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Matrix Gla protein (MGP) [Cleaved into: Matrix Gla protein long form; Matrix Gla protein short form]

 MGP_BOVIN               Reviewed;         103 AA.
P07507; Q54A30;
01-APR-1988, integrated into UniProtKB/Swiss-Prot.
01-AUG-1988, sequence version 1.
15-MAR-2017, entry version 107.
RecName: Full=Matrix Gla protein;
Short=MGP;
Contains:
RecName: Full=Matrix Gla protein long form;
Contains:
RecName: Full=Matrix Gla protein short form;
Flags: Precursor;
Name=MGP;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3387234; DOI=10.1093/nar/16.11.5213;
Kiefer M.C., Bauer D.M., Young D., Hermsen K.M., Masiarz F.K.,
Barr P.J.;
"The cDNA and derived amino acid sequences for human and bovine matrix
Gla protein.";
Nucleic Acids Res. 16:5213-5213(1988).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Chapman K.L., Newman B., Freemont A.J., Hillarby M.C., Grant M.E.,
Boot-Handford R.P., Wallis G.A.;
"Differential expression of matrix Gla protein, alpha enolase, and
annexin V within the epiphyseal growth plate and in human
osteoarthritic tissue.";
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=12658628; DOI=10.1002/mrd.10292;
Ishiwata H., Katsuma S., Kizaki K., Patel O.V., Nakano H.,
Takahashi T., Imai K., Hirasawa A., Shiojima S., Ikawa H., Suzuki Y.,
Tsujimoto G., Izaike Y., Todoroki J., Hashizume K.;
"Characterization of gene expression profiles in early bovine
pregnancy using a custom cDNA microarray.";
Mol. Reprod. Dev. 65:9-18(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Crossbred X Angus; TISSUE=Ileum;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
[5]
PROTEIN SEQUENCE OF 20-98, AND GAMMA-CARBOXYGLUTAMATION AT GLU-56;
GLU-60; GLU-67 AND GLU-71.
PubMed=3877721;
Price P.A., Williamson M.K.;
"Primary structure of bovine matrix Gla protein, a new vitamin K-
dependent bone protein.";
J. Biol. Chem. 260:14971-14975(1985).
[6]
PHOSPHORYLATION AT SER-22; SER-25 AND SER-28.
PubMed=8061611; DOI=10.1002/pro.5560030511;
Price P.A., Rice J.S., Williamson M.K.;
"Conserved phosphorylation of serines in the Ser-X-Glu/Ser(P)
sequences of the vitamin K-dependent matrix Gla protein from shark,
lamb, rat, cow, and human.";
Protein Sci. 3:822-830(1994).
[7]
PARTIAL PROTEIN SEQUENCE, AND PROTEOLYTIC PROCESSING OF C-TERMINAL.
PubMed=1939157;
Hale J.E., Williamson M.K., Price P.A.;
"Carboxyl-terminal proteolytic processing of matrix Gla protein.";
J. Biol. Chem. 266:21145-21149(1991).
-!- FUNCTION: Associates with the organic matrix of bone and
cartilage. Thought to act as an inhibitor of bone formation.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: Requires vitamin K-dependent gamma-carboxylation for its
function.
-!- SIMILARITY: Belongs to the osteocalcin/matrix Gla protein family.
{ECO:0000305}.
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EMBL; X07363; CAA30288.1; -; mRNA.
EMBL; AF210379; AAF25880.1; -; mRNA.
EMBL; AB098895; BAC56385.1; -; mRNA.
EMBL; BC102587; AAI02588.1; -; mRNA.
PIR; S01232; GEBOM.
RefSeq; NP_777132.1; NM_174707.3.
UniGene; Bt.3595; -.
ProteinModelPortal; P07507; -.
SMR; P07507; -.
iPTMnet; P07507; -.
PRIDE; P07507; -.
GeneID; 282660; -.
KEGG; bta:282660; -.
CTD; 4256; -.
HOVERGEN; HBG006353; -.
InParanoid; P07507; -.
KO; K19481; -.
Proteomes; UP000009136; Unplaced.
GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
GO; GO:0005201; F:extracellular matrix structural constituent; IBA:GO_Central.
GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
GO; GO:0030500; P:regulation of bone mineralization; IEA:InterPro.
InterPro; IPR000294; GLA_domain.
InterPro; IPR027118; MGP.
InterPro; IPR002384; Osteocalcin/MGP.
PANTHER; PTHR10109; PTHR10109; 1.
PRINTS; PR00002; GLABONE.
SMART; SM00069; GLA; 1.
SUPFAM; SSF57630; SSF57630; 1.
PROSITE; PS00011; GLA_1; 1.
PROSITE; PS50998; GLA_2; 1.
1: Evidence at protein level;
Chondrogenesis; Complete proteome; Developmental protein;
Differentiation; Direct protein sequencing; Disulfide bond;
Gamma-carboxyglutamic acid; Osteogenesis; Phosphoprotein;
Reference proteome; Secreted; Signal.
SIGNAL 1 19 {ECO:0000269|PubMed:3877721}.
CHAIN 20 102 Matrix Gla protein long form.
{ECO:0000269|PubMed:1939157}.
/FTId=PRO_0000011104.
CHAIN 20 98 Matrix Gla protein short form.
{ECO:0000269|PubMed:1939157}.
/FTId=PRO_0000011105.
PROPEP 99 102 Removed in short form; probably by
carboxypeptidase N.
/FTId=PRO_0000011106.
PROPEP 103 103 Removed in long form; probably by
carboxypeptidase H.
/FTId=PRO_0000011107.
DOMAIN 51 97 Gla. {ECO:0000255|PROSITE-
ProRule:PRU00463}.
MOD_RES 21 21 4-carboxyglutamate; partial.
{ECO:0000255|PROSITE-ProRule:PRU00463,
ECO:0000269|PubMed:3877721}.
MOD_RES 22 22 Phosphoserine.
{ECO:0000269|PubMed:8061611}.
MOD_RES 25 25 Phosphoserine.
{ECO:0000269|PubMed:8061611}.
MOD_RES 28 28 Phosphoserine.
{ECO:0000269|PubMed:8061611}.
MOD_RES 56 56 4-carboxyglutamate. {ECO:0000255|PROSITE-
ProRule:PRU00463,
ECO:0000269|PubMed:3877721}.
MOD_RES 60 60 4-carboxyglutamate. {ECO:0000255|PROSITE-
ProRule:PRU00463,
ECO:0000269|PubMed:3877721}.
MOD_RES 67 67 4-carboxyglutamate. {ECO:0000255|PROSITE-
ProRule:PRU00463,
ECO:0000269|PubMed:3877721}.
MOD_RES 71 71 4-carboxyglutamate. {ECO:0000255|PROSITE-
ProRule:PRU00463,
ECO:0000269|PubMed:3877721}.
DISULFID 73 79
SEQUENCE 103 AA; 12217 MW; 86A89984F92BF38A CRC64;
MKSLLLLSIL AALAVAALCY ESHESLESYE INPFINRRNA NSFISPQQRW RAKAQERIRE
LNKPQYELNR EACDDFKLCE RYAMVYGYNA AYDRYFRQRR GAK


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