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Melanin-concentrating hormone receptor 1 (MCH receptor 1) (MCH-R1) (MCHR-1) (G-protein coupled receptor 24) (MCH-1R) (MCH1R) (MCHR) (SLC-1) (Somatostatin receptor-like protein)

 MCHR1_HUMAN             Reviewed;         422 AA.
Q99705; B2RBX6; Q5R3J1; Q96S47; Q9BV08;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
15-AUG-2003, sequence version 2.
05-DEC-2018, entry version 162.
RecName: Full=Melanin-concentrating hormone receptor 1;
Short=MCH receptor 1;
Short=MCH-R1;
Short=MCHR-1;
AltName: Full=G-protein coupled receptor 24;
AltName: Full=MCH-1R;
Short=MCH1R;
Short=MCHR;
AltName: Full=SLC-1;
AltName: Full=Somatostatin receptor-like protein;
Name=MCHR1; Synonyms=GPR24, SLC1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=10441476; DOI=10.1006/bbrc.1999.1104;
Shimomura Y., Mori M., Sugo T., Ishibashi Y., Abe M., Kurokawa T.,
Onda H., Nishimura O., Sumino Y., Fujino M.;
"Isolation and identification of melanin-concentrating hormone as the
endogenous ligand of the SLC-1 receptor.";
Biochem. Biophys. Res. Commun. 261:622-626(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA], VARIANTS MET-25; VAL-28; ASP-32; HIS-210;
MET-305; GLN-317; SER-377 AND MET-411, AND CHARACTERIZATION OF VARIANT
ASP-32.
PubMed=15941924; DOI=10.1530/eje.1.01917;
Wermter A.-K., Reichwald K., Buech T., Geller F., Platzer C., Huse K.,
Hess C., Remschmidt H., Gudermann T., Preibisch G., Siegfried W.,
Goldschmidt H.-P., Li W.-D., Price R.A., Biebermann H., Krude H.,
Vollmert C., Wichmann H.-E., Illig T., Soerensen T.I.A., Astrup A.,
Larsen L.H., Pedersen O., Eberle D., Clement K., Blundell J.,
Wabitsch M., Schaefer H., Platzer M., Hinney A., Hebebrand J.;
"Mutation analysis of the MCHR1 gene in human obesity.";
Eur. J. Endocrinol. 152:851-862(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-32.
PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
Beare D.M., Dunham I.;
"A genome annotation-driven approach to cloning the human ORFeome.";
Genome Biol. 5:R84.1-R84.11(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-32.
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor
vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-32.
TISSUE=Brain;
King M.M., Aronstam R.S., Sharma S.V.;
"cDNA clones of human proteins involved in signal transduction
sequenced by the Guthrie cDNA resource center (www.cdna.org).";
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-32.
TISSUE=Brain;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=10591208; DOI=10.1038/990031;
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M.,
Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K.,
Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P.,
Bird C.P., Blakey S.E., Bridgeman A.M., Buck D., Burgess J.,
Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G.,
Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R.,
Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E.,
Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G.,
Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S.,
Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A.,
Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M.,
Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T.,
Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J.,
Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T.,
Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T.,
Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L.,
Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M.,
Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J.,
Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S.,
Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T.,
Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I.,
Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H.,
Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L.,
Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z.,
Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P.,
Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S.,
Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J.,
Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T.,
Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J.,
Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S.,
Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E.,
Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P.,
Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E.,
O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X.,
Khan A.S., Lane L., Tilahun Y., Wright H.;
"The DNA sequence of human chromosome 22.";
Nature 402:489-495(1999).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ASP-32.
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-32.
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[10]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-422.
PubMed=8977118; DOI=10.1016/S0014-5793(96)01160-X;
Kolakowski L.F. Jr., Jung B.P., Nguyen T., Johnson M.P., Lynch K.R.,
Cheng R., Heng H.H.Q., George S.R., O'Dowd B.F.;
"Characterization of a human gene related to genes encoding
somatostatin receptors.";
FEBS Lett. 398:253-258(1996).
[11]
FUNCTION.
