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Mas-related G-protein coupled receptor member A8

 MRGA8_MOUSE             Reviewed;         305 AA.
Q91ZC4;
19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
12-SEP-2018, entry version 89.
RecName: Full=Mas-related G-protein coupled receptor member A8;
Name=Mrgpra8; Synonyms=Mrga8;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/SvJ;
PubMed=11551509; DOI=10.1016/S0092-8674(01)00483-4;
Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.;
"A diverse family of GPCRs expressed in specific subsets of
nociceptive sensory neurons.";
Cell 106:619-632(2001).
-!- FUNCTION: Orphan receptor. May be a receptor for RFamide-family
neuropeptides such as NPFF and NPAF, which are analgesic in vivo.
May regulate nociceptor function and/or development, including the
sensation or modulation of pain (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Expressed in a subset of sensory neurons that
includes nociceptors. Expressed in the subclass of non-peptidergic
sensory neurons that are IB4(+) and VR1(-).
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
Mas subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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EMBL; AY042198; AAK91794.1; -; Genomic_DNA.
RefSeq; NP_997419.1; NM_207536.1.
UniGene; Mm.297430; -.
ProteinModelPortal; Q91ZC4; -.
PRIDE; Q91ZC4; -.
DNASU; 404237; -.
GeneID; 404237; -.
KEGG; mmu:404237; -.
CTD; 404237; -.
MGI; MGI:3033111; Mrgpra8.
HOVERGEN; HBG003592; -.
InParanoid; Q91ZC4; -.
KO; K08396; -.
PhylomeDB; Q91ZC4; -.
PRO; PR:Q91ZC4; -.
Proteomes; UP000000589; Unplaced.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0004930; F:G-protein coupled receptor activity; IBA:GO_Central.
CDD; cd15105; 7tmA_MrgprA; 1.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR026233; MRGPCRA.
InterPro; IPR026234; MRGPCRFAMILY.
PANTHER; PTHR11334; PTHR11334; 1.
PANTHER; PTHR11334:SF33; PTHR11334:SF33; 1.
Pfam; PF00001; 7tm_1; 2.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR02109; MRGPCRA.
PRINTS; PR02108; MRGPCRFAMILY.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; G-protein coupled receptor;
Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
Transmembrane; Transmembrane helix.
CHAIN 1 305 Mas-related G-protein coupled receptor
member A8.
/FTId=PRO_0000069754.
TOPO_DOM 1 17 Extracellular. {ECO:0000255}.
TRANSMEM 18 38 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 39 46 Cytoplasmic. {ECO:0000255}.
TRANSMEM 47 67 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 68 85 Extracellular. {ECO:0000255}.
TRANSMEM 86 106 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 107 129 Cytoplasmic. {ECO:0000255}.
TRANSMEM 130 150 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 151 172 Extracellular. {ECO:0000255}.
TRANSMEM 173 193 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 194 207 Cytoplasmic. {ECO:0000255}.
TRANSMEM 208 228 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 229 243 Extracellular. {ECO:0000255}.
TRANSMEM 244 264 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 265 305 Cytoplasmic. {ECO:0000255}.
CARBOHYD 151 151 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 159 159 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 305 AA; 35004 MW; D6BEB232DA58534F CRC64;
MDKTILGSID IETLIRHLMI IIFGLVGLTG NAIVFWLLGF HLHRNAFLVY ILNLALADFF
YLLCHIINSI MFLLKVPSPN IILDHCFYTI MIVLYITGLS MLSAISTERC LSVLCPIWYR
CHRPEHTSTA MCAVIWVMSL LISILNGYFC NFSSPKYVNN SVCQASDIFI RTYPIFLFVL
LCLSTLALLA RLFSGAGKRK FTRLFVTIML AILVFLLCGL PLGFFWFLSP WIEDRFIVLD
YRLFFASVVL TVVNSCANPI IYFFVGSFRH RLKQQTLKMF LQRALQDTPE TPENMVEMSR
SKAEP


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