Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Matrix metalloproteinase-17 (MMP-17) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (MTMMP4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP) (MT4MMP)

 MMP17_MOUSE             Reviewed;         578 AA.
Q9R0S3; Q80UM9;
24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 3.
20-JUN-2018, entry version 156.
RecName: Full=Matrix metalloproteinase-17;
Short=MMP-17;
EC=3.4.24.-;
AltName: Full=Membrane-type matrix metalloproteinase 4;
Short=MT-MMP 4;
Short=MTMMP4;
AltName: Full=Membrane-type-4 matrix metalloproteinase;
Short=MT4-MMP;
Short=MT4MMP;
Flags: Precursor;
Name=Mmp17; Synonyms=Mt4mmp;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Embryonic brain;
PubMed=10471807; DOI=10.1016/S0014-5793(99)01065-0;
Kajita M., Kinoh H., Ito N., Takamura A., Itoh Y., Okada A., Sato H.,
Seiki M.;
"Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded
by a novel major transcript: isolation of complementary DNA clones for
human and mouse mt4-mmp transcripts.";
FEBS Lett. 457:353-356(1999).
[2]
SEQUENCE REVISION TO C-TERMINUS.
Seiki M.;
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
TISSUE=Brain;
PubMed=10799478; DOI=10.1074/jbc.275.19.14046;
English W.R., Puente X.S., Freije J.M.P., Knaeuper V., Amour A.,
Merryweather A., Lopez-Otin C., Murphy G.;
"Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis
factor-alpha convertase activity but does not activate pro-MMP2.";
J. Biol. Chem. 275:14046-14055(2000).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Embryonic brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
GPI-ANCHOR, AND MUTAGENESIS OF GLU-248.
PubMed=10567400; DOI=10.1074/jbc.274.48.34260;
Itoh Y., Kajita M., Kinoh H., Mori H., Okada A., Seiki M.;
"Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a
glycosylphosphatidylinositol-anchored proteinase.";
J. Biol. Chem. 274:34260-34266(1999).
-!- FUNCTION: Endopeptidase that degrades various components of the
extracellular matrix, such as fibrin. May be involved in the
activation of membrane-bound precursors of growth factors or
inflammatory mediators, such as tumor necrosis factor-alpha. May
also be involved in tumoral process. Not obvious if able to
proteolytically activate progelatinase A. Does not hydrolyze
collagen types I, II, III, IV and V, gelatin, fibronectin,
laminin, decorin nor alpha1-antitrypsin.
{ECO:0000269|PubMed:10799478}.
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
Note=Binds 1 zinc ion per subunit. {ECO:0000250};
-!- COFACTOR:
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
-!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor;
Extracellular side. Secreted, extracellular space, extracellular
matrix.
-!- TISSUE SPECIFICITY: Expressed by monocytes and macrophages.
-!- DOMAIN: The conserved cysteine present in the cysteine-switch
motif binds the catalytic zinc ion, thus inhibiting the enzyme.
The dissociation of the cysteine from the zinc ion upon the
activation-peptide release activates the enzyme.
-!- PTM: The precursor is cleaved by a furin endopeptidase.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the peptidase M10A family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AB021224; BAA82708.2; -; mRNA.
EMBL; AJ010731; CAB92315.1; -; mRNA.
EMBL; CH466529; EDL19513.1; -; Genomic_DNA.
EMBL; BC051917; AAH51917.1; -; mRNA.
CCDS; CCDS19695.1; -.
RefSeq; NP_035976.3; NM_011846.5.
UniGene; Mm.42047; -.
ProteinModelPortal; Q9R0S3; -.
SMR; Q9R0S3; -.
STRING; 10090.ENSMUSP00000031390; -.
MEROPS; M10.017; -.
iPTMnet; Q9R0S3; -.
PhosphoSitePlus; Q9R0S3; -.
REPRODUCTION-2DPAGE; Q9R0S3; -.
PaxDb; Q9R0S3; -.
PeptideAtlas; Q9R0S3; -.
PRIDE; Q9R0S3; -.
Ensembl; ENSMUST00000031390; ENSMUSP00000031390; ENSMUSG00000029436.
GeneID; 23948; -.
KEGG; mmu:23948; -.
UCSC; uc008zsy.1; mouse.
CTD; 4326; -.
MGI; MGI:1346076; Mmp17.
eggNOG; KOG1565; Eukaryota.
eggNOG; ENOG410XQ5D; LUCA.
GeneTree; ENSGT00760000118870; -.
HOGENOM; HOG000217928; -.
HOVERGEN; HBG052484; -.
InParanoid; Q9R0S3; -.
KO; K07997; -.
OMA; DRYWVFK; -.
OrthoDB; EOG091G03DP; -.
TreeFam; TF315428; -.
Reactome; R-MMU-1592389; Activation of Matrix Metalloproteinases.
PRO; PR:Q9R0S3; -.
Proteomes; UP000000589; Chromosome 5.
Bgee; ENSMUSG00000029436; -.
CleanEx; MM_MMP17; -.
Genevisible; Q9R0S3; MM.
GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO; GO:0031012; C:extracellular matrix; IEA:InterPro.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0042756; P:drinking behavior; IMP:MGI.
GO; GO:0001822; P:kidney development; IMP:MGI.
CDD; cd00094; HX; 1.
CDD; cd04278; ZnMc_MMP; 1.
Gene3D; 2.110.10.10; -; 1.
Gene3D; 3.40.390.10; -; 1.
InterPro; IPR000585; Hemopexin-like_dom.
InterPro; IPR036375; Hemopexin-like_dom_sf.
InterPro; IPR018487; Hemopexin-like_repeat.
InterPro; IPR033739; M10A_MMP.
InterPro; IPR024079; MetalloPept_cat_dom_sf.
InterPro; IPR028726; MMP17.
InterPro; IPR001818; Pept_M10_metallopeptidase.
InterPro; IPR021190; Pept_M10A.
InterPro; IPR006026; Peptidase_Metallo.
InterPro; IPR002477; Peptidoglycan-bd-like.
InterPro; IPR036365; PGBD-like_sf.
PANTHER; PTHR10201:SF21; PTHR10201:SF21; 1.
Pfam; PF00045; Hemopexin; 4.
Pfam; PF00413; Peptidase_M10; 1.
Pfam; PF01471; PG_binding_1; 1.
PIRSF; PIRSF001191; Peptidase_M10A_matrix; 1.
PRINTS; PR00138; MATRIXIN.
SMART; SM00120; HX; 4.
SMART; SM00235; ZnMc; 1.
SUPFAM; SSF47090; SSF47090; 1.
SUPFAM; SSF50923; SSF50923; 1.
PROSITE; PS51642; HEMOPEXIN_2; 4.
PROSITE; PS00142; ZINC_PROTEASE; 1.
1: Evidence at protein level;
Calcium; Cell membrane; Cleavage on pair of basic residues;
Complete proteome; Disulfide bond; Extracellular matrix; Glycoprotein;
GPI-anchor; Hydrolase; Lipoprotein; Membrane; Metal-binding;
Metalloprotease; Protease; Reference proteome; Repeat; Secreted;
Signal; Zinc; Zymogen.
SIGNAL 1 39 {ECO:0000255}.
PROPEP 40 124 {ECO:0000250}.
/FTId=PRO_0000028821.
CHAIN 125 558 Matrix metalloproteinase-17.
/FTId=PRO_0000028822.
PROPEP 559 578 Removed in mature form. {ECO:0000255}.
/FTId=PRO_0000028823.
REPEAT 333 382 Hemopexin 1.
REPEAT 386 432 Hemopexin 2.
REPEAT 436 479 Hemopexin 3.
REPEAT 480 527 Hemopexin 4.
MOTIF 107 114 Cysteine switch. {ECO:0000250}.
ACT_SITE 248 248
METAL 109 109 Zinc; in inhibited form. {ECO:0000250}.
METAL 247 247 Zinc; catalytic. {ECO:0000255|PROSITE-
ProRule:PRU10095}.
METAL 251 251 Zinc; catalytic. {ECO:0000255|PROSITE-
ProRule:PRU10095}.
METAL 257 257 Zinc; catalytic. {ECO:0000255|PROSITE-
ProRule:PRU10095}.
LIPID 558 558 GPI-anchor amidated serine.
{ECO:0000255}.
CARBOHYD 136 136 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 322 322 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 336 527 {ECO:0000250}.
MUTAGEN 248 248 E->A: Loss of activity.
{ECO:0000269|PubMed:10567400}.
CONFLICT 45 45 A -> G (in Ref. 3; CAB92315).
{ECO:0000305}.
CONFLICT 277 277 L -> V (in Ref. 1; BAA82708).
{ECO:0000305}.
