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Mediator of RNA polymerase II transcription subunit 4 (Activator-recruited cofactor 36 kDa component) (ARC36) (Mediator complex subunit 4) (TRAP/SMCC/PC2 subunit p36 subunit) (Vitamin D3 receptor-interacting protein complex 36 kDa component) (DRIP36)

 MED4_HUMAN              Reviewed;         270 AA.
Q9NPJ6; B4DX67; Q53GB4; Q53H68; Q5T912; Q6FHC4; Q6IA79; Q9BS95;
Q9NYR5;
28-FEB-2003, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
22-NOV-2017, entry version 152.
RecName: Full=Mediator of RNA polymerase II transcription subunit 4;
AltName: Full=Activator-recruited cofactor 36 kDa component;
Short=ARC36;
AltName: Full=Mediator complex subunit 4;
AltName: Full=TRAP/SMCC/PC2 subunit p36 subunit;
AltName: Full=Vitamin D3 receptor-interacting protein complex 36 kDa component;
Short=DRIP36;
Name=MED4; Synonyms=ARC36, DRIP36, VDRIP; ORFNames=HSPC126;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=10235266; DOI=10.1038/19783;
Rachez C., Lemon B.D., Suldan Z., Bromleigh V., Gamble M.,
Naeaer A.M., Erdjument-Bromage H., Tempst P., Freedman L.P.;
"Ligand-dependent transcription activation by nuclear receptors
requires the DRIP complex.";
Nature 398:824-828(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND PROTEIN SEQUENCE OF 14-27
AND 30-42.
PubMed=10882111; DOI=10.1016/S1097-2765(00)80254-3;
Malik S., Gu W., Wu W., Qin J., Roeder R.G.;
"The USA-derived transcriptional coactivator PC2 is a submodule of
TRAP/SMCC and acts synergistically with other PCs.";
Mol. Cell 5:753-760(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Umbilical cord blood;
PubMed=11042152; DOI=10.1101/gr.140200;
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
"Cloning and functional analysis of cDNAs with open reading frames for
300 previously undefined genes expressed in CD34+ hematopoietic
stem/progenitor cells.";
Genome Res. 10:1546-1560(2000).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
TISSUE=Placenta, and Testis;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S.,
Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W.,
Korn B., Zuo D., Hu Y., LaBaer J.;
"Cloning of human full open reading frames in Gateway(TM) system entry
vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain, and Small intestine;
Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
Tanaka A., Yokoyama S.;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15057823; DOI=10.1038/nature02379;
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E.,
Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E.,
Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.,
Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R.,
Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S.,
Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M.,
Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J.,
Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E.,
Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L.,
Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J.,
Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S.,
Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J.,
Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M.,
King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A.,
Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S.,
Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I.,
Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S.,
Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A.,
Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B.,
Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L.,
Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M.,
Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
"The DNA sequence and analysis of human chromosome 13.";
Nature 428:522-528(2004).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[9]
IDENTIFICATION IN ARC COMPLEX, AND PROTEIN SEQUENCE OF 81-88; 154-165
AND 173-183.
PubMed=10235267; DOI=10.1038/19789;
Naeaer A.M., Beaurang P.A., Zhou S., Abraham S., Solomon W.B.,
Tjian R.;
"Composite co-activator ARC mediates chromatin-directed
transcriptional activation.";
Nature 398:828-832(1999).
[10]
IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN THE
MEDIATOR COMPLEX.
PubMed=15175163; DOI=10.1016/j.molcel.2004.05.006;
Sato S., Tomomori-Sato C., Parmely T.J., Florens L., Zybailov B.,
Swanson S.K., Banks C.A.S., Jin J., Cai Y., Washburn M.P.,
Conaway J.W., Conaway R.C.;
"A set of consensus mammalian mediator subunits identified by
multidimensional protein identification technology.";
Mol. Cell 14:685-691(2004).
[11]
IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR
COMPLEX, AND ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE
II.
PubMed=15989967; DOI=10.1016/j.molcel.2005.05.015;
Zhang X., Krutchinsky A., Fukuda A., Chen W., Yamamura S., Chait B.T.,
Roeder R.G.;
"MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation
enriched in RNA polymerase II and is required for ER-mediated
transcription.";
Mol. Cell 19:89-100(2005).
[12]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19369195; DOI=10.1074/mcp.M800588-MCP200;
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,
Mann M., Daub H.;
"Large-scale proteomics analysis of the human kinome.";
Mol. Cell. Proteomics 8:1751-1764(2009).
