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Melanoma-associated antigen 1 (Antigen MZ2-E) (Cancer/testis antigen 1.1) (CT1.1) (MAGE-1 antigen)

 MAGA1_HUMAN             Reviewed;         309 AA.
P43355; B2RC81; O00346;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
18-JUL-2018, entry version 156.
RecName: Full=Melanoma-associated antigen 1;
AltName: Full=Antigen MZ2-E;
AltName: Full=Cancer/testis antigen 1.1;
Short=CT1.1;
AltName: Full=MAGE-1 antigen;
Name=MAGEA1; Synonyms=MAGE1, MAGE1A;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1840703; DOI=10.1126/science.1840703;
van der Bruggen P., Traversari C., Chomez P., Lurquin C., De Plaen E.,
van den Eynde B., Knuth A., Boon T.;
"A gene encoding an antigen recognized by cytolytic T lymphocytes on a
human melanoma.";
Science 254:1643-1647(1991).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Skin;
PubMed=8037761; DOI=10.1006/bbrc.1994.1963;
Ding M., Beck R.J., Keller C.J., Fenton R.G.;
"Cloning and analysis of MAGE-1-related genes.";
Biochem. Biophys. Res. Commun. 202:549-555(1994).
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ALA-32.
PubMed=15059299;
Wang L.P., Chen H.S., Mei M.H., Qin L.L., Cong X., Fei R., Xu J.,
Wei L.;
"The genetic polymorphism of melanoma-associated antigen 1 in Chinese
normal donors and hepatoma patients.";
Zhonghua Gan Zang Bing Za Zhi 12:151-155(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-32.
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor
vector.";
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=10854409; DOI=10.1101/gr.10.6.758;
Mallon A.-M., Platzer M., Bate R., Gloeckner G., Botcherby M.R.M.,
Nordsiek G., Strivens M.A., Kioschis P., Dangel A., Cunningham D.,
Straw R.N.A., Weston P., Gilbert M., Fernando S., Goodall K.,
Hunter G., Greystrong J.S., Clarke D., Kimberley C., Goerdes M.,
Blechschmidt K., Rump A., Hinzmann B., Mundy C.R., Miller W.,
Poustka A., Herman G.E., Rhodes M., Denny P., Rosenthal A.,
Brown S.D.M.;
"Comparative genome sequence analysis of the Bpa/Str region in mouse
and man.";
Genome Res. 10:758-775(2000).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15772651; DOI=10.1038/nature03440;
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A.,
Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G.,
Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S.,
Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R.,
Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L.,
Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A.,
Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S.,
Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R.,
Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M.,
Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N.,
Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D.,
Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W.,
Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C.,
Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C.,
Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
Corby N., Connor R.E., David R., Davies J., Davis C., Davis J.,
Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S.,
Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I.,
Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L.,
Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P.,
Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S.,
Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A.,
Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J.,
Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J.,
Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S.,
de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z.,
Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C.,
Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W.,
Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T.,
Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I.,
Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N.,
Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J.,
Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E.,
Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S.,
Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T.,
Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S.,
Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L.,
Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A.,
Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L.,
Williams G., Williams L., Williamson A., Williamson H., Wilming L.,
Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H.,
Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A.,
Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A.,
Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T.,
Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence of the human X chromosome.";
Nature 434:325-337(2005).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-32.
TISSUE=Skin;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[10]
MUTAGENESIS.
TISSUE=Blood;
PubMed=8113684; DOI=10.1084/jem.179.3.921;
Gaugler B., van den Eynde B., van der Bruggen P., Romero P.,
Gaforio J.J., De Plaen E., Lethe B.G., Brasseur F., Boon T.;
"Human gene MAGE-3 codes for an antigen recognized on a melanoma by
autologous cytolytic T lymphocytes.";
J. Exp. Med. 179:921-930(1994).
[11]
SUBCELLULAR LOCATION.
PubMed=7927954; DOI=10.1002/ijc.2910590324;
Schultz-Thater E., Juretic A., Dellabona P., Luscher U., Siegrist W.,
Harder F., Heberer M., Zuber M., Spagnoli G.C.;
"MAGE-1 gene product is a cytoplasmic protein.";
Int. J. Cancer 59:435-439(1994).
[12]
FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH SNW1 AND HDCA1.
PubMed=15316101; DOI=10.1093/nar/gkh735;
Laduron S., Deplus R., Zhou S., Kholmanskikh O., Godelaine D.,
De Smet C., Hayward S.D., Fuks F., Boon T., De Plaen E.;
"MAGE-A1 interacts with adaptor SKIP and the deacetylase HDAC1 to
repress transcription.";
Nucleic Acids Res. 32:4340-4350(2004).
[13]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=20068231; DOI=10.1126/scisignal.2000475;
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
Mann M.;
"Quantitative phosphoproteomics reveals widespread full
phosphorylation site occupancy during mitosis.";
Sci. Signal. 3:RA3-RA3(2010).
[14]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[15]
X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 161-169 IN COMPLEX WITH HLA
CLASS I HISTOCOMPATIBILITY COMPLEX.
PubMed=15537658; DOI=10.1074/jbc.M411323200;
Hulsmeyer M., Chames P., Hillig R.C., Stanfield R.L., Held G.,
Coulie P.G., Alings C., Wille G., Saenger W., Uchanska-Ziegler B.,
Hoogenboom H.R., Ziegler A.;
"A major histocompatibility complex-peptide-restricted antibody and t
cell receptor molecules recognize their target by distinct binding
modes: crystal structure of human leukocyte antigen (HLA)-A1-MAGE-A1
in complex with FAB-HYB3.";
J. Biol. Chem. 280:2972-2980(2005).
[16]
X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 161-169 IN COMPLEX WITH HLA
CLASS I HISTOCOMPATIBILITY COMPLEX.
PubMed=19177349; DOI=10.1002/pro.4;
Kumar P., Vahedi-Faridi A., Saenger W., Ziegler A.,
Uchanska-Ziegler B.;
"Conformational changes within the HLA-A1:MAGE-A1 complex induced by
binding of a recombinant antibody fragment with TCR-like
specificity.";
Protein Sci. 18:37-49(2009).
[17]
VARIANT [LARGE SCALE ANALYSIS] THR-278.
PubMed=16959974; DOI=10.1126/science.1133427;
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal
cancers.";
Science 314:268-274(2006).
-!- FUNCTION: May be involved in transcriptional regulation through
interaction with SNW1 and recruiting histone deactelyase HDAC1.
May inhibit notch intracellular domain (NICD) transactivation. May
play a role in embryonal development and tumor transformation or
aspects of tumor progression. Antigen recognized on a melanoma by
autologous cytolytic T-lymphocytes. {ECO:0000269|PubMed:15316101}.
-!- SUBUNIT: Interacts with SNW1 and HDCA1.
{ECO:0000269|PubMed:15316101, ECO:0000269|PubMed:15537658,
ECO:0000269|PubMed:19177349}.
-!- INTERACTION:
P00431:CCP1 (xeno); NbExp=4; IntAct=EBI-740978, EBI-4389;
Q8IYX8-2:CEP57L1; NbExp=3; IntAct=EBI-740978, EBI-10181988;
Q8N140:EID3; NbExp=3; IntAct=EBI-740978, EBI-744483;
Q13547:HDAC1; NbExp=2; IntAct=EBI-740978, EBI-301834;
Q9NX55:HYPK; NbExp=3; IntAct=EBI-740978, EBI-1048743;
Q9NQG6:MIEF1; NbExp=6; IntAct=EBI-740978, EBI-740987;
P53102:MND1 (xeno); NbExp=3; IntAct=EBI-740978, EBI-24091;
Q5JS98:PBX3; NbExp=3; IntAct=EBI-740978, EBI-10244393;
P28004:PRP45 (xeno); NbExp=3; IntAct=EBI-740978, EBI-20640;
Q9H0T7:RAB17; NbExp=3; IntAct=EBI-740978, EBI-721615;
P53140:RMD9 (xeno); NbExp=3; IntAct=EBI-740978, EBI-23904;
Q9NUL5:RYDEN; NbExp=3; IntAct=EBI-740978, EBI-10313866;
A0A0C4DFY0:SELPLG; NbExp=6; IntAct=EBI-740978, EBI-10209116;
P31947:SFN; NbExp=3; IntAct=EBI-740978, EBI-476295;
Q9NR46:SH3GLB2; NbExp=3; IntAct=EBI-740978, EBI-749607;
Q03782:SNU56 (xeno); NbExp=3; IntAct=EBI-740978, EBI-627;
Q13573:SNW1; NbExp=3; IntAct=EBI-740978, EBI-632715;
Q2L6J1:TRIM31; NbExp=3; IntAct=EBI-740978, EBI-10239267;
Q9BZY9:TRIM31; NbExp=4; IntAct=EBI-740978, EBI-747544;
P17255:VMA1 (xeno); NbExp=4; IntAct=EBI-740978, EBI-20245;
Q8TBZ8:ZNF564; NbExp=3; IntAct=EBI-740978, EBI-10273713;
-!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
-!- TISSUE SPECIFICITY: Expressed in many tumors of several types,
such as melanoma, head and neck squamous cell carcinoma, lung
carcinoma and breast carcinoma, but not in normal tissues except
for testes. Never expressed in kidney tumors, leukemias and
lymphomas.
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EMBL; M77481; AAA03229.1; -; Genomic_DNA.
EMBL; AY148486; AAN62752.1; -; mRNA.
EMBL; BT009789; AAP88791.1; -; mRNA.
EMBL; AK314979; BAG37478.1; -; mRNA.
EMBL; U82670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471172; EAW72885.1; -; Genomic_DNA.
EMBL; BC017555; AAH17555.1; -; mRNA.
CCDS; CCDS76051.1; -.
PIR; JC2358; JC2358.
RefSeq; NP_004979.3; NM_004988.4.
UniGene; Hs.72879; -.
PDB; 1W72; X-ray; 2.15 A; C/F=161-169.
PDB; 3BO8; X-ray; 1.80 A; C=161-169.
PDBsum; 1W72; -.
PDBsum; 3BO8; -.
ProteinModelPortal; P43355; -.
SMR; P43355; -.
BioGrid; 110274; 92.
CORUM; P43355; -.
DIP; DIP-54794N; -.
IntAct; P43355; 47.
MINT; P43355; -.
STRING; 9606.ENSP00000349085; -.
iPTMnet; P43355; -.
PhosphoSitePlus; P43355; -.
BioMuta; MAGEA1; -.
DMDM; 1170855; -.
EPD; P43355; -.
MaxQB; P43355; -.
PaxDb; P43355; -.
PeptideAtlas; P43355; -.
PRIDE; P43355; -.
ProteomicsDB; 55617; -.
DNASU; 4100; -.
Ensembl; ENST00000356661; ENSP00000349085; ENSG00000198681.
GeneID; 4100; -.
KEGG; hsa:4100; -.
UCSC; uc004fhf.3; human.
CTD; 4100; -.
DisGeNET; 4100; -.
EuPathDB; HostDB:ENSG00000198681.6; -.
GeneCards; MAGEA1; -.
H-InvDB; HIX0017126; -.
HGNC; HGNC:6796; MAGEA1.
HPA; CAB002620; -.
MIM; 300016; gene.
neXtProt; NX_P43355; -.
OpenTargets; ENSG00000198681; -.
PharmGKB; PA30542; -.
eggNOG; KOG4562; Eukaryota.
eggNOG; ENOG4111S70; LUCA.
GeneTree; ENSGT00760000118824; -.
HOGENOM; HOG000231161; -.
HOVERGEN; HBG006315; -.
InParanoid; P43355; -.
OMA; VRFFFPS; -.
OrthoDB; EOG091G0TJ0; -.
PhylomeDB; P43355; -.
TreeFam; TF328505; -.
EvolutionaryTrace; P43355; -.
GeneWiki; MAGEA1; -.
GenomeRNAi; 4100; -.
PRO; PR:P43355; -.
Proteomes; UP000005640; Chromosome X.
Bgee; ENSG00000198681; -.
CleanEx; HS_MAGEA1; -.
Genevisible; P43355; HS.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0005886; C:plasma membrane; TAS:ProtInc.
GO; GO:0042826; F:histone deacetylase binding; IDA:UniProtKB.
GO; GO:0045746; P:negative regulation of Notch signaling pathway; IDA:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR037445; MAGE.
InterPro; IPR021072; MAGE_N.
InterPro; IPR030093; MAGEA1.
InterPro; IPR002190; MHD_dom.
PANTHER; PTHR11736; PTHR11736; 1.
PANTHER; PTHR11736:SF49; PTHR11736:SF49; 1.
Pfam; PF01454; MAGE; 1.
Pfam; PF12440; MAGE_N; 1.
SMART; SM01373; MAGE; 1.
SMART; SM01392; MAGE_N; 1.
PROSITE; PS50838; MAGE; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein;
Polymorphism; Reference proteome; Transcription;
Transcription regulation; Tumor antigen.
CHAIN 1 309 Melanoma-associated antigen 1.
/FTId=PRO_0000156701.
DOMAIN 102 301 MAGE. {ECO:0000255|PROSITE-
ProRule:PRU00127}.
COMPBIAS 33 36 Poly-Ser.
MOD_RES 57 57 Phosphoserine.
{ECO:0000244|PubMed:20068231}.
VARIANT 32 32 T -> A (probable polymorphism;
dbSNP:rs2008160).
{ECO:0000269|PubMed:15059299,
ECO:0000269|PubMed:15489334,
ECO:0000269|Ref.4}.
/FTId=VAR_004283.
VARIANT 63 63 A -> T (in dbSNP:rs2233044).
/FTId=VAR_053491.
VARIANT 72 72 R -> Q (in dbSNP:rs2008144).
/FTId=VAR_011737.
VARIANT 278 278 K -> T (in a breast cancer sample;
somatic mutation).
{ECO:0000269|PubMed:16959974}.
/FTId=VAR_036581.
MUTAGEN 163 163 D->A: Abolishes HLA-A1 binding.
{ECO:0000269|PubMed:8113684}.
MUTAGEN 169 169 Y->A: Abolishes HLA-A1 binding.
{ECO:0000269|PubMed:8113684}.
SEQUENCE 309 AA; 34342 MW; 544EEB1F9F4E9D33 CRC64;
MSLEQRSLHC KPEEALEAQQ EALGLVCVQA ATSSSSPLVL GTLEEVPTAG STDPPQSPQG
ASAFPTTINF TRQRQPSEGS SSREEEGPST SCILESLFRA VITKKVADLV GFLLLKYRAR
EPVTKAEMLE SVIKNYKHCF PEIFGKASES LQLVFGIDVK EADPTGHSYV LVTCLGLSYD
GLLGDNQIMP KTGFLIIVLV MIAMEGGHAP EEEIWEELSV MEVYDGREHS AYGEPRKLLT
QDLVQEKYLE YRQVPDSDPA RYEFLWGPRA LAETSYVKVL EYVIKVSARV RFFFPSLREA
ALREEEEGV


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