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Mediator of RNA polymerase II transcription subunit 12 (Mediator complex subunit 12) (Protein kohtalo) (Protein motionless) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230)

 MED12_DANRE             Reviewed;        2173 AA.
Q2QCI8;
15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
24-JAN-2006, sequence version 1.
25-OCT-2017, entry version 75.
RecName: Full=Mediator of RNA polymerase II transcription subunit 12;
AltName: Full=Mediator complex subunit 12;
AltName: Full=Protein kohtalo;
AltName: Full=Protein motionless;
AltName: Full=Thyroid hormone receptor-associated protein complex 230 kDa component;
Short=Trap230;
Name=med12; Synonyms=kto, mot, trap230;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
PubMed=16344459; DOI=10.1073/pnas.0509457102;
Hong S.-K., Haldin C.E., Lawson N.D., Weinstein B.M., Dawid I.B.,
Hukriede N.A.;
"The zebrafish kohtalo/trap230 gene is required for the development of
the brain, neural crest, and pronephric kidney.";
Proc. Natl. Acad. Sci. U.S.A. 102:18473-18478(2005).
[2]
FUNCTION.
PubMed=16712834; DOI=10.1016/j.ydbio.2006.04.437;
Rau M.J., Fischer S., Neumann C.J.;
"Zebrafish Trap230/Med12 is required as a coactivator for Sox9-
dependent neural crest, cartilage and ear development.";
Dev. Biol. 296:83-93(2006).
[3]
FUNCTION, AND DEVELOPMENTAL STAGE.
PubMed=17088561; DOI=10.1073/pnas.0605414103;
Wang X., Yang N., Uno E., Roeder R.G., Guo S.;
"A subunit of the mediator complex regulates vertebrate neuronal
development.";
Proc. Natl. Acad. Sci. U.S.A. 103:17284-17289(2006).
-!- FUNCTION: Component of the Mediator complex, a coactivator
involved in regulated gene transcription of nearly all RNA
polymerase II-dependent genes. Mediator functions as a bridge to
convey information from gene-specific regulatory proteins to the
basal RNA polymerase II transcription machinery. Mediator is
recruited to promoters by direct interactions with regulatory
proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general
transcription factors (By similarity). Required for development of
the body axis, brain, ear, kidney, forelimb and neural crest and
for pigmentation. Acts as a coactivator for sox9a and/or sox9b
promoting the expression of several neuronal determination genes.
{ECO:0000250, ECO:0000269|PubMed:16344459,
ECO:0000269|PubMed:16712834, ECO:0000269|PubMed:17088561}.
-!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- DEVELOPMENTAL STAGE: Maternally expressed. Widely expressed in the
early embryo and concentrated in the head by 48 hpf.
{ECO:0000269|PubMed:16344459, ECO:0000269|PubMed:17088561}.
-!- SIMILARITY: Belongs to the Mediator complex subunit 12 family.
{ECO:0000305}.
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EMBL; DQ133567; AAZ73481.1; -; mRNA.
UniGene; Dr.41439; -.
ProteinModelPortal; Q2QCI8; -.
STRING; 7955.ENSDARP00000124576; -.
PaxDb; Q2QCI8; -.
ZFIN; ZDB-GENE-060125-1; med12.
eggNOG; KOG3598; Eukaryota.
eggNOG; ENOG410XP2V; LUCA.
HOVERGEN; HBG052447; -.
InParanoid; Q2QCI8; -.
PhylomeDB; Q2QCI8; -.
PRO; PR:Q2QCI8; -.
Proteomes; UP000000437; Unplaced.
GO; GO:0016592; C:mediator complex; IBA:GO_Central.
GO; GO:0008013; F:beta-catenin binding; IEA:InterPro.
GO; GO:0001105; F:RNA polymerase II transcription coactivator activity; IBA:GO_Central.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IGI:ZFIN.
GO; GO:0021954; P:central nervous system neuron development; IMP:ZFIN.
GO; GO:0043583; P:ear development; IMP:ZFIN.
GO; GO:0048702; P:embryonic neurocranium morphogenesis; IMP:ZFIN.
GO; GO:0035118; P:embryonic pectoral fin morphogenesis; IMP:ZFIN.
GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IMP:ZFIN.
GO; GO:0007492; P:endoderm development; IMP:ZFIN.
GO; GO:0030900; P:forebrain development; IMP:ZFIN.
GO; GO:0021986; P:habenula development; IMP:ZFIN.
GO; GO:0007507; P:heart development; IMP:ZFIN.
GO; GO:0050935; P:iridophore differentiation; IMP:ZFIN.
GO; GO:0001822; P:kidney development; IMP:ZFIN.
GO; GO:0030901; P:midbrain development; IMP:ZFIN.
GO; GO:0014032; P:neural crest cell development; IMP:ZFIN.
GO; GO:0030182; P:neuron differentiation; IMP:ZFIN.
GO; GO:0021982; P:pineal gland development; IMP:ZFIN.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IGI:ZFIN.
GO; GO:0002761; P:regulation of myeloid leukocyte differentiation; IMP:ZFIN.
GO; GO:0021654; P:rhombomere boundary formation; IMP:ZFIN.
GO; GO:0071733; P:transcriptional activation by promoter-enhancer looping; IMP:ZFIN.
GO; GO:0021591; P:ventricular system development; IMP:ZFIN.
InterPro; IPR019035; Mediator_Med12.
InterPro; IPR021989; Mediator_Med12_catenin-bd.
InterPro; IPR021990; Mediator_Med12_LCEWAV.
Pfam; PF09497; Med12; 1.
Pfam; PF12145; Med12-LCEWAV; 1.
Pfam; PF12144; Med12-PQL; 1.
SMART; SM01281; Med12; 1.
2: Evidence at transcript level;
Activator; Complete proteome; Developmental protein; Nucleus;
Reference proteome; Repressor; Transcription;
Transcription regulation.
CHAIN 1 2173 Mediator of RNA polymerase II
transcription subunit 12.
/FTId=PRO_0000312960.
COMPBIAS 1872 2167 Gln-rich.
SEQUENCE 2173 AA; 243992 MW; 9BE52FEAAEB97F88 CRC64;
MAAFGVLSYE HRPLKRPRLG PPDVYPQDPK QKEDELTALN VKQGFNNQPA VSGDEHGSAK
NVNFNSSKIS SNFSSIIAEK LRCNTFPDTG KRKPQVNQKD NFWLVTARSQ SSINNWFTDL
AGTKPLTQLA KKVPIFSKKE EVFGYLAKYS VPVMRSAWMI KMTCAYHAAI TENKMKKRHV
IDPCIEWTPI ITKYLWEQLQ KVAEFYRQSP SQGCGSPLPA PPAEVETAMK QWEYNEKLAM
FMFQDGMLDR HEFLTWVLEC FEKIRPGEDE LLRLLLPLLL QYSGEFVQSA YLSRRLAYFC
