GENTAUR Molecular Products.

 MC4R_DANRE              Reviewed;         326 AA.
 B0V1P1; Q8JGW3;
 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
 08-APR-2008, sequence version 1.
 18-JUL-2018, entry version 74.
 RecName: Full=Melanocortin receptor 4;
          Short=MC4-R;
 Name=mc4r;
 Danio rerio (Zebrafish) (Brachydanio rerio).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
 Cyprinidae; Danio.
 NCBI_TaxID=7955;
 [1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
 PubMed=12091460; DOI=10.1046/j.1471-4159.2002.00934.x;
 Ringholm A., Fredriksson R., Poliakova N., Yan Y.L.,
 Postlethwait J.H., Larhammar D., Schioth H.B.;
 "One melanocortin 4 and two melanocortin 5 receptors from zebrafish
 show remarkable conservation in structure and pharmacology.";
 J. Neurochem. 82:6-18(2002).
 [2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
 PubMed=12620396; DOI=10.1016/S0888-7543(02)00037-X;
 Logan D.W., Bryson-Richardson R.J., Pagan K.E., Taylor M.S.,
 Currie P.D., Jackson I.J.;
 "The structure and evolution of the melanocortin and MCH receptors in
 fish and mammals.";
 Genomics 81:184-191(2003).
 [3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Tuebingen;
 PubMed=23594743; DOI=10.1038/nature12111;
 Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
 Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
 McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
 Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
 Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
 Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
 Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
 Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
 Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
 Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G.,
 Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B.,
 Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S.,
 Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C.,
 Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H.,
 Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C.,
 Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
 McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
 Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
 Humphries M., Sycamore N., Barker D., Saunders D., Wallis J.,
 Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S.,
 Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R.,
 Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R.,
 Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R.,
 Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A.,
 Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
 Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
 Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S.,
 Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J.,
 Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
 Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
 Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
 Stemple D.L.;
 "The zebrafish reference genome sequence and its relationship to the
 human genome.";
 Nature 496:498-503(2013).
 [4]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
 NIH - Zebrafish Gene Collection (ZGC) project;
 Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
 [5]
 FUNCTION, AND INTERACTION WITH MRAP2A AND MRAP2B.
 PubMed=23869017; DOI=10.1126/science.1232995;
 Sebag J.A., Zhang C., Hinkle P.M., Bradshaw A.M., Cone R.D.;
 "Developmental control of the melanocortin-4 receptor by MRAP2
 proteins in zebrafish.";
 Science 341:278-281(2013).
 -!- FUNCTION: Receptor specific to the heptapeptide core common to
     adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH.
     Plays a central role in energy homeostasis and somatic growth.
     This receptor is mediated by G proteins that stimulate adenylate
     cyclase (cAMP). {ECO:0000269|PubMed:23869017}.
 -!- SUBUNIT: Homodimer; disulfide-linked, also forms higher order
     oligomers (By similarity). Interacts with mrap2a; decreasing
     ligand-sensitivity. Interacts with mrap2b; increasing ligand-
     sensitivity and generation of cAMP. {ECO:0000250,
     ECO:0000269|PubMed:23869017}.
 -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
 -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
     {ECO:0000255|PROSITE-ProRule:PRU00521}.
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 EMBL; AY078989; AAL85494.1; -; Genomic_DNA.
 EMBL; AY161850; AAO24745.1; -; Genomic_DNA.
 EMBL; CR925777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
 EMBL; BC163219; AAI63219.1; -; mRNA.
 EMBL; BC163227; AAI63227.1; -; mRNA.
 RefSeq; NP_775385.1; NM_173278.1.
 UniGene; Dr.45846; -.
 ProteinModelPortal; B0V1P1; -.
 SMR; B0V1P1; -.
 STRING; 7955.ENSDARP00000027547; -.
 PaxDb; B0V1P1; -.
 Ensembl; ENSDART00000019555; ENSDARP00000027547; ENSDARG00000015515.
 GeneID; 286833; -.
 KEGG; dre:286833; -.
 CTD; 4160; -.
 ZFIN; ZDB-GENE-021223-2; mc4r.
 eggNOG; KOG3656; Eukaryota.
 eggNOG; ENOG410XRW9; LUCA.
 GeneTree; ENSGT00770000120529; -.
 HOGENOM; HOG000246927; -.
 HOVERGEN; HBG108148; -.
 InParanoid; B0V1P1; -.
 KO; K04202; -.
 OMA; MHTSLHF; -.
 OrthoDB; EOG091G0BVW; -.
 TreeFam; TF332646; -.
 Reactome; R-DRE-375276; Peptide ligand-binding receptors.
 Reactome; R-DRE-418555; G alpha (s) signalling events.
 PRO; PR:B0V1P1; -.
