Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Melanocortin receptor 3 (MC3-R)

 MC3R_MOUSE              Reviewed;         323 AA.
P33033;
01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
01-OCT-1993, sequence version 1.
20-JUN-2018, entry version 136.
RecName: Full=Melanocortin receptor 3;
Short=MC3-R;
Name=Mc3r;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8172596; DOI=10.1042/bj2990367;
Desarnaud F., Labbe O., Eggerickx D., Vassart G., Parmentier M.;
"Molecular cloning, functional expression and pharmacological
characterization of a mouse melanocortin receptor gene.";
Biochem. J. 299:367-373(1994).
[2]
FUNCTION.
PubMed=19036988; DOI=10.1523/JNEUROSCI.3615-08.2008;
Sutton G.M., Perez-Tilve D., Nogueiras R., Fang J., Kim J.K.,
Cone R.D., Gimble J.M., Tschop M.H., Butler A.A.;
"The melanocortin-3 receptor is required for entrainment to meal
intake.";
J. Neurosci. 28:12946-12955(2008).
-!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. This
receptor is mediated by G proteins which activate adenylate
cyclase. Required for expression of anticipatory patterns of
activity and wakefulness during periods of limited nutrient
availability and for the normal regulation of circadian clock
activity in the brain (PubMed:19036988).
{ECO:0000269|PubMed:19036988}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Brain.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; X74983; CAA52918.1; -; Genomic_DNA.
CCDS; CCDS17127.1; -.
PIR; S43850; S43850.
RefSeq; NP_032587.1; NM_008561.3.
UniGene; Mm.57183; -.
ProteinModelPortal; P33033; -.
BioGrid; 201340; 1.
STRING; 10090.ENSMUSP00000047358; -.
BindingDB; P33033; -.
ChEMBL; CHEMBL4774; -.
GuidetoPHARMACOLOGY; 284; -.
PaxDb; P33033; -.
PRIDE; P33033; -.
Ensembl; ENSMUST00000038532; ENSMUSP00000047358; ENSMUSG00000038537.
GeneID; 17201; -.
KEGG; mmu:17201; -.
UCSC; uc008ocl.1; mouse.
CTD; 4159; -.
MGI; MGI:96929; Mc3r.
eggNOG; KOG3656; Eukaryota.
eggNOG; ENOG410XRW9; LUCA.
GeneTree; ENSGT00770000120529; -.
HOGENOM; HOG000246927; -.
HOVERGEN; HBG108148; -.
InParanoid; P33033; -.
KO; K04201; -.
OMA; VHMFLFA; -.
OrthoDB; EOG091G0BVW; -.
PhylomeDB; P33033; -.
TreeFam; TF332646; -.
Reactome; R-MMU-375276; Peptide ligand-binding receptors.
Reactome; R-MMU-418555; G alpha (s) signalling events.
PRO; PR:P33033; -.
Proteomes; UP000000589; Chromosome 2.
Bgee; ENSMUSG00000038537; -.
CleanEx; MM_MC3R; -.
ExpressionAtlas; P33033; baseline and differential.
Genevisible; P33033; MM.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0004977; F:melanocortin receptor activity; ISO:MGI.
GO; GO:0004980; F:melanocyte-stimulating hormone receptor activity; IDA:MGI.
GO; GO:0042923; F:neuropeptide binding; ISO:MGI.
GO; GO:0017046; F:peptide hormone binding; ISO:MGI.
GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; ISO:MGI.
GO; GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; ISO:MGI.
GO; GO:0032922; P:circadian regulation of gene expression; IMP:UniProtKB.
GO; GO:0042309; P:homoiothermy; ISO:MGI.
GO; GO:0045475; P:locomotor rhythm; IMP:UniProtKB.
GO; GO:0008217; P:regulation of blood pressure; ISO:MGI.
GO; GO:0060259; P:regulation of feeding behavior; IMP:UniProtKB.
GO; GO:0002027; P:regulation of heart rate; ISO:MGI.
GO; GO:0055078; P:sodium ion homeostasis; IEA:Ensembl.
CDD; cd15352; 7tmA_MC3R; 1.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR002122; Mcort_3_rcpt.
InterPro; IPR001908; Melancort_rcpt.
InterPro; IPR001671; Melcrt_ACTH_rcpt.
PANTHER; PTHR22750:SF4; PTHR22750:SF4; 1.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00534; MCRFAMILY.
PRINTS; PR00535; MELNOCORTINR.
PRINTS; PR01061; MELNOCORTN3R.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Biological rhythms; Cell membrane; Complete proteome;
G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane;
Palmitate; Receptor; Reference proteome; Transducer; Transmembrane;
Transmembrane helix.
CHAIN 1 323 Melanocortin receptor 3.
/FTId=PRO_0000069719.
TOPO_DOM 1 37 Extracellular. {ECO:0000255}.
TRANSMEM 38 63 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 64 75 Cytoplasmic. {ECO:0000255}.
TRANSMEM 76 100 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 101 118 Extracellular. {ECO:0000255}.
TRANSMEM 119 140 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 141 160 Cytoplasmic. {ECO:0000255}.
TRANSMEM 161 181 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 182 186 Extracellular. {ECO:0000255}.
TRANSMEM 187 210 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 211 245 Cytoplasmic. {ECO:0000255}.
TRANSMEM 246 268 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 269 277 Extracellular. {ECO:0000255}.
TRANSMEM 278 301 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 302 323 Cytoplasmic. {ECO:0000255}.
LIPID 315 315 S-palmitoyl cysteine. {ECO:0000255}.
CARBOHYD 2 2 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 16 16 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 28 28 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 323 AA; 35806 MW; F4B7B02FA4A87B7B CRC64;
MNSSCCLSSV SPMLPNLSEH PAAPPASNRS GSGFCEQVFI KPEVFLALGI VSLMENILVI
LAVVRNGNLH SPMYFFLCSL AAADMLVSLS NSLETIMIAV INSDSLTLED QFIQHMDNIF
DSMICISLVA SICNLLAIAI DRYVTIFYAL RYHSIMTVRK ALTLIGVIWV CCGICGVMFI
IYSESKMVIV CLITMFFAMV LLMGTLYIHM FLFARLHVQR IAVLPPAGVV APQQHSCMKG
AVTITILLGV FIFCWAPFFL HLVLIITCPT NPYCICYTAH FNTYLVLIMC NSVIDPLIYA
FRSLELRNTF KEILCGCNSM NLG