PubMed=10421367; DOI=10.1038/22313;
Chambers J., Ames R.S., Bergsma D., Muir A., Fitzgerald L.R.,
Hervieu G., Dytko G.M., Foley J.J., Martin J., Liu W.S., Park J.,
Ellis C., Ganguly S., Konchar S., Cluderay J., Leslie R., Wilson S.,
Sarau H.M.;
"Melanin-concentrating hormone is the cognate ligand for the orphan G-
protein-coupled receptor SLC-1.";
Nature 400:261-265(1999).
[12]
INTERACTION WITH NCDN.
PubMed=16945926; DOI=10.1074/jbc.M602889200;
Francke F., Ward R.J., Jenkins L., Kellett E., Richter D.,
Milligan G., Baechner D.;
"Interaction of neurochondrin with the melanin-concentrating hormone
receptor 1 interferes with G protein-coupled signal transduction but
not agonist-mediated internalization.";
J. Biol. Chem. 281:32496-32507(2006).
[13]
VARIANTS HIS-250 AND GLN-317, AND CHARACTERIZATION OF VARIANT GLN-317.
PubMed=15166293; DOI=10.1038/oby.2004.89;
Gibson W.T., Pissios P., Trombly D.J., Luan J., Keogh J.,
Wareham N.J., Maratos-Flier E., O'Rahilly S., Farooqi I.S.;
"Melanin-concentrating hormone receptor mutations and human obesity:
functional analysis.";
Obes. Res. 12:743-749(2004).
[14]
VARIANT ARG-34, AND CHARACTERIZATION OF VARIANT ARG-34.
PubMed=15340116; DOI=10.1038/oby.2004.167;
Hawes B.E., Green B., O'Neill K., Fried S., Arreaza M.G., Qiu P.,
Simon J.S.;
"Identification and characterization of single-nucleotide
polymorphisms in MCH-R1 and MCH-R2.";
Obes. Res. 12:1327-1334(2004).
-!- FUNCTION: Receptor for melanin-concentrating hormone, coupled to
both G proteins that inhibit adenylyl cyclase and G proteins that
activate phosphoinositide hydrolysis.
{ECO:0000269|PubMed:10421367}.
-!- SUBUNIT: Interacts with NCDN. {ECO:0000269|PubMed:16945926}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Highest level in brain, particularly in the
frontal cortex and hypothalamus, lower levels in the liver and
heart.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- CAUTION: It is uncertain whether Met-1, Met-6 or Met-70 is the
initiator. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAC14587.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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EMBL; AB063174; BAB60890.1; -; mRNA.
EMBL; AF490537; AAO14670.1; -; mRNA.
EMBL; CR456497; CAG30383.1; -; mRNA.
EMBL; BT006725; AAP35371.1; -; mRNA.
EMBL; AY562945; AAS72373.1; -; mRNA.
EMBL; AK314857; BAG37373.1; -; mRNA.
EMBL; Z86090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471095; EAW60388.1; -; Genomic_DNA.
EMBL; BC001736; AAH01736.1; -; mRNA.
EMBL; BC021146; AAH21146.1; -; mRNA.
EMBL; U71092; AAC14587.1; ALT_SEQ; Genomic_DNA.
CCDS; CCDS14004.1; -.
PIR; JC7080; JC7080.
RefSeq; NP_005288.3; NM_005297.3.
UniGene; Hs.248122; -.
ProteinModelPortal; Q99705; -.
SMR; Q99705; -.
STRING; 9606.ENSP00000249016; -.
BindingDB; Q99705; -.
ChEMBL; CHEMBL344; -.
GuidetoPHARMACOLOGY; 280; -.
TCDB; 9.A.14.13.6; the g-protein-coupled receptor (gpcr) family.
iPTMnet; Q99705; -.
PhosphoSitePlus; Q99705; -.
BioMuta; MCHR1; -.
DMDM; 33860175; -.
PaxDb; Q99705; -.
PeptideAtlas; Q99705; -.
PRIDE; Q99705; -.
ProteomicsDB; 78416; -.
DNASU; 2847; -.
Ensembl; ENST00000249016; ENSP00000249016; ENSG00000128285.
GeneID; 2847; -.
KEGG; hsa:2847; -.
UCSC; uc003ayz.4; human.
CTD; 2847; -.
DisGeNET; 2847; -.
EuPathDB; HostDB:ENSG00000128285.4; -.
GeneCards; MCHR1; -.