 Proteomes; UP000000437; Chromosome 2.
 Bgee; ENSDARG00000015515; -.
 GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
 GO; GO:0005622; C:intracellular; IEA:GOC.
 GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO; GO:0004977; F:melanocortin receptor activity; IDA:UniProtKB.
 GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IDA:ZFIN.
 GO; GO:0097009; P:energy homeostasis; IDA:UniProtKB.
 GO; GO:0006112; P:energy reserve metabolic process; IDA:UniProtKB.
 GO; GO:2000252; P:negative regulation of feeding behavior; IMP:ZFIN.
 GO; GO:0040008; P:regulation of growth; IGI:ZFIN.
 CDD; cd15353; 7tmA_MC4R; 1.
 InterPro; IPR000276; GPCR_Rhodpsn.
 InterPro; IPR017452; GPCR_Rhodpsn_7TM.
 InterPro; IPR000155; Mcort_rcpt_4.
 InterPro; IPR001908; Melancort_rcpt.
 InterPro; IPR001671; Melcrt_ACTH_rcpt.
 Pfam; PF00001; 7tm_1; 1.
 PRINTS; PR00237; GPCRRHODOPSN.
 PRINTS; PR00534; MCRFAMILY.
 PRINTS; PR00535; MELNOCORTINR.
 PRINTS; PR01062; MELNOCORTN4R.
 SMART; SM01381; 7TM_GPCR_Srsx; 1.
 PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
 PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
 1: Evidence at protein level;
 Cell membrane; Complete proteome; Disulfide bond;
 G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane;
 Palmitate; Receptor; Reference proteome; Transducer; Transmembrane;
 Transmembrane helix.
 CHAIN         1    326       Melanocortin receptor 4.
                              /FTId=PRO_0000424026.
 TOPO_DOM      1     46       Extracellular. {ECO:0000255}.
 TRANSMEM     47     67       Helical; Name=1. {ECO:0000255}.
 TOPO_DOM     68     71       Cytoplasmic. {ECO:0000255}.
 TRANSMEM     72     92       Helical; Name=2. {ECO:0000255}.
 TOPO_DOM     93    121       Extracellular. {ECO:0000255}.
 TRANSMEM    122    142       Helical; Name=3. {ECO:0000255}.
 TOPO_DOM    143    163       Cytoplasmic. {ECO:0000255}.
 TRANSMEM    164    184       Helical; Name=4. {ECO:0000255}.
 TOPO_DOM    185    190       Extracellular. {ECO:0000255}.
 TRANSMEM    191    211       Helical; Name=5. {ECO:0000255}.
 TOPO_DOM    212    246       Cytoplasmic. {ECO:0000255}.
 TRANSMEM    247    267       Helical; Name=6. {ECO:0000255}.
 TOPO_DOM    268    281       Extracellular. {ECO:0000255}.
 TRANSMEM    282    302       Helical; Name=7. {ECO:0000255}.
 TOPO_DOM    303    326       Cytoplasmic. {ECO:0000255}.
 LIPID       316    316       S-palmitoyl cysteine. {ECO:0000255}.
 CARBOHYD      2      2       N-linked (GlcNAc...) asparagine.
                              {ECO:0000255}.
 CARBOHYD     15     15       N-linked (GlcNAc...) asparagine.
                              {ECO:0000255}.
 CARBOHYD     94     94       N-linked (GlcNAc...) asparagine.
                              {ECO:0000255}.
 CARBOHYD    108    108       N-linked (GlcNAc...) asparagine.
                              {ECO:0000255}.
 DISULFID     81     81       Interchain. {ECO:0000255|PROSITE-
                              ProRule:PRU00521}.
 CONFLICT     47     47       I -> V (in Ref. 1; AAL85494, 2; AAO24745
                              and 4; AAI63227/AAI63219). {ECO:0000305}.
 SEQUENCE   326 AA;  36435 MW;  40680015C2430C8E CRC64;
 MNTSHHHGLH HSFRNHSQGA LPVGKPSHGD RGSASGCYEQ LLISTEIFLT LGLVSLLENI
 LVIAAIVKNK NLHSPMYFFI CSLAVADLLV SVSNASETVV MALITGGNLT NRESIIKNMD
 NVFDSMICSS LLASIWSLLA IAVDRYITIF YALRYHNIMT QRRAGTIITC IWTFCTVSGV
 LFIVYSESTT VLICLISMFF TMLALMASLY VHMFLLARLH MKRIAALPGN GPIWQAANMK
 GAITITILLG VFVVCWAPFF LHLILMISCP RNPYCVCFMS HFNMYLILIM CNSVIDPLIY
 AFRSQEMRKT FKEICCCWYG LASLCV

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