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Melittin

 MEL_APIFL               Reviewed;          26 AA.
P01504;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
21-JUL-1986, sequence version 1.
23-MAY-2018, entry version 94.
RecName: Full=Melittin;
Name=MELT;
Apis florea (Dwarf honeybee).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Hymenoptera; Apocrita; Aculeata;
Apoidea; Apidae; Apis.
NCBI_TaxID=7463;
[1]
PROTEIN SEQUENCE, AND AMIDATION AT GLN-26.
Kreil G.;
"Structure of melittin isolated from two species of honey bees.";
FEBS Lett. 33:241-244(1973).
-!- FUNCTION: Main toxin of bee venom with strong hemolytic activity.
Integrates into cell membranes and has multiple effects, probably,
as a result of its interaction with negatively charged
phospholipids. It inhibits well known transport pumps such as the
Na(+)-K(+)-ATPase and the H(+)-K(+)-ATPase. Increases the
permeability of cell membranes to ions, particularly Na(+) and
indirectly Ca(2+), because of the Na(+)-Ca(2+)-exchange.
-!- SUBUNIT: Monomer and homotetramer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted. Target cell membrane
{ECO:0000250}. Note=Forms a transmembrane alpha-helix in the
target cell membrane. Forms a membrane channel in the prey (By
similarity). {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
-!- SIMILARITY: Belongs to the melittin family. {ECO:0000305}.
-!- WEB RESOURCE: Name=Protein Spotlight; Note=Why Pooh luvvs hunny
- Issue 12 of July 2001;
URL="https://web.expasy.org/spotlight/back_issues/012";
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PIR; A01765; MEHBCF.
ProteinModelPortal; P01504; -.
SMR; P01504; -.
TCDB; 1.C.18.1.2; the melittin (melittin) family.
PRIDE; P01504; -.
PMAP-CutDB; P01504; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0044218; C:other organism cell membrane; IEA:UniProtKB-SubCell.
GO; GO:0004860; F:protein kinase inhibitor activity; IEA:InterPro.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
GO; GO:0044179; P:hemolysis in other organism; IEA:UniProtKB-KW.
GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
InterPro; IPR002116; Melittin/Api_allergen.
Pfam; PF01372; Melittin; 1.
ProDom; PD014636; Melittin/Api_allergen; 1.
1: Evidence at protein level;
Amidation; Cytolysis; Direct protein sequencing; Hemolysis;
Ion transport; Membrane; Secreted; Target cell membrane;
Target membrane; Toxin; Transmembrane; Transport.
PEPTIDE 1 26 Melittin.
/FTId=PRO_0000044532.
MOD_RES 26 26 Glutamine amide. {ECO:0000269|Ref.1}.
SEQUENCE 26 AA; 2819 MW; F20E8F82400EF01C CRC64;
GIGAILKVLA TGLPTLISWI KNKRKQ


Related products :

Catalog number Product name Quantity
SP-5090-1 Peptides: Melittin Melittin 1 mg
SP-5090-5 Peptides: Melittin Melittin 5 mg
C-1203 Cecropin A (1-7)-Melittin A (2-9) amide CAMEL0, Cecropin A (1-8)-Melittin A (3-9) amide, CM15 98 percent C89H152N22O15 CAS: 157606-25-2 5mg
20499-79-0 Melittin Melittin 1g
orb71767 Melittin peptide This is Melittin peptide. For research use only. 1 mg
orb71502 Cecropin A (1-8)-Melittin (1-18) peptide This is Cecropin A (1-8)-Melittin (1-18) peptide. For research use only. 1 mg
orb71501 Cecropin A (1-7)-Melittin A (2-9) peptide This is Cecropin A (1-7)-Melittin A (2-9) peptide. For research use only. 1 mg
37231-28-0 Melittin about 85 percent Melittin about 85 percent 1g
SP2730b Melittin
SP2730a Melittin 0.5 mg
SP2730b Melittin 1 mg
06-271-83333 Melittin - 0.5 mg
SP2730a Melittin 2
TXL8403-1 Melittin 1 mg.
SP2730b Melittin 1.0 mg
SP2730a Melittin 0.5 mg
TXL8403-5 Melittin 5x1 mg.
AF3202 MELITTIN 1 mg
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06-271-83333 Melittin - 1 mg
RP20415 Melittin,honey bee 3 x 1,0mg
AF3202 MELITTIN CAS №: 20449-79-0 1 mg
RP20415 Melittin,honey bee 1mg


 

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