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Mast/stem cell growth factor receptor Kit

 F6YAJ6_CALJA            Unreviewed;       976 AA.
F6YAJ6;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
27-JUL-2011, sequence version 1.
27-SEP-2017, entry version 51.
SubName: Full=Mast/stem cell growth factor receptor Kit {ECO:0000313|Ensembl:ENSCJAP00000034112};
Name=KIT {ECO:0000313|Ensembl:ENSCJAP00000034112};
Callithrix jacchus (White-tufted-ear marmoset).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000034112, ECO:0000313|Proteomes:UP000008225};
[1] {ECO:0000313|Ensembl:ENSCJAP00000034112, ECO:0000313|Proteomes:UP000008225}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSCJAP00000034112}
IDENTIFICATION.
Ensembl;
Submitted (JUN-2011) to UniProtKB.
-!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
[protein]-L-tyrosine phosphate. {ECO:0000256|RuleBase:RU000311,
ECO:0000256|SAAS:SAAS00701269}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU000311};
Single-pass type I membrane protein
{ECO:0000256|RuleBase:RU000311}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. CSF-1/PDGF receptor subfamily.
{ECO:0000256|RuleBase:RU000311}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000034112}.
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EMBL; ACFV01029870; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACFV01029871; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACFV01029872; -; NOT_ANNOTATED_CDS; Genomic_DNA.
ProteinModelPortal; F6YAJ6; -.
Ensembl; ENSCJAT00000036036; ENSCJAP00000034112; ENSCJAG00000018396.
eggNOG; KOG0200; Eukaryota.
eggNOG; COG0515; LUCA.
GeneTree; ENSGT00760000118923; -.
OMA; PTFKQIV; -.
OrthoDB; EOG091G01TL; -.
TreeFam; TF325768; -.
Proteomes; UP000008225; Chromosome 3.
GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0042629; C:mast cell granule; IEA:GOC.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0019955; F:cytokine binding; IEA:Ensembl.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0002020; F:protease binding; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0004716; F:signal transducer, downstream of receptor, with protein tyrosine kinase activity; IEA:InterPro.
GO; GO:0005020; F:stem cell factor receptor activity; IEA:Ensembl.
GO; GO:0031532; P:actin cytoskeleton reorganization; IEA:Ensembl.
GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
GO; GO:0097067; P:cellular response to thyroid hormone stimulus; IEA:Ensembl.
GO; GO:0002371; P:dendritic cell cytokine production; IEA:Ensembl.
GO; GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; IEA:Ensembl.
GO; GO:0048565; P:digestive tract development; IEA:Ensembl.
GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
GO; GO:0035162; P:embryonic hemopoiesis; IEA:Ensembl.
GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
GO; GO:0038162; P:erythropoietin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0038093; P:Fc receptor signaling pathway; IEA:Ensembl.
GO; GO:0006687; P:glycosphingolipid metabolic process; IEA:Ensembl.
GO; GO:0035701; P:hematopoietic stem cell migration; IEA:Ensembl.
GO; GO:0002327; P:immature B cell differentiation; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
GO; GO:0030032; P:lamellipodium assembly; IEA:Ensembl.
GO; GO:0002320; P:lymphoid progenitor cell differentiation; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:0002551; P:mast cell chemotaxis; IEA:Ensembl.
GO; GO:0032762; P:mast cell cytokine production; IEA:Ensembl.
GO; GO:0043303; P:mast cell degranulation; IEA:Ensembl.
GO; GO:0060374; P:mast cell differentiation; IEA:Ensembl.
GO; GO:0035855; P:megakaryocyte development; IEA:Ensembl.
GO; GO:0097326; P:melanocyte adhesion; IEA:Ensembl.
GO; GO:0030318; P:melanocyte differentiation; IEA:Ensembl.
GO; GO:0097324; P:melanocyte migration; IEA:Ensembl.
GO; GO:0002318; P:myeloid progenitor cell differentiation; IEA:Ensembl.
GO; GO:0043069; P:negative regulation of programmed cell death; IEA:Ensembl.
GO; GO:0001541; P:ovarian follicle development; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:1905065; P:positive regulation of vascular smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
GO; GO:0048070; P:regulation of developmental pigmentation; IEA:Ensembl.
GO; GO:0009314; P:response to radiation; IEA:Ensembl.
GO; GO:0007286; P:spermatid development; IEA:Ensembl.
GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
GO; GO:0030217; P:T cell differentiation; IEA:Ensembl.
Gene3D; 2.60.40.10; -; 5.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR003598; Ig_sub2.
InterPro; IPR013151; Immunoglobulin.
InterPro; IPR011009; Kinase-like_dom.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR027263; SCGF_receptor.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
InterPro; IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam; PF00047; ig; 1.
Pfam; PF07714; Pkinase_Tyr; 1.
PIRSF; PIRSF500951; SCGF_recepter; 1.
SMART; SM00409; IG; 3.
SMART; SM00408; IGc2; 2.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF48726; SSF48726; 3.
SUPFAM; SSF56112; SSF56112; 2.