HGNC; HGNC:4479; MCHR1.
MIM; 601751; gene.
neXtProt; NX_Q99705; -.
OpenTargets; ENSG00000128285; -.
PharmGKB; PA28867; -.
eggNOG; KOG3656; Eukaryota.
eggNOG; ENOG410XRW9; LUCA.
GeneTree; ENSGT00940000154272; -.
HOGENOM; HOG000000704; -.
HOVERGEN; HBG105726; -.
InParanoid; Q99705; -.
KO; K04320; -.
OMA; TSTYILT; -.
OrthoDB; EOG091G0HEN; -.
PhylomeDB; Q99705; -.
TreeFam; TF315737; -.
Reactome; R-HSA-375276; Peptide ligand-binding receptors.
Reactome; R-HSA-416476; G alpha (q) signalling events.
Reactome; R-HSA-418594; G alpha (i) signalling events.
Reactome; R-HSA-5620922; BBSome-mediated cargo-targeting to cilium.
SIGNOR; Q99705; -.
GeneWiki; Melanin-concentrating_hormone_receptor_1; -.
GenomeRNAi; 2847; -.
PRO; PR:Q99705; -.
Proteomes; UP000005640; Chromosome 22.
Bgee; ENSG00000128285; Expressed in 98 organ(s), highest expression level in middle temporal gyrus.
CleanEx; HS_MCHR1; -.
ExpressionAtlas; Q99705; baseline and differential.
Genevisible; Q99705; HS.
GO; GO:0060170; C:ciliary membrane; IEA:Ensembl.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0097730; C:non-motile cilium; ISS:BHF-UCL.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
GO; GO:0042562; F:hormone binding; IEA:Ensembl.
GO; GO:0030273; F:melanin-concentrating hormone receptor activity; IBA:GO_Central.
GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
GO; GO:0008188; F:neuropeptide receptor activity; TAS:ProtInc.
GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; TAS:ProtInc.
GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:Ensembl.
GO; GO:0007631; P:feeding behavior; TAS:ProtInc.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:Reactome.
GO; GO:0006091; P:generation of precursor metabolites and energy; TAS:ProtInc.
GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
GO; GO:0051928; P:positive regulation of calcium ion transport; IEA:Ensembl.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; TAS:ProtInc.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR004047; MCH1_rcpt.
InterPro; IPR008361; MCH_rcpt.
PANTHER; PTHR44627; PTHR44627; 1.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR01507; MCH1RECEPTOR.
PRINTS; PR01783; MCHRECEPTOR.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; G-protein coupled receptor;
Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome;
Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 422 Melanin-concentrating hormone receptor 1.
/FTId=PRO_0000069734.
TOPO_DOM 1 113 Extracellular. {ECO:0000255}.
TRANSMEM 114 136 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 137 148 Cytoplasmic. {ECO:0000255}.
TRANSMEM 149 171 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 172 185 Extracellular. {ECO:0000255}.
TRANSMEM 186 208 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 209 227 Cytoplasmic. {ECO:0000255}.
TRANSMEM 228 250 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 251 278 Extracellular. {ECO:0000255}.
TRANSMEM 279 301 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 302 321 Cytoplasmic. {ECO:0000255}.
TRANSMEM 322 344 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 345 358 Extracellular. {ECO:0000255}.
TRANSMEM 359 381 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 382 422 Cytoplasmic. {ECO:0000255}.
CARBOHYD 82 82 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 85 85 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 92 92 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VARIANT 25 25 T -> M (in dbSNP:rs117372135).
{ECO:0000269|PubMed:15941924}.
/FTId=VAR_026652.
VARIANT 28 28 D -> V (in dbSNP:rs112405400).
{ECO:0000269|PubMed:15941924}.
/FTId=VAR_026653.
VARIANT 32 32 N -> D (no significant functional
differences; dbSNP:rs133072).
{ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:15461802,
ECO:0000269|PubMed:15489334,
ECO:0000269|PubMed:15941924,
ECO:0000269|Ref.4, ECO:0000269|Ref.5,
ECO:0000269|Ref.8}.
/FTId=VAR_016221.
VARIANT 34 34 G -> R (no changes in receptor binding or
functional signaling).
{ECO:0000269|PubMed:15340116}.
