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Matrix protein 2 (Fragment)

 E7D7C1_9INFA            Unreviewed;        69 AA.
E7D7C1;
08-MAR-2011, integrated into UniProtKB/TrEMBL.
08-MAR-2011, sequence version 1.
30-AUG-2017, entry version 26.
RecName: Full=Matrix protein 2 {ECO:0000256|SAAS:SAAS00395487};
Flags: Fragment;
Name=M2 {ECO:0000313|EMBL:ADN23873.1};
Influenza A virus (A/Korean native chicken/Korea/LBM267/2007(H9N2)).
Viruses; ssRNA viruses; ssRNA negative-strand viruses;
Orthomyxoviridae; Influenzavirus A.
NCBI_TaxID=875354 {ECO:0000313|EMBL:ADN23873.1};
[1] {ECO:0000313|EMBL:ADN23873.1}
NUCLEOTIDE SEQUENCE.
STRAIN=A/Korean native chicken/Korea/LBM267/2007
{ECO:0000313|EMBL:ADN23873.1};
Lee H.-J., Kwon J.-S., Lee D.-H., Lee Y.-N., Song C.-S.;
"The genesis of a novel reassortant H3N2 canine influenza virus
through two-way gene flows between ducks and gallinaceous birds.";
Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:ADN23873.1}
NUCLEOTIDE SEQUENCE.
STRAIN=A/Korean native chicken/Korea/LBM267/2007
{ECO:0000313|EMBL:ADN23873.1};
PubMed=22386854; DOI=10.1016/j.meegid.2012.02.001;
Lee H.J., Lee D.H., Lee Y.N., Kwon J.S., Lee Y.J., Lee J.B.,
Park S.Y., Choi I.S., Song C.S.;
"Generation of reassortant influenza viruses within the non-industrial
poultry system.";
Infect. Genet. Evol. 12:933-946(2012).
-!- FUNCTION: Forms a proton-selective ion channel that is necessary
for the efficient release of the viral genome during virus entry.
After attaching to the cell surface, the virion enters the cell by
endocytosis. Acidification of the endosome triggers M2 ion channel
activity. The influx of protons into virion interior is believed
to disrupt interactions between the viral ribonucleoprotein (RNP),
matrix protein 1 (M1), and lipid bilayers, thereby freeing the
viral genome from interaction with viral proteins and enabling RNA
segments to migrate to the host cell nucleus, where influenza
virus RNA transcription and replication occur. Also plays a role
in viral proteins secretory pathway. Elevates the intravesicular
pH of normally acidic compartments, such as trans-Golgi network,
preventing newly formed hemagglutinin from premature switching to
the fusion-active conformation. {ECO:0000256|SAAS:SAAS00108379}.
-!- SUBUNIT: Homotetramer; composed of two disulfide-linked dimers
held together by non-covalent interactions. May interact with
matrix protein 1. {ECO:0000256|SAAS:SAAS00108524}.
-!- SUBCELLULAR LOCATION: Host apical cell membrane
{ECO:0000256|SAAS:SAAS00581620}; Single-pass type III membrane
protein {ECO:0000256|SAAS:SAAS00581620}.
-!- SUBCELLULAR LOCATION: Virion membrane
{ECO:0000256|SAAS:SAAS00581584}.
-!- SIMILARITY: Belongs to the influenza viruses matrix protein M2
family. {ECO:0000256|SAAS:SAAS00581646}.
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EMBL; HQ143691; ADN23873.1; -; Viral_cRNA.
GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0044385; C:integral to membrane of host cell; IEA:UniProtKB-KW.
GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
GO; GO:0005216; F:ion channel activity; IEA:UniProtKB-KW.
GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:UniProtKB-KW.
GO; GO:0051259; P:protein oligomerization; IEA:UniProtKB-KW.
GO; GO:0039521; P:suppression by virus of host autophagy; IEA:UniProtKB-KW.
InterPro; IPR002089; Flu_M2.
Pfam; PF00599; Flu_M2; 1.
ProDom; PD001031; Flu_M2; 1.
3: Inferred from homology;
Disulfide bond {ECO:0000256|SAAS:SAAS00108279};
Host cell membrane {ECO:0000256|SAAS:SAAS00108156};
Host membrane {ECO:0000256|SAAS:SAAS00108156};
Host-virus interaction {ECO:0000256|SAAS:SAAS00108142};
Hydrogen ion transport {ECO:0000256|SAAS:SAAS00108569};
Inhibition of host autophagy by virus {ECO:0000256|SAAS:SAAS00108142};
Ion channel {ECO:0000256|SAAS:SAAS00108471};
Ion transport {ECO:0000256|SAAS:SAAS00108471,
ECO:0000256|SAAS:SAAS00108569};
Membrane {ECO:0000256|SAAS:SAAS00108156,
ECO:0000256|SAAS:SAAS00108211, ECO:0000256|SAM:Phobius};
Transmembrane {ECO:0000256|SAAS:SAAS00108211,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00108211,
ECO:0000256|SAM:Phobius};
Transport {ECO:0000256|SAAS:SAAS00108471,
ECO:0000256|SAAS:SAAS00108569};
Viral ion channel {ECO:0000256|SAAS:SAAS00108471};
Virion {ECO:0000256|SAAS:SAAS00108457}.
TRANSMEM 17 39 Helical. {ECO:0000256|SAM:Phobius}.
NON_TER 1 1 {ECO:0000313|EMBL:ADN23873.1}.
NON_TER 69 69 {ECO:0000313|EMBL:ADN23873.1}.
SEQUENCE 69 AA; 8027 MW; E2E54655261A8337 CRC64;
PTRNGWECKC SDSSDPLVIA ASIIGILHLI LWILDRLFFK CIYRRLKYGL KRGPSTEGVP
ESMREEYRQ


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