PROSITE; PS50835; IG_LIKE; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PROSITE; PS00240; RECEPTOR_TYR_KIN_III; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|PIRSR:PIRSR500951-2,
ECO:0000256|SAAS:SAAS00708816};
Complete proteome {ECO:0000313|Proteomes:UP000008225};
Disulfide bond {ECO:0000256|SAAS:SAAS00803457};
Immunoglobulin domain {ECO:0000256|RuleBase:RU000311,
ECO:0000256|SAAS:SAAS00442402};
Kinase {ECO:0000256|SAAS:SAAS00582553};
Magnesium {ECO:0000256|PIRSR:PIRSR500951-1};
Membrane {ECO:0000256|SAAS:SAAS00602683, ECO:0000256|SAM:Phobius};
Metal-binding {ECO:0000256|PIRSR:PIRSR500951-1};
Nucleotide-binding {ECO:0000256|PIRSR:PIRSR500951-2,
ECO:0000256|SAAS:SAAS00708816};
Receptor {ECO:0000256|RuleBase:RU000311,
ECO:0000256|SAAS:SAAS00600436};
Reference proteome {ECO:0000313|Proteomes:UP000008225};
Repeat {ECO:0000256|SAAS:SAAS00457685};
Signal {ECO:0000256|SAM:SignalP};
Transferase {ECO:0000256|SAAS:SAAS00582553};
Transmembrane {ECO:0000256|SAAS:SAAS00602683,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00602683,
ECO:0000256|SAM:Phobius};
Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00582553}.
SIGNAL 1 25 {ECO:0000256|SAM:SignalP}.
CHAIN 26 976 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003346629.
TRANSMEM 521 543 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 212 308 Ig-like. {ECO:0000259|PROSITE:PS50835}.
DOMAIN 589 937 Protein kinase.
{ECO:0000259|PROSITE:PS50011}.
NP_BIND 596 603 ATP. {ECO:0000256|PIRSR:PIRSR500951-2}.
NP_BIND 671 677 ATP. {ECO:0000256|PIRSR:PIRSR500951-2}.
METAL 568 568 Magnesium.
{ECO:0000256|PIRSR:PIRSR500951-1}.
METAL 797 797 Magnesium.
{ECO:0000256|PIRSR:PIRSR500951-1}.
METAL 810 810 Magnesium.
{ECO:0000256|PIRSR:PIRSR500951-1}.
BINDING 623 623 ATP. {ECO:0000256|PIRSR:PIRSR500951-2}.
BINDING 796 796 ATP. {ECO:0000256|PIRSR:PIRSR500951-2}.
SITE 936 936 Important for interaction with
phosphotyrosine-binding proteins.
{ECO:0000256|PIRSR:PIRSR500951-3}.
SEQUENCE 976 AA; 110125 MW; 006EF00F9B0CF414 CRC64;
MRGARGAWDF LCVLLLLLRV QTGSSQPSVS PEEASPPFID PAKSELIVSV GDEIRLFCND
PGFVKWTFEV LDQMNENKQK EWIMQKAEAT NTGKYTCTNK HGLSSSIYVF VRDPDKLFLV
DRSLYGKEDN DTLVRCPLTD PEVTNYSLKG CQGKPIPKDL RFVPDPKAGI TIKNVKRAYH
RLCLHCSADR KGQSKLSEKF ILKVRPAFKA VPVVSVSKAS YLLREGEEFT VTCTIKDVSS
SVYSSWKKEN SQTKLQEKYN SWHQGDFNYE RQATLTISSV RVNDSGVFMC YASNTFGSAN
VTTTLEVVDK GFINIFPMIN TTVFVNDGEN VDLIVEYEAF PRPEHQQWIY MNRTFTDKWE
DYPKSENESN IRYVSELHLT RLKDTEGGTY TFLVSNSDVS SSIAFTVYVN TKPEILTYDR
LMNGMLQCVA AGFPEPTIDW YFCPGTEQRC SAPVLPVDVQ IQNTSGPPFG KLVVQSSIDS
SAFKHNGTVE CKAYNDVGKT SAYFNFAFKG NNKEQIQPHT LFTPLLIGFV VVAGMMCIIV
MILTYKYLQK PMYEVQWKVV EEINGNNYVY IDPTQLPYDH KWEFPRNRLS FGKTLGAGAF
GKVVEATAYG LIKSDTAMTV AVKMLKPSAH LTEREALMSE LKVLSYLGNH MNIVNLLGAC
TIGGPTLVIT EYCCYGDLLN FLRRKRDSFI CSKQEDHAEA ALYKNLLHSK ESSCSDSTNE
YMDMKPGVSY VVPTKAEKRR SARVGSYIER DVTPAIMEDD ELALDLEDLL SFSYQVAKGM
AFLASKNCIH RDLAARNILL THGRITKICD FGLARDIKND SNYVVKGNAR LPVKWMAPES
IFNCVYTFES DVWSYGIFLW ELFSLGSSPY PGMPVDSKFY KMIKEGFRML SPEHAPAEMY
DIMKTCWDAD PLKRPTFKQI VQLIEKQISE STNHIYSNLT NCSPSQQKPV VDHSVRINSV
GSTASSSQPL LVRDDV


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