SEQUENCE 578 AA; 64333 MW; 168C933B63A1EB7B CRC64;
MGRRPRGPGS PRGPGPPRPG PGLPPLLLVL ALAAHGGCAA PAPRAEDLSL GVEWLSRFGY
LPPADPASGQ LQTQEELSKA ITAMQQFGGL ETTGILDEAT LALMKTPRCS LPDLPPGAQS
RRKRQTPPPT KWSKRNLSWR VRTFPRDSPL GRDTVRALMY YALKVWSDIT PLNFHEVAGN
AADIQIDFSK ADHNDGYPFD GPGGTVAHAF FPGDHHTAGD THFDDDEPWT FRSSDAHGMD
LFAVAVHEFG HAIGLSHVAA PSSIMQPYYQ GPVGDPLRYG LPYEDRVRVW QLYGVRESVS
PTAQLDTPEP EEPPLLPEPP NNRSSTPPQK DVPHRCTAHF DAVAQIRGEA FFFKGKYFWR
LTRDRHLVSL QPAQMHRFWR GLPLHLDSVD AVYERTSDHK IVFFKGDRYW VFKDNNVEEG
YPRPVSDFSL PPGGIDAVFS WAHNDRTYFF KDQLYWRYDD HTRRMDPGYP AQGPLWRGVP
SMLDDAMRWS DGASYFFRGQ EYWKVLDGEL EAAPGYPQST ARDWLVCGEP LADAEDVGPG
PQGRSGAQDG LAVCSCTSDA HRLALPSLLL LTPLLWGL


Related products :

Catalog number Product name Quantity
E0554h ELISA Homo sapiens,Human,Matrix metalloproteinase-17,Membrane-type matrix metalloproteinase 4,Membrane-type-4 matrix metalloproteinase,MMP17,MMP-17,MT4MMP,MT4MMP,MT4-MMP,MT-MMP 4,MTMMP4 96T
U0554h CLIA Homo sapiens,Human,Matrix metalloproteinase-17,Membrane-type matrix metalloproteinase 4,Membrane-type-4 matrix metalloproteinase,MMP17,MMP-17,MT4MMP,MT4MMP,MT4-MMP,MT-MMP 4,MTMMP4 96T
E0554h ELISA kit Homo sapiens,Human,Matrix metalloproteinase-17,Membrane-type matrix metalloproteinase 4,Membrane-type-4 matrix metalloproteinase,MMP17,MMP-17,MT4MMP,MT4MMP,MT4-MMP,MT-MMP 4,MTMMP4 96T
E0554m ELISA Matrix metalloproteinase-17,Membrane-type matrix metalloproteinase 4,Membrane-type-4 matrix metalloproteinase,Mmp17,MMP-17,Mouse,MT4MMP,Mt4mmp,MT4-MMP,MT-MMP 4,MTMMP4,Mus musculus 96T
E0554m ELISA kit Matrix metalloproteinase-17,Membrane-type matrix metalloproteinase 4,Membrane-type-4 matrix metalloproteinase,Mmp17,MMP-17,Mouse,MT4MMP,Mt4mmp,MT4-MMP,MT-MMP 4,MTMMP4,Mus musculus 96T
U0554m CLIA Matrix metalloproteinase-17,Membrane-type matrix metalloproteinase 4,Membrane-type-4 matrix metalloproteinase,Mmp17,MMP-17,Mouse,MT4MMP,Mt4mmp,MT4-MMP,MT-MMP 4,MTMMP4,Mus musculus 96T
U2056Rb CLIA Matrix metalloproteinase-14,Membrane-type matrix metalloproteinase 1,Membrane-type-1 matrix metalloproteinase,MMP14,MMP-14,MT1MMP,MT1-MMP,MT-MMP 1,MTMMP1,Oryctolagus cuniculus,Rabbit 96T
E2056r ELISA kit Matrix metalloproteinase-14,Membrane-type matrix metalloproteinase 1,Membrane-type-1 matrix metalloproteinase,Mmp14,MMP-14,MT1MMP,MT1-MMP,Mtmmp,MT-MMP,MT-MMP 1,MTMMP1,Rat,Rattus norvegicus 96T
EIAAB25006 Homo sapiens,Human,Matrix metalloproteinase-16,Membrane-type matrix metalloproteinase 3,Membrane-type-3 matrix metalloproteinase,MMP16,MMP-16,MMPX2,MMP-X2,MT3MMP,MT3-MMP,MT-MMP 3,MTMMP3
E2056m ELISA Matrix metalloproteinase-14,Membrane-type matrix metalloproteinase 1,Membrane-type-1 matrix metalloproteinase,Mmp14,MMP-14,MMP-X1,Mouse,MT1MMP,MT1-MMP,Mtmmp,MT-MMP,MT-MMP 1,MTMMP1,Mus musculus 96T
EIAAB25004 Homo sapiens,Human,Matrix metalloproteinase-15,Membrane-type matrix metalloproteinase 2,Membrane-type-2 matrix metalloproteinase,MMP15,MMP-15,MT2MMP,MT2-MMP,MT-MMP 2,MTMMP2,SMCP-2