[13]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Leukemic T-cell;
PubMed=19690332; DOI=10.1126/scisignal.2000007;
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
Rodionov V., Han D.K.;
"Quantitative phosphoproteomic analysis of T cell receptor signaling
reveals system-wide modulation of protein-protein interactions.";
Sci. Signal. 2:RA46-RA46(2009).
[14]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[15]
ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22814378; DOI=10.1073/pnas.1210303109;
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
Aldabe R.;
"N-terminal acetylome analyses and functional insights of the N-
terminal acetyltransferase NatB.";
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
-!- FUNCTION: Component of the Mediator complex, a coactivator
involved in the regulated transcription of nearly all RNA
polymerase II-dependent genes. Mediator functions as a bridge to
convey information from gene-specific regulatory proteins to the
basal RNA polymerase II transcription machinery. Mediator is
recruited to promoters by direct interactions with regulatory
proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general
transcription factors.
-!- SUBUNIT: Component of the Mediator complex, which is composed of
MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13,
MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21,
MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31,
CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8
subunits form a distinct module termed the CDK8 module. Mediator
containing the CDK8 module is less active than Mediator lacking
this module in supporting transcriptional activation. Individual
preparations of the Mediator complex lacking one or more distinct
subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and
TRAP. {ECO:0000269|PubMed:10235267, ECO:0000269|PubMed:15175163,
ECO:0000269|PubMed:15989967}.
-!- INTERACTION:
Q08117:AES; NbExp=3; IntAct=EBI-394607, EBI-717810;
Q4VCS5-2:AMOT; NbExp=5; IntAct=EBI-394607, EBI-3891843;
Q8TAB5:C1orf216; NbExp=3; IntAct=EBI-394607, EBI-747505;
Q8IYE0-2:CCDC146; NbExp=3; IntAct=EBI-394607, EBI-10247802;
Q8TD31-3:CCHCR1; NbExp=5; IntAct=EBI-394607, EBI-10175300;
Q8WYA6:CTNNBL1; NbExp=3; IntAct=EBI-394607, EBI-748128;
Q8NE31:FAM13C; NbExp=3; IntAct=EBI-394607, EBI-751248;
Q96NE9:FRMD6; NbExp=3; IntAct=EBI-394607, EBI-741729;
O95954:FTCD; NbExp=3; IntAct=EBI-394607, EBI-10192648;
Q96CN9:GCC1; NbExp=4; IntAct=EBI-394607, EBI-746252;
Q96CS2:HAUS1; NbExp=3; IntAct=EBI-394607, EBI-2514791;
Q8IY31:IFT20; NbExp=3; IntAct=EBI-394607, EBI-744203;
Q9BVG8:KIFC3; NbExp=3; IntAct=EBI-394607, EBI-2125614;
Q9BVG8-5:KIFC3; NbExp=4; IntAct=EBI-394607, EBI-14069005;
Q32MZ4-4:LRRFIP1; NbExp=3; IntAct=EBI-394607, EBI-10240044;
Q8N8X9:MAB21L3; NbExp=3; IntAct=EBI-394607, EBI-10268010;
Q96EZ8:MCRS1; NbExp=5; IntAct=EBI-394607, EBI-348259;
Q93074:MED12; NbExp=6; IntAct=EBI-394607, EBI-394357;
O95402:MED26; NbExp=9; IntAct=EBI-394607, EBI-394392;
Q9NWA0:MED9; NbExp=10; IntAct=EBI-394607, EBI-394653;
O14777:NDC80; NbExp=3; IntAct=EBI-394607, EBI-715849;
O00560:SDCBP; NbExp=3; IntAct=EBI-394607, EBI-727004;
Q96ES7:SGF29; NbExp=3; IntAct=EBI-394607, EBI-743117;
Q96GM5:SMARCD1; NbExp=5; IntAct=EBI-394607, EBI-358489;
Q969G3:SMARCE1; NbExp=3; IntAct=EBI-394607, EBI-455078;
Q99909:SSX3; NbExp=5; IntAct=EBI-394607, EBI-10295431;
O95379:TNFAIP8; NbExp=6; IntAct=EBI-394607, EBI-1049336;
P40222:TXLNA; NbExp=5; IntAct=EBI-394607, EBI-359793;
Q8N3L3:TXLNB; NbExp=4; IntAct=EBI-394607, EBI-6116822;
Q8N6Y0:USHBP1; NbExp=5; IntAct=EBI-394607, EBI-739895;
-!- SUBCELLULAR LOCATION: Nucleus.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q9NPJ6-1; Sequence=Displayed;
Name=2;
IsoId=Q9NPJ6-2; Sequence=VSP_047072;
-!- SIMILARITY: Belongs to the Mediator complex subunit 4 family.