/FTId=VAR_026654.
VARIANT 103 103 G -> R (in dbSNP:rs11914085).
/FTId=VAR_049417.
VARIANT 210 210 R -> H (in dbSNP:rs750210146).
{ECO:0000269|PubMed:15941924}.
/FTId=VAR_026655.
VARIANT 250 250 Y -> H. {ECO:0000269|PubMed:15166293}.
/FTId=VAR_026656.
VARIANT 305 305 T -> M (in dbSNP:rs550313335).
{ECO:0000269|PubMed:15941924}.
/FTId=VAR_026657.
VARIANT 317 317 R -> Q (in dbSNP:rs45439291).
{ECO:0000269|PubMed:15166293,
ECO:0000269|PubMed:15941924}.
/FTId=VAR_026658.
VARIANT 377 377 P -> S (in dbSNP:rs539260735).
{ECO:0000269|PubMed:15941924}.
/FTId=VAR_026659.
VARIANT 411 411 T -> M (in dbSNP:rs149604804).
{ECO:0000269|PubMed:15941924}.
/FTId=VAR_026660.
SEQUENCE 422 AA; 45963 MW; 3986919A18183818 CRC64;
MSVGAMKKGV GRAVGLGGGS GCQATEEDPL PNCGACAPGQ GGRRWRLPQP AWVEGSSARL
WEQATGTGWM DLEASLLPTG PNASNTSDGP DNLTSAGSPP RTGSISYINI IMPSVFGTIC
LLGIIGNSTV IFAVVKKSKL HWCNNVPDIF IINLSVVDLL FLLGMPFMIH QLMGNGVWHF
GETMCTLITA MDANSQFTST YILTAMAIDR YLATVHPISS TKFRKPSVAT LVICLLWALS
FISITPVWLY ARLIPFPGGA VGCGIRLPNP DTDLYWFTLY QFFLAFALPF VVITAAYVRI
LQRMTSSVAP ASQRSIRLRT KRVTRTAIAI CLVFFVCWAP YYVLQLTQLS ISRPTLTFVY
LYNAAISLGY ANSCLNPFVY IVLCETFRKR LVLSVKPAAQ GQLRAVSNAQ TADEERTESK
GT


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EIAAB28476 GPR120,GPR129,G-protein coupled receptor 120,G-protein coupled receptor 129,G-protein coupled receptor GT01,G-protein coupled receptor PGR4,Homo sapiens,Human,O3FAR1,Omega-3 fatty acid receptor 1,PGR4
EIAAB36674 AGR16,Edg5,Endothelial differentiation G-protein coupled receptor 5,G-protein coupled receptor H218,Rat,Rattus norvegicus,S1P receptor 2,S1P receptor Edg-5,S1P2,S1pr2,Sphingosine 1-phosphate receptor
EIAAB29406 5-oxo-ETE G-protein coupled receptor,GPR170,G-protein coupled receptor 170,G-protein coupled receptor R527,G-protein coupled receptor TG1019,Homo sapiens,Human,OXER1,Oxoeicosanoid receptor 1,TG1019
18-461-10700 2-oxoglutarate receptor 1 - Alpha-ketoglutarate receptor 1; G-protein coupled receptor 80; G-protein coupled receptor 99; P2Y purinoceptor 15; P2Y-like nucleotide receptor; P2Y-like GPCR Polyclonal 0.05 ml
18-461-10811 2-oxoglutarate receptor 1 - Alpha-ketoglutarate receptor 1; G-protein coupled receptor 80; G-protein coupled receptor 99; P2Y purinoceptor 15; P2Y-like nucleotide receptor; P2Y-like GPCR Polyclonal 0.05 ml
EIAAB12927 EGF-like module receptor 4,EMR4,EMR4P,GPR127,G-protein coupled receptor 127,G-protein coupled receptor PGR16,Homo sapiens,Human,PGR16,Putative EGF-like module-containing mucin-like hormone receptor-li
18-461-10342 Leucine-rich repeat-containing G-protein coupled receptor 5 - Orphan G-protein coupled receptor HG38; G-protein coupled receptor 49; G-protein coupled receptor 67 Polyclonal 0.05 ml
18-461-10341 Leucine-rich repeat-containing G-protein coupled receptor 5 - Orphan G-protein coupled receptor HG38; G-protein coupled receptor 49; G-protein coupled receptor 67 Polyclonal 0.05 ml
