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Melanocyte-stimulating hormone receptor (MSH-R) (Melanocortin receptor 1) (MC1-R)

 MSHR_PIG                Reviewed;         320 AA.
Q9TU05; Q2M499; Q2M4A0; Q2M4A3; Q6QZW6; Q9TV86; Q9TV87; Q9TV88;
Q9XS81;
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
21-DEC-2004, sequence version 3.
10-MAY-2017, entry version 87.
RecName: Full=Melanocyte-stimulating hormone receptor;
Short=MSH-R;
AltName: Full=Melanocortin receptor 1;
Short=MC1-R;
Name=MC1R;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS MET-95; PRO-102;
MET-192 AND VAL-213.
STRAIN=Jeju native black; TISSUE=Blood;
Cho I.C., Jung J.K., Jung Y.H., Jeon J.T.;
"The complete sequence of pig (Sus scrofa) MC1R gene.";
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS MET-95; VAL-164 AND
THR-243.
Shi K., Wang A., Li N.;
"Single nucleotide polymorphisms (SNPs) analysis on the extension
(MC1R), the white (KIT) and the agouti (ASIP) loci and their
association with coat color phenotypes of pigs.";
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-313, AND VARIANTS MC1R*1;
MC1R*2; MC1R*3 AND MC1R*4.
PubMed=9799269;
Kijas J.M.H., Wales R., Tornsten A., Chardon P., Moller M.,
Andersson L.;
"Melanocortin receptor 1 (MC1R) mutations and coat color in pigs.";
Genetics 150:1177-1185(1998).
-!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The
activity of this receptor is mediated by G proteins which activate
adenylate cyclase. Plays a role in the regulation of eumelanin
(black/brown) and phaeomelanin (red/yellow) synthesis.
-!- SUBUNIT: Interacts with MGRN1, but does not undergo MGRN1-mediated
ubiquitination; this interaction competes with GNAS-binding and
thus inhibits agonist-induced cAMP production. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- POLYMORPHISM: Variation is correlated with coat color. MC1R*2 is
associated with the black color of European large black and
Chinese meishan pigs. MC1R*3 is associated with the black color in
the hampshire breed. MC1R*4 is found in recessive red animals.
{ECO:0000269|PubMed:9799269}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
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EMBL; AY520823; AAS17973.1; -; Genomic_DNA.
EMBL; AF181964; AAD53963.1; ALT_SEQ; Genomic_DNA.
EMBL; AY916520; AAX18256.1; -; Genomic_DNA.
EMBL; AY916523; AAX18259.1; -; Genomic_DNA.
EMBL; AY916524; AAX18260.1; -; Genomic_DNA.
EMBL; AF082487; AAD14569.1; -; Genomic_DNA.
EMBL; AF082488; AAD14570.1; -; Genomic_DNA.
EMBL; AF082489; AAD14571.1; -; Genomic_DNA.
EMBL; AF082490; AAD14572.1; -; Genomic_DNA.
RefSeq; NP_001008690.1; NM_001008690.1.
UniGene; Ssc.42761; -.
ProteinModelPortal; Q9TU05; -.
SMR; Q9TU05; -.
STRING; 9823.ENSSSCP00000027395; -.
PaxDb; Q9TU05; -.
GeneID; 494018; -.
KEGG; ssc:494018; -.
CTD; 4157; -.
eggNOG; KOG3656; Eukaryota.
eggNOG; ENOG410XRW9; LUCA.
HOVERGEN; HBG108148; -.
InParanoid; Q9TU05; -.
KO; K04199; -.
Proteomes; UP000008227; Unplaced.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0004980; F:melanocyte-stimulating hormone receptor activity; IEA:InterPro.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR001671; Melcrt_ACTH_rcpt.
InterPro; IPR000761; MSH_rcpt.
PANTHER; PTHR22750:SF70; PTHR22750:SF70; 1.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00534; MCRFAMILY.
PRINTS; PR00536; MELNOCYTESHR.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
3: Inferred from homology;
Cell membrane; Complete proteome; G-protein coupled receptor;
Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome;
Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 320 Melanocyte-stimulating hormone receptor.
/FTId=PRO_0000069840.
TOPO_DOM 1 40 Extracellular. {ECO:0000255}.
TRANSMEM 41 66 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 67 75 Cytoplasmic. {ECO:0000255}.
TRANSMEM 76 96 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 97 121 Extracellular. {ECO:0000255}.
TRANSMEM 122 143 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 144 166 Cytoplasmic. {ECO:0000255}.
TRANSMEM 167 186 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 187 194 Extracellular. {ECO:0000255}.
TRANSMEM 195 214 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 215 243 Cytoplasmic. {ECO:0000255}.
TRANSMEM 244 269 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 270 282 Extracellular. {ECO:0000255}.
TRANSMEM 283 303 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 304 320 Cytoplasmic. {ECO:0000255}.
CARBOHYD 32 32 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VARIANT 95 95 V -> M (in allele MC1R*2 and strain Jeju
native black). {ECO:0000269|Ref.1,
ECO:0000269|Ref.2}.
VARIANT 102 102 L -> P (in allele MC1R*2 and strain Jeju
native black; may form a constitutively
active receptor). {ECO:0000269|Ref.1}.
VARIANT 124 124 D -> N (in allele MC1R*3).
VARIANT 164 164 A -> V (in allele MC1R*4).
{ECO:0000269|Ref.2}.
VARIANT 192 192 L -> M (in strain: Jeju native black).
{ECO:0000269|Ref.1}.
VARIANT 213 213 M -> V (in strain: Jeju native black).
{ECO:0000269|Ref.1}.
VARIANT 243 243 A -> T (in allele MC1R*4).
{ECO:0000269|Ref.2}.
SEQUENCE 320 AA; 34592 MW; 90D6B380078739FA CRC64;
MPVLGPERRL LASLSSAPPA APRLGLAANQ TNQTGPQCLE VSIPDGLFLS LGLVSLVENV
LVVAAIAKNR NLHSPMYYFV CCLAVSDLLV SVSNVLETAV LLLLEAGALA AQAAVVQQLD
NVMDVLICGS MVSSLCFLGA IAVDRYVSIF YALRYHSIVT LPRAGRAIAA IWAGSVLSST
LFIAYYHHTA VLLGLVSFFV AMLALMAVLY VHMLARACQH GRHIARLHKT QHPTRQGCGL
KGAATLTILL GVFLLCWAPF FLHLSLVVLC PQHPTCGCVF KNVNLFLALV ICNSIVDPLI
YAFRSQELRK TLQEVLQCSW


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