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Mannose-6-phosphate isomerase (EC 5.3.1.8) (Fragment)

 A0A219YGR5_HELME        Unreviewed;       240 AA.
A0A219YGR5;
25-OCT-2017, integrated into UniProtKB/TrEMBL.
25-OCT-2017, sequence version 1.
05-DEC-2018, entry version 5.
RecName: Full=Mannose-6-phosphate isomerase {ECO:0000256|RuleBase:RU000611};
EC=5.3.1.8 {ECO:0000256|RuleBase:RU000611};
Flags: Fragment;
Name=mpi {ECO:0000313|EMBL:APX55944.1};
Heliconius melpomene rosina.
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Lepidoptera; Glossata; Ditrysia;
Papilionoidea; Nymphalidae; Heliconiinae; Heliconiini; Heliconius.
NCBI_TaxID=171916 {ECO:0000313|EMBL:APX55944.1};
[1] {ECO:0000313|EMBL:APX55944.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Hros_141 {ECO:0000313|EMBL:APX55944.1};
Jenks R., Maroja L.S.;
"No balancing selection detected at pgi or mpi in Heliconius
butterflies.";
Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
-!- CATALYTIC ACTIVITY:
Reaction=D-mannose 6-phosphate = D-fructose 6-phosphate;
Xref=Rhea:RHEA:12356, ChEBI:CHEBI:58735, ChEBI:CHEBI:61527;
EC=5.3.1.8; Evidence={ECO:0000256|RuleBase:RU000611};
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Evidence={ECO:0000256|RuleBase:RU000611};
Note=Binds 1 zinc ion per subunit.
{ECO:0000256|RuleBase:RU000611};
-!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-
phosphate: step 1/2. {ECO:0000256|RuleBase:RU004248}.
-!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 1
family. {ECO:0000256|RuleBase:RU004189}.
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EMBL; KU291524; APX55944.1; -; mRNA.
UniPathway; UPA00126; UER00423.
GO; GO:0004476; F:mannose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
Gene3D; 2.60.120.10; -; 2.
InterPro; IPR001250; Man6P_Isoase-1.
InterPro; IPR016305; Mannose-6-P_Isomerase.
InterPro; IPR018050; Pmannose_isomerase-type1_CS.
InterPro; IPR014710; RmlC-like_jellyroll.
InterPro; IPR011051; RmlC_Cupin_sf.
PANTHER; PTHR10309; PTHR10309; 1.
Pfam; PF01238; PMI_typeI; 1.
PRINTS; PR00714; MAN6PISMRASE.
SUPFAM; SSF51182; SSF51182; 1.
TIGRFAMs; TIGR00218; manA; 1.
PROSITE; PS00965; PMI_I_1; 1.
PROSITE; PS00966; PMI_I_2; 1.
2: Evidence at transcript level;
Isomerase {ECO:0000256|RuleBase:RU000611,
ECO:0000313|EMBL:APX55944.1}; Zinc {ECO:0000256|RuleBase:RU000611}.
NON_TER 1 1 {ECO:0000313|EMBL:APX55944.1}.
NON_TER 240 240 {ECO:0000313|EMBL:APX55944.1}.
SEQUENCE 240 AA; 27132 MW; C2A76C46E1033D88 CRC64;
KVLSIRKALS IQAHPTKDHA EQLHKSFPNM YKDPNHKPEL AIALTPFEAL CGFRPIPQIQ
EYLKKIPEIX QVLPQEALNA FXEDGSNLKG XIHXLMTCDK EKIALSLQXY LSRLEXEDVN
TQASLLFPLI QRLQSDFTGD VGCWIPYFMN YIILQPGQAI FLKPNLPHAY LSGDCVECMA
CSDNVVRAGL TPKHIDVPTL IDMLDYTSYT KQELLFVPQL EDENSCIWSP PVPDFAVVKI


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