{ECO:0000305}.
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EMBL; AF300618; AAG22542.1; -; mRNA.
EMBL; AF230381; AAF37289.1; -; mRNA.
EMBL; AF161475; AAF29090.1; -; mRNA.
EMBL; AK001934; BAA91987.1; -; mRNA.
EMBL; CR457276; CAG33557.1; -; mRNA.
EMBL; CR541830; CAG46629.1; -; mRNA.
EMBL; AK222713; BAD96433.1; -; mRNA.
EMBL; AK301835; BAG63279.1; -; mRNA.
EMBL; AK223017; BAD96737.1; -; mRNA.
EMBL; AL158196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC005189; AAH05189.1; -; mRNA.
CCDS; CCDS59241.1; -. [Q9NPJ6-2]
CCDS; CCDS9408.1; -. [Q9NPJ6-1]
RefSeq; NP_001257558.1; NM_001270629.1. [Q9NPJ6-2]
RefSeq; NP_054885.1; NM_014166.3. [Q9NPJ6-1]
UniGene; Hs.181112; -.
UniGene; Hs.741275; -.
ProteinModelPortal; Q9NPJ6; -.
SMR; Q9NPJ6; -.
BioGrid; 118849; 368.
CORUM; Q9NPJ6; -.
IntAct; Q9NPJ6; 88.
MINT; MINT-1196457; -.
STRING; 9606.ENSP00000258648; -.
iPTMnet; Q9NPJ6; -.
PhosphoSitePlus; Q9NPJ6; -.
DMDM; 29840770; -.
EPD; Q9NPJ6; -.
MaxQB; Q9NPJ6; -.
PaxDb; Q9NPJ6; -.
PeptideAtlas; Q9NPJ6; -.
PRIDE; Q9NPJ6; -.
DNASU; 29079; -.
Ensembl; ENST00000258648; ENSP00000258648; ENSG00000136146. [Q9NPJ6-1]
Ensembl; ENST00000378586; ENSP00000367849; ENSG00000136146. [Q9NPJ6-2]
GeneID; 29079; -.
KEGG; hsa:29079; -.
UCSC; uc001vby.3; human. [Q9NPJ6-1]
CTD; 29079; -.
DisGeNET; 29079; -.
EuPathDB; HostDB:ENSG00000136146.14; -.
GeneCards; MED4; -.
HGNC; HGNC:17903; MED4.
HPA; HPA006232; -.
MIM; 605718; gene.
neXtProt; NX_Q9NPJ6; -.
OpenTargets; ENSG00000136146; -.
PharmGKB; PA134877001; -.
eggNOG; KOG4552; Eukaryota.
eggNOG; ENOG410XQ30; LUCA.
GeneTree; ENSGT00390000012063; -.
HOGENOM; HOG000043883; -.
HOVERGEN; HBG052450; -.
InParanoid; Q9NPJ6; -.
KO; K15146; -.
OMA; SGEIHMS; -.
OrthoDB; EOG091G0M8S; -.
PhylomeDB; Q9NPJ6; -.
TreeFam; TF324421; -.
Reactome; R-HSA-1989781; PPARA activates gene expression.
Reactome; R-HSA-212436; Generic Transcription Pathway.
Reactome; R-HSA-381340; Transcriptional regulation of white adipocyte differentiation.
ChiTaRS; MED4; human.
GeneWiki; MED4; -.
GenomeRNAi; 29079; -.
PRO; PR:Q9NPJ6; -.
Proteomes; UP000005640; Chromosome 13.
Bgee; ENSG00000136146; -.
CleanEx; HS_MED4; -.
ExpressionAtlas; Q9NPJ6; baseline and differential.
Genevisible; Q9NPJ6; HS.
GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
GO; GO:0016592; C:mediator complex; IDA:UniProtKB.
GO; GO:0016020; C:membrane; IDA:UniProtKB.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; NAS:UniProtKB.
GO; GO:0004872; F:receptor activity; IDA:UniProtKB.