Related products :

Catalog number Product name Quantity
18-461-10318 Melanocyte-stimulating hormone receptor - MSH-R; Melanotropin receptor; Melanocortin receptor 1; MC1-R Polyclonal 0.05 ml
18-461-10126 Melanocyte-stimulating hormone receptor - MSH-R; Melanotropin receptor; Melanocortin receptor 1; MC1-R Polyclonal 0.05 ml
EIAAB25492 MC1R,MC1-R,Melanocortin receptor 1,Melanocyte-stimulating hormone receptor,MSH-R,Pig,Sus scrofa
MC3R MC1R Gene melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
18-783-78666 SHEEP ANTI HUMAN MSH ALPHA - MSH-R; Melanotropin receptor; Melanocortin receptor 1; MC1-R Polyclonal 0.05 ml
EIAAB25491 Mc1r,MC1-R,Melanocortin receptor 1,Melanocyte-stimulating hormone receptor,Mouse,MSH-R,Msh-r,Mus musculus
EIAAB25493 Homo sapiens,Human,MC1R,MC1-R,Melanocortin receptor 1,Melanocyte-stimulating hormone receptor,MSHR,MSH-R
EIAAB25490 BDF3,Bos taurus,Bovine,MC1R,MC1-R,Melanocortin receptor 1,Melanocyte-stimulating hormone receptor,MSHR,MSH-R
CSB-EL013558PI Pig melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) (MC1R) ELISA kit, Species Pig, Sample Type serum, plasma 96T
CSB-EL013558DO Dog melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) (MC1R) ELISA kit, Species Dog, Sample Type serum, plasma 96T
CSB-EL013558CA Cat melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) (MC1R) ELISA kit, Species Cat, Sample Type serum, plasma 96T
48-751 Melanocortin 4 Receptor Antibody 0.05 mg
Y212510 Melanocortin 3 Receptor 200ul
45-881 Melanocortin 3 Receptor Antibody. 0.1 mg
5199 Melanocortin-4 receptor 0.5 mg
45-881 Melanocortin 3 Receptor Antibody 0.1 mg
5199 Melanocortin-4 receptor 0.1 mg
18-461-10125 Melanocortin receptor 4 - MC4-R Polyclonal 0.05 ml
Y212510 Melanocortin 3 Receptor Antibody 200ul
E0594r Rat ELISA Kit FOR Melanocortin receptor 3 96T
18-461-10517 Melanocortin receptor 4 - MC4-R Polyclonal 0.05 ml
18-461-10645 Melanocortin receptor 5 - MC5-R; MC-2 Polyclonal 0.05 ml
EH1367 Melanocortin receptor 4 Elisa Kit 96T
AF1666a Melanocortin 3 Receptor Antibody 0.1mg
18-461-10644 Melanocortin receptor 5 - MC5-R; MC-2 Polyclonal 0.05 ml


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur