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Melanocyte-stimulating hormone receptor (MSH-R) (Melanocortin receptor 1) (MC1-R)

 MSHR_MOUSE              Reviewed;         315 AA.
Q01727; Q75NA3;
01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
20-JUN-2018, entry version 145.
RecName: Full=Melanocyte-stimulating hormone receptor;
Short=MSH-R;
AltName: Full=Melanocortin receptor 1;
Short=MC1-R;
Name=Mc1r; Synonyms=Msh-r;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Skin;
PubMed=1325670; DOI=10.1126/science.1325670;
Mountjoy K.G., Robbins L.S., Mortrud M., Cone R.D.;
"The cloning of a family of genes that encode the melanocortin
receptors.";
Science 257:1248-1251(1992).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=MSM/Ms;
PubMed=15653560; DOI=10.1093/jhered/esi022;
Wada A., Kunieda T., Nishimura M., Kakizoe-Ishida Y., Watanabe N.,
Ohkawa K., Tsudzuki M.;
"A nucleotide substitution responsible for the tawny coat color
mutation carried by the MSKR inbred strain of mice.";
J. Hered. 96:145-149(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The
activity of this receptor is mediated by G proteins which activate
adenylate cyclase.
-!- SUBUNIT: Interacts with MGRN1, but does not undergo MGRN1-mediated
ubiquitination; this interaction competes with GNAS-binding and
thus inhibits agonist-induced cAMP production. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Melanocytes and corticoadrenal tissue.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
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EMBL; X65635; CAA46589.1; -; mRNA.
EMBL; AB177607; BAD16659.1; -; Genomic_DNA.
EMBL; AB177608; BAD16660.1; -; Genomic_DNA.
EMBL; AB306322; BAG85190.1; -; Genomic_DNA.
EMBL; CH466525; EDL11741.1; -; Genomic_DNA.
EMBL; BC119294; AAI19295.1; -; mRNA.
EMBL; BC119296; AAI19297.1; -; mRNA.
CCDS; CCDS22756.1; -.
PIR; S25581; S25581.
RefSeq; NP_032585.2; NM_008559.2.
UniGene; Mm.324942; -.
ProteinModelPortal; Q01727; -.
SMR; Q01727; -.
BioGrid; 201338; 1.
STRING; 10090.ENSMUSP00000095929; -.
BindingDB; Q01727; -.
ChEMBL; CHEMBL4077; -.
GuidetoPHARMACOLOGY; 282; -.
PhosphoSitePlus; Q01727; -.
PaxDb; Q01727; -.
PRIDE; Q01727; -.
Ensembl; ENSMUST00000098324; ENSMUSP00000095929; ENSMUSG00000074037.
GeneID; 17199; -.
KEGG; mmu:17199; -.
UCSC; uc009nvs.2; mouse.
CTD; 4157; -.
MGI; MGI:99456; Mc1r.
eggNOG; KOG3656; Eukaryota.
eggNOG; ENOG410XRW9; LUCA.
GeneTree; ENSGT00770000120529; -.
HOGENOM; HOG000246927; -.
HOVERGEN; HBG108148; -.
InParanoid; Q01727; -.
KO; K04199; -.
OMA; LCTIAAD; -.
OrthoDB; EOG091G0BVW; -.
TreeFam; TF332646; -.
Reactome; R-MMU-375276; Peptide ligand-binding receptors.
Reactome; R-MMU-418555; G alpha (s) signalling events.
PRO; PR:Q01727; -.
Proteomes; UP000000589; Chromosome 8.
Bgee; ENSMUSG00000074037; -.
CleanEx; MM_MC1R; -.
ExpressionAtlas; Q01727; baseline and differential.
Genevisible; Q01727; MM.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0005886; C:plasma membrane; ISO:MGI.
GO; GO:0042562; F:hormone binding; ISO:MGI.
GO; GO:0004977; F:melanocortin receptor activity; IDA:BHF-UCL.
GO; GO:0004980; F:melanocyte-stimulating hormone receptor activity; IDA:MGI.
GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:MGI.
GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; ISO:MGI.
GO; GO:0035556; P:intracellular signal transduction; IDA:BHF-UCL.
GO; GO:0042438; P:melanin biosynthetic process; IMP:MGI.
GO; GO:0032720; P:negative regulation of tumor necrosis factor production; ISO:MGI.
GO; GO:0043473; P:pigmentation; IMP:MGI.
GO; GO:2000253; P:positive regulation of feeding behavior; ISO:MGI.
GO; GO:0010739; P:positive regulation of protein kinase A signaling; IDA:BHF-UCL.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IDA:BHF-UCL.
GO; GO:0090037; P:positive regulation of protein kinase C signaling; IDA:BHF-UCL.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:BHF-UCL.
GO; GO:0060259; P:regulation of feeding behavior; ISO:MGI.
GO; GO:0019233; P:sensory perception of pain; IMP:MGI.
GO; GO:0070914; P:UV-damage excision repair; ISO:MGI.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR001671; Melcrt_ACTH_rcpt.
InterPro; IPR000761; MSH_rcpt.
PANTHER; PTHR22750:SF2; PTHR22750:SF2; 1.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00534; MCRFAMILY.
PRINTS; PR00536; MELNOCYTESHR.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; G-protein coupled receptor;
Glycoprotein; Lipoprotein; Membrane; Palmitate; Receptor;
Reference proteome; Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 315 Melanocyte-stimulating hormone receptor.
/FTId=PRO_0000069834.
TOPO_DOM 1 35 Extracellular. {ECO:0000255}.
TRANSMEM 36 61 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 62 70 Cytoplasmic. {ECO:0000255}.
TRANSMEM 71 91 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 92 116 Extracellular. {ECO:0000255}.
TRANSMEM 117 138 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 139 161 Cytoplasmic. {ECO:0000255}.
TRANSMEM 162 181 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 182 189 Extracellular. {ECO:0000255}.
TRANSMEM 190 209 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 210 238 Cytoplasmic. {ECO:0000255}.
TRANSMEM 239 264 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 265 277 Extracellular. {ECO:0000255}.
TRANSMEM 278 298 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 299 315 Cytoplasmic. {ECO:0000255}.
LIPID 313 313 S-palmitoyl cysteine. {ECO:0000255}.
CARBOHYD 17 17 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 27 27 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CONFLICT 101 101 A -> V (in Ref. 1; CAA46589).
{ECO:0000305}.
CONFLICT 216 216 A -> V (in Ref. 1; CAA46589).
{ECO:0000305}.
SEQUENCE 315 AA; 35226 MW; 9240C7D02B336235 CRC64;
MSTQEPQKSL LGSLNSNATS HLGLATNQSE PWCLYVSIPD GLFLSLGLVS LVENVLVVIA
ITKNRNLHSP MYYFICCLAL SDLMVSVSIV LETTIILLLE AGILVARVAL VQQLDNLIDV
LICGSMVSSL CFLGIIAIDR YISIFYALRY HSIVTLPRAR RAVVGIWMVS IVSSTLFITY
YKHTAVLLCL VTFFLAMLAL MAILYAHMFT RACQHAQGIA QLHKRRRSIR QGFCLKGAAT
LTILLGIFFL CWGPFFLHLL LIVLCPQHPT CSCIFKNFNL FLLLIVLSST VDPLIYAFRS
QELRMTLKEV LLCSW


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