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Mediator of RNA polymerase II transcription subunit 28 (Endothelial-derived protein 1) (Mediator complex subunit 28) (Merlin and Grb2-interacting cytoskeletal protein) (Magicin) (Tumor angiogenesis marker EG-1)

 MED28_HUMAN             Reviewed;         178 AA.
Q9H204; Q9BZJ5;
01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
27-SEP-2017, entry version 135.
RecName: Full=Mediator of RNA polymerase II transcription subunit 28;
AltName: Full=Endothelial-derived protein 1;
AltName: Full=Mediator complex subunit 28;
AltName: Full=Merlin and Grb2-interacting cytoskeletal protein;
Short=Magicin;
AltName: Full=Tumor angiogenesis marker EG-1;
Name=MED28; Synonyms=EG1; ORFNames=FKSG20;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
PubMed=11779215; DOI=10.1006/bbrc.2001.6119;
Liu C., Zhang L., Shao Z.-M., Beatty P., Sartippour M., Lane T.F.,
Barsky S.H., Livingston E., Nguyen M.H.;
"Identification of a novel endothelial-derived gene EG-1.";
Biochem. Biophys. Res. Commun. 290:602-612(2002).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Wang Y.-G., Gong L.;
"Cloning of FKSG20, a novel gene expressed in adrenal gland tumor
tissues.";
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA].
Mai N., Liu C.;
"A gene from tumor.";
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN THE
MEDIATOR COMPLEX.
PubMed=15175163; DOI=10.1016/j.molcel.2004.05.006;
Sato S., Tomomori-Sato C., Parmely T.J., Florens L., Zybailov B.,
Swanson S.K., Banks C.A.S., Jin J., Cai Y., Washburn M.P.,
Conaway J.W., Conaway R.C.;
"A set of consensus mammalian mediator subunits identified by
multidimensional protein identification technology.";
Mol. Cell 14:685-691(2004).
[6]
FUNCTION IN SIGNALING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
INTERACTION WITH ACTIN; NF2 AND GRB2.
PubMed=15467741; DOI=10.1038/sj.onc.1208110;
Wiederhold T., Lee M.-F., James M., Neujahr R., Smith N., Murthy A.,
Hartwig J., Gusella J.F., Ramesh V.;
"Magicin, a novel cytoskeletal protein associates with the NF2 tumor
suppressor merlin and Grb2.";
Oncogene 23:8815-8825(2004).
[7]
INTERACTION WITH CCNC; MED1; MED6; MED12; MED13; MED16; MED17; MED20;
MED21 AND MED24, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION
IN THE MEDIATOR COMPLEX, AND ASSOCIATION OF THE MEDIATOR COMPLEX WITH
RNA POLYMERASE II.
PubMed=15989967; DOI=10.1016/j.molcel.2005.05.015;
Zhang X., Krutchinsky A., Fukuda A., Chen W., Yamamura S., Chait B.T.,
Roeder R.G.;
"MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation
enriched in RNA polymerase II and is required for ER-mediated
transcription.";
Mol. Cell 19:89-100(2005).
[8]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
-!- FUNCTION: Component of the Mediator complex, a coactivator
involved in the regulated transcription of nearly all RNA
polymerase II-dependent genes. Mediator functions as a bridge to
convey information from gene-specific regulatory proteins to the
basal RNA polymerase II transcription machinery. Mediator is
recruited to promoters by direct interactions with regulatory
proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general
transcription factors. May be part of a complex containing
NF2/merlin that participates in cellular signaling to the actin
cytoskeleton downstream of tyrosine kinase signaling pathways.
{ECO:0000269|PubMed:15467741}.
-!- SUBUNIT: Component of the Mediator complex, which is composed of
MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13,
MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21,
MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31,
CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8
subunits form a distinct module termed the CDK8 module. Mediator
containing the CDK8 module is less active than Mediator lacking
this module in supporting transcriptional activation. Individual
preparations of the Mediator complex lacking one or more distinct
subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and
TRAP. Forms a ternary complex with NF2/merlin and GRB2. Binds to
actin. {ECO:0000269|PubMed:15175163, ECO:0000269|PubMed:15989967}.
-!- INTERACTION:
P03255:- (xeno); NbExp=2; IntAct=EBI-514199, EBI-2603114;
P06241:FYN; NbExp=6; IntAct=EBI-514199, EBI-515315;
P62993:GRB2; NbExp=3; IntAct=EBI-514199, EBI-401755;
P06239:LCK; NbExp=4; IntAct=EBI-514199, EBI-1348;
Q5TCQ9:MAGI3; NbExp=2; IntAct=EBI-514199, EBI-310506;
Q9D8C6:Med11 (xeno); NbExp=2; IntAct=EBI-514199, EBI-6260909;
Q15528:MED22; NbExp=2; IntAct=EBI-514199, EBI-394687;
Q9NX70:MED29; NbExp=3; IntAct=EBI-514199, EBI-394656;
Q96HR3:MED30; NbExp=6; IntAct=EBI-514199, EBI-394659;
Q9CQI9:Med30 (xeno); NbExp=2; IntAct=EBI-514199, EBI-309220;
Q9D7W5:Med8 (xeno); NbExp=2; IntAct=EBI-514199, EBI-7990252;
P35240:NF2; NbExp=4; IntAct=EBI-514199, EBI-1014472;
P35240-1:NF2; NbExp=2; IntAct=EBI-514199, EBI-1014500;
Q96LA8:PRMT6; NbExp=2; IntAct=EBI-514199, EBI-912440;
Q9UHX1:PUF60; NbExp=6; IntAct=EBI-514199, EBI-1053259;
Q8NA61:SPERT; NbExp=3; IntAct=EBI-514199, EBI-741724;
P12931:SRC; NbExp=3; IntAct=EBI-514199, EBI-621482;
P07947:YES1; NbExp=2; IntAct=EBI-514199, EBI-515331;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15467741}.
Cytoplasm {ECO:0000269|PubMed:15467741}. Membrane
{ECO:0000269|PubMed:15467741}; Peripheral membrane protein
{ECO:0000269|PubMed:15467741}. Note=According to PubMed:15467741,
it is cytoplasmic and mainly membrane-associated.
-!- TISSUE SPECIFICITY: Widely expressed. Highly expressed in vascular
tissues such as placenta, testis and liver.
{ECO:0000269|PubMed:15467741}.
-!- INDUCTION: Up-regulated by endothelial cells when exposed to tumor
conditional media. {ECO:0000269|PubMed:11779215}.
-!- SIMILARITY: Belongs to the Mediator complex subunit 28 family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAK11563.1; Type=Frameshift; Positions=165; Evidence={ECO:0000305};
-!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
and Haematology;
URL="http://atlasgeneticsoncology.org/Genes/MED28ID50131ch4p15.html";
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
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EMBL; AF321617; AAG38612.1; -; mRNA.
EMBL; AF358829; AAK32724.1; -; mRNA.
EMBL; AF318059; AAL26906.1; -; mRNA.
EMBL; AF317680; AAK11563.1; ALT_FRAME; mRNA.
EMBL; BC011936; AAH11936.1; -; mRNA.
CCDS; CCDS33963.1; -.
RefSeq; NP_079481.2; NM_025205.4.
UniGene; Hs.731966; -.
ProteinModelPortal; Q9H204; -.
BioGrid; 123219; 86.
CORUM; Q9H204; -.
IntAct; Q9H204; 57.
MINT; MINT-1434492; -.
STRING; 9606.ENSP00000237380; -.
iPTMnet; Q9H204; -.
PhosphoSitePlus; Q9H204; -.
BioMuta; MED28; -.
DMDM; 59799838; -.
EPD; Q9H204; -.
MaxQB; Q9H204; -.
PaxDb; Q9H204; -.
PeptideAtlas; Q9H204; -.
PRIDE; Q9H204; -.
DNASU; 80306; -.
Ensembl; ENST00000237380; ENSP00000237380; ENSG00000118579.
GeneID; 80306; -.
KEGG; hsa:80306; -.
UCSC; uc003gpk.2; human.
CTD; 80306; -.
DisGeNET; 80306; -.
EuPathDB; HostDB:ENSG00000118579.11; -.
GeneCards; MED28; -.
HGNC; HGNC:24628; MED28.
HPA; HPA035900; -.
HPA; HPA035901; -.
MIM; 610311; gene.
neXtProt; NX_Q9H204; -.
OpenTargets; ENSG00000118579; -.
PharmGKB; PA134935853; -.
eggNOG; ENOG410IETV; Eukaryota.
eggNOG; ENOG4111HUA; LUCA.
GeneTree; ENSGT00390000006192; -.
HOGENOM; HOG000113540; -.
HOVERGEN; HBG052448; -.
InParanoid; Q9H204; -.
KO; K15141; -.
PhylomeDB; Q9H204; -.
TreeFam; TF326988; -.
Reactome; R-HSA-1989781; PPARA activates gene expression.
Reactome; R-HSA-381340; Transcriptional regulation of white adipocyte differentiation.
SIGNOR; Q9H204; -.
ChiTaRS; MED28; human.
GeneWiki; MED28; -.
GenomeRNAi; 80306; -.
PRO; PR:Q9H204; -.
Proteomes; UP000005640; Chromosome 4.
Bgee; ENSG00000118579; -.
CleanEx; HS_MED28; -.
ExpressionAtlas; Q9H204; baseline and differential.
Genevisible; Q9H204; HS.
GO; GO:0030864; C:cortical actin cytoskeleton; IEA:Ensembl.
GO; GO:0016592; C:mediator complex; IBA:GO_Central.
GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO; GO:0051151; P:negative regulation of smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0019827; P:stem cell population maintenance; IEA:Ensembl.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR021640; Mediator_Med28.
Pfam; PF11594; Med28; 1.
1: Evidence at protein level;
Actin-binding; Activator; Coiled coil; Complete proteome; Cytoplasm;
Membrane; Nucleus; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 178 Mediator of RNA polymerase II
transcription subunit 28.
/FTId=PRO_0000113981.
COILED 109 145 {ECO:0000255}.
SEQUENCE 178 AA; 19520 MW; 63DE023972908066 CRC64;
MAAPLGGMFS GQPPGPPQAP PGLPGQASLL QAAPGAPRPS SSTLVDELES SFEACFASLV
SQDYVNGTDQ EEIRTGVDQC IQKFLDIARQ TECFFLQKRL QLSVQKPEQV IKEDVSELRN
ELQRKDALVQ KHLTKLRHWQ QVLEDINVQH KKPADIPQGS LAYLEQASAN IPAPLKPT


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