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Melatonin receptor type 1B-B (Mel-1B-R-B) (Mel1b receptor B) (Melatonin receptor Mel1b Z2.6-4) (zMel1b-1)

 MR1BB_DANRE             Reviewed;         347 AA.
P51049; Q5RGH4; Q804I8;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-JUL-2008, sequence version 2.
20-JUN-2018, entry version 126.
RecName: Full=Melatonin receptor type 1B-B;
Short=Mel-1B-R-B;
Short=Mel1b receptor B;
AltName: Full=Melatonin receptor Mel1b Z2.6-4;
AltName: Full=zMel1b-1;
Name=mtnr1bb; Synonyms=mel1br, mtnr1br, mtnr1br-2;
ORFNames=si:ch211-214k5.4, si:ch211-224h1.2;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen;
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G.,
Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B.,
Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S.,
Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C.,
Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H.,
Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C.,
Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
Humphries M., Sycamore N., Barker D., Saunders D., Wallis J.,
Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S.,
Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R.,
Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R.,
Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R.,
Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A.,
Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S.,
Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J.,
Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the
human genome.";
Nature 496:498-503(2013).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-233.
Danilova N.P.;
"Zebrafish melatonin receptors.";
Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 134-286.
PubMed=7576645; DOI=10.1016/0896-6273(95)90090-X;
Reppert S.M., Weaver D.R., Cassone V.M., Godson C.,
Kolakowski L.F. Jr.;
"Melatonin receptors are for the birds: molecular analysis of two
receptor subtypes differentially expressed in chick brain.";
Neuron 15:1003-1015(1995).
[4]
INDUCTION.
PubMed=17622340; DOI=10.1371/journal.pone.0000587;
Shang E.H., Zhdanova I.V.;
"The circadian system is a target and modulator of prenatal cocaine
effects.";
PLoS ONE 2:E587-E587(2007).
-!- FUNCTION: High affinity receptor for melatonin. The activity of
this receptor is mediated by pertussis toxin sensitive G proteins
that inhibits adenylate cyclase activity (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- INDUCTION: By cocaine, which increases the levels of day-time
expression. {ECO:0000269|PubMed:17622340}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-----------------------------------------------------------------------
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EMBL; BX897671; CAI11795.1; -; Genomic_DNA.
EMBL; CR933018; CAM14076.1; -; Genomic_DNA.
EMBL; AY166826; AAO23297.1; -; mRNA.
EMBL; U31824; AAA92496.1; -; mRNA.
RefSeq; NP_571469.1; NM_131394.1.
UniGene; Dr.83649; -.
ProteinModelPortal; P51049; -.
SMR; P51049; -.
STRING; 7955.ENSDARP00000107818; -.
PaxDb; P51049; -.
Ensembl; ENSDART00000078226; ENSDARP00000072688; ENSDARG00000086493.
Ensembl; ENSDART00000181941; ENSDARP00000147236; ENSDARG00000086493.
GeneID; 30668; -.
KEGG; dre:30668; -.
CTD; 30668; -.
ZFIN; ZDB-GENE-990415-156; mtnr1bb.
eggNOG; ENOG410IHFY; Eukaryota.
eggNOG; ENOG4111ZZV; LUCA.
GeneTree; ENSGT00440000033318; -.
HOGENOM; HOG000037953; -.
HOVERGEN; HBG052528; -.
InParanoid; P51049; -.
KO; K04286; -.
OMA; EVHCKAS; -.
OrthoDB; EOG091G0GO0; -.
PhylomeDB; P51049; -.
TreeFam; TF331693; -.
Reactome; R-DRE-373076; Class A/1 (Rhodopsin-like receptors).
Reactome; R-DRE-418594; G alpha (i) signalling events.
PRO; PR:P51049; -.
Proteomes; UP000000437; Chromosome 10.
Bgee; ENSDARG00000086493; -.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0008502; F:melatonin receptor activity; IEA:InterPro.
GO; GO:0007623; P:circadian rhythm; IBA:GO_Central.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR002278; Mel_1A/1B_rcpt.
InterPro; IPR027459; Mel_rcpt_1.
InterPro; IPR000025; Melatonin_rcpt.
PANTHER; PTHR43962; PTHR43962; 1.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR01149; MELATONIN1AR.
PRINTS; PR00857; MELATONINR.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Biological rhythms; Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
Reference proteome; Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 347 Melatonin receptor type 1B-B.
/FTId=PRO_0000069745.
TOPO_DOM 1 36 Extracellular. {ECO:0000255}.
TRANSMEM 37 57 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 58 72 Cytoplasmic. {ECO:0000255}.
TRANSMEM 73 93 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 94 105 Extracellular. {ECO:0000255}.
TRANSMEM 106 126 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 127 148 Cytoplasmic. {ECO:0000255}.
TRANSMEM 149 169 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 170 191 Extracellular. {ECO:0000255}.
TRANSMEM 192 212 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 213 244 Cytoplasmic. {ECO:0000255}.
TRANSMEM 245 265 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 266 278 Extracellular. {ECO:0000255}.
TRANSMEM 279 299 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 300 347 Cytoplasmic. {ECO:0000255}.
CARBOHYD 10 10 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 104 181 {ECO:0000255|PROSITE-ProRule:PRU00521}.
CONFLICT 25 25 A -> P (in Ref. 2; AAO23297).
{ECO:0000305}.
CONFLICT 63 63 R -> K (in Ref. 2; AAO23297).
{ECO:0000305}.
CONFLICT 143 143 Y -> C (in Ref. 3; AAA92496).
{ECO:0000305}.
SEQUENCE 347 AA; 38979 MW; 5BB93B61AE83D563 CRC64;
MPENIAFLTN STDLGHVGRA LGSSARPAWA IAVLASVLIF TTVVDVLGNL LVIISVFRNR
KLRNAGNVFV VSLAFADLVV AFYPYPLVLY AIFHDGWSLG ETQCKISGFL MGLSVIGSVF
NITGIAINRY CYICHSFAYG RLYSFRNTLL LVALIWALTV LAILPNFFVG SLSYDPRVYS
CTFTQTASSS YTVVVVVVHF LVPIAVVTFC YLRIWVLVIQ VRRKVKSEER SRVRPSDLRN
FVTMFVVFVL FAICWAPLNL IGLVVAINPE VMAPRVPEWL FVVSYFMAYF NSCLNAIIYG
LLNRNFRKEY VRIMTAVWIP RRFVTETSRA ATDGMRSKPS PAINNNE


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