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Mediator of RNA polymerase II transcription subunit 14 (Mediator complex subunit 14) (Mediator of RNA polymerase II complex subunit pmc1)

 MED14_SCHPO             Reviewed;         879 AA.
Q9P7Y4; O74344;
06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 2.
20-JUN-2018, entry version 103.
RecName: Full=Mediator of RNA polymerase II transcription subunit 14;
AltName: Full=Mediator complex subunit 14;
AltName: Full=Mediator of RNA polymerase II complex subunit pmc1;
Name=med14; Synonyms=pmc1; ORFNames=SPBC1A4.10c, SPBP23A10.01c;
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
Schizosaccharomycetes; Schizosaccharomycetales;
Schizosaccharomycetaceae; Schizosaccharomyces.
NCBI_TaxID=284812;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=972 / ATCC 24843;
PubMed=11859360; DOI=10.1038/nature724;
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[2]
IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN THE
MEDIATOR COMPLEX.
STRAIN=972 / ATCC 24843;
PubMed=10625684; DOI=10.1074/jbc.275.2.1351;
Spaehr H., Beve J., Larsson T., Bergstroem J., Karlsson K.-A.,
Gustafsson C.M.;
"Purification and characterization of RNA polymerase II holoenzyme
from Schizosaccharomyces pombe.";
J. Biol. Chem. 275:1351-1356(2000).
-!- FUNCTION: Component of the Mediator complex, a coactivator
involved in the regulated transcription of nearly all RNA
polymerase II-dependent genes. Mediator functions as a bridge to
convey information from gene-specific regulatory proteins to the
basal RNA polymerase II transcription machinery. Mediator is
recruited to promoters by direct interactions with regulatory
proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general
transcription factors.
-!- SUBUNIT: Component of the Mediator complex.
{ECO:0000269|PubMed:10625684}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
-!- SIMILARITY: Belongs to the Mediator complex subunit 14 family.
{ECO:0000305}.
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EMBL; CU329671; CAA20115.1; -; Genomic_DNA.
PIR; T39859; T50388.
RefSeq; NP_595813.2; NM_001021716.3.
PDB; 5N9J; X-ray; 3.40 A; A=2-580.
PDB; 5U0P; EM; 4.40 A; N=1-879.
PDB; 5U0S; EM; 7.80 A; N=1-879.
PDBsum; 5N9J; -.
PDBsum; 5U0P; -.
PDBsum; 5U0S; -.
SMR; Q9P7Y4; -.
BioGrid; 277203; 71.
IntAct; Q9P7Y4; 1.
STRING; 4896.SPBC1A4.10c.1; -.
MaxQB; Q9P7Y4; -.
PaxDb; Q9P7Y4; -.
PRIDE; Q9P7Y4; -.
EnsemblFungi; SPBC1A4.10c.1; SPBC1A4.10c.1:pep; SPBC1A4.10c.
GeneID; 2540678; -.
KEGG; spo:SPBC1A4.10c; -.
EuPathDB; FungiDB:SPBC1A4.10c; -.
PomBase; SPBC1A4.10c; med14.
InParanoid; Q9P7Y4; -.
KO; K15156; -.
OrthoDB; EOG092C0NN4; -.
PRO; PR:Q9P7Y4; -.
Proteomes; UP000002485; Chromosome II.
GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
GO; GO:0005829; C:cytosol; HDA:PomBase.
GO; GO:0016592; C:mediator complex; IDA:PomBase.
GO; GO:0005634; C:nucleus; HDA:PomBase.
GO; GO:0001104; F:RNA polymerase II transcription cofactor activity; IBA:GO_Central.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IC:PomBase.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR013947; Mediator_Med14.
Pfam; PF08638; Med14; 1.
1: Evidence at protein level;
3D-structure; Activator; Complete proteome; Nucleus;
Reference proteome; Transcription; Transcription regulation.
CHAIN 1 879 Mediator of RNA polymerase II
transcription subunit 14.
/FTId=PRO_0000096361.
STRAND 11 15 {ECO:0000244|PDB:5N9J}.
HELIX 16 37 {ECO:0000244|PDB:5N9J}.
TURN 38 40 {ECO:0000244|PDB:5N9J}.
HELIX 43 70 {ECO:0000244|PDB:5N9J}.
HELIX 71 73 {ECO:0000244|PDB:5N9J}.
HELIX 74 111 {ECO:0000244|PDB:5N9J}.
HELIX 118 125 {ECO:0000244|PDB:5N9J}.
HELIX 130 135 {ECO:0000244|PDB:5N9J}.
HELIX 137 142 {ECO:0000244|PDB:5N9J}.
HELIX 151 171 {ECO:0000244|PDB:5N9J}.
HELIX 177 179 {ECO:0000244|PDB:5N9J}.
STRAND 181 184 {ECO:0000244|PDB:5N9J}.
STRAND 186 193 {ECO:0000244|PDB:5N9J}.
STRAND 197 199 {ECO:0000244|PDB:5N9J}.
STRAND 201 205 {ECO:0000244|PDB:5N9J}.
HELIX 212 218 {ECO:0000244|PDB:5N9J}.
TURN 219 221 {ECO:0000244|PDB:5N9J}.
STRAND 227 230 {ECO:0000244|PDB:5N9J}.
HELIX 235 254 {ECO:0000244|PDB:5N9J}.
HELIX 258 287 {ECO:0000244|PDB:5N9J}.
HELIX 291 293 {ECO:0000244|PDB:5N9J}.
STRAND 294 299 {ECO:0000244|PDB:5N9J}.
TURN 300 303 {ECO:0000244|PDB:5N9J}.
STRAND 304 309 {ECO:0000244|PDB:5N9J}.
STRAND 327 334 {ECO:0000244|PDB:5N9J}.
HELIX 339 344 {ECO:0000244|PDB:5N9J}.
STRAND 356 364 {ECO:0000244|PDB:5N9J}.
STRAND 367 371 {ECO:0000244|PDB:5N9J}.
HELIX 379 401 {ECO:0000244|PDB:5N9J}.
STRAND 408 411 {ECO:0000244|PDB:5N9J}.
STRAND 414 419 {ECO:0000244|PDB:5N9J}.
STRAND 422 428 {ECO:0000244|PDB:5N9J}.
TURN 430 432 {ECO:0000244|PDB:5N9J}.
STRAND 435 445 {ECO:0000244|PDB:5N9J}.
HELIX 448 458 {ECO:0000244|PDB:5N9J}.
HELIX 464 485 {ECO:0000244|PDB:5N9J}.
TURN 486 488 {ECO:0000244|PDB:5N9J}.
STRAND 490 492 {ECO:0000244|PDB:5N9J}.
STRAND 500 504 {ECO:0000244|PDB:5N9J}.
HELIX 506 508 {ECO:0000244|PDB:5N9J}.
HELIX 511 513 {ECO:0000244|PDB:5N9J}.
STRAND 515 521 {ECO:0000244|PDB:5N9J}.
TURN 522 525 {ECO:0000244|PDB:5N9J}.
STRAND 526 532 {ECO:0000244|PDB:5N9J}.
STRAND 534 536 {ECO:0000244|PDB:5N9J}.
STRAND 538 544 {ECO:0000244|PDB:5N9J}.
HELIX 553 575 {ECO:0000244|PDB:5N9J}.
SEQUENCE 879 AA; 100834 MW; C6449D586FB613E8 CRC64;
MEPPAIPHIT EGFYPLPEIV ETFSHHVLQE LVSLAEVLPS MSNVEKKKKI LDWLLRSRAF
TMRLLVLARW VHLSPSVHRC IDVVAFLQGQ KFCFQNLVHV LQDIRYQLSF ARLRNSDLVT
ALDILSTGTS LRLANAPTSK LYMLSESPLS TKQILQTLHA LNMLIRIRLS LYEIIPTPFQ
HFTIANGRCT FTVPNEFSVS LTTNSQDPKS TGISFQWIVV DFQFHLPDFS STPAKYRVFI
ELHLNEEIAA AFVLQKPILP LIYNILHKFC LYQRLNLLSQ QTFQLSRESW LGHLRGVYDE
KPPRLRLYYW PQLNVKKEGK PGKIGHYIHI FVNTQPISAF ERTLSSKRSS CEYDHFLLLV
EWHHDGIVEH VPLDDHMDAQ HLLLLITQKH AQLILEQIRK ELHPNIFSEH VGGGLKIHVF
DNEIIVKVNS VTGRLVLSSS ASPLSPPRHL RAAEKNIALN TQPPAQILNR LYFFCIQTQL
LEVAQCAELH AVQGYYSFPY LTFSKGKWRK DGDSLWVLAY NVESNSWSVR LLNAAGQTLY
TQDVHTTKGT LSIESFSRLS YLLEVQILLF NVQTACQARG MPFEYLPIPP KALIEDDFTT
YVQTGCLCIM MPSSNEDMLP VVFVRAHDGQ LIFDSRIKGK LPYQSETETE KNCYIDWRTG
RITIRVQNFS SFEKTWIGLL KLVALSKTSA FNVDCITLKH VDFTYLDDEK FRATIHDDNT
FTLHFFNRHS PFHLISQFLQ DTFSDGPSAI QPLRVIMDRT RGVLVAQELG YVVLARSLRQ
YRIILSKNHG IQVLLNRHGC ILQDLSYLSA DSRYLEGTQT LTSQWEPCSW LNTVWEGDLG
DDELNGQIEA APEMHLIKMN KTADLTAILK RILAISRKK


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