E2056m ELISA kit Matrix metalloproteinase-14,Membrane-type matrix metalloproteinase 1,Membrane-type-1 matrix metalloproteinase,Mmp14,MMP-14,MMP-X1,Mouse,MT1MMP,MT1-MMP,Mtmmp,MT-MMP,MT-MMP 1,MTMMP1,Mus muscu 96T
E2056h ELISA kit Homo sapiens,Human,Matrix metalloproteinase-14,Membrane-type matrix metalloproteinase 1,Membrane-type-1 matrix metalloproteinase,MMP14,MMP-14,MMP-X1,MT1MMP,MT1-MMP,MT-MMP 1,MTMMP1 96T
U2056r CLIA kit Matrix metalloproteinase-14,Membrane-type matrix metalloproteinase 1,Membrane-type-1 matrix metalloproteinase,Mmp14,MMP-14,MT1MMP,MT1-MMP,Mtmmp,MT-MMP,MT-MMP 1,MTMMP1,Rat,Rattus norvegicus 96T
E2056Rb ELISA Matrix metalloproteinase-14,Membrane-type matrix metalloproteinase 1,Membrane-type-1 matrix metalloproteinase,MMP14,MMP-14,MT1MMP,MT1-MMP,MT-MMP 1,MTMMP1,Oryctolagus cuniculus,Rabbit 96T
U2056m CLIA Matrix metalloproteinase-14,Membrane-type matrix metalloproteinase 1,Membrane-type-1 matrix metalloproteinase,Mmp14,MMP-14,MMP-X1,Mouse,MT1MMP,MT1-MMP,Mtmmp,MT-MMP,MT-MMP 1,MTMMP1,Mus musculus 96T
E2056r ELISA Matrix metalloproteinase-14,Membrane-type matrix metalloproteinase 1,Membrane-type-1 matrix metalloproteinase,Mmp14,MMP-14,MT1MMP,MT1-MMP,Mtmmp,MT-MMP,MT-MMP 1,MTMMP1,Rat,Rattus norvegicus 96T
E2056h ELISA Homo sapiens,Human,Matrix metalloproteinase-14,Membrane-type matrix metalloproteinase 1,Membrane-type-1 matrix metalloproteinase,MMP14,MMP-14,MMP-X1,MT1MMP,MT1-MMP,MT-MMP 1,MTMMP1 96T
E2056Rb ELISA kit Matrix metalloproteinase-14,Membrane-type matrix metalloproteinase 1,Membrane-type-1 matrix metalloproteinase,MMP14,MMP-14,MT1MMP,MT1-MMP,MT-MMP 1,MTMMP1,Oryctolagus cuniculus,Rabbit 96T
U2056m CLIA kit Matrix metalloproteinase-14,Membrane-type matrix metalloproteinase 1,Membrane-type-1 matrix metalloproteinase,Mmp14,MMP-14,MMP-X1,Mouse,MT1MMP,MT1-MMP,Mtmmp,MT-MMP,MT-MMP 1,MTMMP1,Mus muscul 96T
U2056r CLIA Matrix metalloproteinase-14,Membrane-type matrix metalloproteinase 1,Membrane-type-1 matrix metalloproteinase,Mmp14,MMP-14,MT1MMP,MT1-MMP,Mtmmp,MT-MMP,MT-MMP 1,MTMMP1,Rat,Rattus norvegicus 96T
U2056h CLIA kit Homo sapiens,Human,Matrix metalloproteinase-14,Membrane-type matrix metalloproteinase 1,Membrane-type-1 matrix metalloproteinase,MMP14,MMP-14,MMP-X1,MT1MMP,MT1-MMP,MT-MMP 1,MTMMP1 96T
U2056Rb CLIA kit Matrix metalloproteinase-14,Membrane-type matrix metalloproteinase 1,Membrane-type-1 matrix metalloproteinase,MMP14,MMP-14,MT1MMP,MT1-MMP,MT-MMP 1,MTMMP1,Oryctolagus cuniculus,Rabbit 96T
U2056h CLIA Homo sapiens,Human,Matrix metalloproteinase-14,Membrane-type matrix metalloproteinase 1,Membrane-type-1 matrix metalloproteinase,MMP14,MMP-14,MMP-X1,MT1MMP,MT1-MMP,MT-MMP 1,MTMMP1 96T
E2056b ELISA kit Bos taurus,Bovine,Matrix metalloproteinase-14,Membrane-type matrix metalloproteinase 1,Membrane-type-1 matrix metalloproteinase,MMP14,MMP-14,MT1MMP,MT1-MMP,MT-MMP 1,MTMMP1 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur