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Maspardin (Spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog)

 SPG21_RAT               Reviewed;         261 AA.
Q5XIC4;
21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
23-NOV-2004, sequence version 1.
12-SEP-2018, entry version 80.
RecName: Full=Maspardin;
AltName: Full=Spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog;
Name=Spg21;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Heart;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: May play a role as a negative regulatory factor in CD4-
dependent T-cell activation. {ECO:0000250}.
-!- SUBUNIT: Interacts with CD4. Interacts with ALDH16A1.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
-!- SIMILARITY: Belongs to the AB hydrolase superfamily.
{ECO:0000305}.
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EMBL; BC083760; AAH83760.1; -; mRNA.
RefSeq; NP_001006988.1; NM_001006987.1.
UniGene; Rn.19459; -.
ProteinModelPortal; Q5XIC4; -.
SMR; Q5XIC4; -.
STRING; 10116.ENSRNOP00000039361; -.
ESTHER; ratno-SPG21; Maspardin-ACP33-SPG21_like.
iPTMnet; Q5XIC4; -.
PhosphoSitePlus; Q5XIC4; -.
PaxDb; Q5XIC4; -.
PRIDE; Q5XIC4; -.
DNASU; 300791; -.
Ensembl; ENSRNOT00000051504; ENSRNOP00000039361; ENSRNOG00000015019.
GeneID; 300791; -.
KEGG; rno:300791; -.
UCSC; RGD:1359141; rat.
CTD; 51324; -.
RGD; 1359141; Spg21.
eggNOG; ENOG410IETY; Eukaryota.
eggNOG; ENOG410XPCG; LUCA.
GeneTree; ENSGT00390000007857; -.
HOGENOM; HOG000236323; -.
HOVERGEN; HBG080704; -.
InParanoid; Q5XIC4; -.
KO; K19367; -.
PRO; PR:Q5XIC4; -.
Proteomes; UP000002494; Chromosome 8.
Bgee; ENSRNOG00000015019; Expressed in 10 organ(s), highest expression level in lung.
ExpressionAtlas; Q5XIC4; baseline and differential.
Genevisible; Q5XIC4; RN.
GO; GO:0005829; C:cytosol; ISS:UniProtKB.
GO; GO:0030140; C:trans-Golgi network transport vesicle; ISS:UniProtKB.
GO; GO:0042609; F:CD4 receptor binding; ISS:UniProtKB.
Gene3D; 3.40.50.1820; -; 1.
InterPro; IPR029058; AB_hydrolase.
InterPro; IPR000073; AB_hydrolase_1.
InterPro; IPR026151; Maspardin.
PANTHER; PTHR15913; PTHR15913; 1.
Pfam; PF00561; Abhydrolase_1; 1.
SUPFAM; SSF53474; SSF53474; 2.
2: Evidence at transcript level;
Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome.
CHAIN 1 261 Maspardin.
/FTId=PRO_0000227984.
DOMAIN 87 159 AB hydrolase-1. {ECO:0000255}.
MOD_RES 257 257 Phosphoserine.
{ECO:0000250|UniProtKB:Q9NZD8}.
SEQUENCE 261 AA; 29576 MW; 000E08692F45E1C0 CRC64;
MGEIKVSPDY NWFRSTVPLK KIIVDDDDSK IWSLYDAGPR SIRCPLIFLP PVSGTADVFF
QQILALTGWG YRVIALQYPV YWDHLEFCDG FRKLLDHLQL DKVHLFGASL GGFLAQKFAE
YTHKSPRVHS LILCNAFSDT SIFNQTWTAN SFWLMPAFML KKIVLGNFSS GPVDPMMADA
IDFMVDRLES LGQSELASRL TLNCQNSYVE PHKIRDIPVT IMDIHLLQFH GTKYAAIDPS
VVSAEELDVQ KGQLDLSQEE P


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