GENTAUR Molecular Products.

 Q95YH6_DROME            Unreviewed;      1497 AA.
 Q95YH6;
 01-DEC-2001, integrated into UniProtKB/TrEMBL.
 01-DEC-2001, sequence version 1.
 23-MAY-2018, entry version 110.
 SubName: Full=Mekk1b {ECO:0000313|EMBL:BAB62892.1};
 Name=Mekk1 {ECO:0000313|FlyBase:FBgn0024329};
 Synonyms=d-mekk1b {ECO:0000313|EMBL:BAB62892.1};
 ORFNames=CG7717 {ECO:0000313|FlyBase:FBgn0024329};
 Drosophila melanogaster (Fruit fly).
 Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
 Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
 Ephydroidea; Drosophilidae; Drosophila; Sophophora.
 NCBI_TaxID=7227 {ECO:0000313|EMBL:BAB62892.1};
 [1] {ECO:0000313|EMBL:BAB62892.1}
 NUCLEOTIDE SEQUENCE.
 PubMed=11574474; DOI=10.1093/emboj/20.19.5421;
 Inoue H., Tateno M., Fujimura-Kamada K., Takaesu G., Adachi-Yamada T.,
 Ninomiya-Tsuji J., Irie K., Nishida Y., Matsumoto K.;
 "A Drosophila MAPKKK, D-MEKK1, mediates stress responses through
 activation of p38 MAPK.";
 EMBO J. 20:5421-5430(2001).
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 EMBL; AB069962; BAB62892.1; -; mRNA.
 ProteinModelPortal; Q95YH6; -.
 PRIDE; Q95YH6; -.
 FlyBase; FBgn0024329; Mekk1.
 eggNOG; KOG4645; Eukaryota.
 eggNOG; ENOG410XQZE; LUCA.
 OrthoDB; EOG091G00SM; -.
 SignaLink; Q95YH6; -.
 ChiTaRS; Mekk1; fly.
 Bgee; FBgn0024329; -.
 ExpressionAtlas; Q95YH6; baseline and differential.
 GO; GO:0005737; C:cytoplasm; ISS:FlyBase.
 GO; GO:0005524; F:ATP binding; IEA:InterPro.
 GO; GO:0004709; F:MAP kinase kinase kinase activity; IDA:FlyBase.
 GO; GO:0031434; F:mitogen-activated protein kinase kinase binding; IPI:FlyBase.
 GO; GO:0071475; P:cellular hyperosmotic salinity response; IMP:FlyBase.
 GO; GO:0071243; P:cellular response to arsenic-containing substance; IMP:FlyBase.
 GO; GO:0071276; P:cellular response to cadmium ion; IMP:FlyBase.
 GO; GO:0034605; P:cellular response to heat; IDA:FlyBase.
 GO; GO:0043652; P:engulfment of apoptotic cell; IMP:FlyBase.
 GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IGI:FlyBase.
 GO; GO:0000165; P:MAPK cascade; IDA:FlyBase.
 GO; GO:0002385; P:mucosal immune response; IMP:FlyBase.
 GO; GO:0031452; P:negative regulation of heterochromatin assembly; IMP:FlyBase.
 GO; GO:0045793; P:positive regulation of cell size; IMP:FlyBase.
 GO; GO:0046330; P:positive regulation of JNK cascade; IMP:FlyBase.
 GO; GO:0001934; P:positive regulation of protein phosphorylation; IGI:FlyBase.
 GO; GO:0006468; P:protein phosphorylation; IDA:FlyBase.
 GO; GO:0006979; P:response to oxidative stress; IMP:FlyBase.
 InterPro; IPR011009; Kinase-like_dom_sf.
 InterPro; IPR000719; Prot_kinase_dom.
 InterPro; IPR017441; Protein_kinase_ATP_BS.
 InterPro; IPR008271; Ser/Thr_kinase_AS.
 Pfam; PF00069; Pkinase; 1.
 SMART; SM00220; S_TKc; 1.
 SUPFAM; SSF56112; SSF56112; 1.
 PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
 PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
 PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
 2: Evidence at transcript level;
 DOMAIN     1208   1468       Protein kinase.
                              {ECO:0000259|PROSITE:PS50011}.
 SEQUENCE   1497 AA;  169126 MW;  7B4B9F3D278CD935 CRC64;
 MRRKKVEYRV KQTPSRPVQM TRNRIGALEE DLPPEDELAA HYEAFGTTPP RTRLKIKNRD
 WERKQKVVNV TASADLPASV GGTPKKTRTA RSRVLRRNTM DCALLNEMFV NDESKRTDKR
 LQSLLRDSER EMKNSLATTA VAAPRGNSFH ETAHPLESLD QIMPLNSEAM APIPLRIASK
 VVESCNRYRC VSSRPIGYRS SAPPLAFAAQ LPAGMLRSDG RATPGLGKRK DFHETFANLI
 KLGSVDRQDA KLSQEEHTWQ TELKDLIWLE LQAWQADRTV EQQDKYLFEA RQGVSDLLTH
 IINYKFQPRY RREPSLISLD SGTHSDSNSN ASSPLPSKMC QGCMSLYCKD CMDHQKLALR
 EVEGMLTRLE AAEALYPSSQ AMGALHPIYK SQSFVGRIKS MCLWYNITKQ NKLKLSILGK
 ILARLQDEKF SWPVCTSSYI ATDSGSSSAS GVENDDSAVN SMDSSKPPSM AGSASRKGVT
 PCHKVQFMLN DATHVPGETS SSNESTSTEV SQWSSECSHS HMRKGSMHDI NIFSVEPLGT
 CSSNGTGEQS TGLYRKFIEN VLKSRGLAKS LAFLHKLHNV ALYKAHIALE KPGAEDFDYE
 SDAESIEEDV PRLDPEISRE QVVELRTYGY WSEEAQSINL PSYIPTFVFL SGIPLQFMHE
 FLRMRLETRP VRPNPLSLEQ LMKELREGLT LALTHRERYQ RHITTALVEN EAELGSYISI
 LNHYDATVRK TFELYLEYID QLVLVAVPEG NQKSVLEKEW MFTKLISPMI KGMHTLASQK
 FCGIISKLLR SISERLVKRT VELDQQIDGT ADTDDNEEVK WQLLTICRET QSLLTVERER
 SIKVLFFAKT FCRDVETTDF HREHYEHDVA NQQHDFICSD VKAAFKLLQQ DVLQVRNKLT
 AIIEGVQKRC CLSNMRDLDE QDKQAVLSRT REILHQGYKF GFEYHKDVIR LFEQKIMDQK
 DSGAHTVDLA LGIIAYAKMW MHFVMERCER GRGMRPRWAS QGLEFLILAC DPQITQHLDD
 DEFEALKQQM DRCISHVIGI TSEPEKVAKK KASPRTRKTS SPATSRSRTP TRTPMSAGMV
 LNPNTPPLQS PPYNKLLHPQ FSLKEDVSGT SYSPVDSSDY VDTPCQRSAN GELRLLVPQT
 PPTPASPGKS SLESTPLALR QERVRDAVNR LDMDLEDGLR ERRLIGQVKS LNSSDKVHIR
 ARSVHFRWHR GIKIGQGRFG KVYTAVNNNT GELMAMKEIA IQPGETRALK NVAEELKILE
 GIKHKNLVRY YGIEVHREEL LIFMELCSEG TLESLVELTG NLPEALTRRF TAQLLSGVSE
 LHKHGIVHRD IKTANIFLVD GSNSLKLGDF GSAVKIQAHT TVPGELQGYV GTQAYMAPEV
 FTKTNSDGHG RAADIWSVGC VVVEMASGKR PWAQFDSNFQ IMFKVGMGEK PQAPESLSQE
 GHDFIDHCLQ HDPKRRLTAV ELLEHNFCKY GRDECSSEQL QMQVRGSFRR NVATSSS

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