R-SCE-425410; Metal ion SLC transporters.
Reactome; R-SCE-6798695; Neutrophil degranulation.
Reactome; R-SCE-6803544; Ion influx/efflux at host-pathogen interface.
Reactome; R-SCE-917937; Iron uptake and transport.
PRO; PR:P38778; -.
Proteomes; UP000002311; Chromosome VIII.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005770; C:late endosome; IDA:SGD.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0005802; C:trans-Golgi network; IDA:SGD.
GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
GO; GO:0015086; F:cadmium ion transmembrane transporter activity; IBA:GO_Central.
GO; GO:0022890; F:inorganic cation transmembrane transporter activity; IDA:SGD.
GO; GO:0005384; F:manganese ion transmembrane transporter activity; IBA:GO_Central.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0015295; F:solute:proton symporter activity; IBA:GO_Central.
GO; GO:0006877; P:cellular cobalt ion homeostasis; IGI:SGD.
GO; GO:0030026; P:cellular manganese ion homeostasis; IMP:SGD.
GO; GO:0006824; P:cobalt ion transport; IGI:SGD.
GO; GO:0006826; P:iron ion transport; IBA:GO_Central.
GO; GO:0006828; P:manganese ion transport; IMP:SGD.
HAMAP; MF_00221; NRAMP; 1.
InterPro; IPR001046; NRAMP_fam.
PANTHER; PTHR11706; PTHR11706; 1.
Pfam; PF01566; Nramp; 1.
PRINTS; PR00447; NATRESASSCMP.
TIGRFAMs; TIGR01197; nramp; 1.
3: Inferred from homology;
Complete proteome; Manganese; Membrane; Metal-binding;
Reference proteome; Transmembrane; Transmembrane helix; Transport;
Vacuole.
CHAIN 1 549 Manganese transporter SMF2.
/FTId=PRO_0000212606.
TRANSMEM 91 109 Helical. {ECO:0000255}.
TRANSMEM 130 147 Helical. {ECO:0000255}.
TRANSMEM 161 185 Helical. {ECO:0000255}.
TRANSMEM 196 214 Helical. {ECO:0000255}.
TRANSMEM 312 332 Helical. {ECO:0000255}.
TRANSMEM 350 372 Helical. {ECO:0000255}.
TRANSMEM 432 452 Helical. {ECO:0000255}.
TRANSMEM 521 541 Helical. {ECO:0000255}.
SEQUENCE 549 AA; 59768 MW; 4C200057B82D65E3 CRC64;
MTSQEYEPIQ WSDESQTNND SVNDAYADVN TTHESRRRTT LQPNSTSQSM IGTLRKYARF
IGPGLMVSVS YMDPGNYSTA VAAGSAHRYK LLFSVLVSNF MAAFWQYLCA RLGAVTGLDL
AQNCKKHLPF GLNITLYILA EMAIIATDLA EVVGTAISLN ILFHIPLALG VILTVVDVLI
VLLAYKPNGS MKGIRIFEAF VSLLVVLTVV CFTVELFYAK LGPAKEIFSG FLPSKAVFEG
DGLYLSLAIL GATVMPHSLY LGSGVVQPRL REYDIKNGHY LPDANDMDNN HDNYRPSYEA
ISETLHFTIT ELLISLFTVA LFVNCAILIV SGATLYGSTQ NAEEADLFSI YNLLCSTLSK
GAGTVFVLAL LFSGQSAGIV CTLSGQMVSE GFLNWTVSPA LRRSATRAVA ITPCLILVLV
AGRSGLSGAL NASQVVLSLL LPFVSAPLLY FTSSKKIMRV QLNRTKELSR TTDKKPVADR
TEDDETIELE EMGIGSSSQE RSLVSPAPEY KDMSNGMIVT VLAIIVWLII SGLNFYMLLG
FTTGKEVHL


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