EIAAB35102 GPR100,G-protein coupled receptor 100,G-protein coupled receptor GPCR142,Homo sapiens,Human,Insulin-like peptide INSL5 receptor,Relaxin family peptide receptor 4,Relaxin-3 receptor 2,RLN3 receptor 2,R
EIAAB36682 Edg8,Endothelial differentiation G-protein-coupled receptor 8,Nerve growth factor-regulated G-protein-coupled receptor 1,Nrg1,NRG-1,Rat,Rattus norvegicus,S1P receptor 5,S1P receptor Edg-8,S1P5,S1pr5,S
18-461-10047 Nicotinic acid receptor 2 - G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74B Polyclonal 0.05 ml
18-461-10046 Nicotinic acid receptor 2 - G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74B Polyclonal 0.05 ml
18-461-10045 Nicotinic acid receptor 2 - G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74B Polyclonal 0.05 ml
EIAAB27701 GPR154,GPRA,G-protein coupled receptor 154,G-protein coupled receptor for asthma susceptibility,G-protein coupled receptor PGR14,Homo sapiens,Human,Neuropeptide S receptor,NPSR1,PGR14
18-461-10430 Oxoeicosanoid receptor 1 - G-protein coupled receptor TG1019; 5-oxo-ETE G-protein coupled receptor; G-protein coupled receptor 170; G-protein coupled receptor R527 Polyclonal 0.05 ml
18-461-10719 Oxoeicosanoid receptor 1 - G-protein coupled receptor TG1019; 5-oxo-ETE G-protein coupled receptor; G-protein coupled receptor 170; G-protein coupled receptor R527 Polyclonal 0.05 ml
EIAAB27655 GPR74,G-protein coupled receptor 74,G-protein coupled receptor HLWAR77,Homo sapiens,Human,Neuropeptide FF receptor 2,Neuropeptide G-protein coupled receptor,NPFF2,NPFFR2,NPGPR
EIAAB36500 Gpr106,G-protein coupled receptor 106,G-protein coupled receptor affecting testicular descent,Great,Leucine-rich repeat-containing G-protein coupled receptor 8,Lgr8,Mouse,Mus musculus,Relaxin family p
EIAAB36499 GPR106,G-protein coupled receptor 106,G-protein coupled receptor affecting testicular descent,GREAT,Homo sapiens,Human,Leucine-rich repeat-containing G-protein coupled receptor 8,LGR8,Relaxin family p
EIAAB36673 Edg5,Endothelial differentiation G-protein coupled receptor 5,Gpcr13,Lpb2,Lysophospholipid receptor B2,Mouse,Mus musculus,S1P receptor 2,S1P receptor Edg-5,S1P2,S1pr2,Sphingosine 1-phosphate receptor
EIAAB36677 Edg3,Endothelial differentiation G-protein coupled receptor 3,Lpb3,Lysophospholipid receptor B3,Mouse,Mus musculus,S1P receptor 3,S1P receptor Edg-3,S1P3,S1pr3,Sphingosine 1-phosphate receptor 3,Sphin
EIAAB36681 Edg8,Endothelial differentiation G-protein-coupled receptor 8,Lpb4,Lysophospholipid receptor B4,Mouse,Mus musculus,S1P receptor 5,S1P receptor Edg-8,S1P5,S1pr5,Sphingosine 1-phosphate receptor 5,Sphin
EIAAB36669 Edg1,Endothelial differentiation G-protein coupled receptor 1,Lpb1,Lysophospholipid receptor B1,Mouse,Mus musculus,S1P receptor 1,S1P receptor Edg-1,S1P1,S1pr1,Sphingosine 1-phosphate receptor 1,Sphin
EIAAB29407 2-oxoglutarate receptor 1,Alpha-ketoglutarate receptor 1,GPR80,GPR99,G-protein coupled receptor 80,G-protein coupled receptor 99,Homo sapiens,Human,OXGR1,P2RY15,P2Y purinoceptor 15,P2Y15,P2Y15,P2Y-lik


 

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