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Mas-related G-protein coupled receptor member D (Beta-alanine receptor) (G-protein coupled receptor TGR7)

 MRGRD_MOUSE             Reviewed;         321 AA.
Q91ZB8;
19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
28-FEB-2018, entry version 108.
RecName: Full=Mas-related G-protein coupled receptor member D;
AltName: Full=Beta-alanine receptor;
AltName: Full=G-protein coupled receptor TGR7;
Name=Mrgprd; Synonyms=Gm499, Mrgd;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
STRAIN=C57BL/6J;
PubMed=11551509; DOI=10.1016/S0092-8674(01)00483-4;
Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.;
"A diverse family of GPCRs expressed in specific subsets of
nociceptive sensory neurons.";
Cell 106:619-632(2001).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=15037633; DOI=10.1074/jbc.M314240200;
Shinohara T., Harada M., Ogi K., Maruyama M., Fujii R., Tanaka H.,
Fukusumi S., Komatsu H., Hosoya M., Noguchi Y., Watanabe T.,
Moriya T., Itoh Y., Hinuma S.;
"Identification of a G protein-coupled receptor specifically
responsive to beta-alanine.";
J. Biol. Chem. 279:23559-23564(2004).
-!- FUNCTION: May regulate nociceptor function and/or development,
including the sensation or modulation of pain. Functions as a
specific membrane receptor for beta-alanine. The receptor couples
with G-protein G(q) and G(i) (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Expressed in a subset of sensory neurons that
includes nociceptors. Expressed in the subclass of non-peptidergic
sensory neurons that are IB4(+) and VR1(-).
{ECO:0000269|PubMed:11551509}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
Mas subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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EMBL; AY042209; AAK91800.1; -; Genomic_DNA.
EMBL; AB154412; BAD20640.1; -; Genomic_DNA.
CCDS; CCDS22057.1; -.
RefSeq; NP_987075.1; NM_203490.3.
UniGene; Mm.370299; -.
ProteinModelPortal; Q91ZB8; -.
STRING; 10090.ENSMUSP00000063021; -.
GuidetoPHARMACOLOGY; 152; -.
PhosphoSitePlus; Q91ZB8; -.
PaxDb; Q91ZB8; -.
PRIDE; Q91ZB8; -.
Ensembl; ENSMUST00000062163; ENSMUSP00000063021; ENSMUSG00000051207.
GeneID; 211578; -.
KEGG; mmu:211578; -.
UCSC; uc009kra.1; mouse.
CTD; 116512; -.
MGI; MGI:3033142; Mrgprd.
eggNOG; ENOG410IWY7; Eukaryota.
eggNOG; ENOG41117F1; LUCA.
GeneTree; ENSGT00550000074531; -.
HOGENOM; HOG000015412; -.
HOVERGEN; HBG003592; -.
InParanoid; Q91ZB8; -.
KO; K08392; -.
OMA; CGMAGNS; -.
OrthoDB; EOG091G0EM7; -.
PhylomeDB; Q91ZB8; -.
TreeFam; TF336336; -.
PRO; PR:Q91ZB8; -.
Proteomes; UP000000589; Chromosome 7.
Bgee; ENSMUSG00000051207; -.
CleanEx; MM_MRGPRD; -.
ExpressionAtlas; Q91ZB8; differential.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0004930; F:G-protein coupled receptor activity; IBA:GO_Central.
CDD; cd15108; 7tmA_MrgprD; 1.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR026232; MRGPCRD.
InterPro; IPR026234; MRGPCRFAMILY.
PANTHER; PTHR11334; PTHR11334; 1.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR02110; MRGPCRD.
PRINTS; PR02108; MRGPCRFAMILY.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; G-protein coupled receptor;
Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
Transmembrane; Transmembrane helix.
CHAIN 1 321 Mas-related G-protein coupled receptor
member D.
/FTId=PRO_0000069758.
TOPO_DOM 1 8 Extracellular. {ECO:0000255}.
TRANSMEM 9 29 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 30 30 Cytoplasmic. {ECO:0000255}.
TRANSMEM 31 51 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 52 72 Extracellular. {ECO:0000255}.
TRANSMEM 73 93 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 94 146 Cytoplasmic. {ECO:0000255}.
TRANSMEM 147 167 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 168 181 Extracellular. {ECO:0000255}.
TRANSMEM 182 202 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 203 220 Cytoplasmic. {ECO:0000255}.
TRANSMEM 221 241 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 242 260 Extracellular. {ECO:0000255}.
TRANSMEM 261 281 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 282 321 Cytoplasmic. {ECO:0000255}.
CARBOHYD 2 2 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 321 AA; 36126 MW; B0642547A75077B3 CRC64;
MNSTLDSSPA PGLTISPTMD LVTWIYFSVT FLAMATCVGG MAGNSLVIWL LSCNGMQRSP
FCVYVLNLAV ADFLFLFCMA SMLSLETGPL LIVNISAKIY EGMRRIKYFA YTAGLSLLTA
ISTQRCLSVL FPIWYKCHRP RHLSSVVSGA LWALAFLMNF LASFFCVQFW HPNKHQCFKV
DIVFNSLILG IFMPVMILTS TILFIRVRKN SLMQRRRPRR LYVVILTSIL VFLTCSLPLG
INWFLLYWVD VKRDVRLLYS CVSRFSSSLS SSANPVIYFL VGSQKSHRLQ ESLGAVLGRA
LRDEPEPEGR ETPSTCTNDG V


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