GO; GO:0001104; F:RNA polymerase II transcription cofactor activity; IDA:UniProtKB.
GO; GO:0046966; F:thyroid hormone receptor binding; IDA:UniProtKB.
GO; GO:0003712; F:transcription cofactor activity; IDA:UniProtKB.
GO; GO:0042809; F:vitamin D receptor binding; NAS:UniProtKB.
GO; GO:0030521; P:androgen receptor signaling pathway; IDA:UniProtKB.
GO; GO:0030518; P:intracellular steroid hormone receptor signaling pathway; IDA:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0006366; P:transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IDA:UniProtKB.
InterPro; IPR019258; Mediator_Med4.
PANTHER; PTHR13208; PTHR13208; 1.
Pfam; PF10018; Med4; 1.
1: Evidence at protein level;
Acetylation; Activator; Alternative splicing; Coiled coil;
Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein;
Reference proteome; Transcription; Transcription regulation.
INIT_MET 1 1 Removed. {ECO:0000244|PubMed:22814378}.
CHAIN 2 270 Mediator of RNA polymerase II
transcription subunit 4.
/FTId=PRO_0000096383.
COILED 24 48 {ECO:0000255}.
COILED 90 131 {ECO:0000255}.
COMPBIAS 262 269 Poly-Ser.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000244|PubMed:22814378}.
MOD_RES 32 32 Phosphoserine.
{ECO:0000244|PubMed:19369195,
ECO:0000244|PubMed:19690332}.
VAR_SEQ 1 46 Missing (in isoform 2).
{ECO:0000303|PubMed:14702039}.
/FTId=VSP_047072.
CONFLICT 105 105 S -> G (in Ref. 8; AAH05189).
{ECO:0000305}.
CONFLICT 120 120 I -> T (in Ref. 5; CAG46629).
{ECO:0000305}.
CONFLICT 127 127 Q -> R (in Ref. 6; BAD96737).
{ECO:0000305}.
CONFLICT 152 152 A -> P (in Ref. 5; CAG33557).
{ECO:0000305}.
CONFLICT 183 183 R -> K (in Ref. 2; AAF37289).
{ECO:0000305}.
CONFLICT 218 218 P -> S (in Ref. 6; BAD96433).
{ECO:0000305}.
CONFLICT 251 251 N -> D (in Ref. 8; AAH05189).
{ECO:0000305}.
CONFLICT 265 265 S -> T (in Ref. 2; AAF37289 and 5;
CAG46629). {ECO:0000305}.
SEQUENCE 270 AA; 29745 MW; 05641357EBFA85F4 CRC64;
MAASSSGEKE KERLGGGLGV AGGNSTRERL LSALEDLEVL SRELIEMLAI SRNQKLLQAG
EENQVLELLI HRDGEFQELM KLALNQGKIH HEMQVLEKEV EKRDSDIQQL QKQLKEAEQI
LATAVYQAKE KLKSIEKARK GAISSEEIIK YAHRISASNA VCAPLTWVPG DPRRPYPTDL
EMRSGLLGQM NNPSTNGVNG HLPGDALAAG RLPDVLAPQY PWQSNDMSMN MLPPNHSSDF
LLEPPGHNKE NEDDVEIMST DSSSSSSESD


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10-288-22355F RNA polymerase transcriptional regulation mediator. subunit 6 homolog - Activator-recruited cofactor 33 kDa component; ARC33; NY-REN-28 antigen 0.05 mg
10-288-22355F RNA polymerase transcriptional regulation mediator. subunit 6 homolog - Activator-recruited cofactor 33 kDa component; ARC33; NY-REN-28 antigen 0.1 mg
18-003-43107 Cofactor required for Sp1 transcriptional activation subunit 9 - Transcriptional coactivator CRSP33; RNA polymerase transcriptional regulation mediator subunit 7 homolog; hMED7; Activator-recruited co 0.05 mg Aff Pur
10-288-22393F Cofactor required for Sp1 transcriptional activation subunit 9 - Transcriptional coactivator CRSP33; RNA polymerase transcriptional regulation mediator subunit 7 homolog; hMED7; Activator-recruited co 0.1 mg
10-288-22393F Cofactor required for Sp1 transcriptional activation subunit 9 - Transcriptional coactivator CRSP33; RNA polymerase transcriptional regulation mediator subunit 7 homolog; hMED7; Activator-recruited co 0.05 mg
EIAAB06531 Cdk8,Cell division protein kinase 8,Cyclin-dependent kinase 8,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Mouse,Mus musculus
EIAAB06530 CDK8,Cell division protein kinase 8,Cyclin-dependent kinase 8,Homo sapiens,Human,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Protein kinase K35
EIAAB08492 COG complex subunit 1,Cog1,Component of oligomeric Golgi complex 1,Conserved oligomeric Golgi complex subunit 1,Ldlb,Low density lipoprotein receptor defect B-complementing protein,Mouse,Mus musculus
EIAAB08495 COG complex subunit 2,Cog2,Component of oligomeric Golgi complex 2,Conserved oligomeric Golgi complex subunit 2,Ldlc,Low density lipoprotein receptor defect C-complementing protein,Mouse,Mus musculus
EIAAB08494 COG complex subunit 2,COG2,Component of oligomeric Golgi complex 2,Conserved oligomeric Golgi complex subunit 2,Homo sapiens,Human,LDLC,Low density lipoprotein receptor defect C-complementing protein
EIAAB32776 Homo sapiens,Human,LMP7,Low molecular mass protein 7,Macropain subunit C13,Multicatalytic endopeptidase complex subunit C13,Proteasome component C13,Proteasome subunit beta type-8,Proteasome subunit b
25-191 MED6 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information 0.05 mg
EIAAB08503 13S Golgi transport complex 90 kDa subunit,Bos taurus,Bovine,COG complex subunit 5,COG5,Component of oligomeric Golgi complex 5,Conserved oligomeric Golgi complex subunit 5,GTC-90
EIAAB32718 HC9,Homo sapiens,Human,Macropain subunit C9,Multicatalytic endopeptidase complex subunit C9,Proteasome component C9,Proteasome subunit alpha type-4,Proteasome subunit L,PSC9,PSMA4
EIAAB32876 11S regulator complex subunit beta,Activator of multicatalytic protease subunit 2,Homo sapiens,Human,PA28b,PA28beta,Proteasome activator 28 subunit beta,Proteasome activator complex subunit 2,PSME2,RE
EIAAB32714 Macropain subunit C8,Mouse,Multicatalytic endopeptidase complex subunit C8,Mus musculus,Proteasome component C8,Proteasome subunit alpha type-3,Proteasome subunit K,Psma3
EIAAB32715 Macropain subunit C9,Mouse,Multicatalytic endopeptidase complex subunit C9,Mus musculus,Proteasome component C9,Proteasome subunit alpha type-4,Proteasome subunit L,Psma4
EIAAB32716 Macropain subunit C9,Multicatalytic endopeptidase complex subunit C9,Proteasome component C9,Proteasome subunit alpha type-4,Proteasome subunit L,Psma4,Rat,Rattus norvegicus
EIAAB32711 Macropain subunit C8,Multicatalytic endopeptidase complex subunit C8,Proteasome component C8,Proteasome subunit alpha type-3,Proteasome subunit K,Psma3,Rat,Rattus norvegicus
EIAAB32871 11S regulator complex subunit alpha,Activator of multicatalytic protease subunit 1,Mouse,Mus musculus,PA28a,PA28alpha,Proteasome activator 28 subunit alpha,Proteasome activator complex subunit 1,Psme1
EIAAB32875 11S regulator complex subunit beta,Activator of multicatalytic protease subunit 2,Mouse,Mus musculus,PA28b,Pa28b1,PA28beta,Proteasome activator 28 subunit beta,Proteasome activator complex subunit 2,P
EIAAB32873 11S regulator complex subunit beta,Activator of multicatalytic protease subunit 2,PA28b,PA28beta,Proteasome activator 28 subunit beta,Proteasome activator complex subunit 2,Psme2,Rat,Rattus norvegicus
EIAAB32869 11S regulator complex subunit alpha,Activator of multicatalytic protease subunit 1,PA28a,PA28alpha,Proteasome activator 28 subunit alpha,Proteasome activator complex subunit 1,Psme1,Rat,Rattus norvegi
18-003-44182 Proteasome subunit alpha type-1 - EC 3.4.25.1; Proteasome component C2; Macropain subunit C2; Multicatalytic endopeptidase complex subunit C2; Proteasome nu chain; 30 kDa prosomal protein; PROS-30 Pol 0.1 mg Protein A


 

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