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Mas-related G-protein coupled receptor member D (Beta-alanine receptor) (G-protein coupled receptor TGR7)

 MRGRD_RAT               Reviewed;         319 AA.
Q7TN41; Q6L788;
19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
01-OCT-2003, sequence version 1.
23-MAY-2018, entry version 99.
RecName: Full=Mas-related G-protein coupled receptor member D;
AltName: Full=Beta-alanine receptor;
AltName: Full=G-protein coupled receptor TGR7;
Name=Mrgprd; Synonyms=Mrgd;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE.
STRAIN=Sprague-Dawley;
PubMed=12909716; DOI=10.1073/pnas.1732949100;
Zylka M.J., Dong X., Southwell A.L., Anderson D.J.;
"Atypical expansion in mice of the sensory neuron-specific Mrg G
protein-coupled receptor family.";
Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Cerebellum;
PubMed=15037633; DOI=10.1074/jbc.M314240200;
Shinohara T., Harada M., Ogi K., Maruyama M., Fujii R., Tanaka H.,
Fukusumi S., Komatsu H., Hosoya M., Noguchi Y., Watanabe T.,
Moriya T., Itoh Y., Hinuma S.;
"Identification of a G protein-coupled receptor specifically
responsive to beta-alanine.";
J. Biol. Chem. 279:23559-23564(2004).
-!- FUNCTION: May regulate nociceptor function and/or development,
including the sensation or modulation of pain. Functions as a
specific membrane receptor for beta-alanine. The receptor couples
with G-protein G(q) and G(i) (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Co-expressed in the small diameter neurons
with P2X3 and VR1 in dorsal root ganglia.
{ECO:0000269|PubMed:15037633}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
Mas subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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EMBL; AF518246; AAQ08318.1; -; Genomic_DNA.
EMBL; AB154411; BAD20639.1; -; mRNA.
RefSeq; NP_001001506.1; NM_001001506.1.
RefSeq; XP_006230787.1; XM_006230725.3.
UniGene; Rn.162482; -.
ProteinModelPortal; Q7TN41; -.
STRING; 10116.ENSRNOP00000017958; -.
GuidetoPHARMACOLOGY; 152; -.
PhosphoSitePlus; Q7TN41; -.
PaxDb; Q7TN41; -.
PRIDE; Q7TN41; -.
Ensembl; ENSRNOT00000017958; ENSRNOP00000017958; ENSRNOG00000013448.
GeneID; 293648; -.
KEGG; rno:293648; -.
UCSC; RGD:738040; rat.
CTD; 116512; -.
RGD; 738040; Mrgprd.
eggNOG; ENOG410IWY7; Eukaryota.
eggNOG; ENOG41117F1; LUCA.
GeneTree; ENSGT00550000074531; -.
HOGENOM; HOG000015412; -.
HOVERGEN; HBG003592; -.
InParanoid; Q7TN41; -.
KO; K08392; -.
OMA; CGMAGNS; -.
OrthoDB; EOG091G0EM7; -.
PhylomeDB; Q7TN41; -.
TreeFam; TF336336; -.
PRO; PR:Q7TN41; -.
Proteomes; UP000002494; Chromosome 1.
Bgee; ENSRNOG00000013448; -.
ExpressionAtlas; Q7TN41; baseline and differential.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0004930; F:G-protein coupled receptor activity; TAS:RGD.
CDD; cd15108; 7tmA_MrgprD; 1.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR026232; MRGPCRD.
InterPro; IPR026234; MRGPCRFAMILY.
PANTHER; PTHR11334; PTHR11334; 1.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR02110; MRGPCRD.
PRINTS; PR02108; MRGPCRFAMILY.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; G-protein coupled receptor;
Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
Transmembrane helix.
CHAIN 1 319 Mas-related G-protein coupled receptor
member D.
/FTId=PRO_0000069759.
TOPO_DOM 1 30 Extracellular. {ECO:0000255}.
TRANSMEM 31 51 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 52 64 Cytoplasmic. {ECO:0000255}.
TRANSMEM 65 85 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 86 92 Extracellular. {ECO:0000255}.
TRANSMEM 93 113 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 114 144 Cytoplasmic. {ECO:0000255}.
TRANSMEM 145 165 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 166 184 Extracellular. {ECO:0000255}.
TRANSMEM 185 205 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 206 220 Cytoplasmic. {ECO:0000255}.
TRANSMEM 221 241 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 242 260 Extracellular. {ECO:0000255}.
TRANSMEM 261 281 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 282 319 Cytoplasmic. {ECO:0000255}.
CONFLICT 55 55 R -> S (in Ref. 2; BAD20639).
{ECO:0000305}.
SEQUENCE 319 AA; 35830 MW; 500F41492DE002F7 CRC64;
MNYTPYSSPA PGLTISPTMD PVTWVYFSVT FLAMATCVCG IVGNSMVIWL LSFHRVQRSP
FCTYVLNLAV ADLLFLLCMA SLLSLETGPL LTASTSARVY EGMKRIKYFA YTAGLSLLTA
ISTQRCLSVL FPIWYKCHRP QHLSGVVCGV LWALALLMNF LASFFCVQFW HPDKYQCFKV
DMVFNSLILG IFMPVMVLTS AIIFIRMRKN SLLQRRQPRR LYVVILTSVL VFLTCSLPLG
INWFLLYWVE LPQAVRLLYV CSSRFSSSLS SSANPVIYFL VGSQKSHRLQ ESLGAVLGRA
LQDEPEGRET PSTCTNDGV


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