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Mas-related G-protein coupled receptor member A7

 MRGA7_MOUSE             Reviewed;         305 AA.
Q91ZC5;
19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
22-NOV-2017, entry version 85.
RecName: Full=Mas-related G-protein coupled receptor member A7;
Name=Mrgpra7; Synonyms=Mrga7;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
STRAIN=129/SvJ;
PubMed=11551509; DOI=10.1016/S0092-8674(01)00483-4;
Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.;
"A diverse family of GPCRs expressed in specific subsets of
nociceptive sensory neurons.";
Cell 106:619-632(2001).
-!- FUNCTION: Orphan receptor. May be a receptor for RFamide-family
neuropeptides such as NPFF and NPAF, which are analgesic in vivo.
May regulate nociceptor function and/or development, including the
sensation or modulation of pain (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Expressed in a subset of sensory neurons that
includes nociceptors. Expressed in the subclass of non-peptidergic
sensory neurons that are IB4(+) and VR1(-).
{ECO:0000269|PubMed:11551509}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
Mas subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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EMBL; AY042197; AAK91793.1; -; Genomic_DNA.
RefSeq; NP_997418.1; NM_207535.1.
UniGene; Mm.297430; -.
ProteinModelPortal; Q91ZC5; -.
iPTMnet; Q91ZC5; -.
PhosphoSitePlus; Q91ZC5; -.
PRIDE; Q91ZC5; -.
GeneID; 404236; -.
KEGG; mmu:404236; -.
CTD; 404236; -.
MGI; MGI:3033109; Mrgpra7.
HOVERGEN; HBG003592; -.
InParanoid; Q91ZC5; -.
PhylomeDB; Q91ZC5; -.
PRO; PR:Q91ZC5; -.
Proteomes; UP000000589; Unplaced.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0004930; F:G-protein coupled receptor activity; IBA:GO_Central.
CDD; cd15105; 7tmA_MrgprA; 1.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR026233; MRGPCRA.
InterPro; IPR026234; MRGPCRFAMILY.
PANTHER; PTHR11334; PTHR11334; 1.
PANTHER; PTHR11334:SF33; PTHR11334:SF33; 1.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR02109; MRGPCRA.
PRINTS; PR02108; MRGPCRFAMILY.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; G-protein coupled receptor;
Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
Transmembrane helix.
CHAIN 1 305 Mas-related G-protein coupled receptor
member A7.
/FTId=PRO_0000069753.
TOPO_DOM 1 17 Extracellular. {ECO:0000255}.
TRANSMEM 18 38 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 39 46 Cytoplasmic. {ECO:0000255}.
TRANSMEM 47 67 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 68 81 Extracellular. {ECO:0000255}.
TRANSMEM 82 102 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 103 129 Cytoplasmic. {ECO:0000255}.
TRANSMEM 130 150 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 151 167 Extracellular. {ECO:0000255}.
TRANSMEM 168 188 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 189 211 Cytoplasmic. {ECO:0000255}.
TRANSMEM 212 232 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 233 244 Extracellular. {ECO:0000255}.
TRANSMEM 245 265 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 266 305 Cytoplasmic. {ECO:0000255}.
SEQUENCE 305 AA; 35034 MW; 2544FDB3B9E26D39 CRC64;
MDETSPRSID IESLIPNLMI IIFGLVGLTG NAIVLWLLGF CLHRNAFLVY ILNLALADFL
FLLCHFINSA MFLLKVPIPN GIFVYCFYTI KMVLYITGLS MLSAISTERC LSVLCPIWYH
CRRPEHTSTV MCAVIWIFSV LICILKEYFC DFFGTKLGNY YVCQASNFFM GAYLMFLFVV
LCLSTLALLA RLFCGAEKMK FTRLFVTIML TILVFLLCGL PWGFFWFLLI WIKGGFSVLD
YRLYLASIVL TVVNSCANPI IYFFVGSFRH RLKHQTLKMV LQSALQDTPE THENMVEMSR
IKAEQ


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