TRRLNLLLSD GSIGPGPGGH QAHGISAQQG NALPPTPTSQ PAGGNQPQTP FTDFYICPQH
RPVVFGLSCM LQSIVLCCPS ALVWHYSLTD SRNKTGSPLD LLPIAPSNLP MPGGNSTFNQ
QVRAKVREIE EQIKERGQAV EFRWSFDKCQ ETTAGFTISR VLHTLEVLDN HSFEKSDFSN
SLDSLYNRIF GSGQSKDGHE MSPDDDAVVT LLCEWAVSCK RSGPHRAMVV AKLLEKRQTE
IEAERCGESE VVDEKGSVSS GSLSAATLPV FQDVLLQFLD TQAPVLTEPG NESERVEFSN
LVLLFYELIR HDVFSHNIYM CTLISRGDLA SNSHLPRPRS PSDEPSDESE RKDQDAGSSV
KMEDTGMSES MEIDHNSSAN FDEMFSPPMH CESKGSPSPE KQAQEQESKS TAKDKGMDPA
FPLVYEQPRH IQYATHFPIP QEESASHECN QRLVVLYGVG KQRDEARHAI KKITKDILKV
LNRKSTAETG GEEGQKRKRS KPEAFPTAED IFSKFQHLSH FDQHQVTSQV SRNVLEQITS
FALGMSYHLP LVQHIQFIFD LMEYSLNISG LIDFAIQLLN ELSLVEAELL LKSSNLAGSY
TTGLCLCIVA VLRRYHSCLI LNPDQTAQVF DGLRIVVKSG VNPADCSSAE RCILAYLYDL
YTSCSHLKSK FGEIFSEFCS KVKNSIYYNI DPSDSNMLWD QMFMIDAITN PTAHNLNHSM
LGKITNELND SPANRYSFVC NVLMDVCVDH RDPERVNDIG ILCAELTAYC RSLSAEWLGV
LKALCCSSNN GNCGFNDLLC NVDVSDLSFH DSLATFVAIL IARQCLLLED LVRCVAIPSL
LNAACSEQDS EPGARLTCRI LLHLFRTPQR NPCPQDGTKS DKSIVGIRSS CDRHLLAASQ
NSIVVGAVFA VLKAVFMLGD AELKGSGFSH PAGLDDIGED DMGSKKSGGR NVSIETASLV
VYAKYVLKSI CHQEWVGERC LKSLSEDSSA LQDPVLVNIQ AQRLLQLICY PHRQLDSEEG
DNPQRQRIKR ILQNMDQWTM RQSSLELQLM IKQSSNNELY SLLENIAKAT IEVFQKSAEM
NSSNPSWNGS AVSGSSVSNS NSASKLKPVL SSSERSGVWL VAPLIGKLPT SVQGHVLKAA
GEELEKGQHL GPSSRKERDR QKQKSMSLLS QQPFLSLVLT CLKGQDEQRE GLLTSLYSQV
QQIVTNWRED QYQDDCKAKQ MMHEALKLRL NLVGGMFDTV QRSTQQTTEW AVLLLDIISS
GTVDMQSNNE LFTTVLDMLS VLINGTLAAD MSSISQGSME ENKRAYMNLV KKLRKELGDR
QSESLEKVRQ LLPLPKQTRD VITCEPQGSL IDTKGNKIAG FEKEGLQVST KQKISPWDVF
EGLKHSAPLS WGWFGTIRVD RKVTKFEEQQ RLLLYHTHIK PKQRSYYLAP LNLPQEEEEP
LTPVPPEPDK KLDTAKVEKS VSNVPTKKKK KKPASTVKQE DYKPHNTVMQ YAPGMTPDLP
LSMGQTNMSY RMGYQAPMNM YAQNQPLPPG GPGLEPPFRP RVPMNKMPPR PNYTMPNMQT
AGMGNLMGME KQYQMNYKPM PNMAQGQMLR HQLQGHNHLI GQQIRQVTPN PQYSSMQPAQ
NIPQGYTSYG SHMGMQPHPS QTPGMVPNSY GNQGFQTGHP ATNPTMVDSI RQMQQRPGYV
HQQAPAAYGH TIQSTQRFPH QSMQQTPMMH GLAQSHLGVQ GIHPNMRPNQ MMEQQQQQQQ
QQQQQQQQQQ QVHQQQQHIR QGPVFRPQQQ QQVQQQVQQQ VQQQQVQQQQ VQQQVQPQQV
QQQQVQQQQQ QQVSAAQPPA QALGMQALPP QQPMFQRQGM QQTQQQQQTA ALVRQLQQQL
SSTQPAQNNS SYY


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